期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 37, 期 5, 页码 773-785出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/08853282221121879
关键词
Polymer-matrix composite; carboxymethyl chitosan; hydroxyapatite; gelatin; silver particles; copper particles
资金
- Mexican National Council for Science and Technology (CONACyT) [SEP-CONACyT CB 2015-01-252439]
The wound dressing composite films containing OCMC and gelatin, along with Ag-Cu/HA composite, showed improved thermal stability, enhanced antibacterial activity, and cell viability exceeding 100%, making them suitable for wound healing dressings and regenerating biomaterials.
Wound dressing composite films of O-carboxymethyl chitosan (OCMC) and gelatin were prepared and mixed with hydroxyapatite (HA) composited with Silver (Ag) and Copper (Cu) at different concentrations. The chemical, thermal, morphological, and biological properties of the composite films were studied. The analysis by FTIR confirmed the presence of interactions between gelatin and OCMC, and at the same time, the polymer matrix interactions with Ag-Cu/HA complex. The inclusion of nanoparticle to the composite was associated with an improvement of the thermal stability, morphological roughness, a 9-12% more hydrophobic behavior (composite C1, C5, and C8), increase in antibacterial activity from 23.2 to 33.1% for gram negative bacteria and from 37.28 to 40.59% for gram positive bacteria, and with a cell viability greater than 100% for 24 and 72 h. The films obtained can serve as a wound healing dressing and regenerating biomaterial.
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