☆ 4.5 Review

Advances on the roles of tenascin-C in cancer

JOURNAL OF CELL SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition

Yu-Chen Lee et al.

Summary: The study reveals that tumor-induced endothelial cells transitioning into osteoblasts lead to bone formation, enhancing the metastatic potential of prostate cancer cells. Tenascin C (TNC) is identified as a major protein secreted during this process, promoting prostate cancer cell migration through various signaling pathways. Targeting TNC may hold promise for prostate cancer therapy.

ONCOGENE (2022)

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Article Biochemistry & Molecular Biology

Modulating tenascin-C functions by targeting the MAtrix REgulating MOtif, MAREMO

Thomas Loustau et al.

Summary: The extracellular matrix molecule Tenascin-C (TNC) promotes cancer and chronic inflammation through various mechanisms and contributes to an immune suppressive tumor microenvironment. Research has identified a highly conserved MAtrix REgulating MOtif (MAREMO) or M-motif in fibronectin and TNC. Mimetic peptides of the M-motif have been found to inhibit the functions of TNC.

MATRIX BIOLOGY (2022)

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Review Cell Biology

Tenascin-C in fibrosis in multiple organs: Translational implications

Swati Bhattacharyya et al.

Summary: Systemic sclerosis is a complex disease characterized by fibrosis in the skin and multiple internal organs. Understanding its pathogenesis and progression is a pressing scientific challenge. Recent studies have identified toll-like receptor 4 (TLR4) signaling as a key driver of fibrosis in systemic sclerosis, with TLR4 sensing danger signals and promoting fibrogenesis. Tenascin-C, an extracellular matrix glycoprotein, is highly upregulated in systemic sclerosis and plays a role in driving fibroblast activation and fibrosis progression.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

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Article Oncology

Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma

Angela Riedel et al.

Summary: Communication between tumors and tumor-draining lymph nodes alters the structure and function of the lymph nodes before metastasis. Tumor-derived lactic acid modulates the function of lymph node fibroblasts, resembling activated fibroblasts, and alters mitochondrial function. The role of lymph nodes in supporting cancer metastasis remains unclear.

CANCER IMMUNOLOGY RESEARCH (2022)

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Article Immunology

Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas

Po Zhang et al.

Summary: This study identified TNC as a biomarker for assessing the immunosuppressive microenvironment status and predicting prognosis of low-grade gliomas (LGGs). Serum TNC level was found to be able to evaluate the tumor immune microenvironment in patients with grade II and grade III glioma.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Revisiting the Tenascins: Exploitable as Cancer Targets?

Richard P. Tucker et al.

Summary: Tumor microenvironment (TME) plays a crucial role in tumor progression and provides potential targets for anti-cancer therapy. The tenascin family, especially tenascin-C and tenascin-W, shows promise as diagnostic and targetable molecules for cancer treatment purposes.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs

Tsunaki Hongu et al.

Summary: Perivascular macrophages play a crucial role in the formation of the pro-metastatic vascular niche by stimulating TLR4 activation via tenascin C. They secrete nitric oxide and tumor necrosis factor to induce the production of niche components by endothelial cells. This mechanism is independent of VEGF and targeting both macrophage-mediated activation and VEGF-regulated angiogenesis shows added potency in preventing lung metastasis in mice.

NATURE CANCER (2022)

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Article Biochemistry & Molecular Biology

Proteomic characteristics of bronchoalveolar lavage fluid in critical COVID-19 patients

Hao-Long Zeng et al.

Summary: Patients with critical COVID-19 exhibit altered extracellular proteomic profiles in BALF, mainly related to inflammatory signaling and oxidative stress response. Several extracellular factors and antigens were identified, with TNC and KL-6 showing potential as biomarkers or therapeutic candidates for COVID-19. The BALF proteome associated with COVID-19 could be a valuable resource for research on anti-inflammatory medications and understanding host response mechanisms.

FEBS JOURNAL (2021)

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Article Oncology

Tenascin-C expression in the lymph node pre-metastatic niche in muscle-invasive bladder cancer

Christopher R. Silvers et al.

Summary: Elevated expression of tenascin-C in regional lymph nodes may be a predictor of bladder cancer metastasis and associated with worse survival. Urinary extracellular vesicles contain cytokines that are positively correlated with lymph node tenascin-C expression. Bladder cancer extracellular vesicles induce tenascin-C expression in fibroblasts in an NF-kappa B-dependent manner.

BRITISH JOURNAL OF CANCER (2021)

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Article Cell Biology

Distinct contributions of partial and full EMT to breast cancer malignancy

Fabiana Lueoend et al.

Summary: EMT is a transient and reversible process where cancer cells transition between epithelial and mesenchymal states. Partial EMT cells contribute to metastasis and chemoresistance, while full EMT cells fail to colonize the lungs but are enriched in recurrent tumors post-chemotherapy.

DEVELOPMENTAL CELL (2021)

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Article Cell Biology

The long non-coding RNA ET-20 mediates EMT by impairing desmosomes in breast cancer cells

Meera Saxena et al.

Summary: The study identified 114 novel lncRNAs associated with EMT, with ET-20 being regulated by the EMT master transcription factor Sox4 and playing a role in promoting EMT by interacting with desmosomal proteins. ET-20 was found to be upregulated in invasive breast cancer cell lines and targeting it could be a potential therapeutic approach to inhibit EMT and breast cancer metastasis.

JOURNAL OF CELL SCIENCE (2021)

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Article Cell Biology

Tenascin-c knockdown suppresses vasculogenic mimicry of gastric cancer by inhibiting ERK- triggered EMT

Xing Kang et al.

Summary: The study found that Tenascin-c (TNC) is upregulated in gastric cancer tissue and is associated with vasculogenic mimicry (VM) formation and poor prognosis. Inhibition of TNC can significantly suppress VM formation and cell proliferation in gastric cancer. Targeting TNC and ERK may be a potential therapeutic approach to inhibit gastric cancer growth and metastasis.

CELL DEATH & DISEASE (2021)

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Article Immunology

Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice

Mariska T. Meijer et al.

Summary: While TNC plays a role in shaping the immune response during lipopolysaccharide-induced inflammation, its role may be superseded by other factors during pneumosepsis caused by a common gram-negative pathogen.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C

Saori Yonebayashi et al.

Summary: TNC is an extracellular matrix glycoprotein expressed during embryogenesis and up-regulated under pathological conditions. Overexpression of TNC is associated with poor clinical prognosis.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis

Jing Song et al.

Summary: This study confirms cit-TNC as an autoantigen targeted by autoreactive CD4(+) T cells and autoantibodies in patients with RA, and suggests that coinciding epitopes recognized by both CD4(+) T cells and B cells may amplify autoimmunity and promote the development of RA.

JCI INSIGHT (2021)

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Article Rheumatology

Tenascin-C-mediated suppression of extracellular matrix adhesion force promotes entheseal new bone formation through activation of Hippo signalling in ankylosing spondylitis

Zihao Li et al.

Summary: This study found that TNC was aberrantly upregulated in ligament and entheseal tissues from patients with AS and animal models. TNC inhibition significantly suppressed entheseal new bone formation. TNC promoted new bone formation by enhancing chondrogenic differentiation during endochondral ossification through the activation of downstream Hippo signaling.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Medicine, Research & Experimental

Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

Devadarssen Murdamoothoo et al.

Summary: The study found that tenascin-C inhibits CD8 T cell infiltration by inducing CXCL12, which may contribute to the low response rates of immune checkpoint therapy in cancer treatment. Blocking the CXCR4 receptor of CXCL12 enhances macrophage and CD8 T cell infiltration, reducing tumor growth and metastasis.

EMBO MOLECULAR MEDICINE (2021)

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Article Medicine, General & Internal

Elevated Serum Tenascin-C Predicts Mortality in Critically Ill Patients With Multiple Organ Dysfunction

Yunyu Xu et al.

Summary: This study found that serum TNC levels were associated with mortality in critically ill patients with multiple organ dysfunction, and could serve as a prognostic tool for predicting mortality in this population.

FRONTIERS IN MEDICINE (2021)

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Article Immunology

Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies

Sayda Dhaouadi et al.

Summary: The newly generated Nb3 and Nb4 nanobodies show high specificity for human TNC and have been characterized to interact with TNC through various methods.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Did Tenascin-C Co-Evolve With the General Immune System of Vertebrates?

Gertraud Orend et al.

Summary: Tenascin-C plays important roles in immunity, interacting with Toll-like receptor 4, integrin alpha 9 beta 1, and chemokines. While tenascins predate the appearance of adaptive immunity, the first tenascin-C appears to have evolved in early chordate lineages. Adaptive immunity evolved independently in jawless and jawed vertebrates, with the former using variable lymphocyte receptors and the latter using immunoglobulins.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Latent TGF-β Activation Is a Hallmark of the Tenascin Family

Alexandre Aubert et al.

Summary: TGF-beta isoforms play a crucial role in regulating tissue homeostasis and immune cell function, while Tenascin family members are able to modulate the bioavailability of TGF-beta through their C-terminal domains. This regulation likely involves a conformational change leading to activation of the latent cytokine and subsequent effects on cell responses, such as cytostasis and epithelial-to-mesenchymal transition in mammary epithelial cells. These findings suggest a novel common function for the Tenascin family in maintaining tissue homeostasis under both healthy and pathological conditions.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Tenascin-C in Heart Diseases-The Role of Inflammation

Kyoko Imanaka-Yoshida

Summary: Tenascin-C is a large ECM glycoprotein transiently expressed in the heart during embryonic development, but rarely detected in normal adults, with its expression strongly up-regulated in inflammation. TNC appears to worsen adverse ventricular remodeling by aggravating inflammation/fibrosis, and high levels predict poor prognosis in patients with various heart diseases, making it a potential biomarker for disease stratification and therapy selection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes

Caroline Spenle et al.

Summary: The study using a novel syngeneic tongue OSCC grafting model found high TNC expression and TIL infiltration in irradiated tumors, while TNC knockout host showed less immune suppressive TME and tendency towards more tumor regression, which could be significant for future anti-cancer targeting of OSCC.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles

Qi Dong et al.

Summary: Primary tumors modify the microenvironment of distant organs to create a supportive pre-metastatic niche, facilitating metastasis. Extracellular vesicles play a critical role in PMN formation by delivering functional molecules to recipient cells in target organs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression

Xiaomin Cai et al.

Summary: Biophysical cues, such as mechanical properties, play a critical role in tissue growth and homeostasis. YAP and TAZ are key mechanotransducers that control transcriptional programs for cell proliferation, differentiation, and transformation. However, the regulatory mechanisms and downstream transcriptome responses of YAP/TAZ signaling remain largely unknown.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Microbiology

Tenascin C Has a Modest Protective Effect on Acute Lung Pathology during Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia in Mice

Mariska T. Meijer et al.

Summary: The study found that TNC plays a moderate protective role against tissue pathology during the acute inflammatory phase of MRSA-induced pneumonia, but not during the bacterial clearance phase, suggesting a context-dependent effect of TNC. Contrary to previous descriptions, TNC does not seem to play a major role in disease outcome during MRSA-induced pneumonia.

MICROBIOLOGY SPECTRUM (2021)

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Review Oncology

The matrix in cancer

Thomas R. Cox

Summary: Alterations in the extracellular matrix play a crucial role in the development and progression of solid tumours, and our understanding of matrix biology is expanding. New approaches targeting the matrix in cancer are being developed.

NATURE REVIEWS CANCER (2021)

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Article Critical Care Medicine

Tenascin C Plasma Levels in Critically Ill Patients with or Without Sepsis: A Multicenter Observational Study

Mariska T. Meijer et al.

SHOCK (2020)

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Article Urology & Nephrology

Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling.

Haili Zhu et al.

KIDNEY INTERNATIONAL (2020)

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Article Oncology

Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype

Claire Deligne et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Review Immunology

Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy

Rachael M. Zemek et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies

Florent Petitprez et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma

Caroline Spenle et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Alternative splicing controls cell lineage-specific responses to endogenous innate immune triggers within the extracellular matrix

Sean P. Giblin et al.

MATRIX BIOLOGY (2020)

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Article Multidisciplinary Sciences

Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

Zhi-Ling Li et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

ECM deposition is driven by caveolin-1-dependent regulation of exosomal biogenesis and cargo sorting

Lucas Albacete-Albacete et al.

JOURNAL OF CELL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma

Inbar Angel et al.

ONCOGENE (2020)

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Review Immunology

Tenascin-C in Osteoarthritis and Rheumatoid Arthritis

Masahiro Hasegawa et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Biologically Active TNIIIA2 Region in Tenascin-C Molecule: A Major Contributor to Elicit Aggressive Malignant Phenotypes From Tumors/Tumor Stroma

Takuya Iyoda et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Medicine, Research & Experimental

A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy

Ajaybabu Pobbati et al.

THERANOSTICS (2020)

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Article Oncology

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma

Ding Ma et al.

CANCER RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Effects of exosomes on pre-metastatic niche formation in tumors

Yaxin Guo et al.

MOLECULAR CANCER (2019)

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Review Oncology

Interactions in the (Pre)metastatic Niche Support Metastasis Formation

Ginevra Doglioni et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Immunology

Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1

Verena Haage et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Article Biochemistry & Molecular Biology

Tenascin-C increases lung metastasis by impacting blood vessel invasions

Zhen Sun et al.

MATRIX BIOLOGY (2019)

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Article Medicine, Research & Experimental

Stromal integrin α11 regulates PDGFRβ signaling and promotes breast cancer progression

Irina Primac et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Oncology

EWS-FLI1-mediated tenascin-C expression promotes tumour progression by targeting MALAT1 through integrin α5β1-mediated YAP activation in Ewing sarcoma

Shaohui He et al.

BRITISH JOURNAL OF CANCER (2019)

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Article Cell Biology

Tenascin-cmediated vasculogenic mimicry formation via regulation of MMP2/MMP9 in glioma

Hai-ping Cai et al.

CELL DEATH & DISEASE (2019)

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Article Urology & Nephrology

Tenascin-C protects against acute kidney injury by recruiting Wnt ligands

Shuangqin Chen et al.

KIDNEY INTERNATIONAL (2019)

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Review Biotechnology & Applied Microbiology

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Jerome Galon et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Biochemical Research Methods

Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome

Alin Rai et al.

PROTEOMICS (2019)

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Article Oncology

Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin-1 and high tenascin-C and their combination as significant prognostic markers in non-small cell lung cancer

David Onion et al.

ONCOTARGET (2018)

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Review Cell Biology

Internal Affairs: Tenascin-C as a Clinically Relevant, Endogenous Driver of Innate Immunity

Anna M. Marzeda et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2018)

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Article Medicine, General & Internal

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

Franck Pages et al.

LANCET (2018)

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Article Medicine, Research & Experimental

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis

Jacob Insua-Rodriguez et al.

EMBO MOLECULAR MEDICINE (2018)

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Article Multidisciplinary Sciences

Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma

Lucas A. Tomko et al.

SCIENTIFIC REPORTS (2018)

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Editorial Material Oncology

Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity

Reza Mirzaei et al.

ONCOIMMUNOLOGY (2018)

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Article Oncology

Tenascin-C Promotes Tumor Cell Migration and Metastasis through Integrin α9β1-Mediated YAP Inhibition

Zhen Sun et al.

CANCER RESEARCH (2018)

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Review Peripheral Vascular Disease

Multiple Roles of Tenascins in Homeostasis and Pathophysiology of Aorta

Kyoko Imanaka-Yoshida et al.

ANNALS OF VASCULAR DISEASES (2018)

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Article Urology & Nephrology

Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis

Haiyan Fu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Article Multidisciplinary Sciences

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival

Vasilena Gocheva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin expression in endothelial cells

Agata Radwanska et al.

SCIENTIFIC REPORTS (2017)

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Article Oncology

Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment

Rebeca San Martin et al.

CANCER RESEARCH (2017)

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Review Oncology

Pre-metastatic niches: organ-specific homes for metastases

Hector Peinado et al.

NATURE REVIEWS CANCER (2017)

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Article Oncology

Characteristics and Significance of the Pre-metastatic Niche

Yang Liu et al.

CANCER CELL (2016)

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Article Cell Biology

Tenascin-C at a glance

Kim S. Midwood et al.

JOURNAL OF CELL SCIENCE (2016)

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Article Cell Biology

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression

Yekaterina A. Miroshnikova et al.

NATURE CELL BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

Anna M. Piccinini et al.

SCIENCE SIGNALING (2016)

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Article Multidisciplinary Sciences

Vasculogenic mimicry in small cell lung cancer

Stuart C. Williamson et al.

NATURE COMMUNICATIONS (2016)

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Article Cell Biology

Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling

Tristan Rupp et al.

CELL REPORTS (2016)

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Article Biochemistry & Molecular Biology

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

Anna M. Piccinini et al.

SCIENCE SIGNALING (2016)

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Article Oncology

Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation

Elena Jachetti et al.

CANCER RESEARCH (2015)

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Review Cell Biology

Tenascin C in metastasis: A view from the invasive front

Camille M. Lowy et al.

CELL ADHESION & MIGRATION (2015)

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Article Cell Biology

Spatial organization of the tenascin-C microenvironment in experimental and human cancer

Caroline Spenle et al.

CELL ADHESION & MIGRATION (2015)

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Review Cell Biology

Tenascin-C: Exploitation and collateral damage in cancer management

Caroline Spenle et al.

CELL ADHESION & MIGRATION (2015)

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Review Cell Biology

Tenascin-C: Form versus function

Sean P. Giblin et al.

CELL ADHESION & MIGRATION (2015)

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Article Oncology

The emerging roles of YAP and TAZ in cancer

Toshiro Moroishi et al.

NATURE REVIEWS CANCER (2015)

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Article Biochemistry & Molecular Biology

Tenascin-C-derived Peptide TNIIIA2 Highly Enhances Cell Survival and Platelet-derived Growth Factor (PDGF)-dependent Cell Proliferation through Potentiated and Sustained Activation of Integrin α5β1

Rika Tanaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients

Irem Gurbuz et al.

MOLECULAR CANCER (2014)

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Article Biochemistry & Molecular Biology

Tenascin-C is required for normal Wnt/β-catenin signaling in the whisker follicle stem cell niche

Small Hendaoui et al.

MATRIX BIOLOGY (2014)

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Review Physiology

THE BIOLOGY OF YAP/TAZ: HIPPO SIGNALING AND BEYOND

Stefano Piccolo et al.

PHYSIOLOGICAL REVIEWS (2014)

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Article Oncology

AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients

Benoit Langlois et al.

ONCOTARGET (2014)

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Article Cardiac & Cardiovascular Systems

Tenascin-C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation

Tomoko Machino-Ohtsuka et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2014)

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Article Multidisciplinary Sciences

Tenascin C Promiscuously Binds Growth Factors via Its Fifth Fibronectin Type III-Like Domain

Laura De Laporte et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Christine Feig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Cell Biology

Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, Promoting Tumorigenesis in a Neuroendocrine Tumor Model

Falk Saupe et al.

CELL REPORTS (2013)

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Article Oncology

Binding of αvβ1 and αvβ6 integrins to tenascin-C induces epithelial-mesenchymal transition-like change of breast cancer cells

D. Katoh et al.

ONCOGENESIS (2013)

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Article Rheumatology

Endogenous activation of adaptive immunity: Tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease

Michaela Ruhmann et al.

ARTHRITIS AND RHEUMATISM (2012)

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Article Oncology

The prognostic significance of lymphovascular invasion in invasive breast carcinoma

Emad A. Rakha et al.

CANCER (2012)

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Article Biochemistry & Molecular Biology

Tenascin-C Produced by Oxidized LDL-Stimulated Macrophages Increases Foam Cell Formation through Toll-like Receptor-4

Rui Liu et al.

MOLECULES AND CELLS (2012)

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Article Pathology

Tenascin C Induces Epithelial-Mesenchymal Transition-Like Change Accompanied by SRC Activation and Focal Adhesion Kinase Phosphorylation in Human Breast Cancer Cells

Keiki Nagaharu et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Article Cell Biology

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells

Annalisa Pezzolo et al.

CELL RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Advances in tenascin-C biology

Kim S. Midwood et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

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Article Biochemistry & Molecular Biology

The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress

Maria B. Asparuhova et al.

FASEB JOURNAL (2011)

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Article Developmental Biology

Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth

Ellen Van Obberghen-Schilling et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2011)

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Review Multidisciplinary Sciences

Molecular mechanisms and clinical applications of angiogenesis

Peter Carmeliet et al.

NATURE (2011)

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Review Biochemistry & Molecular Biology

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Mina J. Bissell et al.

NATURE MEDICINE (2011)

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Article Biochemistry & Molecular Biology

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

Thordur Oskarsson et al.

NATURE MEDICINE (2011)

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Article Multidisciplinary Sciences

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

Joyce T. O'Connell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Cell Biology

Tenascins and the Importance of Adhesion Modulation

Ruth Chiquet-Ehrismann et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

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Article Pathology

Tumor Lymphangiogenesis and Metastasis to Lymph Nodes Induced by Cancer Cell Expression of Podoplanin

Leah N. Cueni et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

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Article Immunology

Extracellular Matrix of Glioblastoma Inhibits Polarization and Transmigration of T Cells: The Role of Tenascin-C in Immune Suppression

Jyun-Yuan Huang et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Multidisciplinary Sciences

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

Jacqueline D. Shields et al.

SCIENCE (2010)

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Article Immunology

α9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis

Masashi Kanayama et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Cell Biology

The role of tenascin-C in tissue injury and tumorigenesis

Kim S. Midwood et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2009)

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Article Biochemistry & Molecular Biology

A peptide derived from tenascin-C induces β1 integrin activation through syndecan-4

Yohei Saito et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Article Oncology

Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization

Katrin Lange et al.

CANCER RESEARCH (2007)

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Review Oncology

Tenascin-C induced signaling in cancer

Gertraud Orend et al.

CANCER LETTERS (2006)

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Article Dermatology

Modulation of cell-fibronectin matrix interactions during tissue repair

Kim S. Midwood et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2006)

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Article Cell Biology

Fibronectin at a glance

R Pankov et al.

JOURNAL OF CELL SCIENCE (2002)

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Article Oncology

Clinical impact and functional aspects of tenascin-C expression during glioma progression

C Herold-Mende et al.

INTERNATIONAL JOURNAL OF CANCER (2002)

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