期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 624, 期 -, 页码 307-319出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2022.05.121
关键词
polymyxin B; Mucus barrier; Sodium hyaluronate; Mucus permeability; Hydrophilic
资金
- National Basic Research Program of China
- National Natural Science Foundation of China [52003021]
- Beijing Natural Science Foundation Committee [ZK20200127]
- Beijing Key Laboratory and China-Japan Friendship Hospital
The study aimed to improve the bioavailability of polymyxin B (PMB) in pulmonary nebulized drug delivery. A nano-delivery system was developed to penetrate the mucus barrier of the lung, leading to enhanced drug delivery efficiency and improved therapeutic efficacy.
The aim of this study was to improve the bioavailability of polymyxin B (PMB) in pulmonary nebulized drug delivery. To this end, we developed a nano-delivery system that penetrates the mucus barrier of the lung. Hydrophilic hyaluronic acid (HA) was combined with a water-in-oil system containing a poly (lactic acid)-glycolic acid copolymer of PMB to prepare HA@PLGA-PMB nanoparticles (NPs) with good surface properties. HA@PLGA-PMB NPs with suitable electrical properties, particle size, and good hydrophilicity prevented strong interactions between the NPs and mucus, thereby allowing more drugs to enter deeper into the lung. Compared to the free drug PMB, NPs had more than 2-fold higher mucus penetration efficiency in vitro and better delivery to infected alveolar cells during in vivo nebulization. NPs had better biocompatibility, which further reduced the drug toxicity. More importantly, NPs showed better antimicrobial therapeutic efficacy in the treatment of lung infections in mice. These findings may provide support for the clinical application of nebulized pulmonary antibiotics. (c) 2022 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据