期刊
JOURNAL OF CHEMICAL NEUROANATOMY
卷 123, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jchemneu.2022.102105
关键词
Tauopathy; Axonopathy; A? amyloid; Medulla oblongata; Autonomic nervous system; Alzheimer?s disease
资金
- National Natural Science Foundation of China [31640034]
- research team fund of the South-Central Minzu University [XTZ15014, KTZ20039, CZP 18008]
This study used immunohistochemical staining and post-mortem tracing techniques to observe the human medulla oblongatas of AD patients and non-AD subjects. The findings showed that AD patients exhibited tauopathy and axonopathy in the medulla oblongata, which was only occasionally found in non-AD subjects. These results suggest a potential association between AD and autonomic nervous function changes.
The autonomic dysfunctions in Alzheimer's disease (AD) have been identified from many clinical studies, however, there is still a lack of evidence directly verifying the structural abnormalities of the autonomic nervous system in AD. Human medulla oblongatas from four AD patients or five non-AD subjects were obtained and observed by using immunohistochemical staining of hyperphosphorylated tau and A beta amyloid, and post-mortem tracing techniques. We found distinct axonal and somatic immunoreactivities for the tau markers AT8 and Tau-5 in the different areas of the medulla oblongata in AD patients, which was particularly obvious in the dorsal nucleus of the vagus nerve, the nucleus of the solitary tract and the reticular nucleus. The swollen axons, which are a typical feature of axonopathy, were not only identified in the axons with immunohistochemical labeling of AT8 and Tau-5 in the different nuclei of the medulla oblongata, but also in the tracer-labeled afferent and efferent fibres of the vagus nerve in AD patients. Such changes in tauopathy and axonopathy were only occasionally found in the non-AD aged subjects. Interestingly, we did not observe any intra- or extracellular A beta deposits in the medulla oblongatas of the AD patients or of the non-AD subjects. These results in small samples suggest that occurrence of tauopathy and axonopathy in the parasympathetic nuclei of the medulla oblongata in AD patients may implicate the change of autonomic nervous function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据