期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 315, 期 -, 页码 17-26出版社
ELSEVIER
DOI: 10.1016/j.jad.2022.07.042
关键词
Early adversity; Childhood trauma; Childhood maltreatment; Adverse childhood experiences; Depression; Precision medicine
资金
- John D. and Catherine T. MacArthur Foundation Research Network, National Institute on Aging [P01-AG020166]
- National Institute on Aging [U19-AG051426]
- National Institutes of Health National Center for Advancing Translational Sciences (NCATS) Clinical and Translational Science Award (CTSA) program [UL1TR001409, UL1TR001881, 1UL1RR025011]
Different types of childhood maltreatment are key risk factors for psychopathology, with emotional abuse playing a unique role in affective psychopathology. This study used machine learning to identify the most predictive domains and facets of childhood maltreatment for adult depressive affect, finding that subjective experience, particularly reactions to and appraisal of the abuse, were the strongest predictors.
Background: Different types of childhood maltreatment (CM) are key risk factors for psychopathology. Specifically, there is evidence for a unique role of emotional abuse in affective psychopathology in children and youth; however, its predictive power for depressive symptomatology in adulthood is still unknown. Additionally, emotional abuse encompasses several facets, but the strength of their individual contribution to depressive affect has not been examined. Method: Here, we used a machine learning (ML) approach based on Random Forests to assess the performance of domain scores and individual items from the Childhood Trauma Questionnaire (CTQ) in predicting self-reported levels of depressive affect in an adult general population sample. Models were generated in a training sample (N = 769) and validated in an independent test sample (N = 466). Using state-of-the-art methods from interpretable ML, we identified the most predictive domains and facets of CM for adult depressive affect. Results: Models based on individual CM items explained more variance in the independent test sample than models based on CM domain scores (R2 = 7.6 % vs. 6.4 %). Emotional abuse, particularly its more subjective components such as reactions to and appraisal of the abuse, emerged as the strongest predictors of adult depressive affect. Limitations: Assessment of CM was retrospective and lacked information on timing and duration. Moreover, re-ported rates of CM and depressive affect were comparatively low. Conclusions: Our findings corroborate the strong role of subjective experience in CM-related psychopathology across the lifespan that necessitates greater attention in research, policy, and clinical practice.
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