期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 625, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2022.122082
关键词
Gold nanoparticles; Chemotherapy; Green synthesis; Photothermal conversion; Tumor
资金
- Natural Science Foundation of Hebei Province [B2017203229]
- Anhui Provincial Natural Science Foundation [1808085ME143]
- China Postdoctoral Science Foundation [2016 M601284]
- Subsidy for Hebei Key Laboratory of Applied Chemistry after Operation Performance [22567616H]
The synthesis of doxorubicin-loaded gold nanoflowers using a biological antimicrobial peptide as stabilizer and crystal seed grower resulted in high photothermal conversion efficiency and tumor inhibiting ability. This method provides a new approach for the treatment of cancer using a synergistic photothermal and chemotherapy system.
Gold nanoparticles are a kind of good photothermal agents. However, gold nanoparticle photothermal agents have low photothermal conversion efficiency and low tumor inhibiting ability. To overcome these problems, polymyxin E (PE) biomineralized and doxorubicin-loaded gold nanoflowers (DOX-SH@AuNFs) nanodrug was synthesized by the green synthesis method using the biological antimicrobial peptide PE as a stabilizer and grower of crystal seed, and doxorubicin-thiol (DOX-SH) was further loaded on the gold nanoparticles through the Au-S bond. The final DOX-SH@AuNFs displayed a wide absorption band in the UV-Vis spectra, and their photothermal conversion efficiency was 33.9%. Furthermore, the inhibition rate of DOX-SH@AuNFs on A549 cells was as high as 80.1% under the irradiation of near-infrared light at 808 nm. The tumor inhibition rate of DOX-SH@AuNFs was as high as 87.81% in vivo experiments. The high tumor suppression rate was attributed to the high photothermal conversion ability of DOX-SH@AuNFs and the delivery of doxorubicin. Taken together, the method of preparing DOX-SH@AuNFs provides a new idea for the treatment of cancer by photothermal therapy and chemotherapy synergistic system.
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