期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/ijms231810525
关键词
cancer vaccine; cell silicification; PET; MRI; bioluminescence; immunotherapy; fluorodeoxyglucose
资金
- National Institute of Health [NCI 2P30 CA118100]
- UNM Brain & Behavioral Health Institute Mini-Grant [2019-20-002]
- UNM Faculty Start-up funding
- NIH [S10OD02159801]
This study utilizes simultaneous [F-18]FDG-PET/MRI for spatial and quantitative analysis of tumor burden to monitor therapeutic responses to ovarian cancer immunotherapy, providing a possible roadmap for accurate monitoring of therapeutic responses to cancer immunotherapies.
Current imaging approaches used to monitor tumor progression can lack the ability to distinguish true progression from pseudoprogression. Simultaneous metabolic 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) positron emission tomography (PET) and magnetic resonance imaging (MRI) offers new opportunities to overcome this challenge by refining tumor identification and monitoring therapeutic responses to cancer immunotherapy. In the current work, spatial and quantitative analysis of tumor burden were performed using simultaneous [F-18]FDG-PET/MRI to monitor therapeutic responses to a novel silicified cancer cell immunotherapy in a mouse model of disseminated serous epithelial ovarian cancer. Tumor progression was validated by bioluminescence imaging of luciferase expressing tumor cells, flow cytometric analysis of immune cells in the tumor microenvironment, and histopathology. While PET demonstrated the presence of metabolically active cancer cells through [F-18]FDG uptake, MRI confirmed cancer-related accumulation of ascites and tissue anatomy. This approach provides complementary information on disease status without a confounding signal from treatment-induced inflammation. This work provides a possible roadmap to facilitate accurate monitoring of therapeutic responses to cancer immunotherapies.
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