期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 626, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2022.122194
关键词
Ketorolac tromethamine; Swelling study; HET-CAM test; In-vivo study
资金
- National Science Council of Taiwan
- [MOST 110-2320-B-037-014-MY2]
In this study, glutamic acid crosslinked poly(itaconic acid/methacrylic acid) microgels were prepared for pH-responsive delivery of ketorolac tromethamine using aqueous free radical polymerization technique. The microgels showed pH-sensitive behavior with maximum swelling and drug release at pH 7.4. They exhibited low toxicity and high drug loading capacity, making them a promising carrier for controlled drug delivery.
The aim of the current study was to prepare glutamic acid crosslinked poly(itaconic acid/methacrylic acid) microgels for pH-responsive delivery of ketorolac tromethamine, using aqueous free radical polymerization technique. The polymerization of polymer with monomers was carried out by a crosslinking agent N ', N '- methylene bisacrylamide in the presence of initiator ammonium persulfate. The prepared microgels were characterized for structure, surface morphology, thermal stability, and crystallinity. Similarly, studies such as sol-gel analysis, drug loading, and polymer volume fraction were performed for the fabricated microgels. The pH -sensitivity of the developed microgels was investigated at three different pH values i.e., pH 1.2, 4.6, and 7.4 by swelling and in-vitro drug release studies. Maximum swelling and drug release were found at pH 7.4 as compared to pH 1.2 and 4.6, which indicated the pH-sensitive nature of the prepared microgels. The toxicity of the prepared microgels was evaluated by cell line and HET-CAM test, which demonstrated no toxic effect of the prepared microgels. In-vivo study was carried out on rabbits and high plasma concentration was reported for the drug loaded microgels as compared to drug solution and commercial product Keten. Hence, the prepared microgel system could be employed as an excellent carrier for the controlled drug delivery system.
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