期刊
JOURNAL OF CELL SCIENCE
卷 135, 期 18, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.260244
关键词
Immunity; Metastasis; Tenascin-C; Tumor
类别
资金
- Institut National de la Sante et de la Recherche Medicale (INSERM), University Strasbourg
- INCa project TENMAX
- Agence Nationale de la Recherche (ANR) project MatrixNash
- Aviesan ITMO Cancer project Radio3R
- Ligue contre le cancer CCIRGE
- EUCOR
- Academy of Finland [326291]
- University of Oulu DigiHealth-project
- Finnish Cancer Institute
- K. Albin Johansson Cancer Research Fellowship fund
- Deutsche Forschungsgemeinschaft [FOR2722-384170921]
- Chinese Scholarship Council
- INSERM
The extracellular matrix molecule tenascin-C (TNC) plays important roles in tumorigenesis, angiogenesis, immunity, and metastasis, with immune cells being a key target of TNC in cancer. Understanding the diverse mechanisms of TNC can provide valuable insights for cancer disease management and immune therapies.
The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have been extensively reviewed since its discovery over 40 years ago. Here, we will describe recent insights into the roles of TNC in tumorigenesis, angiogenesis, immunity and metastasis. In addition to high levels of expression in tumors, and during chronic inflammation, and bacterial and viral infection, TNC is also expressed in lymphoid organs. This supports potential roles for TNC in immunity control. Advances using murine models with engineered TNC levels were instrumental in the discovery of important functions of TNC as a danger-associated molecular pattern (DAMP) molecule in tissue repair and revealed multiple TNC actions in tumor progression. TNC acts through distinct mechanisms on many different cell types with immune cells coming into focus as important targets of TNC in cancer. We will describe how this knowledge could be exploited for cancer disease management, in particular for immune (checkpoint) therapies.
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