4.6 Article

Subgroup analyses in randomized controlled trials frequently categorized continuous subgroup information

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Critical Care Medicine

Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial*

Jennifer Tom et al.

Summary: This study aimed to explore the prognostic and predictive biomarkers in patients with coronavirus disease 2019 pneumonia treated with tocilizumab. The results showed that multiple biomarkers were prognostic for clinical outcomes in these patients, and high ferritin levels were associated with better clinical outcomes with tocilizumab.

CRITICAL CARE MEDICINE (2022)

Review Medicine, Research & Experimental

A systematic review of subgroup analyses in randomised clinical trials in cardiovascular disease

Korbinian J. Brand et al.

Summary: Subgroup analyses are commonly used in randomized clinical trials to assess treatment effect heterogeneity. While improvements have been observed in the reporting of cardiovascular randomized clinical trials, critical shortcomings such as inconsistent implementation and inadequate pre-specification persist.

CLINICAL TRIALS (2021)

Article Pharmacology & Pharmacy

Encouragement of subgroup assessment by the FDA

Robert Temple

Summary: Responses to drug treatment may vary among subgroups, with differences potentially being related to pharmacokinetics or pharmacodynamics. Assessing effectiveness and toxicity in diverse subgroups is essential to detect these differences and ensure optimal treatment outcomes.

PHARMACEUTICAL STATISTICS (2021)

Review Biotechnology & Applied Microbiology

Recent Advances in Systemic Treatments for HER-2 Positive Advanced Gastric Cancer

Seda Kahraman et al.

Summary: Gastric cancer is the fifth most common cancer worldwide, with advanced cases being particularly difficult to cure. Treatment efforts focus on improving quality of life, tumor response rate, and survival while balancing therapy toxicities. The only available biomarkers for guiding treatment are HER2 overexpression, MSI/PD-L1 status, and FGFR alterations.

ONCOTARGETS AND THERAPY (2021)

Article Pharmacology & Pharmacy

Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers

Dmitriy Matveychuk et al.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2020)

Review Health Care Sciences & Services

Justification and reporting of subgroup analyses were lacking or inadequate in randomized controlled trials

Jingchun Fan et al.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2019)

Article Medicine, General & Internal

Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children

A. Drilon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Cardiac & Cardiovascular Systems

A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation

William T. Abraham et al.

JACC-HEART FAILURE (2018)

Article Mathematical & Computational Biology

Tutorial in biostatistics: data-driven subgroup identification and analysis in clinical trials

Ilya Lipkovich et al.

STATISTICS IN MEDICINE (2017)

Editorial Material Respiratory System

Subgroup analysis and interaction tests: why they are important and how to avoid common mistakes

Juliana Carvalho Ferreira et al.

JORNAL BRASILEIRO DE PNEUMOLOGIA (2017)

Article Clinical Neurology

Comparison of 2 Lumbar Manual Therapies on Temporal Summation of Pain in Healthy Volunteers

Charles W. Penza et al.

JOURNAL OF PAIN (2017)

Article Pharmacology & Pharmacy

General guidance on exploratory and confirmatory subgroup analysis in late-stage clinical trials

Alex Dmitrienko et al.

JOURNAL OF BIOPHARMACEUTICAL STATISTICS (2016)

Article Health Care Sciences & Services

Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes

Julien Tanniou et al.

BMC MEDICAL RESEARCH METHODOLOGY (2016)

Article Medicine, General & Internal

Cumulative subgroup analysis to reduce waste in clinical research for individualised medicine

F. J. Song et al.

BMC MEDICINE (2016)

Editorial Material Medicine, General & Internal

Realizing the Full Potential of Precision Medicine in Health and Health Care

Victor J. Dzau et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Editorial Material Medicine, General & Internal

Uncertainty in the Era of Precision Medicine

David J. Hunter

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Three simple rules to ensure reasonably credible subgroup analyses

James F. Burke et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

Article Medicine, General & Internal

Three simple rules to ensure reasonably credible subgroup analyses

James F. Burke et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

Review Medicine, General & Internal

How to Use a Subgroup Analysis

Xin Sun et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

Article Medicine, General & Internal

Credibility of claims of subgroup effects in randomised controlled trials: systematic review

Xin Sun et al.

BMJ-BRITISH MEDICAL JOURNAL (2012)

Article Mathematical & Computational Biology

A note on dichotomization of continuous response variable in the presence of contamination and model misspecification

Yue Shentu et al.

STATISTICS IN MEDICINE (2010)

Article Medicine, Research & Experimental

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

Kenneth F. Schulz et al.

TRIALS (2010)

Article Medicine, General & Internal

Statistics in medicine - Reporting of subgroup analyses in clinical trials

Rui Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Mathematical & Computational Biology

Estimation of the Youden index and its associated cutoff point

R Fluss et al.

BIOMETRICAL JOURNAL (2005)

Article Statistics & Probability

The impact of dichotomization on the efficiency of testing for an interaction effect in exponential family models

VT Farewell et al.

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION (2004)