Carboxymethyl cellulose/sericin-based hydrogels with intrinsic antibacterial, antioxidant, and anti-inflammatory properties promote re-epithelization of diabetic wounds in rats

Article Multidisciplinary Sciences

Intracellular glucose starvation affects gingival homeostasis and autophagy

Runbo Li et al.

Summary: A low-glucose environment enhances glucose metabolism and promotes wound healing in HGnFs through increased cellular stress levels and autophagy activity.

SCIENTIFIC REPORTS (2022)

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Article Biology

Prevalence, antimicrobial resistance profile, and characterization of multi-drug resistant bacteria from various infected wounds in North Egypt

Mohamed A. Hassan et al.

Summary: This study aimed to investigate the prevalence and characteristics of multi-drug resistant (MDR) bacteria associated with wounds in different hospitals in Alexandria, North Egypt, in order to inform the design of antibacterial wound dressings. Among the bacterial isolates collected, 22 MDR bacteria were identified that could resist different classes of antibiotics. Mono-bacterial infections were more prevalent (60%) than poly-bacterial infections (40%). Gram-negative bacteria were dominant, accounting for 63.6% of the isolates, while Gram-positive bacteria accounted for 36.4%. The study also identified the five most virulent bacteria and their antibiotic resistance profiles.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Multidisciplinary Sciences

Insights into Ag-NPs-mediated pathophysiology and ultrastructural aberrations in ovarian tissues of darkling beetles

Lamia M. El-Samad et al.

Summary: This study demonstrated the adverse effects of silver nanoparticles (Ag-NPs) on the ovaries of Egyptian wild female beetles. By injecting Ag-NPs at different doses, it was found that the sublethal dose was 0.03 mg/g body weight. The detrimental impacts on the ovaries were evaluated through enzyme activity estimation, comet assay for DNA damage, flow cytometry for apoptosis, and transmission electron microscopy for ultrastructural abnormalities. This is the first report discussing the influence of Ag-NPs at the lowest dose on the ovaries of B. polychresta. The findings contribute to understanding the critical effects of low levels of Ag-NPs and the potential use of B. polychresta as a bio-indicator in ecotoxicological analyses.

SCIENTIFIC REPORTS (2022)

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Article Biochemistry & Molecular Biology

Silver nanoparticles instigate physiological, genotoxicity, and ultrastructural anomalies in midgut tissues of beetles

Lamia M. El-Samad et al.

Summary: This study reveals the harmful effects of AgNPs on the midgut tissues of beetles, including disruption of the antioxidant defense system, DNA damage, and cell apoptosis. Additionally, abnormal histopathology and ultrastructure were observed. This study is the first to investigate the effects of low doses of AgNPs on beetle midgut tissues.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Chemistry, Physical

Dynamically crosslinked protien hydrogel composite as multifunctional wound dressing for cutaneous infection

Wanli Xie et al.

Summary: In this study, a dynamic hydrogel loaded with sodium houttuyfonate (SH) was developed for the management of infected skin injuries. The hydrogel exhibited self-recovery and injectability due to its reversible interactions. The SH-loaded hydrogel showed shape-adapted, bactericidal, and pro-healing properties, effectively suppressing infection and accelerating the healing process both in vitro and in vivo.

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Antioxidant and antibacterial polyelectrolyte wound dressing based on chitosan/hyaluronan/phosphatidylcholine dihydroquercetin

Mohamed A. Hassan et al.

Summary: A multifunctional polyelectrolyte wound dressing membrane based on chitosan and hyaluronan enhanced by phosphatidylcholine dihydroquercetin was developed, showing potential in antioxidant, antibacterial, and wound healing applications. The membrane demonstrated excellent hemocompatibility, cellular compatibility, as well as the ability to promote wound healing in in vivo studies.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Carboxymethyl cellulose/tetracycline@UiO-66 nanocomposite hydrogel films as a potential antibacterial wound dressing

Siamak Javanbakht et al.

Summary: Integrating UiO-66 into polymeric CMC hydrogel to prepare novel flexible polymeric hydrogel films with improved mechanical and antibiotic release performances was successful. The release performance showed controlled release over 72 hours and significant antibacterial activity against both E. coli and S. aureus, demonstrating the potential of CMC/TC@UiO-66 films as antibacterial wound dressings.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Multidisciplinary Sciences

Hemostatic and antibacterial PVA/Kaolin composite sponges loaded with penicillin-streptomycin for wound dressing applications

Tamer M. Tamer et al.

Summary: A new hemostatic and antibacterial PVA/Kaolin composite sponge was developed using a freeze-thawing approach and enhanced by Pen-Strep. The physicochemical characteristics were analyzed, showing a porous structure and improved thermal properties of the sponge with high dispersion of kaolin. The composite sponge exhibited enhanced water absorption, antibacterial activity, and no cellular toxicity, indicating its potential application as a multifunctional wound dressing.

SCIENTIFIC REPORTS (2021)

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Review Chemistry, Applied

Developments on carboxymethyl starch-based smart systems as promising drug carriers: A review

Malihe Pooresmaeil et al.

Summary: This review discusses the issues with conventional drug administrations and the application of carboxymethyl starch (CMS) in drug delivery. It summarizes the recent advances and prospects of CMS-based drug delivery systems, aiming to provide comprehensive information for overcoming issues with traditional drug delivery systems.

CARBOHYDRATE POLYMERS (2021)

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Article Engineering, Environmental

Bioactive anti-inflammatory, antibacterial, conductive multifunctional scaffold based on MXene@CeO2 nanocomposites for infection-impaired skin multimodal therapy

Hua Zheng et al.

Summary: This study successfully developed multifunctional MXene@CeO2 nanocomposites for a hydrogel scaffold with various properties for treating MDR-infected skin, including self-healing, anti-inflammatory, antibacterial, antioxidative, conductive, tissue-adhesive, and hemostatic capabilities. The scaffold showed efficacy in promoting cell migration and proliferation, accelerating wound healing, and addressing multidrug resistant infections.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Biomedical

An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing

Bin Hu et al.

Summary: A hyaluronic acid and chitosan based hydrogel with antioxidant, anti-inflammatory, and migration-promoting effects was designed in this study. The hydrogel exhibited excellent drug release capabilities in vitro and dramatically improved diabetic wound healing by flexibly releasing curcumin and epidermal growth factor according to the phases of wound healing.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Environmental

A multi-targeted nanoconjugate for light-driven therapy of chronic wounds

Yuelong Niu et al.

Summary: The pathogenic bacteria-induced diabetic ulcer is a serious problem due to poor healing, but a non-antibiotic strategy utilizing a nanostructure with photothermal therapy shows promise in targeting and killing bacteria, promoting wound healing in diabetic rats.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biochemistry & Molecular Biology

3D-printed antioxidant antibacterial carboxymethyl cellulose/ε-polylysine hydrogel promoted skin wound repair

Xiaoxue Wang et al.

Summary: A novel printable bionic hydrogel with antibacterial and antioxidant properties was developed to effectively treat large and irregular-shaped wounds by inhibiting inflammation and accelerating wound healing. The hydrogels showed excellent properties such as high compression modulus, stable rheological properties, effective antibacterial effects, and the ability to remove excessive reactive oxygen species. In comparison to commercial dressings, these hydrogels demonstrated better expression of VEGF and CD31, accelerated granulation tissue regeneration, and promoted wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Pharmacology & Pharmacy

Naturally-derived targeted therapy for wound healing: Beyond classical strategies

Saeed El-Ashram et al.

Summary: This passage summarizes the important factors affecting wound healing and the potential role of natural products in wound treatment. By studying these factors, it can help in the development of therapeutics that promote wound healing.

PHARMACOLOGICAL RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Fabrication and Characterization of Collagen/PVA Dual-Layer Membranes for Periodontal Bone Regeneration

Tian Zhou et al.

Summary: The developed Col/PVA dual-layer membrane shows promising mechanical and bioactive properties for promoting bone tissue regeneration, making it a potential solution for periodontal defect repair in clinical applications.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

Injectable silk sericin scaffolds with programmable shape-memory property and neuro-differentiation-promoting activity for individualized brain repair of severe ischemic stroke

Jian Wang et al.

Summary: A programmable shape-memory scaffold doped with carbon nanotubes and sericin is successfully injected into stroke cavities, demonstrating its potential for personalized stroke repair. The scaffold allows precise recovery of pre-designed shapes and enables real-time tracking with near-infrared photoluminescence after implantation, showing promise for future applications in stroke treatment.

BIOACTIVE MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Development of Polyvinyl Alcohol/Kaolin Sponges Stimulated by Marjoram as Hemostatic, Antibacterial, and Antioxidant Dressings for Wound Healing Promotion

Tamer M. Tamer et al.

Summary: The study developed composite sponges based on polyvinyl alcohol, marjoram essential oil, and kaolin, which can effectively prevent lethal bleeding and microbial infections in wounds. The sponges exhibit excellent antibacterial, antioxidant, and thrombogenic properties, with potential applications in wound healing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Physical

Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing

Donald R. Griffin et al.

Summary: The study aimed to slow MAP scaffold degradation by changing the chirality of peptides, but unexpectedly, D-peptide crosslinked MAP scaffolds led to accelerated degradation in vivo, promoting tissue regeneration and enhancing wound healing. D-MAP triggered an immune response against D-chiral peptides and intact adaptive immune system was crucial for skin regeneration induced by the hydrogel.

NATURE MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Silk sericin has significantly hypoglycaemic effect in type 2 diabetic mice via anti-oxidation and anti-inflammation

Xuan Dong et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

Physical Double-Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self-Healing, Antioxidant and NIR/pH Stimulus-Responsiveness for Multidrug-Resistant Bacterial Infection and Removable Wound Dressing

Xin Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Engineering, Biomedical

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Zejun Xu et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Multidisciplinary Sciences

Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes

Huanhuan Chen et al.

SCIENCE ADVANCES (2020)

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Article Engineering, Environmental

Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds

Jiahui He et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Multidisciplinary

Nanoenzyme-Reinforced Injectable Hydrogel for Healing Diabetic Wounds Infected with Multidrug Resistant Bacteria

Shenqiang Wang et al.

NANO LETTERS (2020)

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Review Cell & Tissue Engineering

Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

Tong Xiao et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Engineering, Biomedical

Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation

Lin Mao et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Chemistry, Physical

Profiling of Silk Sericin from Cocoons of Three Southern African Wild Silk Moths with a Focus on Their Antimicrobial and Antioxidant Properties

Kanono Comet Manesa et al.

MATERIALS (2020)

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Article Materials Science, Biomaterials

Design and performance of sericin/poly(vinyl alcohol) hydrogel as a drug delivery carrier for potential wound dressing application

Gang Tao et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Chemistry, Applied

Cross-linking of dialdehyde carboxymethyl cellulose with silk sericin to reinforce sericin film for potential biomedical application

Peng Wang et al.

CARBOHYDRATE POLYMERS (2019)

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Article Chemistry, Multidisciplinary

Thermoresponsive in Situ Forming Hydrogel with Sol-Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing

Xu Yan et al.

ACS NANO (2019)

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Article Endocrinology & Metabolism

Insight into multidrug-resistant microorganisms from microbial infected diabetic foot ulcers

Mohamed A. Hassan et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2019)

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Article Biochemistry & Molecular Biology

Hydroxyethyl cellulose hydrogel for wound dressing: Fabrication, characterization and in vitro evaluation

Gomaa F. El Fawal et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Biochemistry & Molecular Biology

Production and characterization of CMC-based antioxidant and antimicrobial films enriched with chickpea hull polysaccharides

Hafiz Muhammad Saleem Akhtar et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Materials Science, Biomaterials

Chitosan/hyaluronan/edaravone membranes for anti-inflammatory wound dressing: In vitro and in vivo evaluation studies

Tamer M. Tamer et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Biochemistry & Molecular Biology

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

Zhuzhen Zhang et al.

NATURE MEDICINE (2018)

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Article Physiology

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

Paulina Krzyszczyk et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Immunology

Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats

Naheed Akhtar et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Nanoparticle-Based Dressing: The Future of Wound Treatment?

Morgane Berthet et al.

TRENDS IN BIOTECHNOLOGY (2017)

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Article Engineering, Biomedical

Engineered human vascularized constructs accelerate diabetic wound healing

Yu-I Shen et al.

BIOMATERIALS (2016)

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Article Dermatology

Wound healing and treating wounds Chronic wound care and management

Jennifer G. Powers et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)

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Article Multidisciplinary Sciences

Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization

Yun Xiao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Review Chemistry, Medicinal

Advances in the treatment of chronic wounds: a patent review

Chris J. van Koppen et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2015)

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Article Surgery

Annona muricata leaves accelerate wound healing in rats via involvement of Hsp70 and antioxidant defence

Soheil Zorofchian Moghadamtousi et al.

INTERNATIONAL JOURNAL OF SURGERY (2015)

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Article Chemistry, Applied

Bacterial cellulose membranes as transdermal delivery systems for diclofenac: In vitro dissolution and permeation studies

Nuno H. C. S. Silva et al.

CARBOHYDRATE POLYMERS (2014)

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Article Biochemistry & Molecular Biology

Sericins exhibit ROS-scavenging, anti-tyrosinase, anti-elastase, and in vitro immunomodulatory activities

Theodora Chlapanidas et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2013)

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Article Pharmacology & Pharmacy

Development of ethyl alcohol-precipitated silk sericin/polyvinyl alcohol scaffolds for accelerated healing of full-thickness wounds

Tippawan Siritienthong et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Review Chemistry, Applied

Cellulose-based hydrogels: Present status and application prospects

Chunyu Chang et al.

CARBOHYDRATE POLYMERS (2011)

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Article Endocrinology & Metabolism

The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity

Darren C. Henstridge et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2010)

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Protective functions of intracellular heat-shock protein (HSP) 70-expression in patients with severe sepsis

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INTENSIVE CARE MEDICINE (2001)

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Carboxymethyl cellulose/sericin-based hydrogels with intrinsic antibacterial, antioxidant, and anti-inflammatory properties promote re-epithelization of diabetic wounds in rats

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