期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ijms232012105
关键词
Parkin; mitophagy; deubiquitinating enzymes; Parkinson disease; DUB inhibitors
资金
- UCL:Eisai Therapeutic Innovation Group
- Medical Research Council [MC_U12266B]
- MRC Confidence-in-Concept award [MC_PC_13078]
Quality control of mitochondria is crucial for cell survival, and defects can lead to severe diseases. Mitophagy plays a key role in removing damaged mitochondria and enhancing mitophagy has the potential to improve cell survival, neuronal function, and lifespan. Deubiquitinating enzymes are important regulators of mitophagy.
The quality control of mitochondria is critical for the survival of cells, and defects in the pathways required for this quality control can lead to severe disease. A key quality control mechanism in cells is mitophagy, which functions to remove damaged mitochondria under conditions of various stresses. Defective mitophagy can lead to a number of diseases including neurodegeneration. It has been proposed that an enhancement of mitophagy can improve cell survival, enhance neuronal function in neurodegeneration and extend health and lifespans. In this review, we highlight the role of deubiquitinating enzymes (DUBs) in the regulation of mitophagy. We summarise the current knowledge on DUBs that regulate mitophagy as drug targets and provide a list of small molecule inhibitors that are valuable tools for the further development of therapeutic strategies targeting the mitophagy pathway in neurodegeneration.
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