4.7 Article

Amyloid Aβ25-35 Aggregates Say 'NO' to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na+/Ca2+ Exchanger

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Diverse injury responses of human oligodendrocyte to mediators implicated in multiple sclerosis

Florian Pernin et al.

Summary: The early lesions of multiple sclerosis involve the degeneration of myelinating processes of oligodendrocytes, while the cell bodies of these cells are relatively preserved. As the disease progresses, there is loss of oligodendrocytes. The injury mediators that contribute to this process include metabolic stress, pro-inflammatory mediators, and excitotoxins. It is important to understand the specific effects of these mediators on human oligodendrocytes in order to develop effective neuroprotective therapies for multiple sclerosis.
Review Cell Biology

Synaptic basis of Alzheimer's disease: Focus on synaptic amyloid beta, P-tau and mitochondria

Albin John et al.

Summary: Alzheimer's disease is a progressive disease associated with synaptic dysfunction, with researchers striving to find more information on disease progression and pathogenesis. Synaptic pathology and mitochondrial oxidative damage are early events in the progression of AD, with synaptic loss and damage being key correlates of cognitive deficits in patients. As the disease advances, significant changes occur at the synapse, shedding light on the disease progression and serving as potential markers and therapeutic targets.

AGEING RESEARCH REVIEWS (2021)

Letter Neurosciences

Immunoproteasome Inhibitor ONX-0914 Affects Long-Term Potentiation in Murine Hippocampus

Alexander Maltsev et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2021)

Article Neurosciences

Modified Snake α-Neurotoxin Averts β-Amyloid Binding to α7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer's Disease Mice

Gennadiy Fonar et al.

Summary: Alzheimer's disease is a common cause of senile dementia, with the interaction between β-amyloid peptide and α7 nicotinic receptors playing a crucial role in the pathology. A chemically modified toxin, mToxin, has been shown to inhibit α7AChR, reduce A beta-induced abnormalities, and enhance pathways supporting long-term potentiation. Additionally, mToxin demonstrates neuroprotective properties and improves memory in an AD animal model, suggesting its potential for tailored AD treatment strategies.

MOLECULAR NEUROBIOLOGY (2021)

Article Clinical Neurology

Guanabenz Sensitizes Glioblastoma Cells to Sunitinib by Inhibiting GADD34-Mediated Autophagic Signaling

Kuo-Hao Ho et al.

Summary: The limited efficacy of sunitinib against glioblastomas can be enhanced by inhibiting protective autophagy, and the combination with the alpha2-selective adrenergic agonist guanabenz may provide a new therapeutic strategy.

NEUROTHERAPEUTICS (2021)

Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction in Alzheimer's Disease: A Biomarker of the Future?

Simon M. Bell et al.

Summary: Alzheimer's disease is the most common cause of dementia globally, characterized by amyloid beta and tau protein accumulation with currently no approved treatment. In addition to protein aggregation, other pathological changes and early alterations in mitochondrial function are present. Mitochondrial dysfunction caused by amyloid and tau may serve as potential biomarkers for early detection of AD, but further research with larger patient cohorts is needed for clinical application.

BIOMEDICINES (2021)

Article Biochemistry & Molecular Biology

Serine/Threonine Phosphatases in LTP: Two B or Not to Be the Protein Synthesis Blocker-Induced Impairment of Early Phase

Alexander V. Maltsev et al.

Summary: This study investigated the role of serine/threonine phosphatase activity in long-term potentiation (LTP) and found a significant increase in PSB-treated slices. Additionally, the relationship between nNOS and PP2B activity was revealed by measuring NO concentration and using the PP2B inhibitor cyclosporin A. Moreover, PP2B in the hippocampus may have bidirectional influences on short-term plasticity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Neurosciences

Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca2+ alteration and multiphasic transmitter release

Cuong Pham et al.

Summary: This study investigated astrocytic responses to the neurotoxic A beta fragment present in Alzheimer's disease patients through fluorescence imaging of signaling pathways. The results showed that A beta 25-35 induced different Ca2+ responses in astrocytes in different states, accompanied by a multiphasic release of signaling molecules.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

PP1/PP2A phosphatase inhibition-induced metaplasticity in protein synthesis blocker-treated hippocampal slices: LTP and LTD, or There and Back again

Alexander Maltsev et al.

Summary: The study shows that blockade of protein synthesis and specific serine/threonine phosphatases (PP1 and PP2A) can lead to a switch from impaired long-term potentiation (LTP) to long-term depression (LTD). Additionally, it is found that these phosphatases influence both basal synaptic transmission and stimulation-induced synaptic plasticity.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Neurosciences

Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes

Tianhui Yang et al.

Summary: GADD34 is upregulated in the cortex of ischemic rats and contributes to brain injury; treatment with a GADD34 inhibitor improves neuronal damage post-ischemia, suggesting it as a potential therapeutic target for ischemic stroke; the expression of GADD34 is increased in plasma exosomes of cerebral ischemic rats, indicating its potential as a biomarker.

NEUROSCIENCE LETTERS (2021)

Review Cell Biology

The Na+/Ca2+ exchanger in Alzheimer's disease

Anna Pannaccione et al.

CELL CALCIUM (2020)

Review Biochemistry & Molecular Biology

Modulation of AMPA Receptors by Nitric Oxide in Nerve Cells

Violetta O. Ivanova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

GADD34 is a modulator of autophagy during starvation

Gennaro Gambardella et al.

SCIENCE ADVANCES (2020)

Article Clinical Neurology

Huntingtin Levels arc Elevated in Hippocampal Post-Mortem Samples of Alzheimer's Disease Brain

Michael Axenhus et al.

CURRENT ALZHEIMER RESEARCH (2020)

Article Clinical Neurology

M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer's disease pathology

Jee Hyun Yi et al.

BRAIN COMMUNICATIONS (2020)

Article Neurosciences

Understanding the Amyloid Hypothesis in Alzheimer's Disease

Giulia Paroni et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Neurosciences

LTP suppression by protein synthesis inhibitors is NO-dependent

Alexander V. Maltsev et al.

NEUROPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Synergism of myocardial β-adrenoceptor blockade and I1-imidazoline receptor-driven signaling: Kinase-phosphatase switching

A. V. Maltsev et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Clinical Neurology

Genistein Decreases APP/tau Phosphorylation and Ameliorates Aβ Over-production Through Inhibiting CIP2A

Yang-Ping Shentu et al.

CURRENT ALZHEIMER RESEARCH (2019)

Review Neurosciences

Amyloid-β and Synaptic Vesicle Dynamics: A Cacophonic Orchestra

Francesca Fagiani et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Multidisciplinary Sciences

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease

Pooja Jadiya et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Key Peptides and Proteins in Alzheimer's Disease

Botond Penke et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2019)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Early and Late LTP

Saltuk Bugra Baltaci et al.

NEUROCHEMICAL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Subarachnoid hemorrhage induces neuronal nitric oxide synthase phosphorylation at Ser(1412) in the dentate gyrus of the rat brain

Kentaro Wada et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Modulation of nNOSser852 phosphorylation and translocation by PKA/PP1 pathway in endothelial cells

Juliana M. Navia-Pelaez et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

Article Pharmacology & Pharmacy

Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid beta

Sara R. Tanqueiro et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Clinical Neurology

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

Md. Torequl Islam

NEUROLOGICAL RESEARCH (2017)

Article Neurosciences

Drosophila Neprilysin 1 Rescues Memory Deficits Caused by Amyloid-β Peptide

Oriane Turrel et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Cardiac & Cardiovascular Systems

Depolarization of mitochondria in neurons promotes activation of nitric oxide synthase and generation of nitric oxide

Prasad V. G. Katakam et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Review Medicine, Research & Experimental

The amyloid hypothesis of Alzheimer's disease at 25years

Dennis J. Selkoe et al.

EMBO MOLECULAR MEDICINE (2016)

Review Neurosciences

Amyloid-beta-Induced Dysregulation of AMPA Receptor Trafficking

Sumasri Guntupalli et al.

NEURAL PLASTICITY (2016)

Review Biochemistry & Molecular Biology

Standing of giants shoulders the story of the mitochondrial Na+Ca2+ exchanger

Israel Sekler

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Neurosciences

Increased GADD34 in oligodendrocytes in Alzheimer's disease

Yasuyuki Honjo et al.

NEUROSCIENCE LETTERS (2015)

Article Biology

Life after the birth of the mitochondrial Na+/Ca2+ exchanger, NCLX

Lulia Nita et al.

SCIENCE CHINA-LIFE SCIENCES (2015)

Article Geriatrics & Gerontology

Induction of GADD34 Regulates the Neurotoxicity of Amyloid β

Niangui Xu et al.

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2015)

Review Biochemistry & Molecular Biology

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

Xinglong Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Biochemistry & Molecular Biology

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Jie Liu et al.

CHANNELS (2014)

Article Multidisciplinary Sciences

A three-dimensional human neural cell culture model of Alzheimer's disease

Se Hoon Choi et al.

NATURE (2014)

Article Endocrinology & Metabolism

Regenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression

Ning Zhou et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

Article Neurosciences

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

Rajnish K. Chaturvedi et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2013)

Review Neurosciences

The role of nitric oxide in pre-synaptic plasticity and homeostasis

Neil Hardingham et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

Kristina Leuner et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Cell Biology

The interplay of mitochondria with calcium: An historical appraisal

Ernesto Carafoli

CELL CALCIUM (2012)

Review Biochemistry & Molecular Biology

Molecular Identity and Functional Properties of the Mitochondrial Na+/Ca2+ Exchanger

Raz Palty et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Association with Endoplasmic Reticulum Promotes Proteasomal Degradation of GADD34 Protein

Wei Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Reduced levels of the tyrosine phosphatase STEP block beta amyloid-mediated GluA1/GluA2 receptor internalization

Yongfang Zhang et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Article Neurosciences

Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease

Charlene Supnet et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Biochemistry & Molecular Biology

Ionic dysregulations typical of ischemia provoke release of glycine and GABA by multiple mechanisms

Elisa Luccini et al.

JOURNAL OF NEUROCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Partial inhibition of complex I activity increases Ca2+-independent glutamate release rates from depolarized synaptosomes

Sean M. Kilbride et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Ganesh M. Shankar et al.

NATURE MEDICINE (2008)

Review Biochemistry & Molecular Biology

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

P. Hemachandra Reddy et al.

TRENDS IN MOLECULAR MEDICINE (2008)

Review Biochemistry & Molecular Biology

Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm

Ratnesh Lal et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)

Article Biochemistry & Molecular Biology

beta-amyloid peptide toxicity in organotypic hippocampal slice culture involves Akt/PKB, GSK-3 beta, and PTEN

Melissa Nassif et al.

NEUROCHEMISTRY INTERNATIONAL (2007)

Article Neurosciences

Effect of β-amyloid peptide on behavior and synaptic plasticity in terrestrial snail

EI Samarova et al.

BRAIN RESEARCH BULLETIN (2005)

Article Biochemistry & Molecular Biology

Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-methyl-D-aspartate receptor

GA Rameau et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Medicine, Research & Experimental

A mitochondrial cascade hypthesis for sporadic Alzheimer's disease

RH Swerdlow et al.

MEDICAL HYPOTHESES (2004)

Article Biochemistry & Molecular Biology

beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

CS Casley et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Review Biochemistry & Molecular Biology

Calcium signalling: a historical account, recent developments and future perspectives

M Brini et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2000)

Review Neurosciences

Postsynaptic protein phosphorylation and LTP

TR Soderling et al.

TRENDS IN NEUROSCIENCES (2000)