期刊
JOURNAL OF INFECTIOUS DISEASES
卷 215, 期 3, 页码 466-474出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw587
关键词
vaccination; DTaP; genetics; GWAS; mouse model; pertussis; antibody titer; antibody longevity; antibody avidity
资金
- Hayward Genetics Foundation
- BMWLR Foundation
The objective of the current study was to investigate the genetics of antibody responses to an acellular pertussis vaccine by a genome-wide association study in mice. Female mice of 28 inbred strains received this vaccine at 6, 8, and 12 weeks of age. The antibody titer and avidity of immunoglobulin (Ig) G specific for diphtheria toxin, pertussis toxin, filamentous hemagglutinin and pertactin were measured at 14 and 24 weeks of age. The magnitude, longevity and avidity of IgG differed significantly among mouse strains. There was significant correlation between antigen- specific IgGs for longevity but not for magnitude and avidity. Association mapping and analysis with PolyPhen software identified 6 genetic markers associated with longevity for all 4 antigens, although the expression levels of these genes did not correlate with longevity phenotype. This study provides novel insights into the genetic basis and potential candidate genes for differences in the IgG responses to vaccination.
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