期刊
JOURNAL OF INFECTIOUS DISEASES
卷 214, 期 2, 页码 196-204出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw139
关键词
H. pylori; sigma(28); HP0102; CagA induction; host-pathogen interaction; chemotaxis
资金
- Council of Scientific and Industrial Research-Indian Institute of Chemical Biology [BSC0119]
- Council of Scientific and Industrial Research
Contact with host cells is recognized as a signal capable of triggering expression of bacterial genes important for host pathogen interaction. Adherence of Helicobacter pylori to the gastric epithelial cell line AGS strongly upregulated expression of a gene, HP0102, in the adhered bacteria in all strains examined, including several Indian clinical isolates. The gene is highly conserved and ubiquitously present in all 69 sequenced H. pylori genomes at the same genomic locus, as well as in 15 Indian clinical isolates. The gene is associated with 2 distinct phenotypes related to pathogenicity. In AGS cell-adhered H. pylori, it has a role in upregulation of cagA expression from a specific sigma(28)-RNAP promoter and consequent induction of the hummingbird phenotype in the infected AGS cells. Furthermore, HP0102 has a role in chemotaxis and a Delta HP0102 mutant exhibited low acid-escape response that might account for the poor colonization efficiency of the mutant.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据