Long non-coding RNAs involved in retinoblastoma

Introduction Retinoblastoma (RB) is the most common childhood tumor that can occur in the retina and develop in a sporadic or heritable form. Although various traditional treatment options have been used for patients with RB, identifying novel strategies for childhood cancers is necessary. Material and methods Recently, molecular-based targeted therapies have opened a greater therapeutic window for RB. Long non-coding RNAs (lncRNAs) presented a potential role as a biomarker for the detection of RB in various stages. Conclusion LncRNAs by targeting several miRNA/transcription factors play critical roles in the stimulation or suppression of RB. In this review, we summarized recent progress on the functions of tumor suppressors or oncogenes lncRNAs in RB.

Automated summary

Retinoblastoma (RB) is the most common childhood tumor that requires novel treatment strategies. Molecular-based targeted therapies have opened up new possibilities for RB, and long non-coding RNAs (lncRNAs) may serve as biomarkers for early detection of RB.