Peripheral Nerve Involvement at First Diagnosis of Multiple Sclerosis A Prospective MR Neurography Study

ObjectivesThe aim of this study was to assess peripheral nerve involvement in patients with multiple sclerosis (MS) at first clinical presentation using quantitative magnetic resonance (MR) neurography in correlation with clinical, laboratory, electrophysiological, and central nervous MR imaging data.Materials and MethodsIn this prospective monocentric study, 30 patients first diagnosed with MS according to the McDonald criteria (19 women; mean age, 32.4 +/- 8.8 years) and 30 age- and sex-matched healthy volunteers were examined with high-resolution 3 T MR neurography using a dual-echo T2-relaxometry sequence covering the tibial and peroneal nerves from proximal thigh to distal calf. Magnetic resonance biomarkers of T2 relaxation time (T2(app)), proton spin density (PSD), and nerve cross-sectional area (CSA) were correlated with clinical symptoms, intrathecal immunoglobulin (Ig) synthesis, nerve conduction study, and lesion load on brain and spine MR imaging. The diagnostic accuracy of MR biomarkers was assessed using receiver-operating characteristic curves.ResultsDiffuse nerve changes were detected along the tibial and peroneal nerves in MS patients, who showed decreased PSD (P < 0.001), increased T2(app) (P < 0.001), and smaller tibial nerve CSA (P < 0.001) compared with healthy subjects. Tibial PSD was identified as best parameter separating patients from controls (area under the curve = 0.876). Intrathecal IgG and IgM synthesis correlated with PSD values (r = -0.44, P = 0.016, and r = -0.42, P = 0.022). Contrast-enhancement of brain or spine lesions was related to larger tibial and peroneal CSA (P < 0.001, P = 0.033). Abnormal electrophysiology correlated with higher tibial and peroneal T2(app) (P < 0.001 and P = 0.033), lower tibial and peroneal PSD (P = 0.018 and P = 0.002), and smaller peroneal CSA (P < 0.001).ConclusionsQuantitative MR neurography reveals peripheral nerve changes in patients with initial diagnosis of MS. Correlation of imaging findings with intrathecal immunoglobulin synthesis may indicate a primary coaffection of the peripheral nervous system in MS.

Automated summary

This study used quantitative magnetic resonance neurography to evaluate peripheral nerve involvement in patients with multiple sclerosis (MS) at first clinical presentation, and correlated the findings with clinical, laboratory, electrophysiological, and central nervous MR imaging data. The results showed diffuse nerve changes in the tibial and peroneal nerves of MS patients, with decreased proton spin density, increased T2 relaxation time, and smaller nerve cross-sectional area compared to healthy subjects. The diagnostic accuracy of magnetic resonance biomarkers was assessed using receiver-operating characteristic curves.