The diagnostic and prognostic value of D-dimer in different types of aortic dissection

Article Cardiac & Cardiovascular Systems

D-dimer levels in patients with nonvalvular atrial fibrillation and acute heart failure treated with edoxaban

Keisuke Kida et al.

Summary: D-dimer levels can predict ischemic stroke in patients with nonvalvular atrial fibrillation (NVAF) and acute heart failure (AHF). Edoxaban may be effective in lowering and maintaining D-dimer levels.

JOURNAL OF CARDIOLOGY (2022)

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Article Clinical Neurology

High D-Dimer Concentration Is a Significant Independent Prognostic Factor in Patients with Acute Large Vessel Occlusion Undergoing Endovascular Thrombectomy

Yoshinori Hisamitsu et al.

Summary: This study aimed to investigate prognostic factors that affect the modified Rankin Scale score at 3 months after onset of acute stroke in patients with large vessel occlusion who underwent endovascular thrombectomy. The results showed that age, National Institutes of Health Stroke Scale score, and D-dimer concentration on admission were significant prognostic factors related to modified Rankin Scale score at 3 months. Multivariate logistic regression analysis showed that D-dimer concentration was the only significant independent prognostic factor. Therefore, patients with high D-dimer concentration may have worse prognosis and alternative treatment options should be considered.

WORLD NEUROSURGERY (2022)

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Article Medicine, General & Internal

Predictive Role of the D-Dimer Level in Acute Kidney Injury in Living Donor Liver Transplantation: A Retrospective Observational Cohort Study

Jaesik Park et al.

Summary: This study found an association between high D-dimer levels and the risk of acute kidney injury (AKI) in patients undergoing living donor liver transplantation (LDLT). High D-dimer levels, combined with diabetes mellitus, platelet count, and hourly urine output, were independent predictors of postoperative AKI development. Patients with high D-dimer levels also had a higher incidence of early allograft dysfunction, longer intensive care unit stay, and higher mortality rate.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Determinants of outcomes following surgery for type A acute aortic dissection: the UK National Adult Cardiac Surgical Audit

Umberto Benedetto et al.

Summary: This study aimed to investigate the relationship between surgical outcomes of TAAAD patients in the UK and variables including patient characteristics, intraoperative factors, cardiac centers, and surgeons. The study found significant associations between age, malperfusion, left ventricular ejection fraction, previous cardiac surgery, preoperative mechanical ventilation, preoperative resuscitation, concomitant coronary artery bypass grafting, and surgical outcomes. Additionally, there was an inverse relationship between surgeon annual volume and outcomes.

EUROPEAN HEART JOURNAL (2022)

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Article Cardiac & Cardiovascular Systems

Prognostic nutritional index predicts in-hospital mortality in patients with acute Stanford type A aortic dissection

Hasan Attila Keskin et al.

Summary: In this study, it was found that lower PNI values in ATAAD patients were associated with an increased risk of in-hospital mortality, and PNI may be useful in predicting early mortality in ATAAD patients after surgical repair.

PERFUSION-UK (2021)

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Article Cardiac & Cardiovascular Systems

Admission Values of Plasma Biomarkers Predict the Short-Term Outcomes in Acute Aortic Dissection

Nan Xie et al.

Summary: The study found that D-dimer and type A AAD were independent predictors of in-hospital mortality in patients with AAD. Subgroup analysis of D-dimer further confirmed its association with poor prognosis in type A AAD.

HEART SURGERY FORUM (2021)

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Review Cardiac & Cardiovascular Systems

The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis

Jian Yao et al.

Summary: The meta-analysis included 16 clinical studies with a total of 1135 patients. The results revealed that D-dimer has an excellent diagnostic value for AAD, with high sensitivity and specificity. Meta-regression and subgroup analyses identified publication year, sample size, and cutoff value as sources of heterogeneity, while D-dimer <= 500 ng/ml significantly increased sensitivity in diagnosing suspected AAD patients.

JOURNAL OF CARDIOTHORACIC SURGERY (2021)

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Article Cardiac & Cardiovascular Systems

Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

Hongtu Cui et al.

Summary: Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. The study found that succinate plays an important role in the development of AAD, and plasma succinate concentrations can distinguish patients with AAD from healthy controls. Regulating succinate concentrations through the p38 alpha-CREB-OGDH axis in macrophages may have therapeutic potential for AAD.

EUROPEAN HEART JOURNAL (2021)

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News Item Medicine, General & Internal