Mannose in vaccine delivery

Adjuvants and vaccine delivery systems are used widely to improve the efficacy of vaccines. Their primary roles are to protect antigen from degradation and allow its delivery and uptake by antigen presenting cells (APCs). Carbohydrates, including various structures/forms of mannose, have been broadly utilized to target carbohydrate binding receptors on APCs. This review summarizes basic functions of the immune system, focusing on the role of mannose receptors in antigen recognition by APCs. The most popular strategies to produce mannosylated vaccines via conjugation and formulation are presented. The efficacy of mannosylated vaccines is discussed in detail, taking into consideration factors, such as valency and number of mannose in mannose ligands, mannose density, length of spacers, special arrangement of mannose ligands, and routes of administration of mannosylated vaccines. The advantages and disadvantages of mannosylation strategy and future directions in the development of mannosylated vaccines are also debated.

Automated summary

This article discusses the use of adjuvants and vaccine delivery systems to enhance vaccine efficacy. It focuses on the role of mannose receptors in antigen recognition by antigen presenting cells (APCs). The production strategies and effectiveness of mannosylated vaccines are examined, considering factors such as mannose valency, density, and routes of administration. The advantages, disadvantages, and future directions of mannosylation strategy are also discussed.