☆ 4.7 Review

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Summary: Immunotherapy has been used in cancer treatment for many years and is known to modulate the immune system to suppress tumor formation. A study was conducted to investigate the supportive therapy potential of acidophilus milk and propolis extract in a mouse xenograft breast cancer model. The combination of acidophilus milk and propolis showed the best antitumor effect.

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Caffeic acid phenethyl ester induces radiosensitization via inhibition of DNA damage repair in androgen-independent prostate cancer cells

Km Anjaly et al.

Summary: In this study, the radiomodulatory potential of caffeic acid phenethyl ester (CAPE) in prostate cancer cells was evaluated. CAPE was found to enhance the sensitivity of prostate cancer cells to radiation and induce apoptosis, while inhibiting cell migration. The combination treatment of CAPE and radiation increased DNA damage and cell death by inhibiting DNA repair proteins. Therefore, CAPE may be a potential adjuvant for the treatment of hormone-refractory radioresistant prostate cancer.

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Summary: This article presents the multifaceted anti-cancer action of propolis-derived flavonoid, galangin, discussing its effects in various cancer cells, including antioxidant, anti-inflammatory, antiproliferative, pro-apoptotic, anti-angiogenic, and anti-metastatic. It also explores the co-effects with standard chemotherapeutic drugs and other natural compounds, as well as modern nanotechnological advancements for overcoming the low bioavailability issue of galangin. Further studies are needed to confirm the anti-cancer potential of galangin in vivo malignant systems, but exploring this natural compound may open new perspectives in molecular oncology.

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Summary: Brazil is a leading producer of propolis with a diversity of types, each characterized by a unique chemical fingerprint influenced by local flora. Red propolis is rich in sesquiterpenes, pterocarpans, and isoflavans, brown propolis contains hydrocarbons, aldehydes, and monoterpenes, while green propolis is characterized by polycyclic aromatic hydrocarbons and sesquiterpenes. Principal component analysis and hierarchical cluster analysis successfully differentiate between different types of propolis samples.

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Perspectives for Uses of Propolis in Therapy against Infectious Diseases

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Role of Ginseng, Quercetin, and Tea in Enhancing Chemotherapeutic Efficacy of Colorectal Cancer

Linxian Zhao et al.

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FRONTIERS IN MEDICINE (2022)

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Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.

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Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties

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Summary: This review discusses the effects of bee products, such as propolis, royal jelly, honey, bee venom, and bee pollen, on inflammatory and autoimmune diseases. These bee products or their chemical constituents demonstrate potential therapeutic effects in regulating the production of inflammatory mediators and improving immune responses.

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Breast Disease (2021)

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Bioactive components and mechanisms of poplar propolis in inhibiting proliferation of human hepatocellular carcinoma HepG2 cells

Hui Liu et al.

Summary: The study found that the bioactive components in poplar propolis extract CP were mainly flavonoids and esters. CP induced HepG2 apoptosis through a mitochondrial-dependent intrinsic pathway, as well as through the regulation of various signaling pathways and molecules to achieve anti-proliferation and pro-apoptosis effects.

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Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

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Claudia Musial et al.

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Nano formulated Resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages

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Summary: Tumor associated macrophages in the tumor microenvironment secrete cytokines that regulate cancer cells growth, while Resveratrol nanoparticles reduce the properties of cancer stem like cells. By decreasing cytokine levels, Res-NP inhibits invasion, proliferation, and growth of CSCs in vitro, in vivo, and ex vivo systems.

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Nicolas Ripari et al.

Summary: Propolis is a safe bee-made product with antiviral and immunomodulatory activity. Clinical trials are needed to investigate its effects on individuals with viral diseases, either alone or in combination with antiviral drugs or vaccines. Specific research on the effects of propolis on COVID-19, either in vitro or in infected individuals, should also be conducted to explore its potential as a treatment option.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

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Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper

Anja Sadzak et al.

Summary: The study revealed that myricetin exacerbated the toxicity of copper, leading to cell death, and induced various cell death mechanisms such as apoptosis and necrosis. These findings highlight the potential adverse effects of myricetin in the context of copper-related neurodegeneration.

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Article Chemistry, Medicinal

Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells

Wenbin Xu et al.

Summary: This study demonstrated that quercetin has inhibitory effects on cervical cancer cells and acts synergistically with cisplatin, enhancing the antitumor effect of cisplatin by inhibiting proliferation, migration, and invasion, and promoting apoptosis through downregulating MMP2, ezrin, METTL3, and P-Gp expression.

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Chinese Poplar Propolis Inhibits MDA-MB-231 Cell Proliferation in an Inflammatory Microenvironment by Targeting Enzymes of the Glycolytic Pathway

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The Anti-Leukemic Activity of Natural Compounds

Coralia Cotoraci et al.

Summary: The use of biologically active compounds for the treatment of leukemia shows promise in improving therapeutic options for patients, targeting different types of leukemia cells. This review serves as a basis for further research in developing new alternative therapies in the fight against leukemia, a deadly hematological cancer.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Chinese Propolis Suppressed Pancreatic Cancer Panc-1 Cells Proliferation and Migration via Hippo-YAP Pathway

Lingchen Tao et al.

Summary: The study demonstrated that Chinese propolis has a significant anticancer effect on pancreatic cancer cells Panc-1 by inducing apoptosis, inhibiting cell migration, and activating the Hippo pathway to suppress tumor growth.

MOLECULES (2021)

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Review Nutrition & Dietetics

Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer

Samia S. Messeha et al.

Summary: Research on dietary polyphenolic compounds as antitumor agents is increasing due to the link between immunity and cancer. These compounds affect cancer progression and metastasis by inhibiting the EMT process, potentially reducing the risk of breast cancer.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

The effects of resveratrol on the expression of VEGF, TGF-beta, and MMP-9 in endometrial stromal cells of women with endometriosis

Tahereh Arablou et al.

Summary: Resveratrol, a phytochemical, shows beneficial anti-inflammatory and antioxidant properties for the progression of endometriosis by reducing the expression of VEGF, TGF-beta, and MMP-9 in endometrial stromal cells.

SCIENTIFIC REPORTS (2021)

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Article Pharmacology & Pharmacy

Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS Production

Xiaohui Liang et al.

Summary: Galangin inhibits the growth of MGC 803 cells by inducing apoptosis and decreasing cell proliferation, possibly mediated by modulating the STAT3/ROS axis.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Plant Sciences

Potential Role of Propolis in the Prevention and Treatment of Metabolic Diseases

Georgeta Balica et al.

Summary: Propolis, a resinous mixture produced by bees, has been extensively researched and shown to have anti-inflammatory, antioxidant, antimicrobial, and wound-healing properties. Recent studies have also focused on its potential effects in treating metabolic diseases like diabetes, dyslipidemia, and obesity, with various chemical constituents being investigated for their mechanisms of action. Additionally, the safety profile of propolis in clinical studies was evaluated.

PLANTS-BASEL (2021)

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Article Medicine, Research & Experimental

Exploring the anticancer effects of standardized extracts of poplar-type propolis: In vitro cytotoxicity toward cancer and normal cell lines

Davide Campoccia et al.

Summary: Propolis exhibits antimicrobial, antioxidant, anti-inflammatory, and anticancer activities, influenced by various factors. The Multi Dynamic Extraction Method (MED) can improve the reproducibility of propolis extracts. The study shows that propolis has mild cytotoxicity towards cancer cells, with some selective activity observed, highlighting the importance of assessing selectivity when screening for anticancer drug candidates.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

The FOXO signaling axis displays conjoined functions in redox homeostasis and stemness

Ruthia Soh et al.

Summary: Reactive oxygen species (ROS) were once seen as harmful byproducts of metabolism, but recent studies have highlighted their key role in stem cell self-renewal or differentiation. The interplay between ROS levels, metabolism, and downstream redox signaling pathways influences stem cell fate.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Nutrition & Dietetics

Anticancer Activity of Propolis and Its Compounds

Ewa Forma et al.

Summary: Propolis, a natural material produced by honey bees from various botanical sources, has therapeutic activities such as antibacterial, antifungal, and anti-inflammatory effects, with potential benefits in inhibiting cancer cell proliferation and metastasis. Research suggests that propolis can also stimulate apoptosis, influence the tumor microenvironment, and potentially reduce the side effects of chemotherapy and radiotherapy.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Apis mellifera propolis enhances apoptosis and invasion inhibition in head and neck cancer cells

Nattisa Niyomtham et al.

Summary: The study demonstrated that propolis extract exhibits cytotoxicity and induces apoptosis in head and neck squamous carcinoma cell lines, as well as significantly reduces cell invasion by decreasing MMP-2 and MMP-9 activity. Two flavonoids, galangin and apigenin, were identified in the extract. These results suggest that propolis extract promotes apoptosis and exerts anti-invasion potential in HNSCC cell lines, possibly through the actions of galangin and apigenin.

PEERJ (2021)

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Article Oncology

Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway

Xinbing Zhu et al.

Summary: Pinocembrin (PCB) exhibits anti-proliferation and anti-metastasis activity in breast cancer cells, involving cell cycle (G2/M phase) arrest and apoptosis mechanisms, as well as inhibition of the PI3K/AKT signaling pathway. Low concentrations of PCB also significantly suppress the migration and invasion abilities of breast cancer cells, suggesting its potential as an effective agent for treating breast cancer patients.

FRONTIERS IN ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Multifaceted Role of Flavonoids in Cancer Therapy: Leveraging Autophagy with a Double-Edged Sword

Zhe Zhang et al.

Summary: Flavonoids are considered safe and readily obtainable molecules that have potential in cancer treatment by modulating autophagy. However, their anti-cancer activity may be weakened by the induction of protective autophagy. Research is focusing on exploring new applications and dosage forms to establish flavonoids as ideal candidates for cancer prevention and therapy in clinical settings.

ANTIOXIDANTS (2021)

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Review Oncology

The interplay between reactive oxygen species and antioxidants in cancer progression and therapy: a narrative review

Osama Hussein Bekhet et al.

Summary: This study focused on the roles of reactive oxygen species (ROS) and antioxidants in cancer progression and therapy. Cancer is a diverse disease at the cellular level with different causes. High levels of ROS have protumorigenic activities, while antioxidants play a role in maintaining cellular redox balance.

TRANSLATIONAL CANCER RESEARCH (2021)

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Review Oncology

Combining epigenetic drugs with other therapies for solid tumours - past lessons and future promise

Daphne Morel et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Immunology

The Controversial Role of Autophagy in Tumor Development: A Systematic Review

Bridilla Luiza Colhado Rodrigues et al.

IMMUNOLOGICAL INVESTIGATIONS (2020)

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Review Medicine, Research & Experimental

Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects

Si-Min Tang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Neurosciences

Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities

Wildson Max Barbosa da Silva et al.

NEUROTOXICITY RESEARCH (2020)

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Review Oncology

Autophagy: A Potential Therapeutic Target of Polyphenols in Hepatocellular Carcinoma

Chandramohan Kiruthiga et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

Potential Adverse Effects of Resveratrol: A Literature Review

Abdullah Shaito et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Nutrition & Dietetics

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

Priyanga Selvakumar et al.

NUTRIENTS (2020)

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Article Nutrition & Dietetics

Dietary Antioxidant Intake and Human Papillomavirus Infection: Evidence from a Cross-Sectional Study in Italy

Martina Barchitta et al.

NUTRIENTS (2020)

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Article Biochemistry & Molecular Biology

Effects of Propolis and Phenolic Acids on Triple-Negative Breast Cancer Cell Lines: Potential Involvement of Epigenetic Mechanisms

Joao Henrique Maia Assumpcao et al.

MOLECULES (2020)

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Article Food Science & Technology

Antifungal and Antibacterial Effect of Propolis: A Comparative Hit for Food-BornePseudomonas, Enterobacteriaceae and Fungi

Leonardo Petruzzi et al.

FOODS (2020)

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Article Biotechnology & Applied Microbiology

Antioxidant and Probiotic Properties of Lactobacilli and Bifidobacteria of Human Origins

Hyemin Kim et al.

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2020)

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Article Integrative & Complementary Medicine

Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest

Xia-sen Jiang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Review Oncology

Flavonoids in Cancer Metastasis

Alena Liskova et al.

CANCERS (2020)

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Article Chemistry, Medicinal

Study on antitumor activities of the chrysin-chromene-spirooxindole on Lewis lung carcinoma C57BL/6 mice in vivo

Wen-Hui Zhang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)

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Article Biochemistry & Molecular Biology

Interactions between Cisplatin and Quercetin at Physiological and Hyperthermic Conditions on Cancer Cells In Vitro and In Vivo

Nada Orsolic et al.

MOLECULES (2020)

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Review Cell Biology

Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products

Yiman Liu et al.

CELL PROLIFERATION (2020)

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Article Nutrition & Dietetics

Molecular and cellular mechanisms of the effects of Propolis in inflammation, oxidative stress and glycemic control in chronic diseases

Naseh Pahlavani et al.

NUTRITION & METABOLISM (2020)

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Article Oncology

Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress-mediated apoptosis and G2/M phase arrest

Mengting Ren et al.

ONCOLOGY REPORTS (2020)

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Article Cell Biology

PI3K/Akt and ERK1/2 Signalling Are Involved in Quercetin-Mediated Neuroprotection against Copper-Induced Injury

Klara Zubcic et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Medicine, Research & Experimental

Does propolis affect the quality of life and complications in subjects with irritable bowel syndrome (diagnosed with Rome IV criteria)? A study protocol of the randomized, double-blinded, placebo-controlled clinical trial

Mahsa Miryan et al.

TRIALS (2020)

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Review Biochemistry & Molecular Biology

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

Monica Benvenuto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Agriculture, Multidisciplinary

Chrysin Inhibits Melanoma Tumor Metastasis via Interfering with the FOXM1/β-Catenin Signaling

Zheng Yufei et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Medicine, Research & Experimental

Stabilization of telomere by the antioxidant property of polyphenols: Anti-aging potential

Masomeh Maleki et al.

LIFE SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Temperate Propolis Has Anti-Inflammatory Effects and Is a Potent Inhibitor of Nitric Oxide Formation in Macrophages

Samyah Alanazi et al.

METABOLITES (2020)

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Review Nutrition & Dietetics

Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Ornella I. Selmin et al.

FRONTIERS IN NUTRITION (2020)

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Article Veterinary Sciences

Synergistic interactions between resveratrol and doxorubicin inhibit angiogenesis both in vitro and in vivo

A. Uvez et al.

POLISH JOURNAL OF VETERINARY SCIENCES (2020)

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Review Oncology

Autophagy regulation using luteolin: new insight into its anti-tumor activity

Milad Ashrafizadeh et al.

CANCER CELL INTERNATIONAL (2020)

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Review Biology

Propolis as a novel antibacterial agent

Mohammed Saad Almuhayawi

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Review Oncology

Chemopreventive and Chemotherapeutic Effect of Propolis and Its Constituents: A Mini-review

Hui-Fang Chiu et al.

JOURNAL OF CANCER PREVENTION (2020)

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Article Medicine, General & Internal

Radioprotective Effects of Propolis and Caffeic acid Phenethyl Ester on the Tongue-Tissues of Total-Head Irradiated Rats

Halis Altay et al.

EUROPEAN JOURNAL OF THERAPEUTICS (2020)

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Review Chemistry, Medicinal

Research Progress of the Antiviral Bioactivities of Natural Flavonoids

Lin Wang et al.

NATURAL PRODUCTS AND BIOPROSPECTING (2020)

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Review Food Science & Technology

Anti-proliferative, pro-apoptotic and anti-oxidative activity of Lactobacillus and Bifidobacterium strains: A review of mechanisms and therapeutic perspectives

Adriana Nowak et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

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Review Chemistry, Medicinal

Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target

Ma Carmen Ocana et al.

MEDICINAL RESEARCH REVIEWS (2019)

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Article Biochemical Research Methods

Synthetic isoflavones and doping: A novel class of aromatase inhibitors?

Michele Iannone et al.

DRUG TESTING AND ANALYSIS (2019)

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Article Biochemistry & Molecular Biology

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

Chengcheng Jin et al.

CELL (2019)

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Article Biochemistry & Molecular Biology

Resveratrol Inhibits the Migration and Metastasis of MDA-MB-231 Human Breast Cancer by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition

Yang Sun et al.

MOLECULES (2019)

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Review Biochemistry & Molecular Biology

The microbiome, cancer, and cancer therapy

Beth A. Helmink et al.

NATURE MEDICINE (2019)

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Review Cell Biology

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

Mark S. D'Arcy

CELL BIOLOGY INTERNATIONAL (2019)

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Article Oncology

Caffeic acid phenethyl ester attenuates nuclear factor-κB-mediated inflammatory responses in Muller cells and protects against retinal ganglion cell death

Yanwen Jia et al.

MOLECULAR MEDICINE REPORTS (2019)

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Article Food Science & Technology

Neurotoxic Effect of Ethanolic Extract of Propolis in the Presence of Copper Ions is Mediated through Enhanced Production of ROS and Stimulation of Caspase-3/7 Activity

Vedrana Radovanovic et al.

TOXINS (2019)

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Article Biochemistry & Molecular Biology

Caffeic Acid Phenethyl Ester Inhibits UV-Induced MMP-1 Expression by Targeting Histone Acetyltransferases in Human Skin

Eun Ju Shin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

CAPE-pNO2 Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway

Qin Huang et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Propolis Exerts an Anti-Inflammatory Effect on PMA-Differentiated THP-1 Cells via Inhibition of Purine Nucleoside Phosphorylase

Abdulmalik M. Alqarni et al.

METABOLITES (2019)

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Article Pharmacology & Pharmacy

Caffeic Acid Phenethyl Ester Inhibits the Proliferation of HEp2 Cells by Regulating Stat3/P1k1 Pathway and Inducing S Phase Arrest

Xiabin Ren et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019)

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Article Cell Biology

Anti-angiogenic effect of quercetin and its 8-methyl pentamethyl ether derivative in human microvascular endothelial cells

Gabriella Lupo et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Identification of Resveratrol as Bioactive Compound of Propolis from Western Romania and Characterization of Phenolic Profile and Antioxidant Activity of Ethanolic Extracts

Alexandra Duca et al.

MOLECULES (2019)

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Review Chemistry, Applied

Anti-inflammatory effects of flavonoids

Soheila J. Maleki et al.

FOOD CHEMISTRY (2019)

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Review Immunology

The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

Zuzanna Urban-Wojciuk et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

Karen G. de la Cruz-Lopez et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Cell Biology

Quercetin sensitizes human myeloid leukemia KG-1 cells against TRAIL-induced apoptosis

Adel Naimi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Medicine, Research & Experimental

Genistein potentiates Centchroman induced antineoplasticity in breast cancer via PI3K/Akt deactivation and ROS dependent induction of apoptosis

Shweta Kaushik et al.

LIFE SCIENCES (2019)

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Review Oncology

Toll-like receptor 4 and breast cancer: an updated systematic review

Morteza Khademalhosseini et al.

BREAST CANCER (2019)

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Review Oncology

Flavonoids in Cancer and Apoptosis

Mariam Abotaleb et al.

CANCERS (2019)

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Article Oncology

Helicobacter pylori and Epstein-Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism

Fasciana Teresa et al.

JOURNAL OF ONCOLOGY (2019)

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Article Materials Science, Biomaterials

Intracellular Fenton reaction based on mitochondria-targeted copper(II)-peptide complex for induced apoptosis

Xia Li et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Review Pharmacology & Pharmacy

Immunomodulatory Effects of Propolis and its Components on Basic Immune Cell Functions

K. Wolska et al.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin

Rashida Ginwala et al.

ANTIOXIDANTS (2019)

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Review Biochemistry & Molecular Biology

Telomerase Inhibitors from Natural Products and Their Anticancer Potential

Kumar Ganesan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Cell Biology

MicroRNA: A novel target of curcumin in cancer therapy

Hamed Mirzaei et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Dermatology

Epigenetics of skin cancer: Interventions by selected bioactive phytochemicals

Dhanamjai Penta et al.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2018)

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Article Biochemistry & Molecular Biology

Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis

Satoshi Endo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

Quercetin restrains TGF-β1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression

Jihong Feng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Review Medicine, Research & Experimental

Autophagy in health and disease: A comprehensive review

Sarbari Saha et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Medicine, Research & Experimental

Potential role of propolis in wound healing: Biological properties and therapeutic activities

Ahmad Oryan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Cell Biology

The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

Xiaoming Zhong et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Biochemistry & Molecular Biology

Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review

Takahiro Eitsuka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Oncology

Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action

Priyanshu Bhargava et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2018)

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Article Oncology

Genistein reduces the activation of AKT and EGFR, and the production of IL6 in cholangiocarcinoma cells involving estrogen and estrogen receptors

Pariyada Tanjak et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2018)

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Article Toxicology

Modulatory Potential of Curcumin and Resveratrol on p53 Post-Translational Modifications during Gastric Cancer

Heng Xu et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2018)

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Article Medicine, Research & Experimental

Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction

Lijun Jia et al.

LIFE SCIENCES (2018)

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Article Oncology

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression

Jie Zhu et al.

MOLECULAR MEDICINE REPORTS (2018)

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Article Food Science & Technology

Propolis from Different Geographic Origins Decreases Intestinal Inflammation and Bacteroides spp. Populations in a Model of DSS-Induced Colitis

Kai Wang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

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Article Chemistry, Medicinal

Isoflavonoids from Brazilian red propolis down-regulate the expression of cancer-related target proteins: A pharmacogenomic analysis

Bruno Dias Nani et al.

PHYTOTHERAPY RESEARCH (2018)

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Article Multidisciplinary Sciences

Chemical composition, immunostimulatory, cytotoxic and antiparasitic activities of the essential oil from Brazilian red propolis

Angela Sena-Lopes et al.

PLOS ONE (2018)

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Article

Comprehensive analysis of telomerase inhibition by gallotannin

Nikita Savelyev et al.

Oncotarget (2018)

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Article

Grape seed procyanidin extract against lung cancer: the role of microrna-106b, bioavailability, and bioactivity

Bingye Xue et al.

Oncotarget (2018)

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Article Medicine, Research & Experimental

Quercetin Inhibits the Migration and Invasion of HCCLM3 Cells by Suppressing the Expression of p-Akt1, Matrix Metalloproteinase (MMP) MMP-2, and MMP-9

Jun Lu et al.

MEDICAL SCIENCE MONITOR (2018)

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Article Pharmacology & Pharmacy

Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)

Katarzyna Celinska-Janowicz et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

Xi Li et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Immunology

Targeting veGF/veGFR to Modulate Antitumor immunity

Ju Yang et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

Xinglong Qu et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Endocrinology & Metabolism

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Eric S. Goetzman et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Review Oncology

Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming

Victoire Gouirand et al.

FRONTIERS IN ONCOLOGY (2018)

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Review Oncology

Signaling Pathways Regulating Redox Balance in Cancer Metabolism

Maria Chiara De Santis et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Medicine, Research & Experimental

Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway

Suat Erdogan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Pharmacology & Pharmacy

Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation

Hongyan Wu et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2018)

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Article Multidisciplinary Sciences

Atomic force microscopy reveals new biophysical markers for monitoring subcellular changes in oxidative injury: Neuroprotective effects of quercetin at the nanoscale

Maja Jazvinscak Jembrek et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies

Tracy Murray-Stewart et al.

PLOS ONE (2018)

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Article Nutrition & Dietetics

Associations between Flavonoid Intakes and Gut Microbiota in a Group of Adults with Cystic Fibrosis

Li Li et al.

NUTRIENTS (2018)

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Article

Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells

Seyung S. Chung et al.

Oncotarget (2018)

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Review Pharmacology & Pharmacy

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity

Xiaohong Cen et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Biochemistry & Molecular Biology

Bacterial infections and cancer

Daphne van Elsland et al.

EMBO REPORTS (2018)

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Article Oncology

The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes

Marisa Claudia Alvarez et al.

CLINICAL EPIGENETICS (2018)

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Anti-inflammatory and Antioxidant Properties of Probiotic Bacterium Lactobacillus mucosae AN1 and Lactobacillus fermentum SNR1 Wistar Albino Rats

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FRONTIERS IN MICROBIOLOGY (2018)

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Effect of Natural Compounds on NK Cell Activation

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Article Food Science & Technology

Genistein and daidzein induce apoptosis of colon cancer cells by inhibiting the accumulation of lipid droplets

Yu-Si Liang et al.

FOOD & NUTRITION RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Cytotoxicity of propolis nanopreparations in cancer cell monolayers: multimode of action including apoptotsis and nitric oxide production

Mahmoud S. Sherif et al.

GENERAL PHYSIOLOGY AND BIOPHYSICS (2018)

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Review Nutrition & Dietetics

Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism

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FRONTIERS IN NUTRITION (2018)

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Resveratrol as an anti-cancer agent: A review

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CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2018)

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Review Biochemistry & Molecular Biology

Chemoprevention by resveratrol and pterostilbene: Targeting on epigenetic regulation

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Article Pharmacology & Pharmacy

Phenolic compounds alone or in combination may be involved in propolis effects on human monocytes

Eliza de Oliveira Cardoso et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2017)

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Review Pharmacology & Pharmacy

Flavonoids and platelet aggregation: A brief review

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EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

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Honey and quercetin reduce ochratoxin A-induced DNA damage in the liver and the kidney through the modulation of intestinal microflora

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Resveratrol as MDR reversion molecule in breast cancer: An overview

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Article Oncology

HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model

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Curcumin and Salsalate Suppresses Colonic Inflammation and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated Mice

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Brazilian red propolis effects on peritoneal macrophage activity: Nitric oxide, cell viability, pro-inflammatory cytokines and gene expression

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Comparison of Two Components of Propolis: Caffeic Acid (CA) and Caffeic Acid Phenethyl Ester (CAPE) Induce Apoptosis and Cell Cycle Arrest of Breast Cancer Cells MDA-MB-231

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Implications of Resveratrol on Glucose Uptake and Metabolism

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MOLECULES (2017)

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Structure-Activity and Lipophilicity Relationships of Selected Antibacterial Natural Flavones and Flavanones of Chilean Flora

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Characterization and Biological Evaluation of Propolis from Poland

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Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect

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Strategies to Target Glucose Metabolism in Tumor Microenvironment on Cancer by Flavonoids

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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2017)

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Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

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Mechanisms underlying the wound healing potential of propolis based on its in vitroi antioxidant activity

Xue-Ping Cao et al.

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An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis)

Ahmed A. Albassam et al.

PLANTA MEDICA (2017)

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Natural Products as Lead Compounds for Sodium Glucose Cotransporter (SGLT) Inhibitors

Wolfgang Blaschek

PLANTA MEDICA (2017)

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P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment

Rong-Jane Chen et al.

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Role of phytochemicals in the modulation of miRNA expression in cancer

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FOOD & FUNCTION (2017)

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Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor

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FOOD & FUNCTION (2017)

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Effect of Green and Brown Propolis Extracts on the Expression Levels of microRNAs, mRNAs and Proteins, Related to Oxidative Stress and Inflammation

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NUTRIENTS (2017)

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Review Pharmacology & Pharmacy

Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer

Muthu K. Shanmugam et al.

CURRENT VASCULAR PHARMACOLOGY (2017)

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Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma

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Biological properties of propolis extracts: Something new from an ancient product

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CHEMISTRY AND PHYSICS OF LIPIDS (2017)

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Antitumour activity of resveratrol on human melanoma cells: A possible mechanism related to its interaction with malignant cell telomerase

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

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Quercetin suppresses the metastatic ability of lung cancer through inhibiting Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways

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Phytoestrogens and Related Food Components in the Prevention of Cancer

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CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2017)

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Curcumin mediates anticancer effects by modulating multiple cell signaling pathways

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CLINICAL SCIENCE (2017)

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Review Pharmacology & Pharmacy

Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?

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BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways

Elham Kashafi et al.

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Resveratrol inhibits ovarian tumor growth in an in vivo mouse model

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CANCER (2016)

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Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

J. M. Pitt et al.

ANNALS OF ONCOLOGY (2016)

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Chrysin Inhibits Lymphangiogenesis in Vitro

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BIOLOGICAL & PHARMACEUTICAL BULLETIN (2016)

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Article Medicine, Research & Experimental

Evaluation of the miRNA profiling and effectiveness of the propolis on B-cell acute lymphoblastic leukemia cell line

Ugur Cem Yilmaz et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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SERS assay of telomerase activity at single-cell level and colon cancer tissues via quadratic signal amplification

Muling Shi et al.

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Article Integrative & Complementary Medicine

Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis

Lavanya Reddivari et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Oxidative stress, polarization of macrophages and tumour angiogenesis: Efficacy of caffeic acid

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CHEMICO-BIOLOGICAL INTERACTIONS (2016)

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Article Biochemistry & Molecular Biology

Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress

Annabell Plauth et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Association Between Human Telomerase Reverse Transcriptase Gene Variations and Risk of Developing Breast Cancer

Ezgi Oztas et al.

GENETIC TESTING AND MOLECULAR BIOMARKERS (2016)

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Article Biochemistry & Molecular Biology

Caffeic acid phenethyl ester: Inhibition of metastatic cell behaviours via voltage-gated sodium channel in human breast cancer in vitro

Scott P. Fraser et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

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Review Biochemistry & Molecular Biology

Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases

Nayely Leyva-Lopez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Chemotherapeutic potential of quercetin on human bladder cancer cells

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JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING (2016)

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Article Pharmacology & Pharmacy

Propolis modulates miRNAs involved in TLR-4 pathway, NF-B activation, cytokine production and in the bactericidal activity of human dendritic cells

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JOURNAL OF PHARMACY AND PHARMACOLOGY (2016)

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Functional and mechanistic analysis of telomerase: An antitumor drug target

Yinnan Chen et al.

PHARMACOLOGY & THERAPEUTICS (2016)

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Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

Muthu K. Shanmugam et al.

SEMINARS IN CANCER BIOLOGY (2016)

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Article Biotechnology & Applied Microbiology

Cancer: fundamentals behind pH targeting and the double-edged approach

Tomas Koltai

ONCOTARGETS AND THERAPY (2016)

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Article Multidisciplinary Sciences

Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6

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SCIENTIFIC REPORTS (2016)

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Stimulation through CD40 and TLR-4 Is an Effective Host Directed Therapy against Mycobacterium tuberculosis

Nargis Khan et al.

FRONTIERS IN IMMUNOLOGY (2016)

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Review Nutrition & Dietetics

Flavonoids: an overview

A. N. Panche et al.

JOURNAL OF NUTRITIONAL SCIENCE (2016)

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The pharmacology of resveratrol in animals and humans

Eun-Jung Park et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

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Review Integrative & Complementary Medicine

Propolis: A Complex Natural Product with a Plethora of Biological Activities That Can Be Explored for Drug Development

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EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

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Review Biochemistry & Molecular Biology

Caffeic Acid Phenethyl Ester Is a Potential Therapeutic Agent for Oral Cancer

Ying-Yu Kuo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Review Oncology

Immunology and Immunotherapy of Head and Neck Cancer

Robert L. Ferris

JOURNAL OF CLINICAL ONCOLOGY (2015)

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Article Pharmacology & Pharmacy

Modulatory effects of propolis samples from Latin America (Brazil, Cuba and Mexico) on cytokine production by human monocytes

Bruno J. Conti et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2015)

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Article Toxicology

Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats

Yoshinori Okamoto et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2015)

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Article Biochemistry & Molecular Biology

Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion

Hui-Hui Cao et al.

MOLECULAR CANCER (2015)

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Review Biochemistry & Molecular Biology

Chemoprevention of Breast Cancer by Dietary Polyphenols

Maria-Magdalena Mocanu et al.

MOLECULES (2015)

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Article Biochemistry & Molecular Biology

Studies on Transition Metal-Quercetin Complexes Using Electrospray Ionization Tandem Mass Spectrometry

Yuanzhen Liu et al.

MOLECULES (2015)

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Article Oncology

Anticarcinogenic Effects of Dietary Phytoestrogens and Their Chemopreventive Mechanisms

Kyung-A Hwang et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2015)

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Article Nutrition & Dietetics

Curcumin ameliorates the tumor-enhancing effects of a high-protein diet in an azoxymethane-induced mouse model of colon carcinogenesis

So-Young Byun et al.

NUTRITION RESEARCH (2015)

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Review Cell Biology

Balancing the innate immune system in tumor development

Catharina Hagerling et al.

TRENDS IN CELL BIOLOGY (2015)

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Review Gastroenterology & Hepatology

Role of dietary polyphenols in the management of peptic ulcer

Mohammad Hosein Farzaei et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

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Review Medicine, Research & Experimental

Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects

Ferah Armutcu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)

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Review Biotechnology & Applied Microbiology

Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment

Jian-Li Gao et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Review Pharmacology & Pharmacy

HIF-1α pathway: role, regulation and intervention for cancer therapy

Georgina N. Masoud et al.

ACTA PHARMACEUTICA SINICA B (2015)

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Article Dermatology

Suppression of skin inflammation in keratinocytes and acute/chronic disease models by caffeic acid phenethyl ester

Kyung-Min Lim et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2015)

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Review Emergency Medicine

Propolis: a new frontier for wound healing?

Simona Martinotti et al.

BURNS & TRAUMA (2015)

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Article Biochemistry & Molecular Biology

Identification of microRNAs involved in the modulation of pro-angiogenic factors in atherosclerosis by a polyphenol-rich extract from propolis

Alejandro Cuevas et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)

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Article Pharmacology & Pharmacy

Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling

Hui-Hui Cao et al.

BIOCHEMICAL PHARMACOLOGY (2014)

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Article Integrative & Complementary Medicine

Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

Shulhn-Der Wang et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

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Article Immunology

TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells

Hongliang Fang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2014)

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Article Biochemistry & Molecular Biology

Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cells death in human acute T cell leukemia cell line Prooxidative potential of hydroxylated resveratrol analogs

Malgorzata Kucinska et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2014)

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Article Endocrinology & Metabolism

Regulation of GLUT Transporters by Flavonoids in Androgen-Sensitive and -Insensitive Prostate Cancer Cells

Pedro Gonzalez-Menendez et al.

ENDOCRINOLOGY (2014)

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Review Integrative & Complementary Medicine

Polyphenols as Key Players for the Antileukaemic Effects of Propolis

Murtala B. Abubakar et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

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Article Chemistry, Medicinal

Inhibitory effect of a propolis on Di-n-Propyl Disulfide or n-Hexyl salycilate-induced skin irritation, oxidative stress and inflammatory responses in mice

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FITOTERAPIA (2014)

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Article Toxicology

Epigenetic Targets of Polyphenols in Cancer

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JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2014)

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Article Biochemistry & Molecular Biology

Fenugreek extract diosgenin and pure diosgenin inhibit the hTERT gene expression in A549 lung cancer cell line

Mohammad Rahmati-Yamchi et al.

MOLECULAR BIOLOGY REPORTS (2014)

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Review Biochemistry & Molecular Biology

Recent Advances in the Chemical Composition of Propolis

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MOLECULES (2014)

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Article Biochemistry & Molecular Biology

Antiproliferative Effect of the Isoquinoline Alkaloid Papaverine in Hepatocarcinoma HepG-2 Cells - Inhibition of Telomerase and Induction of Senescence

Sakineh Kazemi Noureini et al.

MOLECULES (2014)

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Article Oncology

Caffeic acid phenylethyl ester and MG132, two novel nonconventional chemotherapeutic agents, induce apoptosis of human leukemic cells by disrupting mitochondrial function

Victoria Cavaliere et al.

TARGETED ONCOLOGY (2014)

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Article Pharmacology & Pharmacy

Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6

Haixia Zhao et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

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Article Gastroenterology & Hepatology

Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester

Yu-Jun He et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Gastroenterology & Hepatology

Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy

Ting-Ting Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Biochemistry & Molecular Biology

Pinocembrin suppresses TGF-β1-induced epithelial-mesenchymal transition and metastasis of human Y-79 retinoblastoma cells through inactivating αvβ3 integrin/FAK/p38α signaling pathway

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CELL AND BIOSCIENCE (2014)

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Review Biotechnology & Applied Microbiology

Caffeic Acid Phenethyl Ester and Therapeutic Potentials

Ghulam Murtaza et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Review Immunology

Chronic Inflammation and Cytokines in the Tumor Microenvironment

Glauben Landskron et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Antigenotoxic potential of rutin and quercetin in Swiss mice exposed to gamma radiation

ShrikantL Patil et al.

Biomedical Journal (2014)

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Article Cell Biology

Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation

Monica Salas et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

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Article Chemistry, Medicinal

Anti-tumor activity evaluation of novel chrys-inorganogermanium(IV) complex in MCF-7 cells

Fen Yang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

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Article Integrative & Complementary Medicine

Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro

Isabel Valenca et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

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Article Integrative & Complementary Medicine

Propolis changes the anticancer activity of temozolomide in U87MG human glioblastoma cell line

Renata Markiewicz-Zukowska et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

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Review Allergy

The Immunomodulatory and Anticancer Properties of Propolis

Godfrey Chi-Fung Chan et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2013)

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Article Integrative & Complementary Medicine

Molecular Mechanisms Underlying the In Vitro Anti-Inflammatory Effects of a Flavonoid-Rich Ethanol Extract from Chinese Propolis (Poplar Type)

Kai Wang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

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Review Integrative & Complementary Medicine

Recent Progress of Propolis for Its Biological and Chemical Compositions and Its Botanical Origin

Viviane Cristina Toreti et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

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Article Medicine, Research & Experimental

Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway

Tae Kwun Ha et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: Structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation

Hyunjeong Kim et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

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Article Toxicology

Quercetin vs chrysin: Effect on liver histopathology in diabetic mice

D. Sirovina et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2013)

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Review Plant Sciences

Chinese herbal medicine-derived compounds for cancer therapy: A focus on hepatocellular carcinoma

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JOURNAL OF ETHNOPHARMACOLOGY (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1α Activation

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JOURNAL OF NUCLEAR MEDICINE (2013)

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Article Chemistry, Medicinal

Synergism Between Propolis and Hyperthermal Intraperitoneal Chemotherapy with Cisplatin on Ehrlich Ascites Tumor in Mice

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JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Article Surgery

In vitro and in vivo evaluation of resveratrol and 3,5-dihydroxy-4′-acetoxy-trans-stilbene in the treatment of human prostate carcinoma and melanoma

Gregory W. Osmond et al.

JOURNAL OF SURGICAL RESEARCH (2013)

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Article Biotechnology & Applied Microbiology

Assessment of DNA damage and lipid peroxidation in diabetic mice: Effects of propolis and epigallocatechin gallate (EGCG)

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MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2013)

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Article Oncology

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells

Kriengsak Lirdprapamongkol et al.

ONCOLOGY REPORTS (2013)

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Review Biotechnology & Applied Microbiology

Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers

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ONCOTARGETS AND THERAPY (2013)

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Review Biochemistry & Molecular Biology

Phytochemical Antioxidants Modulate Mammalian Cellular Epigenome: Implications in Health and Disease

Smitha Malireddy et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

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Review Oncology

Bee venom in cancer therapy

Nada Orsolic

CANCER AND METASTASIS REVIEWS (2012)

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Article Oncology

Caffeic Acid Phenethyl Ester Suppresses the Proliferation of Human Prostate Cancer Cells through Inhibition of p70S6K and Akt Signaling Networks

Chih-Pin Chuu et al.

CANCER PREVENTION RESEARCH (2012)

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Article Biotechnology & Applied Microbiology

Lysine-specifiic histone demethylase 1 (LSD1): A potential molecular target for tumor therapy

Yingwei Chen et al.

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2012)

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Article Pharmacology & Pharmacy

Chemoprevention of azoxymethane-initiated colon cancer in rat by using a novel polymeric nanocarrier-curcumin

Ali Mohammad Alizadeh et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2012)

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Article Integrative & Complementary Medicine

Comparison of Effects of the Ethanolic Extracts of Brazilian Propolis on Human Leukemic Cells As Assessed with the MTT Assay

Gilberto C. Franchi et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)

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Article Integrative & Complementary Medicine

Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity

Joleen Lopes Machado et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)

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Article Biochemistry & Molecular Biology

Neuroprotective Effect of Quercetin Against Hydrogen Peroxide-induced Oxidative Injury in P19 Neurons

Maja Jazvinscak Jembrek et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2012)

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Article Chemistry, Applied

Propolis immunomodulatory activity on TLR-2 and TLR-4 expression by chronically stressed mice

Claudio Lera Orsatti et al.

NATURAL PRODUCT RESEARCH (2012)

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Article Chemistry, Applied

Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis

Chia-Nan Chen et al.

NATURAL PRODUCT RESEARCH (2012)

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Review Cell Biology

Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game

Paqui G. Traves et al.

MEDIATORS OF INFLAMMATION (2012)

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Article Biochemistry & Molecular Biology

Hexose Transporter GLUT1 Harbors Several Distinct Regulatory Binding Sites for Flavones and Tyrphostins

Alejandra Perez et al.

BIOCHEMISTRY (2011)

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Article Biochemistry & Molecular Biology

Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis

Hisanori Hattori et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

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Article Oncology

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

Jing Wu et al.

CANCER LETTERS (2011)

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Article Oncology

Curcumin Modulates MicroRNA-203-Mediated Regulation of the Src-Akt Axis in Bladder Cancer

Sharanjot Saini et al.

CANCER PREVENTION RESEARCH (2011)

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Article Integrative & Complementary Medicine

Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK1/2

Kazuhiro Kunimasa et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2011)

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Article Integrative & Complementary Medicine

Concentration-Dependent Protection by Ethanol Extract of Propolis against gamma-Ray-Induced Chromosome Damage in Human Blood Lymphocytes

A. Montoro et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2011)

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Article Food Science & Technology

Biological activities of Portuguese propolis: Protection against free radical-induced erythrocyte damage and inhibition of human renal cancer cell growth in vitro

Maria J. Valente et al.

FOOD AND CHEMICAL TOXICOLOGY (2011)

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Article Hematology

Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells

Cigir Biray Avci et al.

HEMATOLOGY (2011)

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Article Oncology

Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis

Ewelina Szliszka et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2011)

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Article Plant Sciences

NBM-HD-3, a novel histone deacetylase inhibitor with anticancer activity through modulation of PTEN and AKT in brain cancer cells

Wei-Jan Huang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2011)

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Review Oncology

The mechanisms by which polyamines accelerate tumor spread

Kuniyasu Soda

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2011)

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Article Biochemistry & Molecular Biology

Effects of various agents on DNA fragmentation and telomerase enzyme activities in adenocarcinoma cell lines

Didem Turgut Cosan et al.

MOLECULAR BIOLOGY REPORTS (2011)

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Review Biochemistry & Molecular Biology

Propolis research and the chemistry of plant products

Antonio Salatino et al.

NATURAL PRODUCT REPORTS (2011)

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Article Oncology

The Flavonoid Quercetin Modulates the Hallmark Capabilities of Hamster Buccal Pouch Tumors

Ramamurthi Vidya Priyadarsini et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2011)

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Article Oncology

Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells

Wei-Jiunn Lee et al.

ONCOLOGY REPORTS (2011)

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Article Multidisciplinary Sciences

Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling

Xiangsheng Xiao et al.

PLOS ONE (2011)

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Review Biochemistry & Molecular Biology

Natural products targeting telomere maintenance

Jack Li-Yang Chen et al.

MEDCHEMCOMM (2011)

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Article Oncology

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

Chaim B. Colen et al.

NEOPLASIA (2011)

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Article Oncology

Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin

Min Ding et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2010)

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Review Nutrition & Dietetics

Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management

Ashley J. Vargas et al.

NUTRITION REVIEWS (2010)

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Article Chemistry, Medicinal

Caffeic Acid Phenethyl Ester, a Component of Beehive Propolis, is a Novel Selective Estrogen Receptor Modulator

Bo-in Jung et al.

PHYTOTHERAPY RESEARCH (2010)

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Article Chemistry, Medicinal

The Effect of Propolis on Th1/Th2 Cytokine Expression and Production by Melanoma-bearing Mice Submitted to Stress

F. Missima et al.

PHYTOTHERAPY RESEARCH (2010)

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Article Integrative & Complementary Medicine

Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells

Hiroshi Izuta et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2009)

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Article Oncology

Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1 and Survivin Expression through Wnt/-Catenin Signaling Pathway

Bao-En Shan et al.

CANCER INVESTIGATION (2009)

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Article Oncology

Quercetin Is Able to Demethylate the p16INK4a Gene Promoter

Sainan Tan et al.

CHEMOTHERAPY (2009)

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Article Oncology

Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols

Linette Castillo-Pichardo et al.

CLINICAL & EXPERIMENTAL METASTASIS (2009)

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Article Pharmacology & Pharmacy

Inhibition of store-operated Ca2+ entry channels and K+ channels by caffelic acid phenethylester in T lymphocytes

Joo Hyun Nam et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

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Article Food Science & Technology

Effects of Manisa propolis on telomerase activity in leukemia cells obtained from the bone marrow of leukemia patients

O. Cogulu et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2009)

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Article Dermatology

Psoriasis and Risk of Incident Cancer: An Inception Cohort Study with a Nested Case-Control Analysis

Yolanda B. Brauchli et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

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Article Biochemistry & Molecular Biology

Ethanolic Extract of Propolis (EEP) Enhances the Apoptosis-Inducing Potential of TRAIL in Cancer Cells

Ewelina Szliszka et al.

MOLECULES (2009)

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Article Oncology

Soy Isoflavones Have an Antiestrogenic Effect and Alter Mammary Promoter Hypermethylation in Healthy Premenopausal Women

Wenyi Qin et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2009)

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Article Chemistry, Medicinal

Artepillin C (ARC) in Brazilian Green Propolis Selectively Blocks Oncogenic PAK1 Signaling and Suppresses the Growth of NF Tumors in Mice

Shanta M. Messerli et al.

PHYTOTHERAPY RESEARCH (2009)

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Article Toxicology

Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis

Qiang Zhang et al.

TOXICOLOGY IN VITRO (2009)

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Article Pharmacology & Pharmacy

Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway

Young-Ho Kim et al.

BIOCHEMICAL PHARMACOLOGY (2008)

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Article Biochemistry & Molecular Biology

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition

Suresh Awale et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2008)

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Article Biochemical Research Methods

Antioxidant and free radical scavenging activities of an exopolysaccharide from a probiotic bacterium

Vidya Prabhakar Kodali et al.

Biotechnology Journal (2008)

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Review Oncology

Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy

Mayumi Ono

CANCER SCIENCE (2008)

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Article Oncology

Quercetin inhibition of tumor invasion via suppressing PKCδ/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells

Cheng-Wei Lin et al.

CARCINOGENESIS (2008)

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Article Food Science & Technology

Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis

Qiang Zhang et al.

FOOD AND CHEMICAL TOXICOLOGY (2008)

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Article Oncology

Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK)

Yolanda Sanchez et al.

INTERNATIONAL JOURNAL OF CANCER (2008)

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Article Immunology

IL-12 Produced by Dendritic Cells Augments CD8+ T Cell Activation through the Production of the Chemokines CCL1 and CCL17

Curtis J. Henry et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Plant Sciences

Antileukemic activity of genistein, a major isoflavone present in soy products

Noeel J. -M. Raynal et al.

JOURNAL OF NATURAL PRODUCTS (2008)

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Article Biochemistry & Molecular Biology

Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression

S. Peter Bak et al.

MOLECULAR IMMUNOLOGY (2008)

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Article Oncology

Synergistic Effect of 5-Aza-2 '-Deoxycytidine and Genistein in Combination Against Leukemia

Noel J. -M. Raynal et al.

ONCOLOGY RESEARCH (2008)

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Article Plant Sciences

Radioprotective effects of propolis and quercetin in γ-irradiated mice evaluated by the alkaline comet assay

V. Benkovic et al.

PHYTOMEDICINE (2008)

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Article Genetics & Heredity

Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B

Ki Won Lee et al.

GENES AND NUTRITION (2008)

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Article Hematology

Protein phosphatase 2A (PP2A) has a potential role in CAPE-induced apoptosis of CCRF-CEM cells via effecting human telomerase reverse transcriptase activity

Cigir Biray Avci et al.

HEMATOLOGY (2007)

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Article Oncology

Resveratrol inhibits glucose metabolism in human ovarian cancer cells

Angela Kueck et al.

GYNECOLOGIC ONCOLOGY (2007)

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Article Pharmacology & Pharmacy

Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells

Chang-Koo Shim et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2007)

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Article Oncology

Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells

Elena P. Moiseeva et al.

MOLECULAR CANCER THERAPEUTICS (2007)

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Article Oncology

Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells

Wenshu Chen et al.

CARCINOGENESIS (2007)

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Review Plant Sciences

Propolis and the immune system: a review

J. M. Sforcin

JOURNAL OF ETHNOPHARMACOLOGY (2007)

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Article Oncology

Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation

Mok-Ryeon Ahn et al.

CANCER LETTERS (2007)

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Review Biochemistry & Molecular Biology

Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention

Sonia Ramos

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2007)

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Article Biochemistry & Molecular Biology

Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin

Shunsuke Tanigawa et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

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Article Pharmacology & Pharmacy

Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds

Nada Orsolic et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)

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Review Chemistry, Multidisciplinary

Biomarkers for diet and cancer prevention research: potentials and challenges

Cindy D. Davis et al.

ACTA PHARMACOLOGICA SINICA (2007)

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Article Pharmacology & Pharmacy

The H+-linked monocarboxylate transporter (MCT1/SLC16A1):: A potential therapeutic target for high-risk neuroblastoma

Jun Fang et al.

MOLECULAR PHARMACOLOGY (2006)

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Article Biochemistry & Molecular Biology

Growth inhibitory effects of quercetin on bladder cancer cell

Li Ma et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2006)

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Article Oncology

Chemopreventive effect of trans-resveratrol -: a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis

M Sengottuvelan et al.

CARCINOGENESIS (2006)

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Article Oncology

Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo

S Garvin et al.

CANCER LETTERS (2006)

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Article Plant Sciences

Direct and indirect mechanism(s) of antitumour activity of propolis and its polyphenolic compounds

N Orsolic et al.

PLANTA MEDICA (2006)

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Article Chemistry, Applied

Polyphenolic compounds from propolis modulate immune responses and increase host resistance to tumour cells

JN Orsolic et al.

FOOD AND AGRICULTURAL IMMUNOLOGY (2005)

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Article Medicine, Research & Experimental

Antitumor, hematostimulative and radioprotective action of water-soluble derivative of propolis (WSDP)

N Orsolic et al.

BIOMEDICINE & PHARMACOTHERAPY (2005)

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Article Biochemistry & Molecular Biology

Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetin

R Ferraresi et al.

FREE RADICAL RESEARCH (2005)

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Article Plant Sciences

Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages

N Orsolic et al.

JOURNAL OF ETHNOPHARMACOLOGY (2005)

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Article Pharmacology & Pharmacy

Effects of local administration of propolis and its polyphenolic compounds on tumor formation and growth

N Orsoilc et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)

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Article Veterinary Sciences

Peroral application of water-soluble derivative of propolis (WSDP) and its related polyphenolic compounds and their influence on immunological and antitumour activity

N Orsolic et al.

VETERINARY RESEARCH COMMUNICATIONS (2005)

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Article Oncology

Reversal of hypermethylation and reactivation of p16INK4a RARβ, and MGMT genes by genistein and other isoflavones from soy

MZ Fang et al.

CLINICAL CANCER RESEARCH (2005)

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Review Immunology

Pathogen recognition with Toll-like receptors

T Kawai et al.

CURRENT OPINION IN IMMUNOLOGY (2005)

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Review Endocrinology & Metabolism

Aromatase inhibitors in the treatment of breast cancer

RW Brueggemeier et al.

ENDOCRINE REVIEWS (2005)

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Article Agriculture, Multidisciplinary

Honey-bee products in prevention and/or therapy of murine transplantable tumours

N Orsolic et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2005)

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Article Pharmacology & Pharmacy

Inhibitory effect of propolis on the growth of human leukemia U937

K Aso et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2004)

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Article Urology & Nephrology

Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins

K McEleny et al.

BJU INTERNATIONAL (2004)

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Review Biochemistry & Molecular Biology

Potential toxicity of flavonoids and other dietary phenolics: Significance for their chemopreventive and anticancer properties

G Galati et al.

FREE RADICAL BIOLOGY AND MEDICINE (2004)

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Article Oncology

Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study

J Linseisen et al.

INTERNATIONAL JOURNAL OF CANCER (2004)

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Article Plant Sciences

Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds

N Orsolic et al.

JOURNAL OF ETHNOPHARMACOLOGY (2004)

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Article Oncology

Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway

XM Zhang et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2004)

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Article Biochemistry & Molecular Biology

Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins

L Actis-Goretta et al.

FEBS LETTERS (2003)

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Article Biochemistry & Molecular Biology

Grape extracts suppress the formation of preneoplastic foci and activity of fatty acid synthase in rat liver

S Kweon et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2003)

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Article Oncology

Soy extract inhibits mammary adenocarcinoma growth in a syngeneic mouse model

AL Hewitt et al.

CANCER LETTERS (2003)

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Article Oncology

Inhibitory effect of water-soluble derivative of propolis and its polyphenolic compounds on tumor growth and metastasizing ability: A possible mode of antitumor action

N Orsolic et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2003)

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Article Chemistry, Medicinal

Activation of murine macrophage cell line RAW 264.7 by Korean propolis

S Han et al.

ARCHIVES OF PHARMACAL RESEARCH (2002)

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Review Pharmacology & Pharmacy

The biochemistry and medical significance of the flavonoids

BH Havsteen

PHARMACOLOGY & THERAPEUTICS (2002)

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Article Plant Sciences

Estrogenic effects of ethanol and ether extracts of propolis

YS Song et al.

JOURNAL OF ETHNOPHARMACOLOGY (2002)

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Article Chemistry, Medicinal

Inhibition of angiogenesis by propolis

YS Song et al.

ARCHIVES OF PHARMACAL RESEARCH (2002)

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Article Biochemistry & Molecular Biology

Inhibition of cancer growth by resveratrol is related to its low bioavailability

M Asensi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2002)

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Article Pharmacology & Pharmacy

Genistein and methoxychlor modulate the activity of natural killer cells and the expression of phenotypic markers by thymocytes and splenocytes in F0 and F1 generations of Sprague-Dawley rats

TL Guo et al.

TOXICOLOGY (2002)

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Article Pharmacology & Pharmacy

Differential inhibition of human liver and duodenum sulphotransferase activities by quercetin, a flavonoid present in vegetables, fruit and wine

F Marchetti et al.

XENOBIOTICA (2001)

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Article Pharmacology & Pharmacy

Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α

TL Wadsworth et al.

BIOCHEMICAL PHARMACOLOGY (2001)

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Article Pathology

Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas

F Kumaki et al.

HUMAN PATHOLOGY (2001)

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Article Oncology

Tamoxifen and gonadal steroids inhibit colon cancer growth in association with inhibition of thymidylate synthase, survivin and telomerase expression through estrogen receptor beta mediated system

Y Nakayama et al.

CANCER LETTERS (2000)

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Article Food Science & Technology

Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats

SE Chuang et al.

FOOD AND CHEMICAL TOXICOLOGY (2000)

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Article Nutrition & Dietetics

Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice

RC Santell et al.

JOURNAL OF NUTRITION (2000)

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Article Oncology

Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure

M Mutoh et al.

CARCINOGENESIS (2000)

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