期刊
CARBOHYDRATE POLYMERS
卷 134, 期 -, 页码 541-546出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.07.071
关键词
Chitosan; Dextran sulfate; Heparin; Macro-hydrogel; Nanoparticles; Polyelectrolyte complexes
资金
- French National funding Agency ANR [ANR-10-NANO-0010]
- Agence Nationale de la Recherche (ANR) [ANR-10-NANO-0010] Funding Source: Agence Nationale de la Recherche (ANR)
The controlled assembly of oppositely charged chitosan (CS, M-w similar to 33 x 10(3) to 600 x 10(3) g mol(-1)) and dextran sulfate (DS,M-w = 1.3 x 10(6) g mol(-1)) or heparin (HP, M-w = 1.8 x 10(4) g mol(-1)) led either to nanoparticles or macro-hydrogels, at room temperature. The control over the electrostatic attractive interactions was achieved using 2 mol L-1 NaCl in the polyion solutions and subsequent dialysis to let the assembly occur. Macrohydrogels formed with an excess of polyanion. In the presence of an excess of polycation, colloidal gels were exclusively obtained. At salt concentrations lower than 1 mol L-1, the spontaneous gelation provided macro-hydrogels, whatever the polyion in excess. Rheology measurements showed a similar elastic behaviour for CS-DS and CS-HP hydrogels, though CS-HP hydrogels appeared less cohesive. SAXS experiments revealed an aggregate morphology with internal and surface structure depending on the degree of acetylation (DA) of chitosan. (C) 2015 Elsevier Ltd. All rights reserved.
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