☆ 4.8 Review

Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Nutrition & Dietetics

Probiotic Bifidobacterium lactis Probio-M8 treated and prevented acute RTI, reduced antibiotic use and hospital stay in hospitalized young children: a randomized, double-blind, placebo-controlled study

Mageswaran Uma Mageswary et al.

Summary: The development of probiotics has shown significant growth with health benefits expanding from gut health to respiratory functions. In this study, Bifidobacterium lactis Probio-M8 was found to reduce symptoms of respiratory tract infections, decrease antibiotic use, shorten hospitalization period, and modulate inflammatory cytokines in hospitalized young children, making it a potential natural and non-drug strategy for managing RTIs in a safe manner.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Chemistry, Applied

Preparation and characterization of quinoa starch nanoparticles as quercetin carriers

Fan Jiang et al.

Summary: Quinoa starch nanoparticles (QSNPs) prepared under optimal conditions as a carrier for quercetin showed smaller particle size and higher loading capacity compared to maize starch nanoparticles (MSNPs), resulting in more effective protection and prolongation of quercetin bioactivity.

FOOD CHEMISTRY (2022)

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Article Chemistry, Applied

Multi-layer PLGA-pullulan-PLGA electrospun nanofibers for probiotic delivery

Fatemeh Ajalloueian et al.

Summary: In this study, encapsulation of the probiotic strain Lactobacillus rhamnosus GG (LGG) into electrospun pullulan nanofibers with PLGA layers showed enhanced viability and successful delivery in vitro and in vivo. The multilayer construct provided increased protection and potential mucoadhesion properties, demonstrating potential for commercial interest in protecting sensitive probiotics from oxygen and gastric conditions.

FOOD HYDROCOLLOIDS (2022)

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Article Food Science & Technology

Effect of sub-lethal heat stress on viability of Lacticaseibacillus casei N in spray-dried powders

Jyothna Bommasamudram et al.

Summary: The study found that sub-lethal heat stress before spray drying increases the viability and adaptation of probiotic cultures. Corn starch is an ideal encapsulating agent that can maximize the protection of probiotics. Probiotic powders subjected to heat stress show better survivability during storage.

LWT-FOOD SCIENCE AND TECHNOLOGY (2022)

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Review Gastroenterology & Hepatology

Foundations of gastrointestinal-based drug delivery and future developments

Jacqueline N. Chu et al.

Summary: Gastrointestinal-based drug delivery is preferred for its convenience and improved patient adherence, but absorption of drugs is limited by unique characteristics of the gastrointestinal tract, particularly for biologics. Overcoming challenges and considering unique features of each gastrointestinal compartment are essential for successful drug formulation. Emerging technologies aim to address remaining obstacles in gastrointestinal-based drug delivery.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Biochemistry & Molecular Biology

Oil bodies extracted from high-oil soybeans (Glycine max) exhibited higher oxidative and physical stability than oil bodies from high-protein soybeans

Xuan Zhou et al.

Summary: This study compared the characteristics of soybean oil bodies (SOBs) extracted from high-protein and high-oil genotypes of soybeans. The results showed that SOBs from high-protein soybeans were more easily oxidized and prone to coalescence during storage, while SOBs from high-oil soybeans exhibited superior physicochemical stability, making them more suitable for OB-based product manufacturing.

FOOD & FUNCTION (2022)

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Article Chemistry, Multidisciplinary

Cell-Mediated Biointerfacial Phenolic Assembly for Probiotic Nano Encapsulation

Franco Centurion et al.

Summary: The concept of a cell-mediated catalytic process for forming protective nano-shells on probiotic cells is demonstrated. This method leverages the cell environment to induce the oxidation of phenolic compounds and assemble them into nano-coatings around the cell surfaces. The coated probiotic cells show improved gastric tolerance, enhanced adhesion, and high antioxidant activity.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Applied

Polyelectrolytes-stabilized liposomes for efficient encapsulation of Lactobacillus rhamnosus and improvement of its survivability under adverse conditions

Seyed Fakhreddin Hosseini et al.

Summary: In this study, nanoliposomes coated with chitosan-gelatin polyelectrolytes were successfully synthesized and characterized to improve the survivability of Lactobacillus rhamnosus probiotics, showing increased stability in simulated gastrointestinal fluids. This system may have potential applications as a carrier of probiotic cells in functional food development.

FOOD CHEMISTRY (2022)

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Article Chemistry, Applied

Preparation of pectin-based nanofibers encapsulating Lactobacillus rhamnosus 1.0320 by electrospinning

Cong Xu et al.

Summary: Pectin-based nanofibers were successfully prepared by electrospinning for the first time to encapsulate probiotics. The PVA/PEC nanofibers showed good thermal stability and had potential applications in probiotic preservation. The viability of Lactobacillus rhamnosus 1.0320 encapsulated by electrospinning was highest when the PVA:PEC ratio was 9:1, with a survival rate of 89.26%, even after storage at 4 degrees C for 21 days.

FOOD HYDROCOLLOIDS (2022)

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Article Agriculture, Multidisciplinary

Lactobacillus paracasei 24 Attenuates Lipid Accumulation in HighFat Diet-Induced Obese Mice by Regulating the Gut Microbiota

Zhijing Liu et al.

Summary: This study demonstrates that Lactobacillus paracasei 24 (LP24) can alleviate lipid accumulation in an obese mouse model induced by a high-fat diet. The alleviating effect is achieved through improving blood lipid levels and liver health by regulating the gut microbiota.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Multidisciplinary Sciences

A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea

Jiezhou Pan et al.

Summary: The authors developed a polyphenol-based nanoarmor coating that protects probiotics from antibiotics and enhances their effectiveness against antibiotic-mediated diarrhea. The nanoarmor absorbs antibiotic molecules and allows the bacteria to colonize in the gastrointestinal tract, reducing diarrhea and inflammation caused by antibiotics.

NATURE COMMUNICATIONS (2022)

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Article Food Science & Technology

Effects of Soybean Oil Body as a Milk Fat Substitute on Ice Cream: Physicochemical, Sensory and Digestive Properties

Wan Wang et al.

Summary: This study investigated the use of soybean oil body (SOB) as a milk fat substitute in ice cream. The results showed that SOB substitution increased the stability of ice cream and improved its texture characteristics. It also had potential health benefits due to the increased unsaturated fatty acid content. Therefore, SOB could be an effective way to improve the nutritional value and quality of dairy products.

FOODS (2022)

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Review Biophysics

Cell membrane-based biomimetic nanosystems for advanced drug delivery in cancer therapy: A comprehensive review

Jianing Zhao et al.

Summary: Cell membrane-based DDSs are promising drug delivery systems for cancer therapy, which can enhance delivery efficiency by combining different cell membrane sources and artificial nanocarriers. This review presents the recent advances in CDDSs and their functional mechanisms. A future perspective highlights the limitations of CDDSs and possible resolutions.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Chemistry, Applied

Relationships between the behavior of three different sources of pectin at the oil-water interface and the stability of the emulsion

Hui Niu et al.

Summary: In this study, the structural characterization and chemical compositions of three different pectins were studied. The results showed that sugar beet pectin (SBP) had higher protein contents, feruloylated groups, acetyl groups, and more hairy regions compared to apple pectin (AP) and citrus peel pectin (CPP). Molecular dynamics simulations revealed that the SBP formed a thick viscoelastic film on the oil-water interface. Further studies showed that under high-concentration and acidic conditions, pectin molecules were adsorbed in multiple layers at the oil-water interface, forming a thicker viscoelastic film, which was crucial for the long-term stability of pectin-stabilized emulsions.

FOOD HYDROCOLLOIDS (2022)

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Article Biochemistry & Molecular Biology

Lactobacillus plantarum 23-1 improves intestinal inflammation and barrier function through the TLR4/NF-κB signaling pathway in obese mice

Zhijing Liu et al.

Summary: This study found that lactic acid bacteria LP23-1 can significantly reduce body weight and fat accumulation, improve liver and intestinal damage, and repair intestinal mucosa by regulating lipid metabolism, inhibiting inflammatory response, and enhancing intestinal barrier function. These results reveal the importance of LP23-1 in reducing obesity and developing new functional foods.

FOOD & FUNCTION (2022)

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Article Geriatrics & Gerontology

Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

Chong-Su Kim et al.

Summary: A study on older adults found that probiotics can improve mental flexibility and reduce stress, while also causing changes in gut microbiota.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Food Science & Technology

Purification and antimicrobial mechanism of a novel bacteriocin produced by Lactobacillus rhamnosus 1.0320

Cong Xu et al.

Summary: Bacteriocins produced by lactic acid bacteria have antimicrobial activity against both gram-positive and gram-negative bacteria, causing cell death by increasing cell membrane permeability and disrupting cell membrane integrity.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Immobilization of vaginal Lactobacillus in polymeric nanofibers for its incorporation in vaginal probiotic products

Jessica Alejandra Silva et al.

Summary: This study evaluated the survival of Lactobacillus gasseri and Lactobacillus rhamnosus immobilized in nanofibers, finding that L. rhamnosus had a higher survival rate than L. gasseri. Oxygen-excluding packaging was shown to be an effective strategy to extend the shelf-life of L. rhamnosus in nanofibers.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Review Food Science & Technology

Promising strategies to control persistent enemies: Some new technologies to combat biofilm in the food industry-A review

Senakpon Isaie Ulrich Mevo et al.

Summary: Biofilm is an advanced form of protection that allows bacterial cells to withstand adverse environmental conditions. Inhibition of harmful bacteria biofilm formation is crucial in the food industry due to their enhanced resistance to traditional cleaning and disinfection methods, posing risks to food safety and consumer health. Innovative approaches are emerging to combat bacterial biofilm formation and eradicate mature biofilms in food processing.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Food Science & Technology

The final fate of food: On the establishment of in vitro colon models

Saartje Hernalsteens et al.

Summary: The pursuit of life and health quality drives a deeper exploration of the impact of food components on health, with the digestive system playing a crucial role, and in vitro models serving as a feasible alternative to in vivo studies. Further research is needed in establishing colon models, ensuring the consideration of all operational units, chemical reactions, and substrate supply.

FOOD RESEARCH INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

In vitro digestion of sodium alginate/pectin co-encapsulated Lactobacillus bulgaricus and its application in yogurt bilayer beads

Xinxin Hu et al.

Summary: This study successfully prepared SA/PE hydrogel microspheres using the extrusion method to encapsulate Lactobacillus bulgaricus, resulting in high encapsulation efficiency and viability. Double-layer beads containing probiotic microspheres and yogurt showed good physical and chemical properties, as well as commercial value.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Food Science & Technology

Gut Colonization Mechanisms of Lactobacillus and Bifidobacterium: An Argument for Personalized Designs

Yue Xiao et al.

Summary: Lactobacillus and Bifidobacterium colonization in the gut is influenced by various factors, including species and strain specificity, natural history, genomic adaptability, metabolic interactions, microbiome structure, host genotype, diet, and host-microbe coadaptation. Under these influences, a customized colonization can be achieved through a machine learning prediction model.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 12, 2021 (2021)

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Article Chemistry, Multidisciplinary

Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease

Xin Zhou et al.

Summary: Cell-based therapy for Parkinson's disease faces limitations due to the vulnerability of exogenous cells in vivo. A novel approach of coating individual living cells with lipid bimolecular armor has been developed, enhancing cell protection during treatment. The nano-armor shielded single-cell factory improves colonization rates in the intestinal tract and can produce neurotransmitters-like drugs, demonstrating potential for drug delivery applications.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Polymerization-Mediated Multifunctionalization of Living Cells for Enhanced Cell-Based Therapy

Chao Pan et al.

Summary: A versatile approach for decorating living cells with multimodal coatings is reported, enabling enhanced cell-based therapy by tuning cell behaviors. The dual cytoprotective and targeting effects of these coatings significantly improve the bioavailability and accumulation of decorated cells, leading to increased treatment efficacy in colitis mice. Decorating cells with multifunctional coatings provides a robust platform for developing enhanced cell-based therapy.

ADVANCED MATERIALS (2021)

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Article Food Science & Technology

Probiotics in fruit and vegetable matrices: Opportunities for nondairy consumers

Siegried Lillo-Perez et al.

Summary: Probiotic foods are in high demand due to their health properties, with fruits and vegetables being increasingly used as nondairy matrices. Vegetables provide a beneficial environment for probiotics, protecting them from stress factors.

LWT-FOOD SCIENCE AND TECHNOLOGY (2021)

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Article Chemistry, Applied

Electro-encapsulation of probiotics in gum Arabic-pullulan blend nanofibres using electrospinning technology

Jiage Ma et al.

Summary: In this study, gum arabic-based nanofibers combined with pullulan were prepared and characterized for the first time, serving as wall material for Lactobacillus encapsulation. The addition of gum arabic led to nanofibers with smaller diameter and better thermal stability. The hybrid nanofibers showed improved probiotic survivability compared to freeze-drying, providing a new approach for probiotic protection.

FOOD HYDROCOLLOIDS (2021)

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Article Chemistry, Multidisciplinary

Biomaterials coating for on-demand bacteria delivery: Selective release, adhesion, and detachment

Jun Liu et al.

Summary: A double-layer coating strategy using tannic acid and enteric L100 was reported to encapsulate probiotics for improved delivery in the gastrointestinal tract. The encapsulated Escherichia coli demonstrated enhanced survival and proliferation capabilities, leading to superior efficacy against colitis. This spatiotemporal delivery method shows promise in enhancing the therapeutic efficacy of bacteria-based therapy for GI tract-related diseases.

NANO TODAY (2021)

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Review Pharmacology & Pharmacy

Targeting strategies of oral nano-delivery systems for treating inflammatory bowel disease

Wenjuan Liu et al.

Summary: Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract with increasing incidence. Current treatments are associated with significant adverse effects and limited efficacy. Using oral nano-drug delivery systems for targeted therapy can reduce systemic absorption, increase local drug concentration, and improve therapeutic outcomes.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Food Science & Technology

Yeast cell-derived delivery systems for bioactives

Chen Tan et al.

Summary: Yeast cells are considered emerging bioinspired delivery carriers with great potential in encapsulating hydrophobic and hydrophilic compounds, protection against environmental stresses, controlled release, biocompatibility, and biodegradability. The latest research developments from 2015 to 2021 have focused on intact and pretreated yeast cells, as well as their integration with other systems such as polymeric hydrogels and nano-in micro systems. Promising results have shown the potential of yeast cells in encapsulating, protecting, and controlled releasing food-related bioactives, suggesting a bright future in functional food industries.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Article Food Science & Technology

Impact of a Novel Nano-Protectant on the Viability of Probiotic Bacterium Lactobacillus casei K17

Jinsong Wang et al.

Summary: The three-layer nano protectant containing trehalose, skim milk powder, phytoglycogen nanoparticles, and Pickering emulsions is found to have significant protective effects on Lactobacillus casei, making it suitable for use in feed and functional food products.

FOODS (2021)

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Article Nanoscience & Nanotechnology

Near-Infrared Photo-controlled Permeability of a Biomimetic Polymersome with Sustained Drug Release and Efficient Tumor Therapy

Yuling He et al.

Summary: A biomimetic polymersome with sustained drug release through near-infrared (NIR) pre-activation is highlighted, offering highly efficient tumor therapeutic effect through combined sustained drug release and concurrent hypoxia intensification.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Polyphenol-Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Yuxin Guo et al.

Summary: Polyphenols, commonly found in plants, have beneficial effects on human health and their use in nanoparticles shows promising potential for various biomedical applications. Their coordination with metal ions forms important complexes with applications in surface modification, bioimaging, drug delivery, and disease treatments. The versatility of polyphenol-containing nanoparticles in different biomedical applications has been demonstrated, with challenges for future research being discussed.

ADVANCED MATERIALS (2021)

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Article Chemistry, Applied

Dual pH-/thermo-responsive chitosan-based hydrogels prepared using click chemistry for colon-targeted drug delivery applications

Huong Thi Hoang et al.

Summary: A dual pH-/thermo-responsive hydrogel was successfully designed using a polyelectrolyte complex and chemical crosslinking, demonstrating high drug loading capacity and controlled drug release properties at different pH levels, showing promising applications in colon-targeted drug delivery systems.

CARBOHYDRATE POLYMERS (2021)

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Review Chemistry, Applied

Microencapsulating polymers for probiotics delivery systems: Preparation, characterization, and applications

Seyedehhamideh Razavi et al.

Summary: Probiotics are a promising prevention and treatment strategy for various diseases, but their application is limited by reductions in cell viability. Microencapsulation technology can improve probiotics delivery, and encapsulating materials have a significant influence on probiotic survivability.

FOOD HYDROCOLLOIDS (2021)

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Review Biochemistry & Molecular Biology

Chitosan-based nanocarriers for encapsulation and delivery of curcumin: A review

Qiaobin Hu et al.

Summary: This review highlights the use of chitosan-based nanocarriers for encapsulating and delivering curcumin, and discusses the fabrication techniques and functionalities of different types of chitosan-based nanocarriers. Furthermore, it elaborates on the current pharmaceutical applications of curcumin-loaded chitosan nanoparticles and their role in improving therapeutic effects on chronic diseases.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Microbiology

Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome

Ailing Liu et al.

Summary: Our study demonstrated that co-administering Probio-M8 with conventional therapy can alleviate asthma symptoms and have a positive effect on diseases associated with the gut-lung axis by activating multiple anti-inflammatory pathways. These findings provide new insights into the pathogenesis and treatment of asthma, mechanisms of novel therapeutic strategies, and the application of probiotics-based therapy.

MICROBIOLOGY SPECTRUM (2021)

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Article Food Science & Technology

In-vitro study of Limosilactobacillus fermentum PCC adhesion to and integrity of the Caco-2 cell monolayers as affected by pectins

Thanyaporn Srimahaeak et al.

Summary: The study found that citrus pectins with high and moderate degrees of esterification can enhance adhesion of L. fermentum PCC, while those with low DE can reduce it. Combining with pectins significantly increased TEER, indicating a synergistic action of bacteria and pectins that contributes to the health of the epithelial barrier.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Multidisciplinary Sciences

Mucosal immunity-mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches

Sisi Lin et al.

Summary: The oral delivery of camouflaged probiotics can induce mucosal immune responses, regulate the gut microbiota, maintain gut homeostasis, and provide defense against external threats. Studies show that this approach effectively prevents intestinal barrier breakdown, bacterial translocation, and systemic inflammation.

SCIENCE ADVANCES (2021)

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Review Chemistry, Multidisciplinary

Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Rumiana Tenchov et al.

Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.

ACS NANO (2021)

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Review Pharmacology & Pharmacy

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E. Large et al.

Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

A Bioinspired Versatile Spore Coat Nanomaterial for Oral Probiotics Delivery

Qingling Song et al.

Summary: By anchoring versatile spore coat nanomaterial to the surface of probiotics, the delivery and colonization of probiotics can be enhanced, leading to improved anti-inflammatory effects and other functions of the probiotics. This strategy may guide the development of nanomaterial and material-based microecological agents.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Current progress and prospects of organic nanoparticles against bacterial biofilm

Xinyao Li et al.

Summary: Biofilm plays a crucial role in bacterial pathogenicity and resistance, and exploring effective strategies to control it has become a hot research topic. Organic nanomaterials show great prospects in overcoming bacterial biofilm problems, and their unique properties make them promising in this area.

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Nutritional Interventions and the Gut Microbiome in Children

Saurabh Mehta et al.

Summary: The gut microbiome in infants and children can be influenced by diet, impacting immune function, cognitive development, and overall health. Further research is needed to gather comprehensive data and conclusions.

ANNUAL REVIEW OF NUTRITION, VOL 41, 2021 (2021)

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Article Chemistry, Applied

Improved digestive stability of probiotics encapsulated within poly(vinyl alcohol)/cellulose acetate hybrid fibers

Emine Merve Canga et al.

Summary: Novel cellulose acetate (CA) and poly(vinyl alcohol) (PVA) hybrid fibers were fabricated via angled dual-nozzle electrospinning for encapsulating probiotics with enhanced gastrointestinal stability. CA improved bacterial stability under gastric conditions while PVA provided protection during the electrospinning process. Encapsulated Escherichia coli strain Nissle 1917 (EcN) cells showed increased viability compared to free cells, demonstrating the potential of multi-nozzle electrospinning for probiotic encapsulation.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

Gamma radiation synthesis of a novel amphiphilic terpolymer hydrogel pH-responsive based chitosan for colon cancer drug delivery

Mohamed Mohamady Ghobashy et al.

Summary: The study involves cross-linking chitosan with two anionic polymers through gamma irradiation, creating amphiphilic hydrogel to address bursting drug release issue. The hydrogels show significant sensitivity to pH changes and have the potential for drug delivery system, releasing 96% of 5-FU drug at pH 7 after 7 hours.

CARBOHYDRATE POLYMERS (2021)

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Article Biotechnology & Applied Microbiology

Probiotic bacteria stabilized in orally dissolving nanofibers prepared by high-speed electrospinning

Edit Hirscha et al.

Summary: The utilization of well-selected excipients in electrospinning can decrease osmotic and dehydration stress during production and long-term storage, increasing the viability of probiotic cells. Skim milk showed the best results with a high bacterial survival rate after one year of storage.

FOOD AND BIOPRODUCTS PROCESSING (2021)

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Article Chemistry, Applied

Optimization of Microbial Rennet Encapsulation in Alginate-Chitosan Nanoparticles

Saeedeh Hosseini et al.

Summary: This study evaluated the effects of alginate, chitosan, and CaCl2 on rennet encapsulation and optimized the process using RSM. Encapsulated enzyme showed higher activity at various pH and temperature, and the release mechanism was confirmed to be Fickian.

FOOD CHEMISTRY (2021)

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Article Chemistry, Applied

Enhancing the storage and gastrointestinal passage viability of probiotic powder (Lactobacillus Plantarum) through encapsulation with pickering high internal phase emulsions stabilized with WPI-EGCG covalent conjugate nanoparticles

Xin-Sheng Qin et al.

Summary: This study demonstrated the potential of using WPI-EGCG covalent conjugates stabilized Pickering HIPEs to enhance the viability of probiotic powder during storage and GIT digestion. Experimental results showed that the protective effect of Pickering emulsions can be improved by increasing the c and/or ? value.

FOOD HYDROCOLLOIDS (2021)

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Survival of probiotic bacteria nanoencapsulated within biopolymers in a simulated gastrointestinal model

Reza Atraki et al.

Summary: The encapsulation of probiotic bacteria within nanofiber mats of CS/SA significantly enhances their survival rate in simulated gastrointestinal conditions, providing a protective effect against exposure to gastric and intestinal fluids.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2021)

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Review Chemistry, Multidisciplinary

Oral delivery of micro/nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: Challenges, advances and future perspectives

Aline Martins dos Santos et al.

Summary: Colon-targeted oral drug delivery is a promising approach for treating intestinal diseases, though it faces challenges that require advanced strategies and the use of micro- and nanoparticles for localized therapy. Polysaccharides-based nano-in-microparticulate systems have key properties and advantages for effective colon-specific oral delivery, showing potential for targeted therapy within the colon.

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Decorating Bacteria with a Therapeutic Nanocoating for Synergistically Enhanced Biotherapy

Weiliang Hou et al.

Summary: Combining probiotics with therapeutic nanocoatings can enhance biotherapy synergistically. Silk fibroin nanocoating provides bacteria with improved survival rates and enhanced therapeutic effects.

SMALL (2021)

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Encapsulation of probiotics and nutraceuticals: Applications in functional food industry

Priscilla Magro Reque et al.

Summary: This study discusses the recent developments in probiotics encapsulation for application in nutraceutical and food industries, covering topics such as encapsulation systems, concepts of nutraceuticals and probiotics, current market situation, microbial microencapsulation, and food applications. Studies on the viability and stability of encapsulated probiotics in food matrices are presented, with emphasis on the importance of in vivo human studies to prove the effectiveness of such formulations.

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Article Biotechnology & Applied Microbiology

Improved functionality of Ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation

Mingfei Yao et al.

Summary: In this study, a delivery system was designed through layer-by-layer encapsulation to enhance the effectiveness of Li01 in regulating gut microbiota and relieving inflammatory bowel disease. The improved functionality of Li01 by LbL encapsulation increases its potential for clinical applications in IBD treatment.

NPJ BIOFILMS AND MICROBIOMES (2021)

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Article Food Science & Technology

Alginate/Fish Gelatin-Encapsulated Lactobacillus acidophilus: A Study on Viability and Technological Quality of Bread during Baking and Storage

Milad Hadidi et al.

Summary: The study found that encapsulation of L. acidophilus in alginate/fish gelatin capsules can improve the survival rate of probiotic bacteria during baking and storage, serving as an effective bread enhancer. The fish gelatin used as a second-layer carrier for the bacteria positively impacted the technical quality of bread.

FOODS (2021)

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Article Biochemistry & Molecular Biology

In vitro protein and starch digestion kinetics of individual chickpea cells: from static to more complex in vitro digestion approaches

Katharina Palchen et al.

Summary: This study focuses on the impact of dynamic factors on in vitro digestion models and demonstrates that gradual changes in gastric pH and the addition of salivary amylase significantly alter starch digestion kinetics. The study highlights the potential for introducing dynamic factors into in vitro models while maintaining simplicity and cost-efficiency in the experimental setup.

FOOD & FUNCTION (2021)

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Review Food Science & Technology

Progress in microencapsulation of probiotics: A review

Mingfei Yao et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2020)

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Article Chemistry, Applied

Encapsulation of probiotics in soybean protein-based microparticles preserves viable cell concentration in foods all along the production and storage processes

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An alternative way to encapsulate probiotics within electrospun alginate nanofibers as monitored under simulated gastrointestinal conditions and in kefir

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Probiotic-directed modulation of gut microbiota is basal microbiome dependent

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Polymeric carriers for enhanced delivery of probiotics

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On-Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating

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Probiotic encapsulation in water-in-water emulsion via heteroprotein complex coacervation of type-A gelatin/sodium caseinate

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Viability improvement of Bifidobacterium animalis Bb12 by encapsulation in chitosan/poly(vinyl alcohol) hybrid electrospun fiber mats

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Development of enteric polymer -based microspheres by spray -drying for colonic delivery of Lactobacillus rhamnosus GG

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Colon-targeted delivery systems for nutraceuticals: A review of current vehicles, evaluation methods and future prospects

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Development, characterization and in vitro antioxidant activity of chitosan-coated alginate microcapsules entrapping Viola odorata Linn. extract

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Encapsulation ofLactobacillus acidophilusNCDC 016 cells by spray drying: characterization, survival afterin vitrodigestion, and storage stability

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Preparation and characterization of pectin/chitosan beads containing porous starch embedded with doxorubicin hydrochloride: A novel and simple colon targeted drug delivery system

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Agarose-based freeze-dried capsules prepared by the oil-induced biphasic hydrogel particle formation approach for the protection of sensitive probiotic bacteria

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pH-sensitive Eudragit® L 100 nanoparticles promote cutaneous penetration and drug release on the skin

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Survival and Behavior of Encapsulated Probiotics (Lactobacillus plantarum) in Calcium-Alginate-Soy Protein Isolate-Based Hydrogel Beads in Different Processing Conditions (pH and Temperature) and in Pasteurized Mango Juice

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Alginate/chitosan microcapsules for in-situ delivery of the protein, interleukin-1 receptor antagonist (IL-1Ra), for the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model

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Whey protein-kefiran films as driver of probiotics to the gut

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Viability of Lactobacillus plantarum encapsulated with poly-γ-glutamic acid produced by Bacillus sp. SJ-10 during freeze-drying and in an in vitro gastrointestinal model

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Natural Shape-Retaining Microcapsules With Shells Made of Chitosan-Coated Colloidal Lignin Particles

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Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review

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Extending Viability of Bifidobacterium longum in Chitosan-Coated Alginate Microcapsules Using Emulsification and Internal Gelation Encapsulation Technology

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Pectin-decorated magnetite nanoparticles as both iron delivery systems and protective matrices for probiotic bacteria

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Double layer co-encapsulation of probiotics and prebiotics by electro-hydrodynamic atomization

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Effects of Electrospinning on the Viability of Ten Species of Lactic Acid Bacteria in Poly(Ethylene Oxide) Nanofibers

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Preparation optimization and characterization of chitosan-tripolyphosphate microcapsules for the encapsulation of herbal galactagogue extract

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Development of electrospun nanofibers that enable high loading and long-term viability of probiotics

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Graphene Quantum Dots-Mediated Theranostic Penetrative Delivery of Drug and Photolytics in Deep Tumors by Targeted Biomimetic Nanosponges

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Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment

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Application of spray chilling and electrostatic interaction to produce lipid microparticles loaded with probiotics as an alternative to improve resistance under stress conditions

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Enhanced viability of probiotics (Pediococcus pentosaceus Li05) by encapsulation in microgels doped with inorganic nanoparticles

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Potential probiotic characterization and effect of encapsulation of probiotic yeast strains on survival in simulated gastrointestinal tract condition

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Fast dissolving moxifloxacin hydrochloride antibiotic drug from electrospun Eudragit L-100 nonwoven nanofibrous Mats

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Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy

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Encapsulation of beneficial probiotic bacteria in extracellular matrix from biofilm-forming Bacillus subtilis

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ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Improved Viability and Thermal Stability of the Probiotics Encapsulated in a Novel Electrospun Fiber Mat

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E-coli Nissle microencapsulation in alginate-chitosan nanoparticles and its effect on Campylobacter jejuni in vitro

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In-vitro digestion of probiotic bacteria and omega-3 oil co-microencapsulated in whey protein isolate-gum Arabic complex coacervates

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Pectin-non-starch nanofibers biocomposites as novel gastrointestinal-resistant prebiotics

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Investigation of pectin/starch hydrogel as a carrier for oral delivery of probiotic bacteria

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Review Food Science & Technology

Electrospinning: A novel nano-encapsulation approach for bioactive compounds

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TRENDS IN FOOD SCIENCE & TECHNOLOGY (2017)

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Effect of Eudragit S100 nanoparticles and alginate chitosan encapsulation on the viability of Lactobacillus acidophilus and Lactobacillus rhamnosus

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Review Biochemistry & Molecular Biology

Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health

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Biphasic Supramolecular Self-Assembly of Ferric Ions and Tannic Acid across Interfaces for Nanofilm Formation

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Survival of Lactobacillus Acidophilus as Probiotic Bacteria using Chitosan Nanoparticles

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Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome

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Review Biochemistry & Molecular Biology

Exploring the relationship between exposure to technological and gastrointestinal stress and probiotic functional properties of lactobacilli and bifidobacteria

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Peptide self-assembly: thermodynamics and kinetics

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Preparation and characterisation of rutile titanium dioxide of special hollow microspheres

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MICRO & NANO LETTERS (2016)

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Probiotication of foods: A focus on microencapsulation tool

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TRENDS IN FOOD SCIENCE & TECHNOLOGY (2016)

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In vitro and in vivo study of sodium polyacrylate grafted alginate as microcapsule matrix for live probiotic delivery

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Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue

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Effect of alginate and chitosan on viability and release behavior of Bifidobacterium pseudocatenulatum G4 in simulated gastrointestinal fluid

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The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

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NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

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Eudragit (R): a technology evaluation

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EXPERT OPINION ON DRUG DELIVERY (2013)

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One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering

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Whey protein capsules obtained through electrospraying for the encapsulation of bioactives

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INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2012)

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Relevance and challenges in modeling human gastric and small intestinal digestion

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TRENDS IN BIOTECHNOLOGY (2012)

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Erythrocyte-Inspired Delivery Systems

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Pectin-Based Injectable Biomaterials for Bone Tissue Engineering

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BIOMACROMOLECULES (2011)

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Mussel-Inspired Encapsulation and Functionalization of Individual Yeast Cells

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Multidisciplinary Sciences

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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A review of current and emergent biofilm control strategies

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LWT-FOOD SCIENCE AND TECHNOLOGY (2010)

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Article Biochemistry & Molecular Biology

Encapsulation of Living Bifidobacteria in Ultrathin PVOH Electrospun Fibers

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BIOMACROMOLECULES (2009)

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Article Food Science & Technology

Microencapsulation of Lactobacillus plantarum spp in an alginate matrix coated with whey proteins

Gildas Komenan Gbassi et al.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2009)

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Viscometric study of pectin-mucin interaction and its mucoadhesive bond strength

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Article Chemistry, Multidisciplinary

Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes

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Article Pharmacology & Pharmacy

Mucoadhesive properties of various pectins on gastrointestinal mucosa:: An in vitro evaluation using texture analyzer

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Encapsulation of bacteria and viruses in electrospun nanofibres

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Interaction of various pectin formulations with porcine colonic tissues

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Compound core-shell polymer nanofibers by co-electrospinning

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Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin

P Nangia-Makker et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2002)

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