期刊
JOURNAL OF INFECTIOUS DISEASES
卷 213, 期 12, 页码 1923-1926出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw056
关键词
group B Streptococcus; cellular immunity; colonization
资金
- South African Research Chairs Initiative in Vaccine Preventable Diseases of the Department of Science and Technology
- National Research Foundation
- Novartis Vaccines, Italy
- South African Research Chairs Initiative
We investigated the association between group B Streptococcus (GBS) serotype-specific capsular polysaccharide cellular immunity, measured with enzyme-linked immunospot (ELISPOT) interferon gamma release assay at 20 weeks gestation in pregnant women, and its effect on rectovaginal serotype-specific GBS colonization up to 37 weeks gestation. Among women colonized by serotype III at enrollment, interferon gamma ELISPOT positivity was more common in those in whom colonization was cleared (44.4%) than in those in whom colonization persisted (7.4%; P = .008), with a similar trend observed for serotype Ia. Presence of serotype-specific capsular polysaccharide cell-mediated immunity contributes to the clearance of GBS rectovaginal colonization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据