期刊
JOURNAL OF INFECTIOUS DISEASES
卷 214, 期 5, 页码 707-711出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw226
关键词
Zika virus; flavivirus; nucleoside analogue; antiviral; therapy
资金
- Czech Science Foundation [GA14-29256S]
- Ministry of Education, Youth, and Sports of the Czech Republic, under the NPU I program [LO1218]
- National Subvention for the Development of Research Organizations [RVO:61388963]
- European Virus Archive Goes Global project - European Union [653316]
There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2'-C- or 2'-O-methyl-substituted nucleosides, 2'-C-fluoro-2'-C-methyl-substituted nucleosides, 3'-O-methyl-substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2'-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.
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