期刊
CARBOHYDRATE POLYMERS
卷 133, 期 -, 页码 473-481出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.07.027
关键词
Modified dextrans; Cyclodextrin polymers; Supramolecular association; Surface films; PEGylation
资金
- European Commission for Research in the Framework of NanoS3 Marie Curie Initial Training Network [290251]
The main goal of this work was to develop a supramolecular chemistry strategy to decorate interfaces with polyethylene glycol (PEG) grafts. A series of novel bifunctionalized dextrans, bearing 40-60 PEG pending chains and 12-24 hydrophobic adamantyl groups, have been prepared by copper(I)-catalyzed azide-alkyne cycloaddition. Their binding properties toward native beta CD and beta CD polymers were characterized both in solution and at interface using isothermal titration microcalorimetry and surface plasmon resonance. The polymers were found to form stable layers onto neutral and positively charged beta CD-polymer films pre-adsorbed on gold surfaces, due to multivalent interpolymer host guest interactions. The thickness and stability of the layers could be tuned by varying the ratio between the degrees of substitution by PEG and adamantyl groups. (C) 2015 Elsevier Ltd. All rights reserved.
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