☆ 4.7 Review

Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Biochemistry & Molecular Biology

Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway

Mukesh K. Sriwastva et al.

Summary: Edible mulberry bark-derived nanoparticles (MBELNs) can protect against colitis by activating the AhR-COPS8-mediated anti-inflammatory pathway. These findings suggest that plant-derived nanoparticles may serve as new agents for preventing and treating gut-related inflammatory diseases.

EMBO REPORTS (2022)

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Review Nutrition & Dietetics

FODMAPs, inflammatory bowel disease and gut microbiota: updated overview on the current evidence

Catarina D. Simoes et al.

Summary: The low-FODMAP diet has shown promising results in the management of IBD, improving clinical outcomes and quality of life. However, there are concerns regarding the adequacy of the diet and its impact on the gut microbiota. Personalized and monitored nutrition interventions are important in IBD management.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Review Gastroenterology & Hepatology

New Insights into the Role of Oral Microbiota Dysbiosis in the Pathogenesis of Inflammatory Bowel Disease

Ying Qi et al.

Summary: Inflammatory bowel disease (IBD) is a group of chronic intestinal inflammatory disorders characterized by genetic susceptibility, environmental triggers, and immune system disruption. Dysbiosis of the gut and oral microbiota may exacerbate IBD progression. Ectopic colonization of specific oral bacteria in the gut could lead to chronic intestinal inflammation in IBD patients.

DIGESTIVE DISEASES AND SCIENCES (2022)

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Review Gastroenterology & Hepatology

Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium

Bo Shen et al.

Summary: Inflammatory disorders of the ileal pouch such as pouchitis, Crohn's disease of the pouch, cuffitis, polyps, and extraintestinal manifestations of inflammatory bowel disease are common and require treatment with antibiotics, anti-inflammatory therapy, and biologics. Secondary pouchitis should be evaluated for its etiological factors, while Crohn's disease of the pouch is typically treated with biologics. Management principles for extraintestinal manifestations are similar in patients with and without pouches.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

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Review Immunology

The influence of cytokines on the complex pathology of ulcerative colitis

Hiroshi Nakase et al.

Summary: Ulcerative colitis (UC) is specifically affected by genetic alterations, environmental factors, microbiota, and mucosal immune dysregulation, leading to a lack of response in 30%-55% of patients to current therapies. The expression levels of cytokines associated with treatment depend on disease stage and patient characteristics, suggesting that future targeted therapies should focus on these differences and individual cytokine profiles.

AUTOIMMUNITY REVIEWS (2022)

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Article Biotechnology & Applied Microbiology

Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy

Cui Liu et al.

Summary: The study suggests that TDNPs 2 derived from turmeric are a novel and natural colon-targeting therapeutics that may prevent colitis and promote wound repair in colitis.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Engineering, Biomedical

Exosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutics

Abhimanyu Thakur et al.

Summary: Exosomes are tiny extracellular vesicles that carry various components, such as proteins, lipids, and nucleic acids, and play a crucial role in the malignant progression of cancer. Due to their ability to transport drugs and molecular information, exosomes have been considered as a novel tool for cancer therapeutics.

BIOACTIVE MATERIALS (2022)

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Review Immunology

Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics

Quan Lu et al.

Summary: This review explains the interactions among symbiotic flora, intestinal epithelial cells, and the immune system, clarifies the operating mechanism of the intestinal immune system, and highlights the immunological pathogenesis of IBD with a focus on the development of immunotherapy for IBD.

JOURNAL OF INFLAMMATION RESEARCH (2022)

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Review Pharmacology & Pharmacy

Mesenchymal stem cell-derived small extracellular vesicles and bone regeneration

Xiaoqin Wang et al.

Summary: MSC-derived sEVs show potential in promoting neovascularization and bone and cartilage regeneration. The mechanisms include the transfer of molecules (including microRNAs, mRNAs and proteins) to other key cells. MSC-derived sEVs are of interest as biopharmaceuticals for drug delivery and for the engineering of biologically functionalized materials.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2021)

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Article Immunology

The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next

Yonghee Song et al.

Summary: Research on extracellular vesicles (EVs), specifically exosomes, has rapidly advanced due to their crucial role in intercellular communication and maintaining homeostasis. Exosomes, a subtype of EVs, have unique biogenesis pathways and functions, serving as a novel therapeutic platform for delivering therapeutic materials and managing diseases. Both academia and industry are actively developing exosome-based therapeutics, with some already in clinical trials, showing promising potential in various therapeutic areas.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2021)

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Article Immunology

Milk exosomes: A biogenic nanocarrier for small molecules and macromolecules to combat cancer

Raghuram Kandimalla et al.

Summary: Exosomes are biogenic nanocarriers of endocytic origin found in biofluids like milk, with milk exosomes being a particularly promising source for drug delivery. They are being increasingly explored for delivering both small drug molecules and siRNA to combat cancer, thanks to their biocompatibility and unique properties. Various isolation techniques, physicochemical properties, biodistribution, and applications of milk exosomes in drug delivery were highlighted in this article.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2021)

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Article Nutrition & Dietetics

One-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects

Maria-Carmen Lopez de las Hazas et al.

Summary: Nut consumption has been shown to modulate certain c-miRNAs transported in exosomes, further research is needed to determine the extent to which this finding contributes to the benefits of walnuts.

EUROPEAN JOURNAL OF NUTRITION (2021)

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Review Gastroenterology & Hepatology

Extracellular Vesicles in Inflammatory Bowel Disease: Small Particles, Big Players

M. Valter et al.

Summary: Extracellular vesicles are important mediators of intercellular communication, playing key roles in physiological and pathological processes such as immune regulation and intestinal epithelial repair. Their presence in body fluids offers opportunities for diagnostic, prognostic, and therapeutic applications, particularly in the context of inflammatory bowel disease.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Gastroenterology & Hepatology

M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/β-Catenin Signalling Axis

Feihong Deng et al.

Summary: The study demonstrates that exosomal miR-590-3p derived from M2 macrophages promotes epithelial cell proliferation and wound healing by targeting LATS1 and activating YAP/beta-catenin-regulated transcription, while inhibiting inflammatory signals. This offers a new potential avenue for clinical therapy for ulcerative colitis.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Engineering, Biomedical

'Green' nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases

Menghang Zu et al.

Summary: This study presents a natural nanotherapeutic derived from tea leaves, which possess desirable particle sizes and negative surface charge, and contain a wealth of lipids, functional proteins, and bioactive small molecules. The nanotherapeutics can specifically internalize in macrophages via galactose groups on the surface, showing anti-inflammatory effects and promoting gut microbiota diversity.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

High-quality milk exosomes as oral drug delivery system

Jie Zhong et al.

Summary: Exosomes are nano-sized extracellular vesicles secreted by mammalian cells, including milk exosomes which have the potential to cross biological barriers and serve as promising drug delivery tools for oral administration.

BIOMATERIALS (2021)

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Review Pharmacology & Pharmacy

The Impact of Immune Cell-derived Exosomes on Immune Response Initiation and Immune System Function

Fataneh Tavasolian et al.

Summary: Exosomes are small extracellular vesicles that play a role in cell-to-cell communication by transferring genetic material. They are involved in various immune system functions such as antigen presentation, NK cell and T cell activation/polarisation, immune suppression, and anti-inflammatory processes. Exosomes have potential applications in immunotherapy as delivery vehicles.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Review Biochemistry & Molecular Biology

Therapeutic Potential of Mesenchymal Stem Cells (MSCs) and MSC-Derived Extracellular Vesicles for the Treatment of Spinal Cord Injury

Gang-Un Kim et al.

Summary: Spinal cord injury (SCI) is a serious condition that leads to permanent disability. Research on SCI treatment focuses on reducing neuroinflammation, with Mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (EVs) showing potential therapeutic effects but inconsistent results in animal models. Development of novel agents for regenerative medicine is necessary.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell & Tissue Engineering

Comparative analysis of mouse bone marrow and adipose tissue mesenchymal stem cells for critical limb ischemia cell therapy

Pegah Nammian et al.

Summary: The study compared the effects of allogeneic bone marrow mesenchymal stem cells (BM-MSCs) and adipose tissue mesenchymal stem cells (AT-MSCs) in the treatment of critical limb ischemia (CLI). The results indicated that BM-MSCs had a stronger effect on endothelial cell migration, muscle restructure, functional improvements, and neovascularization in ischemic tissues compared to AT-MSCs. This suggests that BM-MSC transplantation could be a more effective therapy for diseases with insufficient angiogenesis, such as hindlimb ischemia.

STEM CELL RESEARCH & THERAPY (2021)

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Review Cell Biology

Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut

Mousumi Mahapatro et al.

Summary: Cytokines play a crucial role in the gut by regulating immune responses and disease susceptibility loci, influencing gut health. Intestinal epithelial cells act as translators between the microbiota and the immune system, maintaining gut homeostasis.

CELLS (2021)

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Review Pharmacology & Pharmacy

Clinical applications for exosomes: Are we there yet?

Dany Perocheau et al.

Summary: Exosomes, a subset of extracellular vesicles, play a crucial role in cell-cell communication and have shown promising potential as diagnostic biomarkers and therapeutic carriers. Their reduced immunogenicity and ability to cross physiological barriers make them an appealing option for clinical application.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

Plant Exosomes As Novel Nanoplatforms for MicroRNA Transfer Stimulate Neural Differentiation of Stem Cells In Vitro and In Vivo

Xue-Han Xu et al.

Summary: Exosomes derived from ginseng were shown to efficiently promote neural differentiation of BMSCs by transferring miRNAs, demonstrating potential for neural regenerative medicine both in vitro and in vivo.

NANO LETTERS (2021)

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Review Medicine, General & Internal

Newer Biologic and Small-Molecule Therapies for Inflammatory Bowel Disease

Daniel C. Baumgart et al.

Summary: This review discusses newer biologic and small-molecule therapies for inflammatory bowel disease, emphasizing the importance of achieving clinical and endoscopic remission as well as more precise molecular targeting of inflammatory cascades.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cell Biology

M1 Macrophage exosomes MiR-21a-5p aggravates inflammatory bowel disease through decreasing E-cadherin and subsequent ILC2 activation

Jiaxi Lu et al.

Summary: Abnormal immune regulation is a key feature of the pathogenic mechanism of ulcerative colitis, with macrophages and ILC2s playing important roles, particularly in decreased E-cadherin expression. The study found that increased miR-21a-5p expression in peritoneal exosomes correlates negatively with E-cadherin expression, and that miR-21a-5p is derived mainly from M1 macrophages, with KLRG1 promoting excessive ILC2 activation in UC. These findings provide molecular targets and a theoretical basis for understanding and improving the treatment of UC.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Cell Biology

Roles of Macrophages in the Development and Treatment of Gut Inflammation

Xuebing Han et al.

Summary: Macrophages in the intestinal tract play a crucial role in maintaining microbial homeostasis and renewing intestinal epithelial cells, as well as participating in the development of intestinal inflammation. Understanding their functions and roles in inflammatory responses will be crucial for advancing treatments of intestinal inflammatory diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell & Tissue Engineering

Emerging concepts in the treatment of optic neuritis: mesenchymal stem cell-derived extracellular vesicles

Anagha Aneesh et al.

Summary: Mesenchymal stem cell extracellular vesicles (EVs) provide a promising cell-free therapy option for optic neuritis, exhibiting anti-inflammatory and remyelination stimulating properties that have the potential to effectively treat the condition.

STEM CELL RESEARCH & THERAPY (2021)

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Review Cell & Tissue Engineering

Mesenchymal stem cells-derived exosomes for drug delivery

Yao Sun et al.

Summary: Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. Researchers have increasingly focused on using exosomes for drug delivery, especially MSC-EXOs, due to their immune properties, tumor-homing properties, and elastic properties. This review article summarizes the characteristics of MSC-EXOs and introduces production, purification, and drug loading methods to address existing problems and provide suggestions for future studies.

STEM CELL RESEARCH & THERAPY (2021)

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Review Nutrition & Dietetics

Potential Mechanisms Linking Food-Derived MicroRNAs, Gut Microbiota and Intestinal Barrier Functions in the Context of Nutrition and Human Health

Ester Diez-Sainz et al.

Summary: MiRNAs are small non-coding RNA molecules that play a crucial role in regulating gene expression. Dietary plant-derived miRNAs may be incorporated into humans through various mechanisms and have an impact on gut microbiota composition, intestinal barrier permeability, and overall health. The interaction between xenomiRs and gut microbiota could potentially explain the variation in research results regarding dietary miRNA uptake and function in humans.

FRONTIERS IN NUTRITION (2021)

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Review Immunology

Effects of Mesenchymal Stem Cell-Derived Exosomes on Autoimmune Diseases

Ziwei Shen et al.

Summary: Research indicates that mesenchymal stem cell-derived exosomes (MSC-EXOs) have a significant inhibitory effect on effector cells involved in the immune response, and can be used to treat various autoimmune diseases, serving as a promising cell-free treatment strategy.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Endocrinology & Metabolism

Emerging Antioxidant Paradigm of Mesenchymal Stem Cell-Derived Exosome Therapy

Chen Xia et al.

Summary: Mesenchymal stem cell-derived exosomes have antioxidant properties that can explain their therapeutic effects through regulating redox environment and oxidative stress in a variety of diseases.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Review Medicine, General & Internal

From single-target to cellular niche targeting in Crohn's disease: intercepting bad communications

Shikha Nayar et al.

Summary: This review highlights the importance of combinatorial therapies and strategies guided by genetics and genomics in advancing current treatment approaches for Crohn's disease. The study aims to improve our understanding of the mechanisms driving pathogenic niche activation in CD and move towards precision therapeutics in IBD.

EBIOMEDICINE (2021)

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Review Pharmacology & Pharmacy

Exosomes as a New Delivery Vehicle in Inflammatory Bowel Disease

Xiaomei Wang et al.

Summary: Inflammatory bowel disease (IBD) is a type of chronic relapsing inflammatory disease with unclear pathogenesis involving environmental factors, genetic factors, intestinal microbiota disorder, and abnormal immune responses. Exosomes, with sizes ranging from 30-150 nm, are involved in IBD pathogenesis by mediating intercellular communication and regulating cell activity through non-coding RNAs, proteins, and lipids. Understanding the roles of exosomes in IBD may offer new diagnostic markers and therapeutic targets.

PHARMACEUTICS (2021)

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Review Immunology

Indeterminate Colitis - Update on Treatment Options

Niranjani Venkateswaran et al.

Summary: Indeterminate colitis (IC) is a type of inflammatory bowel disease that can be difficult to differentiate from ulcerative colitis (UC) or Crohn's disease (CD) in the early stages, but most patients will ultimately be diagnosed with one of the two diseases after a period of observation.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Review Nutrition & Dietetics

Latest Trend of Milk Derived Exosomes: Cargos, Functions, and Applications

Xin Feng et al.

Summary: This paper reviews the isolation and identification, cargos, functions of milk derived exosomes (MDEs), focusing mainly on their roles in the intestinal tract and immune system. The potential applications of MDEs as drug carriers and disease biomarkers are also discussed. Challenges and future directions for MDEs research are considered.

FRONTIERS IN NUTRITION (2021)

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Article Nutrition & Dietetics

Extracellular Vesicles Derived From Citrus sinensis Modulate Inflammatory Genes and Tight Junctions in a Human Model of Intestinal Epithelium

Stefania Paola Bruno et al.

Summary: Mammalian exosomes play a crucial role in intercellular communication, while extracellular vesicles from edible plants show similarity in size and content with exosomes. A diet rich in fruits and vegetables benefits gut health, and fruit-derived extracellular vesicles can modulate important biological processes and maintain intestinal epithelium function.

FRONTIERS IN NUTRITION (2021)

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Article Cell & Tissue Engineering

Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance

Ting Yu et al.

Summary: The study revealed that EphB2-EVs significantly enhanced the homing to the damaged colon, effectively alleviated intestinal mucosal inflammation, repaired damaged colon tissue, reduced oxidative stress, and demonstrated a strong immunomodulatory effect by modulating Th17/Treg balance and restraining STAT3 activation.

STEM CELL RESEARCH & THERAPY (2021)

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Article Multidisciplinary Sciences

Lemon exosome-like nanoparticles enhance stress survival of gut bacteria by RNase P-mediated specific tRNA decay

Chao Lei et al.

Summary: This study demonstrates that lemon-derived exosome-like nanoparticles enhance lactobacilli bile resistance by limiting the production of specific proteins and regulating tRNA levels. The findings reveal a tRNA-based gene expression regulation mechanism among lactobacilli to increase bile resistance, offering potential implications for understanding the interplay between diet and gut microbiota.

ISCIENCE (2021)

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Review Biology

Mesenchymal Stem Cell-Derived Exosomes and Their Therapeutic Potential for Osteoarthritis

Gi Beom Kim et al.

Summary: Although conventional MSC-based therapies have limitations, MSC-derived exosomes offer advantages such as small dimensions, low immunogenicity, and potent therapeutic effects for osteoarthritis treatment. Exosomes are nano-sized vesicles containing nucleic acids, functional proteins, and bioactive lipids, secreted by various cell types. They play a role in tissue repair, immune regulation, and inflammation reduction, demonstrating potential for a new therapeutic approach in osteoarthritis. Further research is needed to confirm their clinical effectiveness and feasibility.

BIOLOGY-BASEL (2021)

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Review Biology

Extracellular Vesicles as Biomarkers and Therapeutic Tools: From Pre-Clinical to Clinical Applications

Maria Chiara Ciferri et al.

Summary: Extracellular vesicles (EVs) are membrane-bound vesicles released by all cell types, playing a crucial role in intercellular communication and serving as biomarkers for various diseases. EVs isolated from stem/progenitor cells exhibit innate immunosuppressive and anti-inflammatory properties, making them potential vehicles for drug delivery.

BIOLOGY-BASEL (2021)

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Article Biochemistry & Molecular Biology

Serum exosomal pregnancy zone protein as a promising biomarker in inflammatory bowel disease

Jing Shao et al.

Summary: This study found that pregnancy zone protein (PZP) in serum exosomes of IBD patients was significantly higher compared to healthy individuals, suggesting it as a potential biomarker for IBD. The immunosuppressive effects of this exosomal protein were also noted, with elevated levels found in colonic tissue exosomes and serum exosomes of acute colitis mice.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2021)

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Review Immunology

Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes

Maedeh Arabpour et al.

Summary: MSC-derived exosomes have the potential to polarize M2 macrophages and modulate inflammation in various diseases and conditions like CNS diseases, autoimmune diseases, inflammatory bowel disease, and cardiomyopathy.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

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Article Cell Biology

Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway

De-feng Li et al.

Summary: The study identified PHLPP2 as a potential therapeutic target for UC, as its downregulation activated NF-kappa B signaling and promoted IEC pyroptosis, leading to inflammation and disease progression. This finding sheds light on the molecular mechanisms underlying UC pathogenesis, highlighting the importance of targeting PHLPP2 in UC therapy.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Nutrition & Dietetics

Lactobacillus rhamnosus GG Derived Extracellular Vesicles Modulate Gut Microbiota and Attenuate Inflammatory in DSS-Induced Colitis Mice

Lingjun Tong et al.

Summary: Probiotic LGG-EVs show potential in attenuating colitis by inhibiting the TLR4-NF-kappa B-NLRP3 signaling pathway, reducing the release of pro-inflammatory cytokines, and reshaping gut microbiota. These findings suggest a promising therapeutic approach for colitis using oral gavage of LGG-EVs.

NUTRIENTS (2021)

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Article Cell & Tissue Engineering

hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis

Xiu Cai et al.

Summary: The study demonstrated that hucMSC-derived exosomes inhibited the activation of NLRP3 inflammasomes, reducing cell pyroptosis and protecting against DSS-induced colitis. Furthermore, miR-378a-5p played a vital role in this process.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6

Shaopeng Yang et al.

Summary: MSC-derived exosomes can protect against IBD by restoring mucosal barrier repair and intestinal immune homeostasis through TSG-6 in mice.

STEM CELL RESEARCH & THERAPY (2021)

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Review Pharmacology & Pharmacy

Exosomes in Intestinal Inflammation

Kanchana K. Ayyar et al.

Summary: Exosomes are small vesicles released by cells, containing a variety of molecules, and can be found in various tissues of humans and other mammals. A unique exosome profile can be detected in blood and fecal samples of patients with Inflammatory Bowel Disease (IBD), making them potential targets for IBD therapy.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

A Comprehensive Insight into the Role of Exosomes in Viral Infection: Dual Faces Bearing Different Functions

Mabroka H. Saad et al.

Summary: Exosomes, as a subtype of extracellular vesicles, play crucial roles in cellular communication and immune modulation. Recent studies have shown that many viruses exploit exosomes to export viral elements, influencing viral propagation and cellular immunity. Understanding exosome biology in viral infections is essential for developing novel therapeutic strategies and vaccines.

PHARMACEUTICS (2021)

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Review Biochemistry & Molecular Biology

Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development

Bodo C. Melnik et al.

Summary: Human milk contains multiple biologically active components that support infant growth, health, and development. Milk-derived extracellular vesicles (MEVs), specifically milk exosomes (MEX) and their miRNA cargo, play key roles in intestinal maturation, barrier function, and suppression of NF-kappa B signaling. Understanding the molecular biology of milk provides insights into how infants are both breast-fed and breast-programmed.

BIOMOLECULES (2021)

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Article Chemistry, Medicinal

Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?

Moein Ala et al.

Summary: Research has shown that metformin can prevent or alleviate various complications, including cardiovascular diseases, obesity, and cancer. Metformin regulates metabolism, growth, proliferation, inflammation, tumorigenesis, and senescence by activating multiple signaling pathways and molecular mechanisms.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

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Article Chemistry, Multidisciplinary

A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for high-performance delivery of oral antibodies

Yuling Mao et al.

Summary: This study introduces a novel biomimetic nanocomposite for colon-targeted delivery of anti-TNF-alpha antibodies through the oral route, utilizing ginger-derived exosomes and an inorganic framework. The nanocomposite showed stability, colonic targeting, and high efficacy in inflammatory bowel disease therapy.

NANOSCALE (2021)

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Article Gastroenterology & Hepatology

Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway

Le Liu et al.

Summary: The study demonstrated that Fusobacterium nucleatum-derived extracellular vesicles induce epithelial cell death and gut barrier disruption in ulcerative colitis, potentially through the activation of receptor-interacting protein kinase 1 (RIPK1). These findings provide insights for further investigation of the disease.

GUT MICROBES (2021)

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Article Geriatrics & Gerontology

Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration

Hongliang Yu et al.

Summary: The study suggests that exosomes derived from adipose mesenchymal stem cells have potential effectiveness in treating inflammatory bowel disease by promoting intestinal mucosa and epithelial cell regeneration, as well as maintaining intestinal integrity. This provides a theoretical basis for new therapeutic strategies involving cell-free therapy for IBD.

AGING AND DISEASE (2021)

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Article Medicine, Research & Experimental

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the microbiota

Lingjun Tong et al.

Summary: This study demonstrates that mEVs alleviate colitis by regulating intestinal immune homeostasis via inhibiting TLR4-NF-kappa B and NLRP3 signaling pathways, restoring Treg/Th17 cell balance, and reshaping the gut microbiota. The findings suggest that mEVs have the potential to be a therapeutic approach for inflammatory bowel diseases.

THERANOSTICS (2021)

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Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

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Article Gastroenterology & Hepatology

Long-term Evaluation of Allogeneic Bone Marrow-derived Mesenchymal Stromal Cell Therapy for Crohn's Disease Perianal Fistulas

Marieke C. Barnhoorn et al.

JOURNAL OF CROHNS & COLITIS (2020)

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Article Pediatrics

Human breast milk exosomes attenuate intestinal damage

Hiromu Miyake et al.

PEDIATRIC SURGERY INTERNATIONAL (2020)

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Article Cell Biology

Effect of mesenchymal stem cell-derived exosomes on the induction of mouse tolerogenic dendritic cells

Mehri Shahir et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Cell Biology

Extracellular Vesicles with Possible Roles in Gut Intestinal Tract Homeostasis and IBD

Xin Chang et al.

MEDIATORS OF INFLAMMATION (2020)

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Article Biochemistry & Molecular Biology

BMSC-EVs regulate Th17 cell differentiation in UC via H3K27me3

Qianyun Chen et al.

MOLECULAR IMMUNOLOGY (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Biology

Exosome-mediated effects and applications in inflammatory bowel disease

Dickson K. W. Ocansey et al.

BIOLOGICAL REVIEWS (2020)

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Review Pharmacology & Pharmacy

Exosomes in Inflammatory Bowel Disease: What Have We Learned So Far?

Haichao Wang et al.

CURRENT DRUG TARGETS (2020)

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Review Cell Biology

Emerging Role of Exosomes in Diagnosis and Treatment of Infectious and Inflammatory Bowel Diseases

Anais Larabi et al.

CELLS (2020)

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Review Microbiology

The Relationship Between Gut Microbiota and Inflammatory Diseases: The Role of Macrophages

Ji Wang et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Medicine, Research & Experimental

Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis

Katarzyna Bulek et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Agriculture, Dairy & Animal Science

Exosome cargo in milk as a potential marker of cow health

Monica Colitti et al.

JOURNAL OF DAIRY RESEARCH (2020)

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Review Biochemistry & Molecular Biology

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Exosomes derived from T regulatory cells relieve inflammatory bowel disease by transferring miR-195a-3p

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Comparison of Bone Marrow Aspirate Concentrate and Allogenic Human Umbilical Cord Blood Derived Mesenchymal Stem Cell Implantation on Chondral Defect of Knee: Assessment of Clinical and Magnetic Resonance Imaging Outcomes at 2-Year Follow-Up

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Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo

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MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells

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BLOOD (2019)

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Events Within the First Year of Life, but Not the Neonatal Period, Affect Risk for Later Development of Inflammatory Bowel Diseases

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GASTROENTEROLOGY (2019)

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Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

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Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization

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Microbial genes and pathways in inflammatory bowel disease

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Exosome-Induced Regulation in Inflammatory Bowel Disease

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The Role of Extracellular Vesicles in Viral Infection and Transmission

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VACCINES (2019)

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Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitis

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Exosomes Derived From M2b Macrophages Attenuate DSS-Induced Colitis

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Milk-Derived Exosomes and Metabolic Regulation

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ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 7 (2019)

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Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease A Secondary Analysis of the Exenatide-PD Trial

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Cancer Cell Membrane Camouflaged Nanoparticles to Realize Starvation Therapy Together with Checkpoint Blockades for Enhancing Cancer Therapy

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Mesenchymal stem cell-gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect

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Plant-Derived Exosomal Nanoparticles Inhibit Pathogenicity of Porphyromonas gingivalis

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GASTROENTEROLOGY (2018)

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Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction

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Biogenesis and function of extracellular vesicles in cancer

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Gram-Positive Bacterial Extracellular Vesicles and Their Impact on Health and Disease

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Outer Membrane Vesicles From Probiotic and Commensal Escherichia coli Activate NOD1-Mediated Immune Responses in Intestinal Epithelial Cells

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Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction

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Exosomics-A Review of Biophysics, Biology and Biochemistry of Exosomes With a Focus on Human Breast Milk

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Gut microbiota in the pathogenesis of inflammatory bowel disease

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Biological Activities of Extracellular Vesicles and Their Cargos from Bovine and Human Milk in Humans and Implications for Infants

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Exosome levels in human body fluids: A tumor marker by themselves?

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Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa To Inhibit Epithelial Wound Healing

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Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase

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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice

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Body Fluids-Derived Exosomes: Paving the Novel Road to Lung Cancer Diagnosis and Therapy

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ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2017)

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Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7

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Curcumin Encapsulated in Milk Exosomes Resists Human Digestion and Possesses Enhanced Intestinal Permeability in Vitro

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Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

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Exosomes Released from Cells Infected with Crohn's Disease-associated Adherent-Invasive Escherichia coli Activate Host Innate Immune Responses and Enhance Bacterial Intracellular Replication

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INFLAMMATORY BOWEL DISEASES (2016)

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Gut Microbiota Dysbiosis as Risk and Premorbid Factors of IBD and IBS Along the Childhood-Adulthood Transition

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INFLAMMATORY BOWEL DISEASES (2016)

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Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Review Medicine, Research & Experimental

The biology and function of exosomes in cancer

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JOURNAL OF CLINICAL INVESTIGATION (2016)

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Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial

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Article Biotechnology & Applied Microbiology

Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy

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EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

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NATURE COMMUNICATIONS (2016)

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Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice

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From structures to functions: insights into exosomes as promising drug delivery vehicles

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BIOMATERIALS SCIENCE (2016)

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Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

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ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)

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Mesenchymal stromal cells and the innate immune response

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IMMUNOLOGY LETTERS (2015)

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Cytokines, IBD, and Colitis-associated Cancer

Ralph Francescone et al.

INFLAMMATORY BOWEL DISEASES (2015)

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Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

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The global burden of IBD: from 2015 to 2025

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MicroRNAs in Breastmilk and the Lactating Breast: Potential Immunoprotectors and Developmental Regulators for the Infant and the Mother

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Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods

Tamas Baranyai et al.

PLOS ONE (2015)

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Innate and adaptive immunity in inflammatory bowel disease

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AUTOIMMUNITY REVIEWS (2014)

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Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo

Miyoung Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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A Phase 2 Study of Allogeneic Mesenchymal Stromal Cells for Luminal Crohn's Disease Refractory to Biologic Therapy

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CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

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National estimates of the burden of inflammatory bowel disease among racial and ethnic groups in the United States

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JOURNAL OF CROHNS & COLITIS (2014)

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Editorial Material Gastroenterology & Hepatology

IBD Global variations in environmental risk factors for IBD

Gilaad G. Kaplan

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

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Review Cell Biology

Routes and mechanisms of extracellular vesicle uptake

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JOURNAL OF EXTRACELLULAR VESICLES (2014)

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Letter Gastroenterology & Hepatology

Colorectal Cancer in IBD Patients

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AMERICAN JOURNAL OF GASTROENTEROLOGY (2013)

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Review Biochemistry & Molecular Biology

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

Fabio G. Teixeira et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

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Dynamics of exosome internalization and trafficking

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JOURNAL OF CELLULAR PHYSIOLOGY (2013)

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Review Oncology

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

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JOURNAL OF NEURO-ONCOLOGY (2013)

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Article Biotechnology & Applied Microbiology

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

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MOLECULAR THERAPY (2013)

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Article Multidisciplinary Sciences

Extracellular Vesicles Derived from Gut Microbiota, Especially Akkermansia muciniphila, Protect the Progression of Dextran Sulfate Sodium-Induced Colitis

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PLOS ONE (2013)

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Article Biochemistry & Molecular Biology

Immune-related MicroRNAs are Abundant in Breast Milk Exosomes

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INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2012)

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Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands

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ONCOIMMUNOLOGY (2012)

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MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between

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CURRENT OPINION IN CELL BIOLOGY (2011)

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Intestinal epithelial cell-derived integrin αβ6 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response

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JOURNAL OF LEUKOCYTE BIOLOGY (2011)

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Article Gastroenterology & Hepatology

Exosomes derived from interleukin-10-treated dendritic cells can inhibit trinitrobenzene sulfonic acid-induced rat colitis

Xiaojun Yang et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2010)

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Review Gastroenterology & Hepatology

Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease

Noah P. Zimmerman et al.

INFLAMMATORY BOWEL DISEASES (2008)

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Review Biochemistry & Molecular Biology

Bovine milk in human nutrition - a review

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LIPIDS IN HEALTH AND DISEASE (2007)

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Article Gastroenterology & Hepatology

Ulcerative colitis:: Patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort

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AMERICAN JOURNAL OF GASTROENTEROLOGY (2007)

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Article Immunology

Exosomes with immune modulatory features are present in human breast milk

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JOURNAL OF IMMUNOLOGY (2007)

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Article Endocrinology & Metabolism

Gut mucosal homeostasis and cellular mediators after severe thermal trauma and the effect of insulin-like growth factor-I in combination with insulin-like growth factor binding protein-3

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ENDOCRINOLOGY (2007)

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Article Hematology

Human small intestinal epithelial cells constitutively express the key elements for antigen processing and the production of exosomes

XP Lin et al.

BLOOD CELLS MOLECULES AND DISEASES (2005)

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Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes

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NATURE IMMUNOLOGY (2002)

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