期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 36, 页码 11224-11235出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c02334
关键词
hesperidin; lipid metabolism; liver metabolomics; gut microbiota
资金
- National Natural Science Foundation of China [82160168, 81860578]
- Shuangqian Project of Scientific and Technological Innovation of High-end Talents-Natural Science, Jiangxi Province [jxsq2020101063]
- Academic and Technical Leaders Training Program of Major Disciplines in Jiangxi Province-Young Talents Program [20204BCJ23025]
This study investigated the mechanism underlying the impact of hesperidin on nonalcoholic fatty liver. The results showed that hesperidin improved liver dysfunction and serum lipid profiles induced by a high-fat diet, altered the expression of genes involved in lipid metabolism, and changed the composition of the intestinal microbiota. Liver metabolomics analysis indicated that hesperidin enhanced the abundance of metabolites in specific pathways, which were predicted to be positively correlated with the gut bacteria enriched by hesperidin.
The present study investigated the mechanism underlying the impact of hesperidin (HES) on nonalcoholic fatty liver (NAFLD). CS7BL/6J male mice were administered a low-fat diet, high-fat diet (HFD), or HFD plus 0.2% (wt/wt) HES (HFD + HES) diet. After 16 weeks of intervention, the mice in the HFD+HES group showed a lower final body weight and liver weight and improved serum lipid profiles when compared with the HFD group. Alleviation of liver dysfunction induced by HFD was observed in HES-fed mice, and the expression of genes involved in lipid metabolism was also altered. Moreover, HES changed the composition of the intestinal microbiota and enriched specific genera such as Bacteroidota. Liver metabolomics analysis indicated that HES enhanced the abundance of metabolites in arginine-related as well as mitochondrial oxidation-related pathways, and these metabolites were predicted to be positively correlated with the gut genera enriched by HES. Together, these results indicate that HFD-fed mice supplemented with HES showed a markedly regulated hepatic metabolism concurrent with shifts in specific gut bacteria.
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