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Treatment for food allergy: Current status and unmet needs

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

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Article Allergy

Phase 2, randomized multi oral immunotherapy with omalizumab 'real life' study

Sayantani B. Sindher et al.

Summary: This study aimed to determine the minimum daily dose that can achieve desensitization and induce immune responses in multi-food oral immunotherapy (mOIT). The results showed that even at a total protein dose of 300 mg inclusive of multiple allergens, combined with a fixed-dose of omalizumab, early plasma marker changes can be induced.

ALLERGY (2022)

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Article Allergy

Updating the CoFAR Grading Scale for Systemic Allergic Reactions in Food Allergy

R. Sharon Chinthrajah et al.

Summary: Immunotherapy for food allergy is promising, but adverse events and their severity during treatment are not standardized. This study developed a revised grading scale to categorize and assess adverse allergic reactions in food allergy clinical trials. The use of this revised scale would allow for better data aggregation and safety comparisons.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Efficacy and safety of oral immunotherapy in children aged 1–3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study

Stacie M Jones et al.

LANCET (2022)

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Review Allergy

Advances, Practical Implementation, and Unmet Needs Regarding Oral Immunotherapy for Food Allergy

Kirsten P. Perrett et al.

Summary: The treatment of food allergies is continuously evolving, and oral immunotherapy (OIT) has emerged as a significant advancement in recent years. There is a growing demand for OIT, especially for allergens like peanut, egg, and milk, which have substantial evidence of efficacy. However, there are still important questions surrounding the treatment of multiple and less common food allergies, as well as the long-term safety and effectiveness of OIT.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Review Allergy

Omalizumab as an adjuvant in food allergen immunotherapy

Jennifer A. Dantzer et al.

Summary: Omalizumab as an adjunct to food allergen oral immunotherapy has shown potential in reducing the time needed to reach maintenance dosing and adverse events, although serious adverse events may still occur. Limited long-term data suggest a risk of increased reactivity after discontinuation of omalizumab. Further studies are needed to optimize protocols and identify patients who will benefit the most.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

The use of biologics in food allergy

Alessandro Fiocchi et al.

Summary: In recent years, there have been significant changes in the treatment strategies for food allergy, with a better understanding of the effects of anti-IgE treatments in poliallergic patients and OIT-treated patients, as well as specific biologic treatments targeting various mediators.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

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Article Mathematical & Computational Biology

Novel application of a discrete time-to-event model for randomized oral immunotherapy clinical trials with repeat food challenges

Natasha Purington et al.

Summary: The use of time-to-event methodology in food allergy trials allows for a more detailed evaluation of treatment efficacy over time, incorporating information for those who failed or were lost to follow up. This approach provides a dose-time outcome that is interpretable to clinicians and allows for examination of outcomes over time.

STATISTICS IN MEDICINE (2021)

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Article Allergy

Effect of oral immunotherapy in children with milk allergy: The ORIMA study

Mayu Maeda et al.

Summary: The study found that oral immunotherapy significantly reduced allergic symptoms in children with severe cow's milk allergy, but the incidence of adverse events was relatively high, suggesting the need for further research on safety in order to standardize OIT for cow's milk allergy.

ALLERGOLOGY INTERNATIONAL (2021)

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Article Allergy

A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy: Efficacy and Humoral Immune Responses in 50 Children

Kati Palosuo et al.

Summary: Oral immunotherapy with raw egg is effective in desensitizing children with persistent egg allergy, leading to increased tolerance to egg products and improved quality of life. Subjects with high baseline egg-specific IgE concentrations and sensitization to multiple egg allergen components benefit from prolonged treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Allergy

Improvement in Health-Related Quality of Life in Food-Allergic Patients: A Meta-Analysis

Shu Cao et al.

Summary: This meta-analysis found that both oral immunotherapy (OIT) and oral food challenges (OFCs) are associated with an improvement in health-related quality of life (HRQoL) in patients with food allergies. Further well-designed and long-term studies are needed to confirm the sustained benefits of OIT and OFCs.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Allergy

Anti-IgE: A treatment option in allergic rhinitis?

O. Pfaar et al.

Summary: Omalizumab shows promising results in the treatment of allergic rhinitis, particularly in symptom control, safety profile, and comorbidity management. Further research and clinical trials with other biologics in the management of allergic rhinitis are necessary.

ALLERGOLOGIE (2021)

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Article Allergy

Oral Immunotherapy for Hazelnut Allergy: A Single-Center Retrospective Study on 100 Patients

Tomas Moraly et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Allergy

Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy

Edwin H. Kim et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Pediatrics

Efficacy and safety of oral immunotherapy with AR101 in European children with a peanut allergy (ARTEMIS): a multicentre, double-blind, randomised, placebo-controlled phase 3 trial

Jonathan O'BHourihane et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

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Article Allergy

Egg oral immunotherapy in children (SEICAP I): Daily or weekly desensitization pattern

Maria Flora Martin-Munoz et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2019)

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Article Medicine, General & Internal

Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy The PEPITES Randomized Clinical Trial

David M. Fleischer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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Review Medicine, General & Internal

Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety

Derek K. Chu et al.

LANCET (2019)

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Article Allergy

Effect of sleep deprivation and exercise on reaction threshold in adults with peanut allergy: A randomized controlled study

Shelley Dua et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Medicine, General & Internal

Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study

R. Sharon Chinthrajah et al.

LANCET (2019)

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Review Pharmacology & Pharmacy

A drug safety review of treating eosinophilic asthma with monoclonal antibodies

Patrick Mitchell et al.

EXPERT OPINION ON DRUG SAFETY (2019)

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Article Allergy

Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy

Anna Nowak-Wegrzyn et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Allergy

Efficacy, Safety, and Quality of Life in a Multicenter, Randomized, Placebo-Controlled Trial of Low-Dose Peanut Oral Immunotherapy in Children with Peanut Allergy

Katharina Blumchen et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

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Article Pediatrics

Walnut oral immunotherapy for desensitisation of walnut and additional tree nut allergies (Nut CRACKER): a single-centre, prospective cohort study

Arnon Elizur et al.

LANCET CHILD & ADOLESCENT HEALTH (2019)

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Article Medicine, General & Internal

A Phase 2 Randomized Controlled Multisite Study Using Omalizumab-facilitated Rapid Desensitization to Test Continued vs Discontinued Dosing in Multifood Allergic Individuals

Sandra Andorf et al.

ECLINICALMEDICINE (2019)

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Article Allergy

Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial

J. Andrew Bird et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2018)

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Article Medicine, General & Internal

AR101 Oral Immunotherapy for Peanut Allergy

Brian P. Vickery et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Gastroenterology & Hepatology

Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial

Sandra Andorf et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2018)

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Article Allergy

Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective

Brian P. Vickery et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Allergy

Omalizumab facilitates rapid oral desensitization for peanut allergy

Andrew J. MacGinnitie et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Oral immunotherapy combined with omalizumab for high-risk cow's milk allergy: a randomized controlled trial

Masaya Takahashi et al.

SCIENTIFIC REPORTS (2017)

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Article Allergy

A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy

Robert A. Wood et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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Letter Allergy

Wheat oral immunotherapy for wheat-induced anaphylaxis

Sakura Sato et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Article Allergy

Safety and feasibility of oral immunotherapy to multiple allergens for food allergy

Philippe Begin et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2014)

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Article Allergy

The safety and efficacy of sublingual and oral immunotherapy for milk allergy

Corinne A. Keet et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Allergy

Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy

Jessica H. Savage et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Allergy

Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report

Hugh A. Sampson et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Medicine, General & Internal

Oral Immunotherapy for Treatment of Egg Allergy in Children

A. Wesley Burks et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Article Economics

Conjoint Analysis Applications in Health-a Checklist: A Report of the ISPOR Good Research Practices for Conjoint Analysis Task Force

John F. P. Bridges et al.

VALUE IN HEALTH (2011)

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Article Allergy

A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy

Justin M. Skripak et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

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Article Allergy

Sublingual immunotherapy for hazelnut food allergy:: A randomized, double-blind, placebo-controlled study with a standardized hazelnut extract

E Enrique et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

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