Nutraceutical-Based Nanoformulations for Breast and Ovarian Cancer Treatment

Review Food Science & Technology

Dietary fish and omega-3 polyunsaturated fatty acids intake and cancer survival: A systematic review and meta-analysis

Yi Wang et al.

Summary: Through a meta-analysis of observational studies, we found that dietary fish and marine omega-3 PUFA consumption are associated with improved cancer prognosis and reduced mortality in patients.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Article Pharmacology & Pharmacy

Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy

Bo Li et al.

Summary: Breast cancer is a common and dangerous disease, and multi-drug chemotherapy can effectively treat it. In this study, lipid nanoemulsions were developed to deliver PTX and DHA for the treatment of breast cancer. The results showed that the nanoemulsions had a sustained drug release and exhibited high cytotoxicity, effectively inhibiting tumor growth and prolonging survival time.

DRUG DELIVERY (2022)

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Review Instruments & Instrumentation

Pharmaceutical nanoformulation strategies to spatiotemporally manipulate oxidative stress for improving cancer therapies - exemplified by polyunsaturated fatty acids and other ROS-modulating agents

Rui Xue Zhang et al.

Summary: Chronic oxidative stress and inflammation promote tumorigenesis and tumor progression, while certain chemotherapeutic drugs and radiation are applied to produce free radicals against cancer cells. Dietary antioxidants like omega-3 polyunsaturated fatty acids (PUFA) have been combined with cancer therapies to reduce tumor-promoting oxidative stress and protect normal tissue from chemotherapy and radiation-associated toxicity. However, the results of clinical studies are mixed and may even exacerbate adverse effects. Recent publications suggest that nano-formulations can enhance the therapeutic benefits of PUFA and other free-radical generating cytotoxic drugs during chemotherapy by controlling oxidative stress within a nanoscale vicinity. This article critically evaluates the concurrent use of dietary omega-3 PUFA as an adjuvant to cancer therapies, reviews the findings in studies using nanoparticle formulations, and highlights the importance of spatiotemporal manipulation of oxidative stress by pharmaceutical nanotechnology for improving outcomes with cancer therapies.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Editorial Material Health Care Sciences & Services

EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer

Jun Fang

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Review Oncology

Use of Repurposed Drugs in the Treatment of Epithelial Ovarian Cancer A Systematic Review

Luxitaa Goenka et al.

Summary: Epithelial ovarian cancer has limited treatment options, and repurposed drugs may offer potential alternatives. This systematic review examines the clinical use of repurposed agents and suggests that some drugs may have clinical benefits. However, most published studies are observational, highlighting the need for well-designed clinical trials.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2022)

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Article Oncology

Docosahexaenoic Acid in the Inhibition of Tumor Cell Growth in Preclinical Models of Ovarian Cancer

Olena Bilyk et al.

Summary: The study suggests that DHA supplementation can reduce cancer cell growth and enhance the efficacy of carboplatin in preclinical models of OC through increased apoptosis and necrosis. The incorporation of DHA into cell membranes significantly impacts cell killing and tumor growth in both in vitro and in vivo experiments.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022)

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Article Pharmacology & Pharmacy

Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations

Arijit Mondal et al.

Summary: Garlic is a plant that possesses antimicrobial, antiarthritic, antithrombotic, antitumor, hypoglycemic, and hypolipidemic activities. Its anticancer activity, among others, has been extensively studied. Garlic contains several bioactive molecules that inhibit the development of various cancers and affect multiple signaling pathways involved in cancer cell survival.

PHARMACOLOGICAL RESEARCH (2022)

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Article Agriculture, Dairy & Animal Science

Ovarian Cancer: Applications of Chickens to Humans

Animesh Barua et al.

Summary: The lack of spontaneous ovarian cancer models is a barrier to studying early changes in ovarian cancer. Laying hens, which develop ovarian cancer spontaneously, share similarities with women in terms of tumor histology, immune responses, and risk factors. The hen model can be used to develop early detection tests, preventive strategies, immunotherapeutics, prevention of resistance to chemotherapeutics, and explore gene therapies against ovarian cancer.

ANNUAL REVIEW OF ANIMAL BIOSCIENCES (2022)

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Article Oncology

Divergent Metabolic Effects of Metformin Merge to Enhance Eicosapentaenoic Acid Metabolism and Inhibit Ovarian Cancer In Vivo

Mary P. Udumula et al.

Summary: This study found that metformin treatment can promote omega-3 fatty acid metabolism and inhibit inflammatory signaling in ovarian cancer cells, providing an additional potential therapeutic mechanism for the anticancer effects of metformin.

CANCERS (2022)

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Review Environmental Sciences

Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors

Mostefa Fodil et al.

Summary: Currently, there is a significant focus on studying the relationship between diet and breast cancer, particularly in terms of tumor prevention and progression. The role of n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs), such as DHA and EPA, found in marine sources like fatty fish and microalgae, as preventive and anti-progressive molecules in breast cancer cell lines and in vivo studies is being extensively researched. Understanding the cellular and molecular pathways involved in the actions of these fatty acids is crucial for developing realistic therapeutic strategies. The increasing number of clinical trials exploring the use of n-3 LC-PUFAs in various pathologies, including obesity and different cancers, further highlights the importance of investigating the preventive and beneficial effects of these fatty acids against breast cancer development and progression.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Article Pharmacology & Pharmacy

Preparation and Study of Solid Lipid Nanoparticles Based on Curcumin, Resveratrol and Capsaicin Containing Linolenic Acid

Roberta Cassano et al.

Summary: The purpose of this study was to develop solid lipid nanoparticles (SLNs) based on curcumin, resveratrol and capsaicin for the treatment of atopic dermatitis. The results demonstrated that the synthesized SLNs could effectively deliver linolenic acid (LNA) to skin cells and preserve its anti-inflammatory properties.

PHARMACEUTICS (2022)

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Article Immunology

Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis

Zeynab Kavyani et al.

Summary: This umbrella meta-analysis found that supplementation of n-3 PUFAs can significantly improve CRP, TNF-alpha, and IL-6 concentrations in adults with various health conditions, suggesting their potential as adjuvant anti-inflammatory agents.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Targeting the tumor immune microenvironment with nutraceuticals: From bench to clinical trials

Laura Masuelli et al.

Summary: Immune effector cells play a critical role in determining tumor growth outcomes in the tissue microenvironment during neoplastic progression. Nutraceuticals, identified as natural compounds that may impact health and disease statuses, show potential benefits as immunomodulators in cancer treatment with subtle cell-specific effects.

PHARMACOLOGY & THERAPEUTICS (2021)

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Review Oncology

The Synthesis of Nano-Doxorubicin and its Anticancer Effect

Lusha Zhu et al.

Summary: Doxorubicin is a commonly used anti-cancer drug with limited clinical application due to severe side effects, leading researchers to focus on developing nanoformulations to improve its bioavailability and reduce toxicity.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

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Article Medicine, Research & Experimental

pH-sensitive doxorubicin-tocopherol succinate prodrug encapsulated in docosahexaenoic acid-based nanostructured lipid carriers: An effective strategy to improve pharmacokinetics and reduce toxic effects

Eduardo Burgarelli Lages et al.

Summary: This study developed a DOX-hyd-TS/NLC nano carrier for breast cancer treatment, which controlled DOX release via a hydrazone bond, reducing drug release under acidic conditions and demonstrating good therapeutic efficacy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Nanoscience & Nanotechnology

Antitumor Activity of α-Linolenic Acid-Paclitaxel Conjugate Nanoparticles: In vitro and in vivo

Mei-Qi Xu et al.

Summary: The study developed ALA-PTX NPs with high drug loading, simple preparation, and better biocompatibility. Results showed that ALA-PTX NPs exhibited superior cellular uptake and antitumor activity in vitro and in vivo.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Medicine, Research & Experimental

Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance

Chunlei Wang et al.

Summary: This study demonstrated the potential efficacy of a DOX-nano drug delivery system for the treatment of HCC, showing good anti-tumor and MDR-reversing effects.

MEDICAL SCIENCE MONITOR (2021)

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Review Oncology

N-3 Long-Chain Polyunsaturated Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acid, and the Role of Supplementation during Cancer Treatment: A Scoping Review of Current Clinical Evidence

Marnie Newell et al.

Summary: This scoping review examined the clinical evidence of n-3 LCPUFA supplementation in cancer therapy based on 57 clinical trials. The results showed that supplementation with EPA and/or DHA could bring benefits to cancer patients, such as improving immune system, weight maintenance, survival rates, quality of life, and reducing adverse events. However, larger, well-controlled randomized clinical trials are needed to validate these findings before incorporation into treatment.

CANCERS (2021)

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Review Nutrition & Dietetics

Nutraceuticals and Cancer: Potential for Natural Polyphenols

Jessica Maiuolo et al.

Summary: Cancer is a leading global cause of death, influenced by various factors. Natural bioactive compounds show potential in cancer treatment and may help mitigate the side effects of anticancer drugs.

NUTRIENTS (2021)

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Review Health Care Sciences & Services

Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect

Dong Huang et al.

Summary: This review discusses the use of nanomedicine in antitumor therapy, with a focus on enhancing the EPR effect. By analyzing factors such as abnormal angiogenesis and vascular structure, irregular blood flow, and tumor vessel permeability, ways to increase the therapeutic effect of drugs are explored. Nanoparticles such as liposomes, micelles, and polymers play a crucial role in modulating tumor vessels to improve the EPR effect.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Oncology

5-FU@DHA-UIO-66-NH2 potentiates chemotherapy sensitivity of breast cancer cells through a microRNA let-7a-dependent mechanism

Jingquan Li et al.

Summary: This study successfully constructed and characterized 5-FU@DHA-UIO-66-NH2, which effectively reduced the chemotherapy resistance of breast cancer cells. The DHA-modified MOF exhibited stronger inhibitory effects on cell viability and tumorigenesis compared to traditional chemotherapeutic drugs, and showed good biological safety.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Review Food Science & Technology

New Insights on the Effects of Dietary Omega-3 Fatty Acids on Impaired Skin Healing in Diabetes and Chronic Venous Leg Ulcers

Simona Serini et al.

Summary: Long-chain Omega-3 polyunsaturated fatty acids are recognized as powerful regulators of acute inflammation, with potential applications in chronic pathologies. Current research focuses on their specific effects on wound healing, particularly in patients with diabetes or venous insufficiency, highlighting the mechanisms through which these compounds may act. Considerations on optimal dietary doses and future perspectives in this area are also discussed.

FOODS (2021)

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Review Biochemistry & Molecular Biology

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Mudhi AlAli et al.

Summary: Nutraceuticals, essential food constituents with medicinal effects, have active compounds like carotenoids and collagen hydrolysate that positively impact cardiovascular and immune system health. Categorized based on nature and mode of action, they show potential therapeutic activities in disease prevention such as anti-cancer, antioxidant, anti-inflammatory, and anti-lipid effects. Research also covers mechanisms of action, safety for consumers, and future prospects in nutraceutical development.

MOLECULES (2021)

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Article Nutrition & Dietetics

Association Between Pre-diagnostic Dietary Supplements Intake and Ovarian Cancer Survival: Findings From a Prospective Cohort Study in Chinese Women

Jia-Hui Gu et al.

Summary: The study found no association between pre-diagnostic dietary supplements intake and ovarian cancer survival. However, vitamin B supplementation intake was associated with a detrimental effect on survival. Further research is needed to confirm these findings given the low exposure in the present study.

FRONTIERS IN NUTRITION (2021)

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Review Physiology

Bioactive Compounds in Edible Oils and Their Role in Oxidative Stress and Inflammation

Alessandra Mazzocchi et al.

Summary: Edible fats and oils, particularly those containing polyunsaturated fatty acids and phenolic compounds, may have anti-inflammatory, antioxidant, and immunomodulatory effects, contributing to the prevention of chronic diseases. Additionally, a high content of monounsaturated fatty acids in edible oils may improve lipid profiles and reduce damage caused by oxidized lipoproteins and free radicals.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Veterinary Sciences

A Review of Principal Studies on the Development and Treatment of Epithelial Ovarian Cancer in the Laying Hen Gallus gallus

Purab Pal et al.

Summary: Ovarian cancer, often referred to as the silent killer, is the most lethal gynecologic malignancy with no known early detection biomarkers. The laying hen model has emerged as a valuable tool in studying ovarian cancer, providing insights into the pathology and potential prevention strategies for this disease. Studies in this model have shown associations between decreased ovulation, inflammation, and decreased incidence of ovarian cancer development.

COMPARATIVE MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Effects of Dietary n-3 and n-6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

Kamila P. Liput et al.

Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Role of microRNA Let-7d in Female Malignancies and Diseases of the Female Reproductive Tract

Chiara De Santis et al.

Summary: microRNA let-7d is dysregulated in female malignancies and other pregnancy-associated diseases, affecting various cellular processes and potentially serving as a therapeutic target and diagnostic biomarker.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

Characterization of a hyaluronic acid and folic acid-based hydrogel for cisplatin delivery: Antineoplastic effect in human ovarian cancer cells in vitro

Simona Serini et al.

Summary: A hyaluronic acid- and folic acid-based hydrogel (GEL-CIS) was successfully prepared and characterized for the delivery of cisplatin, which showed improved efficacy in inhibiting ovarian cancer cell growth and migration compared to pure cisplatin, as well as modulating the expression of proteins involved in Epithelial Mesenchymal Transition.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Nutrition & Dietetics

Nutraceuticals in the Mediterranean Diet: Potential Avenues for Breast Cancer Treatment

Giuseppina Augimeri et al.

Summary: The traditional Mediterranean Diet, rich in bioactive compounds like polyphenols, retinoids, and PUFAs, has been shown to have beneficial effects against chronic illnesses. These compounds possess antioxidant, anti-inflammatory, and antitumoral properties, making them potential candidates for future anticancer therapeutics in breast cancer.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

Anti-Inflammatory Properties of Diet: Role in Healthy Aging

Kristine Stromsnes et al.

Summary: Inflammation is a physiological process in the body's defenses and tissue repair, but chronic inflammation can stimulate the development of various diseases. As people age, inflammation becomes more chronic. Certain foods, like saturated fats, have pro-inflammatory activity.

BIOMEDICINES (2021)

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Review Biochemistry & Molecular Biology

Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment

Rakesh K. Sindhu et al.

Summary: Flavonoids, a type of polyphenol, show potential in the treatment of breast cancer by regulating tumor-related functions. Plant polyphenols have antioxidant and anticarcinogenic properties that contribute to breast cancer prevention and treatment. Nanotechnology-based approaches may enhance the activity of phyto-bioactive compounds and improve early detection of cancer.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

A novel view on an old drug, 5-fluorouracil: an unexpected RNA modifier with intriguing impact on cancer cell fate

Mounira Chalabi-Dchar et al.

Summary: 5-Fluorouracil (5-FU) is a widely used chemotherapeutic drug for solid tumors, especially colorectal and pancreatic cancers. Its cytotoxic effects are largely attributed to altering RNA metabolism, particularly by creating fluorinated active ribosomes in ribosomal RNA (rRNA) and inducing translational reprogramming. This translational reprogramming, induced by 5-FU integration in ribosomes, is believed to contribute to cell plasticity and ultimately to relapse.

NAR CANCER (2021)

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Article Medicine, Research & Experimental

Zebrafish In Vivo Models of Cancer and Metastasis

Katy R. Astell et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2020)

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Article Nanoscience & Nanotechnology

Enhanced in vitro antitumor efficacy of a polyunsaturated fatty acid-conjugated pH-responsive self-assembled ion-pairing liposome-encapsulated prodrug

Yuxian Wang et al.

NANOTECHNOLOGY (2020)

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Article Chemistry, Medicinal

Folate Receptor Targeting and Cathepsin B-Sensitive Drug Delivery System for Selective Cancer Cell Death and Imaging

Xiangmei Jin et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

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Review Nutrition & Dietetics

Omega-3 PUFA Responders and Non-Responders and the Prevention of Lipid Dysmetabolism and Related Diseases

Simona Serini et al.

NUTRIENTS (2020)

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Review Biochemistry & Molecular Biology

Nutraceutical Compounds Targeting Inflammasomes in Human Diseases

Beatriz Castejon-Vega et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Nutrition & Dietetics

The Cardioprotective Role of Flaxseed in the Prevention of Doxorubicin- and Trastuzumab-Mediated Cardiotoxicity in C57BL/6 Mice

Chantal Y. Asselin et al.

JOURNAL OF NUTRITION (2020)

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Article Medicine, Research & Experimental

Docosahexaenoic acid (DHA) inhibits pro-angiogenic effects of breast cancer cells via down-regulating cellular and exosomal expression of angiogenic genes and microRNAs

Cynthia Aslan et al.

LIFE SCIENCES (2020)

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Article Medicine, Research & Experimental

Co-delivery of doxorubicin, docosahexaenoic acid, and α-tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicity

Eduardo Burgarelli Lages et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Chemistry, Applied

Xanthan gum-based materials for omega-3 PUFA delivery: Preparation, characterization and antineoplastic activity evaluation

Sonia Trombino et al.

CARBOHYDRATE POLYMERS (2019)

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Review Oncology

Ovarian Cancer: An Integrated Review

Christine Stewart et al.

SEMINARS IN ONCOLOGY NURSING (2019)

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Review Nanoscience & Nanotechnology

Nanomedicine-based formulations containing ω-3 polyunsaturated fatty acids: potential application in cardiovascular and neoplastic diseases

Simona Serini et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Reproductive Biology

Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer

Purab Pal et al.

JOURNAL OF OVARIAN RESEARCH (2019)

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Article Nutrition & Dietetics

Anti-Irritant and Anti-Inflammatory Effects of DHA Encapsulated in Resveratrol-Based Solid Lipid Nanoparticles in Human Keratinocytes

Simona Serini et al.

NUTRIENTS (2019)

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Article Oncology

DHA-SBT-1214 Taxoid Nanoemulsion and Anti-PD-L1 Antibody Combination Therapy Enhances Antitumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model

Gulzar Ahmed et al.

MOLECULAR CANCER THERAPEUTICS (2019)

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Article Medicine, General & Internal

Breast cancer

Nadia Harbeck et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

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Article Pharmacology & Pharmacy

A solid lipid nanoparticle formulation of 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine with increased solubility, stability, and antitumor activity

Solange A. Valdes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Chemistry, Medicinal

Glycol Chitosan-Docosahexaenoic Acid Liposomes for Drug Delivery: Synergistic Effect of Doxorubicin-Rapamycin in Drug-Resistant Breast Cancer

Min Woo Kim et al.

MARINE DRUGS (2019)

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Article Nutrition & Dietetics

Treatment with DHA Modifies the Response of MDA-MB-231 Breast Cancer Cells and Tumors from nu/nu Mice to Doxorubicin through Apoptosis and Cell Cycle Arrest

Marnie Newell et al.

JOURNAL OF NUTRITION (2019)

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Article Oncology

Combination of ω-3 fatty acids and cisplatin as a potential alternative strategy for personalized therapy of metastatic melanoma: an in-vitro study

Renata Ottes Vasconcelos et al.

MELANOMA RESEARCH (2019)

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Article Chemistry, Multidisciplinary

An integrated targeting drug delivery system based on the hybridization of graphdiyne and MOFs for visualized cancer therapy

Zhongbo Xue et al.

NANOSCALE (2019)

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Article Oncology

Tumor suppressor let-7a inhibits breast cancer cell proliferation, migration and invasion by targeting MAGE-A1

Y. Z. Mi et al.

NEOPLASMA (2019)

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Article Chemistry, Multidisciplinary

Curcumin- and Fish Oil-Loaded Spongosome and Cubosome Nanoparticles with Neuroprotective Potential against H2O2-Induced Oxidative Stress in Differentiated Human SH-SY5Y Cells

Miora Rakotoarisoa et al.

ACS OMEGA (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Nanostructured Lipid Carrier Co-loaded with Doxorubicin and Docosahexaenoic Acid as a Theranostic Agent: Evaluation of Biodistribution and Antitumor Activity in Experimental Model

Renata S. Fernandes et al.

MOLECULAR IMAGING AND BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Omega-3 PUFA Loaded in Resveratrol-Based Solid Lipid Nanoparticles: Physicochemical Properties and Antineoplastic Activities in Human Colorectal Cancer Cells In Vitro

Simona Serini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Instruments & Instrumentation

QbD-based development of alpha-linolenic acid potentiated nanoemulsion for targeted delivery of doxorubicin in DMBA-induced mammary gland carcinoma: in vitro and in vivo evaluation

Chandra Bhushan Tripathi et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2018)

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Review Oncology

Minimizing Membrane Arachidonic Acid Content as a Strategy for Controlling Cancer: A Review

Mark F. McCarty et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2018)

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Review Biochemistry & Molecular Biology

A Critical Review on the Effect of Docosahexaenoic Acid (DHA) on Cancer Cell Cycle Progression

Marnie Newell et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biochemistry & Molecular Biology

Whole flaxseed diet alters estrogen metabolism to promote 2-methoxtestradiol-induced apoptosis in hen ovarian cancer

Anushka Dikshit et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2017)

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Review Nutrition & Dietetics

Modulation of Ras/ERK and Phosphoinositide Signaling by Long-Chain n-3 PUFA in Breast Cancer and Their Potential Complementary Role in Combination with Targeted Drugs

Simona Serini et al.

NUTRIENTS (2017)

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Review Pharmacology & Pharmacy

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

Munawar A. Mohammed et al.

PHARMACEUTICS (2017)

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Article Engineering, Biomedical

Hyaluronic acid-green tea catechin micellar nanocomplexes: Fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity

Ki Hyun Bae et al.

BIOMATERIALS (2017)

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Review Pharmacology & Pharmacy

Epigenetic regulation of gene expression and M2 macrophage polarization as new potential omega-3 polyunsaturated fatty acid targets in colon inflammation and cancer

Simona Serini et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2016)

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Article Oncology

Docosahexaenoic Acid Modulates Invasion and Metastasis of Human Ovarian Cancer via Multiple Molecular Pathways

Ying-Chun Wang et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2016)

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Article Dermatology

Role of β-catenin signaling in the anti-invasive effect of the omega-3 fatty acid DHA in human melanoma cells

Simona Serini et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2016)

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Article Oncology

Docosahexaenoic Acid Induces Growth Suppression on Epithelial Ovarian Cancer Cells More Effectively than Eicosapentaenoic Acid

Xiao-Hui Wan et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2016)

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Review Nutrition & Dietetics

How plausible is the use of dietary n-3 PUFA in the adjuvant therapy of cancer?

Simona Serini et al.

NUTRITION RESEARCH REVIEWS (2016)

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Article Oncology

H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair

Matteo Ciocci et al.

ONCOTARGET (2016)

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Review Radiology, Nuclear Medicine & Medical Imaging

Imaging of peritoneal deposits in ovarian cancer: A pictorial review

Sheragaru Hanumanthappa Chandrashekhara et al.

WORLD JOURNAL OF RADIOLOGY (2016)

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Review Biochemistry & Molecular Biology

Epidemiologic studies of estrogen metabolism and breast cancer

Regina G. Ziegler et al.

STEROIDS (2015)

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Review Food Science & Technology

Flax and flaxseed oil: an ancient medicine & modern functional food

Ankit Goyal et al.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2014)

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Article Chemistry, Multidisciplinary

Novel Nanostructured Lipid Carrier Co-Loaded with Doxorubicin and Docosahexaenoic Acid Demonstrates Enhanced in Vitro Activity and Overcomes Drug Resistance in MCF-7/Adr Cells

Samuel V. Mussi et al.

PHARMACEUTICAL RESEARCH (2014)

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Article Biotechnology & Applied Microbiology

Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines

Elena Fasano et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Article Oncology

Evaluating human cancer cell metastasis in zebrafish

Yong Teng et al.

BMC CANCER (2013)

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Article Oncology

DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation

Simona Serini et al.

CARCINOGENESIS (2012)

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Article Oncology

Phase I Trial of Intraperitoneal Pemetrexed, Cisplatin, and Paclitaxel in Optimally Debulked Ovarian Cancer

Setsuko K. Chambers et al.

CLINICAL CANCER RESEARCH (2012)

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Article Biochemistry & Molecular Biology

Chick Chorioallantoic Membrane (CAM) Assay as an In Vivo Model to Study the Effect of Newly Identified Molecules on Ovarian Cancer Invasion and Metastasis

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