期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 42, 页码 13754-13764出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c04396
关键词
Gallus gallus domesticus; indicator PCBs; PCB metabolism; pharmacokinetics; carry-over
This study presents toxicokinetic models for the transfer of non-dioxin-like polychlorinated biphenyls (ndl-PCBs) into chicken eggs and meat, improving the prediction of experimental data. The study also calculates the highest level of ndl-PCBs in laying hen feed to ensure safety in meat and eggs, considering the possibility of soil contamination.
Non-dioxin-like polychlorinated biphenyls (ndl-PCBs) are a subclass of persistent bioaccumulative pollutants able to enter the food chain. Toxicokinetic models for the transfer of the six ndl-PCB congeners (PCBs 28, 52, 101, 138, 153, and 180) from contaminated feed and soil into chicken eggs and meat are presented. Three independent controlled feeding study datasets were used to estimate the model parameters and four studies for evaluating the model performance. The yolk deposition of ndl-PCBs is modeled in a novel way that mimics the physiology of yolk growth and development, resulting in improved prediction of the experimental data without introducing an ad hoc time delay between ovulation and oviposition. Using the models, the highest level of 2.4 mu g/kg dry matter (DM) was calculated for the sum of ndl-PCBs in laying hen feed to ensure that the current maximum levels in meat and eggs (40 ng/g fat) will not be exceeded. It is also shown how this highest level in feed should be adapted in case soil, in addition to feed, is also a source of ndl-PCBs for free-range chickens.
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