期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c04862
关键词
rice protein peptide; colitis; anti-inflammatory; gut microbiota; Keap1-Nrf2
资金
- Natural Science Foundation of China [82060781, 31660470]
- Research Program of State Key Laboratory of Food Science and Technology, Nanchang University [SKLF-ZZA-202209]
- Key Project for Science and Technology Research of Jiangxi Province [20182ABC28010, 5511]
- China Postdoctoral Science Foundation [2020M671975]
- Central Government Guide Local Special Fund Project for Scientific and Technological Development of Jiangxi Province [20221ZDD02001]
This study explored the protective effects of industrially produced rice protein peptides (RPP) on acute colitis in mice and found that RPP alleviated colitis symptoms through regulating gut microbiota and activating signaling pathways. These findings suggest that RPP may be used as dietary supplements or functional foods.
Inflammatory bowel disease (IBD), with increasing incidence, causes a range of gastrointestinal symptoms and brings distress and impact on the health and lives of patients. The aim of this study was to explore the protective effects of industrially produced rice protein peptides (RPP) on dextran sulfate sodium (DSS)-induced acute colitis in mice and the potential mechanisms. The results showed that RPP treatment alleviated the symptoms of colitis in mice, including weight loss, colon shortening, and injury, decreased the level of disease activity index (DAI), regulated the balance of inflammatory factors and oxidation, activated Kelch-like ECH-associating protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2) signaling pathway, regulated the expression of related antioxidant proteases, and promoted the expression of intestinal tight junction proteins. In addition, RPP maintained intestinal mucosal barrier function and alleviated acute colitis caused by DSS treatment in mice by increasing the value of F/B, increasing the relative abundance of beneficial bacteria such as Akkermansia, and regulating the level of short-chain fatty acids. In conclusion, RPP alleviated colitis symptoms through the Keap1-Nrf2 signaling pathway and regulating gut microbiota, which had the potential as dietary supplements or functional foods.
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