期刊
JOURNAL OF AUTOIMMUNITY
卷 132, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2022.102887
关键词
Systemic lupus erythematosus; Immune thrombocytopenia; Thrombopoietin; Neonatal fc receptor; Spleen tyrosine kinase; Bruton tyrosine kinase
类别
资金
- National Natural Science Foundation of China [81788101]
- Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFMS) [2021-1-I2M-017, 2021-1-I2M-047, 2021-1-I2M-040, 2021-1-I2M-016, 2021-1-I2M-026, 2021-I2M-1-040]
- Capital's Funds for Health Improvement and Research [2020-2-4019]
- Natural Science Foundation of Hunan Province [2021JJ40996]
This article reviews the pathogenesis and treatment of immune thrombocytopenia (ITP) as a common hematological manifestation of systemic lupus erythematosus (SLE). In addition to traditional treatment methods, the article introduces new therapies and highlights the need for further research to confirm their efficacy.
Immune thrombocytopenia (ITP) is a common hematological manifestation of systemic lupus erythematosus (SLE). The heterogeneity of its clinical characteristics and therapeutic responses reflects a complex pathogenesis. A better understanding of its pathophysiological mechanisms and employing an optimal treatment regimen is therefore important to improve the response rate and prognosis, and avoid unwanted outcomes. Besides glu-cocorticoids, traditional immunosuppressants (i.e. cyclosporine, mycophenolate mofetil) and intravenous im-munoglobulins, new therapies are emerging and promising for the treatment of intractable SLE-ITP, such as thrombopoietin receptor agonists (TPO-RAs), platelet desialylation inhibitors(i.e. oseltamivir), B-cell targeting therapy(i.e. rituximab, belimumab), neonatal Fc receptor(FcRn) inhibitor, spleen tyrosine kinase(Syk) inhibitor and Bruton tyrosine kinase(BTK) inhibitor et al., although more rigorous randomized controlled trials are needed to substantiate their efficacy. In this review, we update our current knowledge on the pathogenesis and treatment of SLE-ITP.
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