期刊
JOURNAL OF INNATE IMMUNITY
卷 9, 期 1, 页码 3-11出版社
KARGER
DOI: 10.1159/000451026
关键词
Surfactant protein A; Surfactant protein D; Female reproductive tract; Urinary tract; Gastrointestinal tract
类别
资金
- University of Cape Town
- Sir Halley Stewart Trust
- Poliomyelitis Research Foundation
- Cancer Association of South Africa
- National Research Foundation of South Africa
Surfactant proteins A (SP-A) and D (SP-D) are established as essential components of our innate immune system for protecting the lung from pathogens and allergens. They essentially exert their protective functions by regulating pulmonary homeostasis. Both proteins are however widely expressed throughout the body, including the female reproductive tract, urinary tract, gastrointestinal tract, the eye, ear, nasal compartment, central nervous system, the coronary artery and the skin. The functions of SP-A and SP-D at these sites are a relatively underinvestigated area, but it is emerging that both SP-A and SP-D contribute significantly to the regulation of inflammation and protection from infection at these sites. This review presents our current understanding of the roles of SP-A and SP-D in non-pulmonary sites. (C) 2016 S. Karger AG, Basel
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