期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 159, 期 -, 页码 120-132出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2016.02.024
关键词
Silver complexes; Antimicrobial/anticancer; DNA interactions; Antioxidant activity
资金
- Irish Technological Sector Research Strand I [PP06TA26]
- DIT Capacity Building Scheme for Strategic Research programme (CaBS)
- DIT Fiosraigh PhD Scholarship Programme
- FAPERJ [E-26/103.032/2012]
- CAPES
- CNPq [152195/2011-4]
- FOCAS Institute, DIT under The Irish National Development Plan
- Centre for Applied Science for Health (ITTD) under The Irish National Development Plan
The complexes [Ag-2(OOC-(CH2)(n)-COO)] (n = 1-10) (1-10) were synthesised and reacted with 1,10-phenanthroline (phen) to yield derivatives formulating as [Ag-2(phen)(x)(OOC-(CH2)(y)-COO)]center dot zH(2)O (x = 2 or 3; y = 1-10; z = 1-4) (11-20) which are highly water-soluble and photo-stable in aqueous solution. The phen derivatives 11-20 exhibit chemotherapeutic potential against Candida albicans, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and against cisplatin-sensitive breast (MCF-7) and resistant ovarian (SKOV-3) cancer cell lines. Cyclic voltammetric analysis and DNA binding and intercalation studies indicate that the mechanism of action of 11-20 is significantly different to that of their silver(I) dicarboxylate precursors and they do not induce DNA damage or ROS generation in mammalian cells. The representative complexes 9 and 19 (containing the undecanedioate ligand) were both found to significantly reduce superoxide and hydrogen peroxide induced oxidative stress in the yeast S. cerevisiae. (C) 2016 Elsevier Inc. All rights reserved.
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