Collagen Family as Promising Biomarkers and Therapeutic Targets in Cancer

Review Medicine, Research & Experimental

Transcriptomic Signatures in Colorectal Cancer Progression

Pavel Ershov et al.

Summary: This review summarizes the key genes and signaling pathways associated with colorectal cancer, and presents a list of core genes that have clinical significance in cancer-related pathways.

CURRENT MOLECULAR MEDICINE (2023)

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Review Biochemistry & Molecular Biology

The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?

Xin Hu et al.

Summary: AFP has been widely used as a biomarker for the diagnosis and prognosis of HCC, and potential novel therapies like AFP vaccines and ACT show promise in treating HCC.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Mammary collagen is under reproductive control with implications for breast cancer

Qiuchen Guo et al.

Summary: Mammographically-detected breast density has an impact on breast cancer risk and progression, and the presence of fibrillar collagen plays a crucial role in breast density. This study investigated the physiological factors influencing collagen production in the breast. Through the analysis of gene expression in female rats, the study revealed a triphasic pattern of collagen gene regulation and reproductive state-dependent composition. The findings were confirmed in human breast tissue from premenopausal women. The study also found a correlation between the collagen gene signature and poor progression-free survival in breast cancer patients. These findings contribute to a better understanding of normal breast function, the etiology of breast density, and breast cancer risk and outcomes.

MATRIX BIOLOGY (2022)

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Article Cell Biology

The Hypoxia-Related Gene COL5A1 Is a Prognostic and Immunological Biomarker for Multiple Human Tumors

Hua Zhu et al.

Summary: COL5A1 is highly expressed in 13 cancers and negatively related to the prognosis of 11 cancers. It is coexpressed with genes encoding major histocompatibility complex, immune activators, immune suppressors, chemokines, chemokine receptors, mismatch repair genes, and immune checkpoints. Different roles for COL5A1 in immunocyte infiltration were identified in different cancers, and its correlation with drug sensitivity was found in several cancers.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Urology & Nephrology

Assessment of prostate-specific antigen screening: an evidence-based report by the German Institute for Quality and Efficiency in Health Care

Ulrike Paschen et al.

Summary: PSA screening reduces the risk of prostate cancer mortality and metastasis, but leads to overdiagnoses and false-positive results, with associated harms such as unnecessary treatments and potential complications from biopsies.

BJU INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

Collagen Family and Other Matrix Remodeling Proteins Identified by Bioinformatics Analysis as Hub Genes Involved in Gastric Cancer Progression and Prognosis

Mihaela Chivu-Economescu et al.

Summary: In this study, through bioinformatics assessment and gene analysis, we identified nine candidate biomarker genes associated with gastric cancer progression and prognosis. The high expression of these genes is correlated with poor overall survival and immune infiltrate, making them potential new therapeutic targets for gastric cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Physiology

Collagen type X alpha 1 promotes proliferation, invasion and epithelial-mesenchymal transition of cervical cancer through activation of TGF-? ;/Smad signaling

Yangyan Sun et al.

Summary: COL10A1 is overexpressed in cervical cancer, promoting cell proliferation and invasion, and participating in epithelial-mesenchymal transition through activation of the TGF-A'/Smad signaling pathway.

PHYSIOLOGY INTERNATIONAL (2022)

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Article

Identification of Cancer-Associated Fibroblast Subtype of Triple-Negative Breast Cancer

Maoli Wang et al.

Journal of Oncology (2022)

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Article Biochemistry & Molecular Biology

Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers

Malin Jansson et al.

Summary: Study found that expression of type IV collagen is associated with poorer breast cancer specific survival and distant metastasis in small breast cancers, suggesting it may serve as a biomarker for predicting the risk of future metastatic disease in breast cancer patients.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Oncology

Comprehensive bioinformatic analysis reveals a cancer-associated fibroblast gene signature as a poor prognostic factor and potential therapeutic target in gastric cancer

Cemre Ucaryilmaz Metin et al.

Summary: This study identified key cancer-associated fibroblasts (CAFs) markers and a poor prognostic gene signature for gastric cancer. Understanding the mechanisms by which these genes contribute to poor patient outcomes can lead to the discovery of more effective molecular targeted agents and increase the therapeutic success in gastric cancer.

BMC CANCER (2022)

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Review Oncology

The extracellular matrix in colorectal cancer and its metastatic settling-Alterations and biological implications

S. Karlsson et al.

Summary: This review focuses on the importance of the extracellular matrix (ECM) in the tumor microenvironment (TME) and its impact on tumor cell behavior and metastatic capability. The study also highlights the potential of ECM as a target for therapy and a source of novel biomarkers in cancer treatment.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

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Review Pathology

COL1A1: A novel oncogenic gene and therapeutic target in malignancies

Xue Li et al.

Summary: COL1A1, a member of the collagen family, is closely associated with malignant tumorigenesis and plays various roles in different tumor types regarding cell processes and prognosis.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Article Multidisciplinary Sciences

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis

Michael Papanicolaou et al.

Summary: The distribution and organization of matrix molecules, particularly collagen I, in the tumor stroma play an important role in breast cancer progression. Cancer-associated fibroblasts (CAFs) remodel the extracellular matrix (ECM) to promote or inhibit tumor growth. It has been found that CAF-secreted collagen XII can alter the organization of collagen I, creating a pro-invasive microenvironment that supports metastatic dissemination. Collagen XII may serve as an indicator of breast cancer patients at high risk of metastatic relapse.

NATURE COMMUNICATIONS (2022)

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Article Genetics & Heredity

Identification and Verification of Potential Biomarkers in Gastric Cancer By Integrated Bioinformatic Analysis

Chenyu Sun et al.

Summary: By using bioinformatics methods, differentially expressed genes related to prognosis and diagnosis in gastric cancer were identified, with COL8A1, COL10A1, CTHRC1, and FAP being associated with worse prognosis.

FRONTIERS IN GENETICS (2022)

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Article Oncology

Preoperative serum CA19-9 should be routinely measured in the colorectal patients with preoperative normal serum CEA: a multicenter retrospective cohort study

Zhenhui Li et al.

Summary: The study revealed that preoperative serum CA19-9 is an independent prognostic factor in CRC patients, showing interactions with CEA. Additionally, it can be used as a routine biomarker for CRC patients, especially those with normal preoperative serum CEA levels.

BMC CANCER (2022)

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Article Genetics & Heredity

COL11A1 serves as a biomarker for poor prognosis and correlates with immune infiltration in breast cancer

Qi Luo et al.

Summary: COL11A1 is abnormally upregulated in breast cancer and is closely related to poor prognosis. It is also associated with immune cell infiltration and tumor immunity, making it a potentially important target for the diagnosis and treatment of breast cancer.

FRONTIERS IN GENETICS (2022)

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Review Oncology

Cancer-associated fibroblasts in the single-cell era

Dor Lavie et al.

Summary: Cancer-associated fibroblasts (CAFs) play a central role in the microenvironment of solid tumors, and recent advances in single-cell technologies have provided insights into their complexity and heterogeneity. Understanding the subsets and functions of CAFs can potentially lead to better therapeutic strategies for cancer.

NATURE CANCER (2022)

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Review Oncology

Collagen XI Alpha 1 Chain, a Novel Therapeutic Target for Cancer Treatment

Yi-Hui Wu et al.

Summary: The upregulation of COL11A1 in various human cancers is associated with poor prognosis. The specific mechanism by which COL11A1 regulates tumor progression is not well understood. Recent studies have shown that COL11A1 interacts with intracellular signaling pathways and there are therapeutic agents targeting COL11A1, indicating its potential as a treatment target for cancers, especially epithelial ovarian cancer.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Type IV collagen as a potential biomarker of metastatic breast cancer

Moa Lindgren et al.

Summary: This study found that levels of cCOLIV and cCA15-3 were significantly elevated in mBC patients, with high levels of cCOLIV correlating with poorer survival. Both cCOLIV alone and in combination with cCA15-3 were superior to cCA15-3 alone in detecting mBC. COL IV was highly expressed in the tissue of LM and BM, suggesting cCOLIV as a potential marker for monitoring BC patients.

CLINICAL & EXPERIMENTAL METASTASIS (2021)

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Article Urology & Nephrology

Association between one-time prostate-specific antigen (PSA) test with free/total PSA ratio and prostate cancer mortality: A 30-year prospective cohort study

Per-Olof Lundgren et al.

Summary: The study examined the long-term association between baseline PSA levels and risk of prostate cancer death after 30 years. Results showed that the risk of prostate cancer death increases with higher baseline PSA levels, but is significantly decreased in men with PSA levels below 2.0 ng/mL and f/t PSA ratio of >= 0.25.

BJU INTERNATIONAL (2021)

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Review Immunology

Immune Modulatory Properties of Collagen in Cancer

Anne Mette Askehoj Romer et al.

Summary: During tumor growth, the extracellular matrix undergoes remodeling, with a tumor-specific ECM of higher collagen density being associated with poor prognosis in cancer. Recent studies suggest that collagen can influence the function and phenotype of tumor-infiltrating immune cells, potentially affecting cancer progression and immunotherapy efficacy. Knowledge of collagen's immune modulatory functions may help improve current cancer therapies and develop new treatments.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Collagen XI alpha 1 chain, a potential therapeutic target for cancer

Ziqiang Liu et al.

Summary: COL11A1 is upregulated in various cancers and is associated with tumor progression, poor prognosis, angiogenesis, invasion, and drug resistance. While the specific mechanism by which COL11A1 regulates tumor progression remains unclear, it shows potential as a target for cancer treatment.

FASEB JOURNAL (2021)

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Review Medicine, General & Internal

Clinical Applications of Liquid Biopsy in Gastric Cancer

Mihaela Chivu-Economescu et al.

Summary: Liquid biopsy represents a new and exciting approach in cancer diagnosis and management, providing a less invasive and more convenient way to obtain tumor information. Despite its potential, the field is facing challenges in reproducibility and translation into clinical practice due to the diversity of study assays. Liquid biopsy in gastric cancer offers a dynamic tumor picture and potential benefits for patients.

FRONTIERS IN MEDICINE (2021)

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Review Medicine, General & Internal

Collagen Biosynthesis, Processing, and Maturation in Lung Ageing

Ceylan Onursal et al.

Summary: Collagen is a key component of the extracellular matrix and plays a crucial role in the pathogenesis of chronic lung diseases. Age-related alterations in collagen composition and crosslinking may contribute to the development of lung diseases in elderly individuals.

FRONTIERS IN MEDICINE (2021)

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Article Multidisciplinary Sciences

Collagen XVII inhibits breast cancer cell proliferation and growth through deactivation of the AKT/mTOR signaling pathway

Muttarin Lothong et al.

Summary: COL17 has been found to suppress breast cancer by affecting cell proliferation and growth, as well as the AKT/mTOR signaling pathway. High expression of COL17 is associated with low-proliferation tumors, extended tumor-free period, and overall survival in breast cancer patients.

PLOS ONE (2021)

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Review Biotechnology & Applied Microbiology

Collagen Structure-Function Mapping Informs Applications for Regenerative Medicine

James D. San Antonio et al.

Summary: Type I collagen is a key protein in vertebrates, playing essential roles in tissue form and function. Understanding the structure-function relationship of collagen and its disease-associated mutations can lead to insights for anti-fibrotic treatments, tissue regeneration, and biomimetic collagen design.

BIOENGINEERING-BASEL (2021)

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Review Chemistry, Multidisciplinary

The mechanics of fibrillar collagen extracellular matrix

Bo Sun

Summary: The extracellular matrix (ECM) is a complex biopolymer network that plays a crucial role in defining the physical microenvironment of cells and hosting biochemical interactions. Understanding the mechanics of ECM is important for physiological processes and diseases. This review covers the mechanics of ECM at different scales and highlights its role in healthy and tumorigenic tissues.

CELL REPORTS PHYSICAL SCIENCE (2021)

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Article Medicine, Research & Experimental

Collagen Type X Alpha 1 (COL10A1) Contributes to Cell Proliferation, Migration, and Invasion by Targeting Prolyl 4-Hydroxylase Beta Polypeptide (P4HB) in Breast Cancer

Weibin Yang et al.

Summary: COL10A1 and P4HB are overexpressed in breast cancer and interact with each other. COL10A1 promotes proliferation and metastasis of breast cancer cells, while P4HB plays a role in these processes.

MEDICAL SCIENCE MONITOR (2021)

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Article Oncology

The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function

Hui Wang et al.

Summary: COL11A1 modulates apoptotic inhibition and chemoresistance in pancreatic cancer cells by activating the Akt/CREB/BCL-2/BAX signaling pathway, suggesting it may serve as a distinct prognostic indicator and an attractive therapeutic target for PDAC.

JOURNAL OF CANCER (2021)

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Article Surgery

COL11A1 Was Involved in Cell Proliferation, Apoptosis and Migration in Non-Small Cell Lung Cancer Cells

Hongbin Tu et al.

Summary: This study revealed that COL11A1 may play a role in promoting malignancy and contributing to the pathogenesis of lung cancer, as evidenced by its association with increased cell proliferation, apoptosis, and migration.

JOURNAL OF INVESTIGATIVE SURGERY (2021)

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Article Medical Laboratory Technology

Diagnostic role of collagen-III and matrix metalloproteinase-1 for early detection of hepatocellular carcinoma

A. M. Attallah et al.

BRITISH JOURNAL OF BIOMEDICAL SCIENCE (2020)

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Article Oncology

Over-expression of CDX2 alleviates breast cancer by up-regulating microRNA let-7b and inhibiting COL11A1 expression

Hongbin Wang et al.

CANCER CELL INTERNATIONAL (2020)

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Article Cell Biology

Identifying the hub gene in gastric cancer by bioinformatics analysis and in vitro experiments

Feiran Wang et al.

CELL CYCLE (2020)

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Review Cell Biology

The roles of tumor-associated macrophages in tumor angiogenesis and metastasis

Luo-Qin Fu et al.

CELLULAR IMMUNOLOGY (2020)

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Article Gastroenterology & Hepatology

High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients

Laura Necula et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

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Review Oncology

Reciprocal Interplay Between Fibrillar Collagens and Collagen-Binding Integrins: Implications in Cancer Progression and Metastasis

Isabelle Bourgot et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

High expression of collagen 1A2 promotes the proliferation and metastasis of esophageal cancer cells

Guangbin Li et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Cell Biology

Involvement of collagen XVII in pluripotency gene expression and metabolic reprogramming of lung cancer stem cells

Han-Shui Hsu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

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Review Oncology

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

Neel I. Nissen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Review Cell Biology

The emerging roles of macrophages in cancer metastasis and response to chemotherapy

Luis Rivera Sanchez et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

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Review Gastroenterology & Hepatology

Cancer-associated fibroblasts in gastrointestinal cancer

Hiroki Kobayashi et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Oncology

Collagen density regulates the activity of tumor-infiltrating T cells

Dorota E. Kuczek et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Cell Biology

The Extracellular Matrix Modulates the Metastatic Journey

FuiBoon Kai et al.

DEVELOPMENTAL CELL (2019)

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Article Oncology

Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study

Nicholas Willumsen et al.

TRANSLATIONAL ONCOLOGY (2019)

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Review Gastroenterology & Hepatology

Recent advances in gastric cancer early diagnosis

Laura Necula et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Article Oncology

A panel of collagen genes are associated with prognosis of patients with gastric cancer and regulated by microRNA-29c-3p: an integrated bioinformatics analysis and experimental validation

Qiang-Nu Zhang et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Up-regulation of collagen proteins in colorectal liver metastasis compared with normal liver tissue

Nick A. van Huizen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Review Radiology, Nuclear Medicine & Medical Imaging

Tumor markers: myths and facts unfolded

S. C. Faria et al.

ABDOMINAL RADIOLOGY (2019)

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Article Multidisciplinary Sciences

Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer

Nicholas Willumsen et al.

SCIENTIFIC REPORTS (2019)

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Review Oncology

Cancer overdiagnosis: a biological challenge and clinical dilemma

Sudhir Srivastava et al.

NATURE REVIEWS CANCER (2019)

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Article Oncology

Cytoplasmic collagen XII as a prognostic biomarker in esophageal squamous cell carcinoma

Bohan Zhang et al.

CANCER BIOLOGY & THERAPY (2018)

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Article Oncology

TGF-β1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer

Joanna Boguslawska et al.

CANCER LETTERS (2018)

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Article Genetics & Heredity

COL5A1 may contribute the metastasis of lung adenocarcinoma

Weibo Liu et al.

GENE (2018)

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Article Oncology

Overexpression of collagen type V 1 chain in human breast invasive ductal carcinoma is mediated by TGF-1

Weimin Ren et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2018)

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Article Cell Biology

Extracellular matrix proteins as diagnostic markers of breast carcinoma

Marta Giussani et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Article Biotechnology & Applied Microbiology

High expression of COL10A1 is associated with poor prognosis in colorectal cancer

Haipeng Huang et al.

ONCOTARGETS AND THERAPY (2018)

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Article Oncology

Knockdown of collagen-1(III) inhibits glioma cell proliferation and migration and is regulated by miR128-3p

Yuan-Feng Gao et al.

ONCOLOGY LETTERS (2018)

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Article Chemistry, Multidisciplinary

Collagen-based three-dimensional culture microenvironment promotes epithelial to mesenchymal transition and drug resistance of human ovarian cancer in vitro

Ming Liu et al.

RSC ADVANCES (2018)

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Article Oncology

Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance

Hui Zhang et al.

BREAST CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis

D. H. Peng et al.

ONCOGENE (2017)

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Article Oncology

siRNA-Mediated suppression of collagen type iv alpha 2 (COL4A2) mRNA inhibits triple-negative breast cancer cell proliferation and migration

He JingSong et al.

ONCOTARGET (2017)

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Article Biochemistry & Molecular Biology

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2017)

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Article Oncology

Collagen type IV alpha 1 (COL4A1) and collagen type XIII alpha 1 (COL13A1) produced in cancer cells promote tumor budding at the invasion front in human urothelial carcinoma of the bladder

Makito Miyake et al.

ONCOTARGET (2017)

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Article Oncology

The highly expressed COL4A1 genes contributes to the proliferation and migration of the invasive ductal carcinomas

Rongzhong Jin et al.

ONCOTARGET (2017)

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Review Biotechnology & Applied Microbiology

New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles

M. A. Zaimy et al.

CANCER GENE THERAPY (2017)

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Article Oncology

The Prognostic and Predictive Value of Soluble Type IV Collagen in Colorectal Cancer: A Retrospective Multicenter Study

Hans Christian Rolff et al.

CLINICAL CANCER RESEARCH (2016)

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Article Oncology

A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets

Dongyu Jia et al.

CANCER LETTERS (2016)

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Article Oncology

COL11A1 is overexpressed in recurrent non-small cell lung cancer and promotes cell proliferation, migration, invasion and drug resistance

Lihua Shen et al.

ONCOLOGY REPORTS (2016)

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Article Multidisciplinary Sciences

Oriented collagen fibers direct tumor cell intravasation

Weijing Han et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Oncology

Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines

Radoslaw Januchowski et al.

JOURNAL OF CANCER (2016)

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Article Oncology

COX-2 modulates mammary tumor progression in response to collagen density

Karla Esbona et al.

BREAST CANCER RESEARCH (2016)

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Article Cell Biology

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

I. Acerbi et al.

INTEGRATIVE BIOLOGY (2015)

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Review Oncology

COL11A1/(pro)collagen 11A1 expression is a remarkable biomarker of human invasive carcinoma-associated stromal cells and carcinoma progression

Fernando Vazquez-Villa et al.

TUMOR BIOLOGY (2015)

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Article Oncology

COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization

Yi-Hui Wu et al.

ONCOTARGET (2015)

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Article Genetics & Heredity

Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1

Qian Xiao et al.

PLOS GENETICS (2015)

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Review Biochemistry & Molecular Biology

The extracellular matrix modulates the hallmarks of cancer

Michael W. Pickup et al.

EMBO REPORTS (2014)

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Review Cell Biology

Extracellular matrix assembly: a multiscale deconstruction

Janna K. Mouw et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer

Y-H Wu et al.

ONCOGENE (2014)

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Article Multidisciplinary Sciences

Discovery and Validation of New Potential Biomarkers for Early Detection of Colon Cancer

Xavier Sole et al.

PLOS ONE (2014)

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Article Oncology

Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop

Daniel Ohlund et al.

BMC CANCER (2013)

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Article Oncology

Collagen type XI α1 facilitates head and neck squamous cell cancer growth and invasion

J. C. Sok et al.

BRITISH JOURNAL OF CANCER (2013)

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Article Pathology

COL4A3 expression correlates with pathogenesis, pathologic behaviors, and prognosis of gastric carcinomas

Xiao-cui Nie et al.

HUMAN PATHOLOGY (2013)

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Article Biochemical Research Methods

Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis

Xia Zou et al.

JOURNAL OF PROTEOMICS (2013)

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Article Genetics & Heredity

Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an Osteogenesis Imperfecta/Ehlers-Danlos Syndrome overlap syndrome

Fransiska Malfait et al.

ORPHANET JOURNAL OF RARE DISEASES (2013)

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Review Biochemistry & Molecular Biology

Lysine post-translational modifications of collagen

Mitsuo Yamauchi et al.

LYSINE-BASED POST-TRANSLATIONAL MODIFICATION OF PROTEINS (2012)

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Article Biochemistry & Molecular Biology

A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis

K. A. Spivey et al.

ONCOGENE (2012)

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Article Oncology

Type I and III collagen degradation products in serum predict patient survival in head and neck squamous cell carcinoma

Sini Nurmenniemi et al.

ORAL ONCOLOGY (2012)

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Article Cell Biology

Overview of the Matrisome-An Inventory of Extracellular Matrix Constituents and Functions

Richard O. Hynes et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

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Article Cell Biology

The Collagen Family

Sylvie Ricard-Blum

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

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Article Gastroenterology & Hepatology

Predictive Value of Serum CEA, CA19-9 and CA72.4 in Early Diagnosis of Recurrence after Radical Resection of Gastric Cancer

Yan Li et al.

HEPATO-GASTROENTEROLOGY (2011)

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Article Biochemistry & Molecular Biology

Microarray-based Transcriptional and Epigenetic Profiling of Matrix Metalloproteinases, Collagens, and Related Genes in Cancer

Andrei V. Chernov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Biochemistry & Molecular Biology

Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-κB and LEF-1

Damian Medici et al.

MATRIX BIOLOGY (2010)

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Article Oncology

Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer

D. Ohlund et al.

BRITISH JOURNAL OF CANCER (2009)

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Article Medicine, General & Internal

Collagen density promotes mammary tumor initiation and progression

Paolo P. Provenzano et al.

BMC MEDICINE (2008)

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Article Oncology

Collagen IV levels are elevated in the serum of patients with primary breast cancer compared to healthy volunteers

C. Mazouni et al.

BRITISH JOURNAL OF CANCER (2008)

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