期刊
JOURNAL OF CATALYSIS
卷 415, 期 -, 页码 142-152出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcat.2022.10.003
关键词
Photocatalysis; Nickel catalysis; C(sp(3))– H amidation; Dioxazolone; DFT calculation
资金
- National Natural Science Foundation of China [21973068, 21801249]
- project of scientific and technologic infrastructure of Suzhou [SZS201708]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
This study describes a new strategy for the direct C(sp3)-H amidation using photoredox-mediated hydrogen atom transfer and transition-metal catalysis under mild conditions. The method provides good reactivity and site selectivity for the construction of C(sp3)-N bonds and can be applied to the late-stage modification of complex molecules.
The direct C(sp3)-H amidation is a highly desirable but challenging approach to construct C(sp3)-N bonds. Herein, we describe a new strategy combining photoredox-mediated hydrogen atom transfer (HAT) and transition-metal catalysis for intermolecular C(sp3)-H amidation of unactivated alkanes, ketones, ethers, amines, and aldehydes with dioxazolones. This protocol, employing synergistic tetrabutylammonium decatungstate (TBADT) anion photocatalysis and nickel catalysis, provides a practical approach to realize a direct intermolecular C(sp3)-H amidation with useful reactivity and site selectivity under mild conditions, which may be applied to the late-stage modification of complex molecules. A combined experimental and computational mechanistic study implies the formation of a key [W10O32]4--Ni(I) species under irradiation of UV-A. The unusual cooperative roles of [W10O32]4- anion and Ni(I) moiety are suggested in generating a C-centered radical from C(sp3)-H bond and an amido group from dioxazolone, respectively. Subsequently, the formation of a [W10O32]4--Ni(III) complex followed by a reductive elimination step is proposed to afford the desired amidation product.
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