4.6 Review

Research on the influence of APOBEC family on the occurrence, diagnosis, and treatment of various tumors

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Article Oncology

APOBEC: A molecular driver in cervical cancer pathogenesis

Sundaramoorthy Revathidevi et al.

Summary: Cervical cancer, a common cancer in women, is primarily caused by HPV infection. Apart from genetic and epigenetic factors, the APOBEC3 family plays a crucial role in the molecular pathogenesis of cancer, including inducing tumor mutations through DNA editing mechanisms.

CANCER LETTERS (2021)

Article Biochemistry & Molecular Biology

APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A

Lai Wong et al.

Summary: The study characterizes APOBEC1 and its potential role in cancer, suggesting that RPA may act as a defense against off-target deamination for certain APOBEC enzymes. The data supports a model where the competition between APOBEC and RPA can better predict genomic damage compared to mRNA expression levels and mutation signature analysis in tumors.

NUCLEIC ACIDS RESEARCH (2021)

Article Genetics & Heredity

Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence

Sarah Moody et al.

Summary: The incidence of esophageal squamous cell carcinoma varies significantly across different geographical regions, and known risk factors cannot fully explain the variation. Research indicates no specific mutational signature indicative of an exogenous exposure that could explain the differences in incidence, with APOBEC activation being a crucial step in ESCC tumor development.

NATURE GENETICS (2021)

Article Multidisciplinary Sciences

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

Christopher B. Driscoll et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots

Pegah Jalili et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Extensive heterogeneity in somatic mutation and selection in the human bladder

Andrew R. J. Lawson et al.

SCIENCE (2020)

Article Medicine, General & Internal

Head and neck squamous cell carcinoma

Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Article Chemistry, Medicinal

Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate

Li Tao et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2019)

Article Genetics & Heredity

APOBEC3A is a prominent cytidine deaminase in breast cancer

Luis M. Cortez et al.

PLOS GENETICS (2019)

Article Multidisciplinary Sciences

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

Tania V. Silvas et al.

SCIENTIFIC REPORTS (2018)

Review Biochemistry & Molecular Biology

APOBEC Enzymes as Targets for Virus and Cancer Therapy

Margaret E. Olson et al.

CELL CHEMICAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

The APOBEC Protein Family: United by Structure, Divergent in Function

Jason D. Salter et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Article Multidisciplinary Sciences

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

Gabriel J. Starrett et al.

NATURE COMMUNICATIONS (2016)

Article Medicine, General & Internal

Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study

Jianxin Shi et al.

PLOS MEDICINE (2016)

Article Multidisciplinary Sciences

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

Emily K. Law et al.

SCIENCE ADVANCES (2016)

Article Medicine, Research & Experimental

The head and neck cancer immune landscape and its immunotherapeutic implications

Rajarsi Mandal et al.

JCI INSIGHT (2016)

Article Genetics & Heredity

Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma

Ling Zhang et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2015)

Article Medicine, General & Internal

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

Stephen M. Ansell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Cell Biology

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

Nicholas McGranahan et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Review Biochemistry & Molecular Biology

APOBEC3 genes: retroviral restriction factors to cancer drivers

Stephen Henderson et al.

TRENDS IN MOLECULAR MEDICINE (2015)

Review Oncology

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

Charles Swanton et al.

CANCER DISCOVERY (2015)

Article Dermatology

Expression of AID in malignant melanoma with BRAFV600E mutation

Risa Okura et al.

EXPERIMENTAL DERMATOLOGY (2014)

Review Oncology

Hypermutation in human cancer genomes: footprints and mechanisms

Steven A. Roberts et al.

NATURE REVIEWS CANCER (2014)

Article Medicine, Research & Experimental

APOBEC3B gene overexpression in non-small-cell lung cancer

Hidefumi Sasaki et al.

BIOMEDICAL REPORTS (2014)

Review Biochemistry & Molecular Biology

Structural features of antiviral DNA cytidine deaminases

Ananda Ayyappan Jaguva Vasudevan et al.

BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

APOBEC3B is an enzymatic source of mutation in breast cancer

Michael B. Burns et al.

NATURE (2013)

Article Multidisciplinary Sciences

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

NATURE (2013)

Article Genetics & Heredity

Evidence for APOBEC3B mutagenesis in multiple human cancers

Michael B. Burns et al.

NATURE GENETICS (2013)

Article Genetics & Heredity

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

Steven A. Roberts et al.

NATURE GENETICS (2013)

Article Multidisciplinary Sciences

Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells

Paulina Prorok et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Medicine, General & Internal

Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Suzanne L. Topalian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Multidisciplinary Sciences

APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells

Masanobu Shinohara et al.

SCIENTIFIC REPORTS (2012)

Article Biochemistry & Molecular Biology

Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast

A. G. Lada et al.

BIOCHEMISTRY-MOSCOW (2011)

Article Biochemistry & Molecular Biology

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

Sebastien Landry et al.

EMBO REPORTS (2011)

Article Medicine, Research & Experimental

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

Qingqing Ding et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Genetics & Heredity

Determinants of sequence-specificity within human AID and APOBEC3G

Michael A. Carpenter et al.

DNA REPAIR (2010)

Article Biochemistry & Molecular Biology

Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification

Rahul M. Kohli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

Mark D. Stenglein et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Review Immunology

The biochemistry of somatic hypermutation

Jonathan U. Peled et al.

ANNUAL REVIEW OF IMMUNOLOGY (2008)

Review Biotechnology & Applied Microbiology

The AID/APOBEC family of nucleic acid mutators

Silvestro G. Conticello

GENOME BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases

SG Conticello et al.

MOLECULAR BIOLOGY AND EVOLUTION (2005)

Review Immunology

Retroviral restriction by APOBEC proteins

RS Harris et al.

NATURE REVIEWS IMMUNOLOGY (2004)

Article Immunology

Constitutive expression of AID leads to tumorigenesis

I Okazaki et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)