Transition Metal-Catalyzed Rearrangement and Cycloisomerization Reactions Toward Hedonic Materials

Over the last century, the fragrance industry had relied on the synthetic chemists for the development of new odors, but also for the replacement of some known materials due to allergy or toxicity. Transition metal-catalyzed transformations have allowed atom economy and synthetic efficiency for several transformations and they caught the attention of fragrance industrials. The metal-catalyzed cyclization reactions have been particularly successful toward the synthesis of key skeletons. This review highlights the developments of selected hedonic materials according to transition metal-catalyzed according to cycloisomerization reactions and related rearrangements.

Automated summary

This article introduces the application of transition metal-catalyzed cyclization reactions in fragrance synthesis, particularly in the synthesis of key skeletons. These reactions can improve atom economy and synthetic efficiency, providing new alternatives for the fragrance industry.