Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Article Hematology

The Relationship Between the Fibrinogen to Albumin Ratio and Early Outcomes in Patients with Acute Pontine Infarction

Mingfeng Zhai et al.

Summary: This study found that a high fibrinogen-to-albumin ratio (FAR) predicted poor 3-month outcomes in patients with acute pontine infarction.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2022)

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Article Biochemistry & Molecular Biology

Long-term cardiovascular outcomes of COVID-19

Yan Xie et al.

Summary: Individuals with COVID-19, even those who were not hospitalized during the acute phase of the infection, are at an increased long-term risk of various cardiovascular disorders. A study using national healthcare databases found that beyond the first 30 days after infection, individuals with COVID-19 have an elevated risk of developing cerebrovascular disorders, heart diseases, and other cardiovascular complications. The risk increases depending on the care setting during the acute phase.

NATURE MEDICINE (2022)

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Review Immunology

NAD+ in COVID-19 and viral infections

Minyan Zheng et al.

Summary: NAD(+) is a promising therapeutic target for COVID-19, and interventions that boost NAD(+) levels may enhance antiviral defense and suppress inflammation. Low NAD(+) concentrations are associated with risk factors for poor COVID-19 outcomes, and viral infections can further deplete NAD(+) and interfere with its roles in antiviral defense and inflammation. Coronaviruses can subvert NAD(+)-mediated actions, but ongoing approaches are exploring ways to boost NAD(+) concentrations to enhance antiviral responses and reduce hyperinflammation.

TRENDS IN IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Early Routine Biomarkers of SARS-CoV-2 Morbidity and Mortality: Outcomes from an Emergency Section

Flavio Maria Ceci et al.

Summary: This study suggests that high levels of LDH, Ferritin, CRP, and D-dimer may serve as potential predictors of COVID-19 severity and death, based on analysis of early routine blood biomarkers in COVID-19 patients.

DIAGNOSTICS (2022)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases

Jason Iles et al.

Summary: This study found that SARS-CoV-2 has a preference for AGE forms of glycated serum albumin, which may explain the severity and pathology of acute respiratory distress.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cell Biology

Oxidative Stress-Related Mechanisms in SARS-CoV-2 Infections

Joanna Wieczfinska et al.

Summary: The COVID-19 pandemic has resulted in high mortality, particularly in patients with comorbidities such as diabetes, hypertension, and COPD. Oxidative stress is believed to play a significant role in the pathogenesis of these comorbidities. Although the exact mechanism of death in critically ill COVID-19 patients is still unclear, lung vasculature injury and loss of lung function are considered crucial. Medications used in COVID-19 treatment that influence reactive oxygen and nitrogen species production may be beneficial. However, oxidative stress is also involved in antiviral immune response, and understanding the redox mechanisms in severe COVID-19 could impact its treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Virology

New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19-A Large Postmortem and Clinical Analysis

Fabian Heinrich et al.

Summary: This study investigated the occurrence and prevention of VTE in critically ill COVID-19 patients and found a high incidence of VTE in these patients. It also found that a change in anticoagulation practice was associated with a prolonged survival time for these patients.

VIRUSES-BASEL (2022)

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Review Pharmacology & Pharmacy

Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implications for the Benefit of High-Dose Intravenous Vitamin C

Claudia Vollbracht et al.

Summary: Oxidative stress plays a crucial role in the pathophysiology of COVID-19 and Long-COVID. Deficiency of vitamin C, a powerful antioxidant, is common in COVID-19 patients and may have serious pathological consequences. Intravenous high dose vitamin C treatment has been investigated and shown to improve oxygenation, reduce inflammation, and promote faster recovery in COVID-19 patients. It may also reduce the risks of severe courses of the disease and the development of Long-COVID.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Infusion of Human Albumin on Acute Pancreatitis Therapy: New Tricks for Old Dog?

Yifei Ma et al.

Summary: A study on the association between HSA infusion and outcomes of acute pancreatitis patients in ICU found that HSA infusion did not benefit in-hospital prognosis and was associated with prolonged hospital and ICU duration.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cell Biology

Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models

Yisheng Jiang et al.

Summary: This study reveals that SARS-CoV-2 infection dysregulates genes associated with NAD(+) metabolism, immune response, and cell death, similar to COVID-19 patients. Treatment with NAD(+) and NMN rescues pneumonia phenotypes and suppresses cell death in infected mice. Moreover, NMN supplementation partially protects aged mice from lethal SARS-CoV-2 infection.

CELL DISCOVERY (2022)

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Review Oncology

Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer

Jeremy A. Snell et al.

Summary: Extrinsic and intrinsic factors interact to determine skin health outcomes. Hypochlorous acid (HOCl) plays important roles as part of the skin exposome, functioning in immunity, disinfection, and anti-inflammatory processes. Recent studies have found that topical HOCl can prevent UV-induced skin cancer.

FRONTIERS IN ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Bioactive Compounds and Their Impact on Protein Modification in Human Cells

Ankush Prasad et al.

Summary: In this study, the effect of four selected bioactive compounds on reducing oxidative stress in differentiating cells was investigated using U-937 cells as a model system. The results showed that these compounds can reduce the formation of MDA adducts, indicating their beneficial effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Endocrinology & Metabolism

Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19)

Yue Zhou et al.

Summary: The Covid-19 outbreak has evolved into a global health crisis, with the increasing prevalence of obesity and diabetes exacerbating the risks of infectious diseases. This study provides a synthesis of recent advances in understanding the relationships between obesity, diabetes, and Covid-19, offering special treatment guidance for these at-risk populations.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2021)

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Review Biochemistry & Molecular Biology

The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

Agnes Ulfig et al.

Summary: Neutrophils play a crucial role in protecting the body against infections by killing pathogens through phagocytosis and the release of hypohalous acids. The formation of hypohalous acids by myeloperoxidase during the oxidative burst is a key mechanism in neutrophil antimicrobial activity. However, these acids can also impact bacterial survival strategies and modulate the immune response in the host system.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Letter Hematology

Albumin Supplementation Dampens Hypercoagulability in COVID-19: A Preliminary Report

Francesco Violi et al.

THROMBOSIS AND HAEMOSTASIS (2021)

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Review Biochemistry & Molecular Biology

Review: Roles of human serum albumin in prediction, diagnoses and treatment of COVID-19

Gulam Rabbani et al.

Summary: The SARS-CoV-2 virus has caused severe disruptions in global society, with diabetes patients being at higher risk of infection. Human serum albumin may influence an individual's susceptibility to the virus and the outcome of COVID-19.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Involvement of RAGE and Oxidative Stress in Inflammatory and Infectious Skin Diseases

Fabrizio Guarneri et al.

Summary: RAGE and its forms play crucial roles in skin diseases, with limited research in the field suggesting involvement in various conditions and potential therapeutic implications for the future.

ANTIOXIDANTS (2021)

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Article Hematology

Oxidative stress mediated platelet activation in patients with congenital analbuminemia: Effect of albumin infusion

Francesco Baratta et al.

Summary: In this study, two cases of congenital analbuminemia were reported, showing abnormal platelet aggregation, activation, and oxidative stress in these patients. Additionally, albumin infusion was found to reduce platelet activation by decreasing oxidative stress.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Biology

Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

Mohamed A. Badawy et al.

Summary: COVID-19-induced oxidative stress is associated with structural damages to human serum albumin, leading to mortality in critically ill patients. Lower S/W ratio and accumulated H2O2 in plasma significantly predict in-hospital mortality, suggesting potential markers for assessing new treatments targeting HSA replacements and oxidative stress.

ELIFE (2021)

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Article Physiology

Happy or Silent Hypoxia in COVID-19-A Misnomer Born in the Pandemic Era

Evangelia Akoumianaki et al.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Lipid peroxidation as a hallmark of severity in COVID-19 patients

Marta Martin-Fernandez et al.

Summary: This study revealed the presence of oxidative stress in COVID-19 patients, with high levels of antioxidant enzymes and oxidative cell damage, while total antioxidant capacity was lower. Elevated lipid peroxidation (LPO) levels above 1948.17 mu M were independently associated with a higher risk of intubation or death at 28 days in COVID-19 patients.

REDOX BIOLOGY (2021)

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Review Medicine, General & Internal

Liver Injury in Patients with Coronavirus Disease 2019 (COVID-19)-A Narrative Review

Liliana Lykowska-Szuber et al.

Summary: COVID-19 affects various organs beyond the respiratory system, with common comorbidities including hypertension, diabetes, cardiovascular and respiratory diseases; Obesity and chronic diseases are associated with increased susceptibility to SARS-CoV2 infection; Liver disease in patients with pre-existing conditions may require special attention in the event of COVID-19 infection.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Medicine, General & Internal

Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

Daniel Ayoubkhani et al.

Summary: Patients discharged from the hospital after COVID-19 were found to have increased rates of multiorgan dysfunction, with higher risk not only limited to the elderly but also varying across ethnic groups.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Pediatrics

Red Blood Cell Contribution to Hemostasis

Andrea H. Gillespie et al.

Summary: Red blood cells play important roles in hemostasis through mechanisms such as influencing blood viscosity and flow dynamics, surface interactions, generation of microparticles, and participation in blood clot formation.

FRONTIERS IN PEDIATRICS (2021)

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Review Biochemistry & Molecular Biology

Serum Albumin Redox States: More Than Oxidative Stress Biomarker

Fuka Tabata et al.

Summary: Serum albumin, the most abundant circulating protein in mammals, has three isoforms based on its redox state, traditionally considered a biomarker of systemic oxidative stress but recent research indicates oxidized albumin itself may worsen pathological conditions. Experimental evidence also suggests its potential as a sensitive protein nutrition biomarker.

ANTIOXIDANTS (2021)

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Review Medicine, Research & Experimental

NAD+ homeostasis in human health and disease

Ruben Zapata-Perez et al.

Summary: Depletion of NAD(+) can lead to various pathological phenotypes, from rare inherited defects to more common age-related diseases. Therapeutic implications of NAD(+) repletion for boosting health and treating diseases are discussed, along with the potential use of NAD(+)-enhancing agents.

EMBO MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Serum albumin levels and inflammation

Arik Sheinenzon et al.

Summary: This study examined the correlation between albumin levels and inflammatory indices in hospitalized patients, showing negative correlations between albumin and CRP/white blood cell levels and positive correlations with platelets/hemoglobin levels. The strongest negative correlation between albumin and CRP was found in the Internal Medicine departments. Linear regression analysis revealed a minor effect of CRP on albumin levels, particularly at very high CRP levels. Further exploration of the mechanisms underlying this negative correlation is needed.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Oxidative Stress and Inflammatory Biomarkers for the Prediction of Severity and ICU Admission in Unselected Patients Hospitalized with COVID-19

Morgane Ducastel et al.

Summary: The study found that oxidative stress, inflammation, and cellular activation biomarkers are associated with disease severity, oxygen needs, and ICU admission in COVID-19 patients. Thiol concentration can effectively predict ICU admission, while calprotectin concentration can effectively predict mortality.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease

Monika Szturmowicz et al.

Summary: NETs, composed of DNA, proteinases, and histones, play a significant role in trapping and eliminating pathogens during bacterial or viral infections. Their activation in COVID-19 has been linked to acute lung injury, multi-organ damage, and mortality, marking a potential target for therapeutic interventions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Albumin Infusion in Critically Ill COVID-19 Patients: Hemodilution and Anticoagulation

Giuliano Ramadori

Summary: SARS-CoV-2 infection leads to hypercoagulation and hypoalbuminemia, with albumin infusion playing a crucial role in improving hemodynamics and reducing the risk of thrombosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cardiac & Cardiovascular Systems

Incidence of thrombotic complications in COVID-19 On behalf of ICODE: The International COVID-19 Thrombosis Biomarkers Colloquium

William J. Jenner et al.

Summary: The incidence of thrombosis is significantly higher in hospitalized patients with COVID-19, especially in critically ill patients and those requiring intensive care unit treatment. Large prospective observational studies are needed to accurately quantify the rate of thrombosis, while randomized controlled trials are investigating optimal thromboprophylactic strategies.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Article Infectious Diseases

Hypoalbuminemia-An Indicator of the Severity and Prognosis of COVID-19 Patients: A Multicentre Retrospective Analysis

Chaoyue Chen et al.

Summary: Hypoalbuminemia is common in COVID-19 patients and associated with more severe clinical manifestations and abnormal biochemical tests, leading to poorer clinical outcomes. Nutritional support therapy may improve the clinical outcome of these patients.

INFECTION AND DRUG RESISTANCE (2021)

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Article Biochemistry & Molecular Biology

Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19

Neven Zarkovic et al.

Summary: The study of 21 critically ill patients admitted to the COVID-19 specialized critical care unit showed that survivors and non-survivors did not differ significantly in clinical or laboratory parameters, but deceased patients had higher levels of lipid peroxidation product HNE protein adducts in their plasma. Survivors, on the other hand, showed prominent and dynamic variations in HNE-protein adduct levels, indicating active oxidative stress response mechanisms towards COVID-19 aggression.

ANTIOXIDANTS (2021)

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Article Gastroenterology & Hepatology

Liver function test abnormalities in COVID-19 patients and factors affecting them - a retrospective study

Mona Mohammed Abdelrahman et al.

Summary: Liver function test abnormalities are common in SARS-CoV-2 positive patients, particularly in severe cases. ESR, CRP, serum ferritin, and D-dimer levels are higher in COVID-19 patients with LFT abnormalities compared to those with normal LFT. Elevated serum ferritin levels may be a potential risk factor for LFT abnormalities.

CLINICAL AND EXPERIMENTAL HEPATOLOGY (2021)

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Article Infectious Diseases

Analysis of endogenous oxidative damage markers and association with pulmonary involvement severity in patients with SARS-CoV-2 pneumonia

Hanifi Yildiz et al.

Summary: This study found that patients with SARS-CoV-2 pneumonia had significantly higher levels of endogenous oxidative damage markers, and oxidative damage was closely associated with the severity of pulmonary involvement.

INFECTIOUS DISEASES NOW (2021)

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Review Critical Care Medicine

Human albumin solutions in intensive care: A review

David Melia et al.

Summary: Albumin plays a crucial role in critically ill patients as a prognostic marker and therapy, but the use of human albumin solution can vary and pose risks. Clinicians should exercise caution and base their decisions on the latest evidence.

JOURNAL OF THE INTENSIVE CARE SOCIETY (2021)

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Article Medicine, General & Internal

Cardiovascular Risk Factors and the Severity of COVID-19 Disease

Imane Motaib et al.

Summary: This study investigated the association between cardiovascular risk levels and the severity of COVID-19 among patients. The results indicated that patients with higher cardiovascular risk levels had significantly higher rates of complications, ICU admission, and death. Assessing cardiovascular risk factors in all COVID-19 patients is important based on these findings.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Letter Oncology

Tocilizumab, an anti-IL-6 receptor antibody, to treat COVID-19-related respiratory failure: a case report

J. -M. Michot et al.

ANNALS OF ONCOLOGY (2020)

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Article Immunology

Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China

Zhongliang Wang et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Critical Care Medicine

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Zhe Xu et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Medicine, Research & Experimental

Clinical and immunological features of severe and moderate coronavirus disease 2019

Guang Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Geriatrics & Gerontology

Age-related NAD(+) decline

Melanie R. McReynolds et al.

EXPERIMENTAL GERONTOLOGY (2020)

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Review Public, Environmental & Occupational Health

Influence of NAD plus as an ageing-related immunomodulator on COVID 19 infection: A hypothesis

Huda M. Omran et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2020)

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Letter Hematology

The role of Neutrophil Extracellular Traps in Covid-19: Only an hypothesis or a potential new field of research?

Chiara Mozzini et al.

THROMBOSIS RESEARCH (2020)

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Article Medicine, Research & Experimental

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

Rubens Cecchini et al.

MEDICAL HYPOTHESES (2020)

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Review Biochemistry & Molecular Biology

COVID-19 and Oxidative Stress

B. Chernyak et al.

BIOCHEMISTRY-MOSCOW (2020)

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Article Biochemistry & Molecular Biology

Measurement of oxidized albumin: An opportunity for diagnoses or treatment of COVID-19

Nasim Rahmani-Kukia et al.

BIOORGANIC CHEMISTRY (2020)

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Review Cell Biology

COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps

Leandro Borges et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Multidisciplinary Sciences

Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review

Ariel Izcovich et al.

PLOS ONE (2020)

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Review Biochemistry & Molecular Biology

Protein Carbonylation and Lipid Peroxidation in Hematological Malignancies

Alba Rodriguez-Garcia et al.

ANTIOXIDANTS (2020)

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Article Medicine, Research & Experimental

COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity

R. Miller et al.

MEDICAL HYPOTHESES (2020)

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Article Gastroenterology & Hepatology

Hyperoxidized Albumin Modulates Platelets and Promotes Inflammation Through CD36 Receptor in Severe Alcoholic Hepatitis

Adil Bhat et al.

HEPATOLOGY COMMUNICATIONS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Prediction of the Development of Pulmonary Fibrosis Using Serial Thin-Section CT and Clinical Features in Patients Discharged after Treatment for COVID-19 Pneumonia

Minhua Yu et al.

KOREAN JOURNAL OF RADIOLOGY (2020)

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Article Immunology

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

Huan Han et al.

EMERGING MICROBES & INFECTIONS (2020)

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Article Hematology

ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension

Yu Zhao et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Review Medicine, General & Internal

Impaired albumin function: a novel potential indicator for liver function damage?

Lejia Sun et al.

ANNALS OF MEDICINE (2019)

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Article Cell Biology

Salivary Antioxidant Barrier, Redox Status, and Oxidative Damage to Proteins and Lipids in Healthy Children, Adults, and the Elderly

Mateusz Maciejczyk et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Biochemistry & Molecular Biology

Advanced lipoxidation end products (ALEs) as RAGE binders: Mass spectrometric and computational studies to explain the reasons why

Marco Mol et al.

REDOX BIOLOGY (2019)

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Article Oncology

NAD+ metabolism controls inflammation during senescence

Timothy Nacarelli et al.

MOLECULAR & CELLULAR ONCOLOGY (2019)

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Article Gastroenterology & Hepatology

Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

Stefaia Basin et al.

HEPATOLOGY COMMUNICATIONS (2019)

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Review Gastroenterology & Hepatology

New Insights About Albumin and Liver Disease

Joana R. Carvalho et al.

ANNALS OF HEPATOLOGY (2018)

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Review Public, Environmental & Occupational Health

MERS transmission and risk factors: a systematic review

Ji-Eun Park et al.

BMC PUBLIC HEALTH (2018)

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Letter Medicine, General & Internal

Hypoalbuminemia is related to inflammation rather than malnutrition in sarcoidosis

Mehdi Mirsaeidi et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Unsaturated aldehyde, 4-hydroxynonenal (HNE) alters the structural integrity of HSA with consequences in the immuno-pathology of rheumatoid arthritis

Farzana Khan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Multidisciplinary Sciences

The higher mortality associated with low serum albumin is dependent on systemic inflammation in end-stage kidney disease

Filipa Caeiro Alves et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

Minoru Inoue et al.

NATURE COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

The impact of oxidative stress on binding of drugs with plasma proteins studied by fluorescence anisotropy methods

Tomasz Wybranowski et al.

GENERAL PHYSIOLOGY AND BIOPHYSICS (2018)

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Review Cardiac & Cardiovascular Systems

The Characteristics and Roles of Advanced Oxidation Protein Products in Atherosclerosis

Hanxiao Ou et al.

CARDIOVASCULAR TOXICOLOGY (2017)

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Article Gastroenterology & Hepatology

Hyperoxidized Albumin Modulates Neutrophils to Induce Oxidative Stress and Inflammation in Severe Alcoholic Hepatitis

Sukanta Das et al.

HEPATOLOGY (2017)

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Article Biochemical Research Methods

Thiol oxidation and di-tyrosine formation in human plasma proteins induced by inflammatory concentrations of hypochlorous acid

Graziano Colombo et al.

JOURNAL OF PROTEOMICS (2017)

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Review Immunology

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

Rudragouda Channappanavar et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

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Review Biochemistry & Molecular Biology

NAD+ in Aging: Molecular Mechanisms and Translational Implications

Evandro F. Fang et al.

TRENDS IN MOLECULAR MEDICINE (2017)

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Article Food Science & Technology

Advanced Oxidation Protein Products-Modified Albumin Induces Differentiation of RAW264.7 Macrophages into Dendritic-Like Cells Which Is Modulated by Cell Surface Thiols

Silvano Garibaldi et al.

TOXINS (2017)

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Article Multidisciplinary Sciences

In-vivo oxidized albumin - a pro-inflammatory agent in hypoalbuminemia

Faiga Magzal et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients

Junjie Hang et al.

SCIENTIFIC REPORTS (2017)

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Article Hematology

Red blood cells in thrombosis

James R. Byrnes et al.

BLOOD (2017)

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Article Critical Care Medicine

Role of albumin in diseases associated with severe systemic inflammation: Pathophysiologic and clinical evidence in sepsis and in decompensated cirrhosis

Antonio Artigas et al.

JOURNAL OF CRITICAL CARE (2016)

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Article Multidisciplinary Sciences

Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression

Lisa Pasterk et al.

SCIENTIFIC REPORTS (2016)

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Article Urology & Nephrology

Pro-inflammatory cytokines: a possible relationship with dialytic adequacy and serum albumin in peritoneal dialysis patients

Sabrina Milan Manani et al.

CLINICAL KIDNEY JOURNAL (2016)

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Letter Cell Biology

Autofluorescence of MDA-modified proteins as an in vitro and in vivo probe in oxidative stress analysis

Min Qiang et al.

PROTEIN & CELL (2014)

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Review Critical Care Medicine

Albumin versus crystalloid solutions in patients with the acute respiratory distress syndrome: a systematic review and meta-analysis

Christopher Uhlig et al.

CRITICAL CARE (2014)

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Article Medicine, Research & Experimental

Biochemical and clinical aspects of advanced oxidation protein products in kidney diseases and metabolic disturbances

Agnieszka Piwowar

POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ (2014)

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Review Medical Laboratory Technology

Human Serum Albumin and Its Relation with Oxidative Stress

Mustafa Erinc Sitar et al.

CLINICAL LABORATORY (2013)

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Article Biochemistry & Molecular Biology

Albumin oxidation leads to neutrophil activation in vitro and inaccurate measurement of serum albumin in patients with diabetic nephropathy

Regina Michelis et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

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Review Biochemistry & Molecular Biology

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

G. Vistoli et al.

FREE RADICAL RESEARCH (2013)

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Article Gastroenterology & Hepatology

Oxidative albumin damage in chronic liver failure: Relation to albumin binding capacity, liver dysfunction and survival

Karl Oettl et al.

JOURNAL OF HEPATOLOGY (2013)

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Review Biochemical Research Methods

Lipoxidation adducts with peptides and proteins: Deleterious modifications or signaling mechanisms?

Rosario M. Domingues et al.

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