Exploring associations between postpartum depression and oxytocin levels in cerebrospinal fluid, plasma and saliva

Background: Postpartum depression (PPD) is a serious mental health concern affecting approximately 17.22 % of new mothers worldwide. In addition to its obstetric effects, oxytocin (OXT) has also been considered to play a role in PPD. However, most previous studies exploring associations between PPD and OXT levels focus on easier accessible compartments such as blood or saliva. Study aim: To explore the possible association between PPD and OXT levels, and to assess the interaction between peripheral secretion and central release of OXT. Methods: In this study, we prospectively measured OXT concentrations in cerebrospinal fluid (CSF), plasma and saliva of 94 women with elective cesarean section by enzyme-linked immunosorbent assay (ELISA) kits. The participants were divided into the PPD group if the score of Edinburgh Postpartum Depression Scale (EPDS) >= 10 at 3 months postpartum, otherwise into the non-PPD (nPPD) group. Results: The incidence of PPD was 30.85 %. OXT concentrations in CSF (r =-0.518, p < 0.001), plasma (r =-0.240, p = 0.020) and saliva (r =-0.263, p = 0.010) were negatively correlated with EPDS score, and were valuable for the prediction of PPD, with AUC and 95%CI of 0.890 (0.809-0.945), 0.683 (0.579-0.775) and 0.699 (0.596-0.790), respectively. Moreover, OXT concentrations in plasma (r = 0.407, p < 0.001) and saliva (r = 0.624, p < 0.001) were positively correlated with CSF OXT concentrations. Limitations: Only full-term pregnant women undergoing elective cesarean section were included in this study, which may affect study generalizability. Conclusions: The central and peripheral release of OXT is coordinated, and OXT level measured prenatally in CSF, plasma, or saliva is valuable for the prediction of PPD.

Automated summary

This study aimed to explore the association between postpartum depression (PPD) and oxytocin (OXT) levels, as well as assess the interaction between peripheral secretion and central release of OXT. The results showed that OXT concentrations in cerebrospinal fluid (CSF), plasma, and saliva were negatively correlated with PPD and could be valuable predictors of PPD. Additionally, OXT concentrations in plasma and saliva were positively correlated with CSF OXT concentrations.