期刊
JOURNAL OF INFECTIOUS DISEASES
卷 214, 期 11, 页码 1666-1671出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw448
关键词
influenza virus; pregnancy; innate immunity; monocytes; plasmacytoid dendritic cells
资金
- Doris Duke Charitable Foundation (Clinical Scientist Development Award) [2013099]
- Stanford Child Heath Research Institute (Talia and John Morgridge Faculty Scholar award)
- McCormick Faculty Award
- Stanford Human Immunology Project Consortium (Infrastructure and Opportunity Fund) [U19AI090019, U19A1057229]
- Stanford Child Health Research Institute (Stanford clinical and translational science award) [UL1 TR000093]
- National Institutes of Health (NIH) [T32 AI78896-05]
- Smith Family Stanford Graduate Fellowship
- NIH/National Center for Research Resources (clinical and translational science award) [UL1 RR025744]
Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to influenza A virus infection in 21 pregnant and 21 nonpregnant women. In pregnant women, monocytes and pDCs exhibit an exaggerated proinflammatory immune response to 2 strains of influenza A virus, compared with nonpregnant women, characterized by increased expression of major histocompatibility complex class II (approximately 2.0-fold), CD69 (approximately 2.2-fold), interferon gamma-induced protein 10 (approximately 2.0-fold), and macrophage inflammatory protein 1 beta (approximately 1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following influenza A virus infection.
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