Treatment for food allergy: Current status and unmet needs

The treatment of food allergy has traditionally relied on avoidance of the offending food(s) and use of emergency medications in the event of accidental exposures. However, this long-standing paradigm is beginning to shift, as a variety of treatment approaches have been and are being developed. This report provides an overview of the past, present, and future landscape of interventional clinical trials for the treatment of food allergy. It focuses on specific issues related to participant characteristics, protocol design, and study end points in the key clinical trials in the literature and examine how differences between studies may impact the clinical significance of the study results. Recommendations are provided for the optimization of future trial designs and focus on specific unmet needs in this rapidly evolving field. (J Allergy Clin Immunol 2023;151:1-14.)

Automated summary

The traditional approach for treating food allergies has been to avoid the offending food and use emergency medications if accidental exposures occur. However, the treatment landscape is evolving with the development of various approaches. This report discusses past, present, and future clinical trials for food allergy treatment, focusing on participant characteristics, protocol design, and study endpoints. It also provides recommendations for optimizing trial design and addressing unmet needs in this rapidly evolving field.