4.8 Review

Nanoparticles incorporated in nanofibers using electrospinning: A novel nano-in-nano delivery system

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Physical

Electrospun Nanofibers Revisited: An Update on the Emerging Applications in Nanomedicine

Nehal E. Elsadek et al.

Summary: Electrospinning is a customizable drug delivery technique that fabricates drug-loaded nanofibers using various polymers. These nanofibers have applications in cancer therapy, microbial infections, and regenerative medicine. They offer controlled drug release, high loading capability, and cost-effectiveness, making them promising for improving chemotherapy efficiency, antimicrobial drug delivery, wound healing, and tissue regeneration.

MATERIALS (2022)

Article Multidisciplinary Sciences

New biodegradable nanoparticles-in-nanofibers based membranes for guided periodontal tissue and bone regeneration with enhanced antibacterial activity

Dina Abdelaziz et al.

Summary: A new series of nanofibrous scaffolds were prepared in this study for GTR/GBR applications, with enhanced cell viability and antibacterial activity through the incorporation of hydroxyapatite nanoparticles and green-synthesized silver nanoparticles, respectively. The scaffolds showed a desirable degradation profile, losing around 40-70% of their mass in 8 weeks, making them promising for both GTR and GBR applications.

JOURNAL OF ADVANCED RESEARCH (2021)

Article Pharmacology & Pharmacy

Anticancer efficiency of curcumin-loaded mesoporous silica nanoparticles/nanofiber composites for potential postsurgical breast cancer treatment

Zahra Mohebian et al.

Summary: In this study, Curcumin was successfully incorporated into mesoporous silica nanoparticles and then embedded into a polymer via a blending electrospinning process to create a nanofiber-mediated drug release system. The resulting composite nanofibers showed sustained drug release properties and demonstrated high cytotoxicity and low migration in treating breast cancer cells, suggesting a promising potential for post-surgical breast cancer treatment.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

Article Chemistry, Applied

Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles

Shohreh Fahimirad et al.

Summary: The study successfully fabricated electrospun nanofibers containing curcumin-loaded chitosan nano-encapsulated particles. Electrospraying curcumin on the surface enhanced antibacterial, antioxidant, and cell proliferation properties, as well as higher swelling and water vapor transition rates, leading to significant improvement in wound healing in vivo.

CARBOHYDRATE POLYMERS (2021)

Article Materials Science, Biomaterials

Regenerated cellulose nanofibers from cellulose acetate: Incorporating hydroxyapatite (HAp) and silver (Ag) nanoparticles (NPs), as a scaffold for tissue engineering applications

Hasham S. Sofi et al.

Summary: Cellulose nanofibers with good biocompatibility, hydrophilicity, and antimicrobial properties were easily fabricated. The nanofibers were characterized for their compatibility with fibroblasts and showed potential for tissue engineering applications. Additionally, degradation studies indicated faster degradation in enzymes compared to PBS, showcasing the nanofibers' potential in biomedical fields.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Pharmacology & Pharmacy

Development and characterization of chitosan nanoparticles loaded nanofiber hybrid system for vaginal controlled release of benzydamine

Fatmanur Tugcu-Demiroz et al.

Summary: Vaginal infections caused by various pathogens can be treated with systemic and local treatments. Novel vaginal drug delivery systems offer localized treatment with minimal side effects. This study compared nanofiber and gel formulations containing benzydamine nanoparticles, showing potential for prolonged drug release and protection from vaginal infections.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Electrospun pectin/modified copper-based metal-organic framework (MOF) nanofibers as a drug delivery system

Shahrzad Zirak Hassan Kiadeh et al.

Summary: The study demonstrates that MOF-contained pectin nanofibers have potential application value in improving mechanical strength, antibacterial properties, as well as inducing angiogenesis.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Pharmacology & Pharmacy

Topical delivery of heparin from PLGA nanoparticles entrapped in nanofibers of sericin/gelatin scaffolds for wound healing

Duygu Deniz Akolpoglu Basaran et al.

Summary: Skin regeneration is a crucial issue in tissue engineering, and developing effective biomaterials for enhanced regeneration while meeting the healing requirements is a challenge. This study encapsulated heparin in PLGA nanoparticles and incorporated them into Ser/Gel nanofibers to create a controlled release system promoting skin tissue regeneration. Sericin addition slowed down scaffold degradation, and the scaffold with a Ser/Gel ratio of 1/2 was considered the most promising candidate due to its proper fiber morphology, high water retention, and low degradation degree.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

Nanofibers of cellulose acetate containing ZnO nanoparticles/graphene oxide for wound healing applications

Amany A. Aly et al.

Summary: The combination of nanostructured zinc oxide or graphene oxide with cellulose acetate enhances the functionality of nanofibers for wound healing bio-composite materials. The resulting nanofibers exhibit improved mechanical properties and cell viability, as well as promoting cell adhesion and proliferation for wound healing applications.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Engineering, Biomedical

Bioactive anti-oxidative polycaprolactone/gelatin electrospun nanofibers containing selenium nanoparticles/vitamin E for wound dressing applications

Mohsen Doostmohammadi et al.

Summary: The study prepared PCL/GEL/Se NPs/VE scaffolds containing Se NPs and VE, evaluated their effect on wound healing through in-vivo studies, and demonstrated their support for cell proliferation and attachment, wound healing activity, and significant antioxidant efficacy. The results suggest that these scaffolds have potential for further research as a candidate for promoting wound healing.

JOURNAL OF BIOMATERIALS APPLICATIONS (2021)

Article Materials Science, Biomaterials

Aloe Vera extract-based composite nanofibers for wound dressing applications

Raul Barbosa et al.

Summary: Composite nanofibers made of natural materials such as Aloe vera extract, pullulan, chitosan, and citric acid were successfully produced via Forcespinning technology, exhibiting good water absorption capabilities and synergistic antibacterial activity. These nanofibers have potential applications in wound dressing due to their porous structure and high surface area, providing protection from infection while maintaining good thermal stability.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Review Biochemistry & Molecular Biology

Electrospun Medicated Nanofibers for Wound Healing: Review

Xinkuan Liu et al.

Summary: With the increasing demand for wound care and treatment worldwide, traditional dressings are unable to meet market needs. Electrospinning technology has become a focus of research, with electrospun nanofiber membranes possessing a unique structure and biological function similar to ECM, making them advanced dressings. Electrospun dressings have the potential to encapsulate and deliver active substances that promote wound healing.

MEMBRANES (2021)

Article Polymer Science

A Composite Nanosystem as a Potential Tool for the Local Treatment of Glioblastoma: Chitosan-Coated Solid Lipid Nanoparticles Embedded in Electrospun Nanofibers

Barbara Vigani et al.

Summary: A novel composite nanosystem was developed for the treatment of glioblastoma, utilizing chitosan-coated Solid Lipid Nanoparticles embedded in nanofibers for local delivery of lipophilic anti-proliferative drugs. The coated nanoparticles showed higher accumulation in human glioblastoma cells compared to uncoated ones.

POLYMERS (2021)

Article Chemistry, Physical

Graphene oxide with acid-activated bacterial membrane anchoring for improving synergistic antibacterial performances

Shaohu Huo et al.

Summary: A new nanocomposite material with synergistic antibacterial effects was introduced, which could effectively kill bacteria, reduce infection risk, and promote wound healing.

APPLIED SURFACE SCIENCE (2021)

Article Biochemistry & Molecular Biology

Plausible role of chitosan in drug and gene delivery against resistant breast cancer cells

Tanaji Nandgude et al.

Summary: Chitosan as a potential drug delivery carrier shows promise in the treatment of breast cancer. Studies have found that modified chitosan can achieve more precise drug delivery, leading to more effective treatment of breast cancer cells.

CARBOHYDRATE RESEARCH (2021)

Article Engineering, Chemical

Osteoconductive and Antibacterial Poly(lactic acid) Fibrous Membranes Impregnated with Biobased Nanocarbons for Biodegradable Bone Regenerative Scaffolds

Huan Xu et al.

Summary: By directly electrospinning microfibers impregnated with coffee-ground-derived quantum dots, osteoconductive and antibacterial porous poly(lactic acid) membranes can be fabricated, allowing for regulation of microfiber diameter and distribution, as well as enhancing hydrophilicity. The quantum dots have high affinity to the PLA matrix, leading to a significant increase in tensile strength and elastic modulus of the QD-modified PLA membranes while maintaining extensibility. Additionally, osteoblast adhesion and stretching are greatly enhanced on the electrospun membranes with the presence of quantum dots, resulting in improved cell viability and biomimetic mineralization.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2021)

Review Biochemistry & Molecular Biology

A review on chitosan and chitosan-based bionanocomposites: Promising material for combatting global issues and its applications

Motia Azmana et al.

Summary: This article discusses the attempts to replace petrochemical products with renewable and biodegradable components, with a focus on chitosan as a unique bio-based polymer with excellent intrinsic properties. Chitosan-based materials have been successfully utilized in nanotechnology, leading to the development of bionanocomposites with improved physical and chemical characteristics. The review also highlights the future research scope and motivates researchers for outstanding research works in this field.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Pharmacology & Pharmacy

Prolonged proliferation and delayed senescence of the adipose-derived stem cells grown on the electrospun composite nanofiber co-encapsulated with TiO2 nanoparticles and metformin-loaded mesoporous silica nanoparticles

Raheleh Pourpirali et al.

Summary: This study demonstrates that the nanofibers coencapsulated with nTiO2 and MET@MSNs can prolong the in vitro expansion of human adipose-derived stem cells without inducing cellular senescence and aging. The platform enhances adhesion, metabolic activity, and proliferation rate of the cells, and leads to the upregulation of autophagy and stemness markers as well as the down-regulation of senescence marker. Moreover, it results in increased telomere length and telomerase activity in the cells cultured on the nanofibers compared to other types.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Engineering, Biomedical

Dual drug release mechanisms through mesoporous silica nanoparticle/electrospun nanofiber for enhanced anticancer efficiency of curcumin

Liguo Xu et al.

Summary: The study developed a novel drug-loaded nanofibrous scaffold using electrospinning, which showed a higher cytotoxicity and more pronounced anticancer effect through a combination of burst and sustained release mechanisms. This approach may have a highly promising application as a localized implantable scaffold for potential postoperative breast cancer therapy.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

Review Engineering, Biomedical

In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: Innovative nanofiber designs, stem cell approaches, and future perspectives

Isha Behere et al.

Summary: This article reviews recent developments in multifunctional electrospun nanofibers for wound healing applications, starting from the electrospinning process and processing parameters, discussing the potential of MEN scaffolds produced by different techniques for wound healing, and exploring possible future nanofiber-based models.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

Review Chemistry, Multidisciplinary

Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy

P. Soma Yasaswi et al.

Summary: GBM, a life-threatening IV grade glioma brain cancer, remains a challenge to treat due to the toxic nature and fast degradation of TMZ, along with lack of targeting ability increasing chances of systemic toxicities. Nano-enabled technology improves the efficiency of TMZ and reduces toxicity to healthy tissues.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Biochemistry & Molecular Biology

Bi-faceted delivery of phytochemicals through chitosan nanoparticles impregnated nanofibers for cancer therapeutics

Poornima Balan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Biochemistry & Molecular Biology

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Malgorzata Zienkiewicz-Strzalka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Instruments & Instrumentation

Ciprofloxacin-loaded polymeric nanoparticles incorporated electrospun fibers for drug delivery in tissue engineering applications

Cemre Guenday et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

Review Nanoscience & Nanotechnology

Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications

Heshu Sulaiman Rahman et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Review Pharmacology & Pharmacy

Recent advances in theranostic polymeric nanoparticles for cancer treatment: A review

Shikha Indoria et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Chemistry, Multidisciplinary

One-step treatment of periodontitis based on a core-shell micelle-in-nanofiber membrane with time-programmed drug release

Xiaochen Liu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Review Chemistry, Multidisciplinary

Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing

Hariharan Ezhilarasu et al.

NANOMATERIALS (2020)

Article Pharmacology & Pharmacy

Localized delivery of active targeting micelles from nanofibers patch for effective breast cancer therapy

Sivaraj Mehnath et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Nanoscience & Nanotechnology

Materials design for bone-tissue engineering

Gerry L. Koons et al.

NATURE REVIEWS MATERIALS (2020)

Review Pharmacology & Pharmacy

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

Erika Maria Tottoli et al.

PHARMACEUTICS (2020)

Review Materials Science, Biomaterials

Electrospun nanofibers for the delivery of active drugs through nasal, oral and vaginal mucosa: Current status and future perspectives

Hasham S. Sofi et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Chemistry, Physical

Encapsulation of emulsion droplets and nanoparticles in nanofibers as sustainable approach for their transport and storage

Chadapon Srikamut et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

Article Materials Science, Biomaterials

Simple and robust fabrication and characterization of conductive carbonized nanofibers loaded with gold nanoparticles for bone tissue engineering applications

Houra Nekounam et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Meeting Abstract Nutrition & Dietetics

Curcumin improves hippocampal function in healthy older adults: a three month randomised controlled trial

Andrew Scholey et al.

PROCEEDINGS OF THE NUTRITION SOCIETY (2020)

Article Orthopedics

Bone Graft Substitutes: Current Concepts and Future Expectations

David C. Lobb et al.

JOURNAL OF HAND SURGERY-AMERICAN VOLUME (2019)

Article Biotechnology & Applied Microbiology

Polymers, responsiveness and cancer therapy

Anil M. Pethe et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Electrospinning of silica nanoparticles-entrapped nanofibers for sustained gentamicin release

Xiaobo Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Chemistry, Multidisciplinary

Dual-drug loaded micelle for combinatorial therapy targeting HIF and mTOR signaling pathways for ovarian cancer treatment

Bhuvana S. Doddapaneni et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Review Chemistry, Medicinal

Stem Cell Therapy: Curcumin Does the Trick

Simin Sharifi et al.

PHYTOTHERAPY RESEARCH (2019)

Article Pharmacology & Pharmacy

Novel lavender oil and silver nanoparticles simultaneously loaded onto polyurethane nanofibers for wound-healing applications

Hasham S. Sofi et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Article Materials Science, Characterization & Testing

Skin wound healing acceleration by Ag nanoparticles embedded in PVA/PVP/Pectin/Mafenide acetate composite nanofibers

Reza Alipour et al.

POLYMER TESTING (2019)

Article Chemistry, Multidisciplinary

Hierarchically Patterned Polydopamine-Containing Membranes for Periodontal Tissue Engineering

Mohammad Mandi Hasani-Sadrabadi et al.

ACS NANO (2019)

Article Dermatology

Photoallergic Contact Dermatitis

Ozge Askin et al.

CURRENT DERMATOLOGY REPORTS (2019)

Article Biochemistry & Molecular Biology

Selectivity and sensitivity of molybdenum oxide-polycaprolactone nanofiber composites on skin cancer: Preliminary in-vitro and in-vivo implications

Indrakumar Janani et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2018)

Article Chemistry, Physical

Enhanced drug delivery, mechanical properties and antimicrobial activities in poly(lactic acid) nanofiber with mesoporous Fe3O4-COOH nanoparticles

Chao Han et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2018)

Review Nanoscience & Nanotechnology

Recent advances in smart delivery systems for extended drug release in cancer therapy

Regina-Veronicka Kalaydina et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Review Biochemistry & Molecular Biology

Enhancing the Delivery of Chemotherapeutics: Role of Biodegradable Polymeric Nanoparticles

Jyoti Ahlawat et al.

MOLECULES (2018)

Review Materials Science, Biomaterials

Electrospinning and electrospray of bio-based and natural polymers for biomaterials development

Rosane M. D. Soares et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

Review Pharmacology & Pharmacy

Recent advances in gold and silver nanoparticle based therapies for lung and breast cancers

Parth Malik et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Biochemistry & Molecular Biology

A novel biocompatible drug delivery system of chitosan/temozolomide nanoparticles loaded PCL-PU nanofibers for sustained delivery of temozolomide

Mohammad Irani et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Article Nanoscience & Nanotechnology

Coffee Grounds to Multifunctional Quantum Dots: Extreme Nanoenhancers of Polymer Biocomposites

Huan Xu et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Engineering, Biomedical

Antimicrobial photodynamic therapy minimizes the deleterious effect of nicotine in female rats with induced periodontitis

Erivan Clementino Gualberto et al.

LASERS IN MEDICAL SCIENCE (2016)

Article Engineering, Biomedical

Electrospinning of PVA/chitosan nanocomposite nanofibers containing gelatin nanoparticles as a dual drug delivery system

Shahrzad Fathollahipour et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2015)

Review Immunology

How bacterial pathogens colonize their hosts and invade deeper tissues

David Ribet et al.

MICROBES AND INFECTION (2015)

Review Chemistry, Multidisciplinary

Electrospinning of polymeric nanofibers for drug delivery applications

Xiuli Hu et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Review Chemistry, Multidisciplinary

Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

Mark J. Ernsting et al.

JOURNAL OF CONTROLLED RELEASE (2013)

Article Chemistry, Multidisciplinary

Chitosan/siRNA Nanoparticles Encapsulated in PLGA Nanofibers for siRNA Delivery

Menglin Chen et al.

ACS NANO (2012)

Article Oncology

Reactivation of RASSF1A in Breast Cancer Cells by Curcumin

Liping Du et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2012)

Article Chemistry, Multidisciplinary

Electronic-Structure-Dependent Bacterial Cytotoxicity of Single-Walled Carbon Nanotubes

Chad D. Vecitis et al.

ACS NANO (2010)

Review Microbiology

Periodontitis: a polymicrobial disruption of host homeostasis

Richard P. Darveau

NATURE REVIEWS MICROBIOLOGY (2010)

Review Pharmacology & Pharmacy

Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery

Hyuk Sang Yoo et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

Review Biochemistry & Molecular Biology

Terpenoids: natural inhibitors of NF-kappa B signaling with anti-inflammatory and anticancer potential

A. Salminen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Review Polymer Science

Putting Electrospun Nanofibers to Work for Biomedical Research

Jingwei Xie et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2008)

Article Chemistry, Multidisciplinary

Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex

Yong-Il Chung et al.

JOURNAL OF CONTROLLED RELEASE (2007)

Review Anatomy & Morphology

Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix

J Li et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2003)