期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/ijms23169492
关键词
Canavalia lineata; isoflavonoid; cajanin; anti-inflammation
资金
- National Institute of Biological Resources (NIBR) [201913103]
- KRIBB Research Initiative Program
The bioactive components of Canavalia lineata (Thunb.) DC pods were investigated, and several compounds were identified. Among them, the isoflavonoid derivative cajanin (7) showed the strongest anti-inflammatory activity, highlighting its potential as a candidate for treating inflammatory diseases.
The bioactive components of Canavalia lineata (Thunb.) DC pods were investigated using bioactivity-guided isolation, and the chemical structures of flavonoids 1-3, isoflavonoid derivatives 4-11, and phenolic compounds 12 and 13 were identified by comparing NMR, MS, and CD spectral data with previously reported spectroscopic data. Compounds 1-13 were evaluated for their anti-inflammatory effects on LPS-stimulated RAW264.7 macrophages. Among these compounds, the isoflavonoid derivative cajanin (7) exhibited the most potent anti-inflammatory activity (IC50 of NO = 19.38 +/- 0.05 mu M; IC50 of IL-6 = 7.78 +/- 0.04 mu M; IC50 of TNF-alpha = 26.82 +/- 0.11 mu M), exerting its anti-inflammatory effects by suppressing the activation and nuclear translocation of the transcription factor NF-kappa B by phosphorylating I kappa B and p65. These results suggested that cajanin (7) may be a potential candidate for improving the treatment of inflammatory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据