Trilayer dissolving polymeric microneedle array loading Rose Bengal transfersomes as a novel adjuvant in early-stage cutaneous melanoma management

Article Biochemistry & Molecular Biology

Amalgamated Microneedle Array Bearing Ribociclib-Loaded Transfersomes Eradicates Breast Cancer via CD44 Targeting

Madhu Sharma et al.

Summary: HR+/HER2- metastatic breast cancer is a common and dangerous condition in women. A novel MN system using HA-PVA-PVP microneedle array is developed to deliver RB for breast cancer treatment, reducing toxicity and improving efficacy.

BIOMACROMOLECULES (2022)

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Article Pharmacology & Pharmacy

Inclusion complexed iloperidone loaded dissolving microneedles: Characterization, in-vitro study, and dermatopharmacokinetics

Rupali S. Bhadale et al.

Summary: This study aimed to improve the permeability of the antipsychotic drug iloperidone by incorporating it into dissolving microneedles, providing a new approach for the treatment of schizophrenia. Through various characterization and stability studies, the optimized microneedles were found to release the drug steadily over 24 hours and achieve the highest deposition of drugs in the skin. The findings suggest that dissolving microneedles can serve as an effective transdermal drug delivery platform.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Oncology

Spatiotemporal trends of the global burden of melanoma in 204 countries and territories from 1990 to 2019: Results from the 2019 global burden of disease study

Zhen Li et al.

Summary: This study aimed to estimate the latest magnitudes and temporal trends of melanoma burden at the national, regional, and global levels. The results showed that the incidence, deaths, and disability-adjusted life-years (DALYs) of melanoma have been increasing globally, but with significant variations across regions. High burden areas are experiencing a continuing increase in incidence, indicating the need for targeted strategies to reduce the burden.

NEOPLASIA (2022)

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Review Surgery

Malignant melanoma: evolving practice management in an era of increasingly effective systemic therapies db2.tmp srctitleChangeRecord1-20220420.115456.log srctitleChangeRecord2-20220420.120439.log srctitle_new2.ksh srctitle_new3.ksh WOSType1.TXT WOSType2.TXT

Ken Newcomer et al.

Summary: Melanoma is an aggressive form of skin cancer that can be cured through surgical excision. Systemic treatments have also shown significant improvements in survival rates.

CURRENT PROBLEMS IN SURGERY (2022)

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Review Chemistry, Multidisciplinary

Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

Mary B. McGuckin et al.

Summary: The poor aqueous solubility of many drugs poses challenges to drug delivery scientists. Drug nanocrystals have emerged as a promising approach to improve the delivery of hydrophobic drugs through various administration routes.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Medicine, Research & Experimental

Elucidating the Impact of Surfactants on the Performance of Dissolving Microneedle Array Patches

Qonita Kurnia Anjani et al.

Summary: The addition of surfactants in the manufacture of dissolving microneedle array patches (MAPs) was explored in this study. The results showed that the incorporation of surfactants improved the reduction in microneedle height, increased the drug loading and insertion depth, and enhanced delivery efficiency.

MOLECULAR PHARMACEUTICS (2022)

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Review Engineering, Biomedical

Microneedle-mediated transdermal drug delivery for treating diverse skin diseases

Dan Yang et al.

Summary: This review discusses the emergence of versatile microneedles for transdermal delivery of various drugs, especially focusing on their application in treating different skin diseases such as superficial tumors, scars, psoriasis, herpes, acne, and alopecia. It also summarizes the promises and challenges of widespread translation of microneedles for transdermal drug delivery in dermatology.

ACTA BIOMATERIALIA (2021)

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Article Materials Science, Biomaterials

Selective delivery of silver nanoparticles for improved treatment of biofilm skin infection using bacteria-responsive microparticles loaded into dissolving microneedles

Andi Dian Permana et al.

Summary: This study explored the potential of utilizing silver nanoparticles synthesized using green tea extract as antibiofilm agents against Staphylococcus aureus and Pseudomonas aeruginosa biofilms. By incorporating silver nanoparticles into bacteria-responsive microparticles, the dermatokinetic profiles of silver nanoparticles were enhanced, leading to the eradication of bacterial bioburdens in an ex vivo biofilm model in rat skin. These findings demonstrate the feasibility and efficacy of loading silver nanoparticles into responsive microparticles for improved antibiofilm activities.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Pharmacology & Pharmacy

Strategy for osteoarthritis therapy: Improved the delivery of triptolide using liposome-loaded dissolving microneedle arrays

Ping Zhou et al.

Summary: The study found that the triptolide liposome-loaded dissolving microneedle system can effectively improve symptoms of osteoarthritis, reduce joint swelling and inflammatory response, and may be a promising treatment option.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Polymeric microneedles for transdermal delivery of nanoparticles: Frontiers of formulation, sterility and stability aspects

Salwa et al.

Summary: Researchers believe that polymeric microneedles have potential in transdermal drug delivery, but there are still challenges such as limited loading capacity and unmanageable drug release rate. Recent studies combining nanocarriers with polymeric microneedles have opened up new possibilities for treating various diseases.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Enhanced Stability of Indocyanine Green by Encapsulation in Zein-Phosphatidylcholine Hybrid Nanoparticles for Use in the Phototherapy of Cancer

Eun-Hye Lee et al.

Summary: Encapsulating ICG in zein-phosphatidylcholine hybrid nanoparticles (Z/PC-NP) was found to be more effective in stabilizing and enhancing the phototoxicity of ICG compared to encapsulating in phosphatidylcholine nanoparticles (PC-NP), showing promising potential as an improved ICG formulation with higher stabilization effect.

PHARMACEUTICS (2021)

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Review Chemistry, Applied

Nanotechnology-based rose Bengal: A broad-spectrum biomedical tool

Sara Demartis et al.

Summary: Rose Bengal, an anionic xanthene dye derived from fluorescein, originally used as a textile dye, is now primarily known in ophthalmology and biomedical field. It exhibits intrinsic cytotoxicity against tumor and microbial cells, making it suitable for sono-photodynamic therapy. However, due to its disadvantageous bio-pharmaceutical profile, it is currently approved only for ocular diagnostics.

DYES AND PIGMENTS (2021)

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Article Chemistry, Multidisciplinary

Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium yoelii

Fabiana Volpe-Zanutto et al.

Summary: Malaria affects over 200 million people annually and artemether and lumefantrine are the primary treatment options. Dissolving microneedles were developed to deliver the drugs intradermally, with studies in animals demonstrating significant efficacy.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Pharmacology & Pharmacy

QbD-driven development of dissolving microneedle patch loaded with ultradeformable liposomes encapsulated Noopept: Exploring a patient friendly, once-daily option to manage dementia

Praveen K. Srivastava et al.

Summary: The study successfully addressed the issue of low oral bioavailability of Noopept by developing NPT loaded ultradeformable liposomes (UDL) and incorporating them into fast dissolving microneedle patch (MNP). Through optimization and evaluation, NPT UDL MNP exhibited sufficient penetrative force, stability, and safety, with transdermal administration showing non-toxicity on HaCaT cells and higher bioavailability in animal studies.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride

Alejandro J. Paredes et al.

Summary: The study developed long-acting dissolving and implantable PLGA MAPs for systemic release of FND for at least two weeks, using micromoulding methodology to obtain mechanically strong tip-loaded MAPs with pyramidal geometry. In vitro studies demonstrated that these patches could release the drug continuously, deposit a certain amount of FND in the skin, and gradually release it into the receptor compartment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Medicine, Research & Experimental

Improving Dermal Delivery of Rose Bengal by Deformable Lipid Nanovesicles for Topical Treatment of Melanoma

Sara Demartis et al.

Summary: Cutaneous melanoma is an aggressive form of skin cancer with limited therapeutic options leading to increased mortality rates. This study proposes the use of deformable lipid nanovesicles for targeted dermal delivery of Rose Bengal to melanoma lesions, effectively eradicating them without the need for external stimuli. These transfersomes not only improve the penetration of RB into deeper skin layers but also protect it from degradation, showing potential as an alternative tool for fighting against primary melanoma lesions.

MOLECULAR PHARMACEUTICS (2021)

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Review Polymer Science

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

Faisal Khaled Aldawood et al.

Summary: Drug delivery through the skin offers advantages such as avoiding hepatic metabolism and maintaining steady plasma concentration, but only a limited number of drugs with ideal properties can achieve therapeutic concentrations. Microneedles are a promising physical enhancement method to expand the spectrum of drugs for transdermal delivery. Different materials used for microneedles have implications for transdermal drug delivery, but challenges in sustained delivery, efficacy, cost-effective fabrication, and large-scale manufacturing remain. Microneedles have potential impact on drug delivery, vaccine delivery, disease diagnostics, and cosmetics applications.

POLYMERS (2021)

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Article Pharmacology & Pharmacy

Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment

Long Xi et al.

Acta Pharmaceutica Sinica B (2021)

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Review Pharmacology & Pharmacy

Topical treatments for skin cancer

Jason K. Cullen et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Chemistry, Analytical

Novel Design Approaches in the Fabrication of Polymeric Microarray Patches via Micromoulding

Inken K. Ramoeller et al.

MICROMACHINES (2020)

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Article Chemistry, Physical

Reverse immune suppressive microenvironment in tumor draining lymph nodes to enhance anti-PD1 immunotherapy via nanovaccine complexed microneedle

Zhongzheng Zhou et al.

NANO RESEARCH (2020)

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Review Pharmacology & Pharmacy

Nanoparticles for topical drug delivery: Potential for skin cancer treatment

Vinu Krishnan et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Pharmacology & Pharmacy

A TLR9-adjuvanted vaccine formulated into dissolvable microneedle patches or cationic liposomes protects against leishmaniasis after skin or subcutaneous immunization

Juliane S. Lanza et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Medicine, Research & Experimental

Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules

Akmal Sabri et al.

MOLECULAR PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis

Andi Dian Permana et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Rapidly dissolving microneedles for the delivery of cubosome-like liquid crystalline nanoparticles with sustained release of rapamycin

Ana Ramalheiro et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Vinpocetine loaded ultradeformable liposomes as fast dissolving microneedle patch: Tackling treatment challenges of dementia

Praveen K. Srivastava et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Article Biochemistry & Molecular Biology

Enhanced transdermal lymphatic delivery of doxorubicin via hyaluronic acid based transfersomes/microneedle complex for tumor metastasis therapy

Hengjia Yang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Multidisciplinary

Improved Dermal Delivery of Cyclosporine A Loaded in Solid Lipid Nanoparticles

Abderrazzaq Essaghraoui et al.

NANOMATERIALS (2019)

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Review Surgery

Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review

Noemi Vanerio et al.

PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY (2019)

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Review Oncology

It is finally time for adjuvant therapy in melanoma

S. Napolitano et al.

CANCER TREATMENT REVIEWS (2018)

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Review Oncology

Cutaneous melanoma: From pathogenesis to therapy (Review)

Giulia C. Leonardi et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2018)

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Article Pharmacology & Pharmacy

Investigation of microemulsion and microemulsion gel formulations for dermal delivery of clotrimazole

Ji Zhang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Biotechnology & Applied Microbiology

Development of transethosomes formulation for dermal fisetin delivery: Box-Behnken design, optimization, in vitro skin penetration, vesicles-skin interaction and dermatokinetic studies

Thasleem Moolakkadath et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Review Immunology

Melanoma treatment in review

Beatriz Domingues et al.

IMMUNOTARGETS AND THERAPY (2018)

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Article Materials Science, Multidisciplinary

Designing of PVA/Rose Bengal long-pass optical window applications

S. M. El-Bashir et al.

RESULTS IN PHYSICS (2017)

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Article Oncology

Intralesional rose bengal in melanoma elicits tumor immunity via activation of dendritic cells by the release of high mobility group box 1

Hao Liu et al.

ONCOTARGET (2016)

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Article Pharmacology & Pharmacy

A proposed model membrane and test method for microneedle insertion studies

Eneko Larraneta et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Article Chemistry, Physical

Ultrasonic energy in liposome production: process modelling and size calculation

A. A. Barba et al.

SOFT MATTER (2014)

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Review Pharmacology & Pharmacy

Structural and dynamical aspects of skin studied by multiphoton excitation fluorescence microscopy-based methods

Maria Bloksgaard et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Article Medicine, Research & Experimental

Nanocolloidal Carriers of Isotretinoin: Antimicrobial Activity against Propionibacterium acnes and Dermatokinetic Modeling

Kaisar Raza et al.

MOLECULAR PHARMACEUTICS (2013)

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Article Chemistry, Multidisciplinary

Size-Dependent Properties of Small Unilamellar Vesicles Formed by Model Lipids

Chun-Min Lin et al.

LANGMUIR (2012)

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Article Optics

Effect of temperature on the photobehavior of Rose Bengal associated with dipalmitoylphosphatidyl choline liposomes

Estefania Hugo et al.

JOURNAL OF LUMINESCENCE (2011)

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Article Engineering, Biomedical

Topical delivery and photodynamic evaluation of a multivesicular liposomal Rose Bengal

Maha Fadel M. Ali

LASERS IN MEDICAL SCIENCE (2011)

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Article Chemistry, Multidisciplinary

A water gradient can be used to regulate drug transport across skin

Sebastian Bjorklund et al.

JOURNAL OF CONTROLLED RELEASE (2010)

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Article Chemistry, Applied

Absorption and emission spectral shifts of rose bengal associated with DMPC liposomes

Cheng-Chung Chang et al.

DYES AND PIGMENTS (2008)

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Review Pharmacology & Pharmacy

Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products

Bernard Van Eerdenbrugh et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Article Dermatology

Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs

Frank Stracke et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)

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Review Pharmacology & Pharmacy

Can drug-bearing liposomes penetrate intact skin?

GMM El Maghraby et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2006)

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Article Dermatology

Epidermal thickness at different body sites: Relationship to age, gender, pigmentation, blood content, skin type and smoking habits

J Sandby-Moller et al.

ACTA DERMATO-VENEREOLOGICA (2003)

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Review Pharmacology & Pharmacy

Novel mechanisms and devices to enable successful transdermal drug delivery

BW Barry

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2001)

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Trilayer dissolving polymeric microneedle array loading Rose Bengal transfersomes as a novel adjuvant in early-stage cutaneous melanoma management

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