Cell division cycle 42 positively correlates with T helper 2 cytokine, effusion viscosity, and hearing loss degree in otitis media with effusion patients

Article Medical Laboratory Technology

PBMC CDC42 reveals the disease activity and treatment efficacy of TNF inhibitor in patients with ankylosing spondylitis

Qian Zhang et al.

Summary: The deficiency of blood CDC42 is associated with increased pro-inflammatory cytokines, disease activity, and unsatisfactory response to TNF inhibitor in AS patients.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Clinical Neurology

Longitudinal Variations of CDC42 in Patients With Acute Ischemic Stroke During 3-Year Period: Correlation With CD4+ T Cells, Disease Severity, and Prognosis

Xiao Cheng et al.

Summary: CDC42 expression is associated with disease severity and prognosis in patients with acute ischemic stroke (AIS). CDC42 is reduced in AIS patients and positively correlated with Th2 cells and IL-4, while negatively correlated with Th17 cells and IL-17A. CDC42 can be used as a biomarker to continuously monitor disease progression and recurrence risk in AIS patients.

FRONTIERS IN NEUROLOGY (2022)

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Article Public, Environmental & Occupational Health

Otitis Media and Its Association With Hearing Loss in Chinese Adults: A Population Based Study of 4 Provinces in China

Yanan Luo et al.

Summary: This study investigated the relationship between otitis media and hearing loss in Chinese adults and found that otitis media is associated with an increased risk of hearing loss, especially for rural patients.

FRONTIERS IN PUBLIC HEALTH (2022)

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Article Medicine, Research & Experimental

Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis

Jun Yang et al.

Summary: The expression levels of CDC42 were found to be negatively correlated with disease susceptibility, severity, inflammation, and mortality risk in patients with acute pancreatitis (AP).

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Article Pediatrics

Postoperative results of ventilation tube insertion: a retrospective multicenter study for suggestion of grading system of otitis media with effusion

Chan Il Song et al.

Summary: This study visualized and classified the clinical manifestations of OME using a new grading system, and found a significant correlation between the grading system and age at VTI, nature of middle ear effusion, recurrence rate of OME, and rate of revision VTI. The grade of the ear affected the duration of ventilation tube retention after VTI.

BMC PEDIATRICS (2021)

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Article Medicine, Research & Experimental

RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?

Fukun Guo

Summary: The article discusses the effects of deleting RhoA and Cdc42 genes on T cell development, activation, differentiation, as well as T cell-mediated allergic airway inflammation and colitis.

PRECISION CLINICAL MEDICINE (2021)

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Article Medicine, General & Internal

Neutrophil-lymphocyte and platelet-lymphocyte ratios in otitis media with effusion in children: Diagnostic role and audiologic correlations

Ahmet Yukkaldiran et al.

Summary: The study found that hearing loss in children with otitis media with effusion was negatively correlated with neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and mean platelet volume, but positively correlated with lymphocyte and platelet levels. Specific blood parameters could be used to estimate the presence of serous otitis media and predict hearing loss in these children.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

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Article Otorhinolaryngology