Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death

Article Biochemistry & Molecular Biology

Heat Shock Protein 60 Restricts Release of Mitochondrial dsRNA to Suppress Hepatic Inflammation and Ameliorate Non-Alcoholic Fatty Liver Disease in Mice

Ying-Hsien Huang et al.

Summary: Heat shock protein 60 (HSP60) can provide hepatoprotection in the context of non-alcoholic fatty liver disease (NAFLD) by inhibiting dsRNA release and the TLR3/MDA5/pIRF3 pathway.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Gastroenterology & Hepatology

Is there a role of lipid-lowering therapies in the management of fatty liver disease?

Ismini Tzanaki et al.

Summary: Atherogenic dyslipidemia is highly prevalent in non-alcoholic fatty liver disease (NAFLD) and contributes to the increased cardiovascular risk associated with this condition. Alongside insulin resistance, it plays an important role in the development and progression of NAFLD/non-alcoholic steatohepatitis (NASH). Statins have shown potential benefits in reducing hepatic steatosis, inflammation, and fibrosis in NAFLD/NASH patients, but data for other lipid-lowering therapies are limited and conflicting.

WORLD JOURNAL OF HEPATOLOGY (2022)

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Article Medicine, Research & Experimental

Anti-inflammatory effect of trans-anethol in a rat model of myocardial ischemia-reperfusion injury

Marwa Matboli et al.

Summary: This study investigated the potential anti-inflammatory role of trans-anethole (TNA) in myocardial ischemia-reperfusion injury (MI/R) and its mechanism of action. The results showed that TNA could alleviate cardiac injury, improve cardiac function, and attenuate the inflammatory response through modulation of specific gene and protein expression.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

Nuclear Receptors Linking Metabolism, Inflammation, and Fibrosis in Nonalcoholic Fatty Liver Disease

Tobias Puengel et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are chronic liver diseases that can lead to end-stage liver disease and hepatocellular carcinoma (HCC) worldwide. The metabolic syndrome is closely linked to NAFLD, and comorbidities such as type 2 diabetes, obesity, and insulin resistance worsen liver disease, while NAFLD increases cardiovascular risk in affected patients. Therapeutic strategies targeting multiple drug targets or drugs with multiple mechanisms of actions are needed for effective treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Endocrinology & Metabolism

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss

Sjaak Pouwels et al.

Summary: Given the increasing prevalence of diabetes and obesity worldwide, the deleterious effects of non-alcoholic fatty liver disease (NAFLD) are becoming a growing challenge for public health. NAFLD is closely associated with metabolic disorders and can range from mild forms to severe forms with potential liver failure. Advanced fibrosis is a major predictor of morbidity and liver-related mortality. Diagnosis of NAFLD is established through liver biopsy and treatment options include weight loss, dietary modification, and addressing underlying metabolic syndrome.

BMC ENDOCRINE DISORDERS (2022)

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Review Cell Biology

Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review

Narjes Nasiri-Ansari et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease worldwide, strongly associated with obesity, type 2 diabetes, and other metabolic syndrome features. The term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has recently been proposed. Growing evidence supports the strong correlation between NAFLD and increased cardiovascular disease risk, independent of the presence of diabetes, hypertension, and obesity. Liver sinusoidal endothelial cell dysfunction appears to be implicated in the progression of NAFLD and may contribute to atherosclerosis and cardiovascular disease.

CELLS (2022)

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Article Cardiac & Cardiovascular Systems

Dilated cardiomyopathy-linked heat shock protein family D member 1 mutations cause up-regulation of reactive oxygen species and autophagy through mitochondrial dysfunction

Hirokazu Enomoto et al.

Summary: This study identified that mutations in HSPD1 caused mitochondrial dysfunction, leading to mitophagy, increased ROS, and cardiac atrophy.

CARDIOVASCULAR RESEARCH (2021)

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Article Chemistry, Medicinal

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Justin D. Dietrich et al.

Summary: TNFα is a key soluble cytokine involved in systemic inflammation, and development of drugs targeting it has proven challenging. A fragment-based drug discovery approach led to the identification of lead compounds with improved binding efficiency and drug-like properties.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Cryo-EM structure of human mitochondrial HSPD1

David P. Klebl et al.

Summary: The structure of HSPD1 in the apo state was determined using cryo-EM, revealing its mostly single ring assemblies without co-chaperonin. Compared to GroEL, HSPD1 shows a rotation and increased flexibility of the apical domain. This new insight into the structural changes during the catalytic cycle of HSPD1 may lead to new treatments targeting HSPD1 against various diseases, including glioblastoma.

ISCIENCE (2021)

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Review Nutrition & Dietetics

A comprehensive review of long non-coding RNAs in the pathogenesis and development of non-alcoholic fatty liver disease

Arezoo Gowhari Shabgah et al.

Summary: Long non-coding RNAs (lncRNAs) have emerged as significant regulatory molecules in non-alcoholic fatty liver disease (NAFLD), playing important roles in triglyceride, cholesterol, and lipoprotein metabolism. By up- or down-regulating downstream molecules in fatty acid metabolism, lncRNAs may influence fatty acid deposition in the liver.

NUTRITION & METABOLISM (2021)

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Review Biochemistry & Molecular Biology

Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy

Jianan Zhao et al.

Summary: This article summarizes the latest research on metabolic dysfunction-associated fatty liver disease (MAFLD) and discusses the roles and potential mechanisms of programmed cell death forms in the development of the disease.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2021)

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Review Gastroenterology & Hepatology

Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications

Samar H. Ibrahim

Summary: Liver sinusoidal endothelial cells (LSECs) play a crucial role in the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD) by undergoing capillarization and expressing adhesion molecules. They regulate hepatic immune cell populations by mediating leukocyte subset adhesion in NAFLD, highlighting their role in the inflammatory response.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

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Article Medicine, Research & Experimental

Probiotic-prebiotic-synbiotic modulation of (YAP1, LATS1 and NF2 mRNAs/miR-1205/lncRNA SRD5A3-AS1) panel in NASH animal model

Shaimaa H. Gadallah et al.

Summary: The prophylactic efficacy of gut microbiota-based treatments on nonalcoholic steatohepatitis (NASH) management was investigated through modulation of Hippo signaling pathway-related genes and their epigenetic regulators. Both probiotic mixture and prebiotic inulin fiber attenuated steatosis, inflammation, and fibrosis in NASH rats induced by a high sucrose high fat diet. The treatments also led to improvements in liver function and modulation of RNA panel related to NASH progression.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

mRNA-miRNA-lncRNA Regulatory Network in Nonalcoholic Fatty Liver Disease

Marwa Matboli et al.

Summary: This study aimed to construct a bioinformatics-based co-regulatory network of mRNAs and ncRNAs in NAFLD, which was validated in an animal model. The network revealed key players involved in NAFLD pathogenesis, with significant differences in expression levels between NAFLD and normal controls. This provides valuable insights for potential diagnostic and management strategies for NAFLD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

5-HT1A receptors mediate the analgesic effect of rosavin in a mouse model of oxaliplatin-induced peripheral neuropathic pain

Daxian Li et al.

Summary: The study found that rosavin can significantly alleviate oxaliplatin-induced cold allodynia in mice, and this effect may be related to the activity of 5-HT1A receptors.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2021)

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Article Cell Biology

Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis

Maria Vulf et al.

Summary: The study identified differential expression of miRNAs at different stages of NAFLD development and their regulatory effects on genes; analysis of target genes and metabolic pathways revealed changes in RNA-dependent epigenetic regulation in steatosis and steatohepatitis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Clinical Significance of HSPD1/MMP14/ITGB1/miR-6881-5P/Lnc-SPARCL1-1:2 RNA Panel in NAFLD/NASH Diagnosis: Egyptian Pilot Study

Reda Albadawy et al.

Summary: This pilot study evaluated the potential of the Nod-like receptor (NLR) signaling pathway related RNA panel in diagnosing non-alcoholic steatohepatitis (NASH). Upregulation of Lnc-SPARCL1-1:2 lncRNA led to increased levels of miR-6881-5P and subsequent mRNA levels of HSPD1, MMP14, and ITGB1 were observed. ROC curve analysis showed discriminative cutoff values that aided in distinguishing NASH cases from controls, as well as differentiating between NAFLD, simple steatosis, and NASH.

BIOMEDICINES (2021)

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Review Biochemistry & Molecular Biology

MicroRNAs in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Zhiqiang Fang et al.

Summary: NAFLD is a chronic liver disorder closely associated with cardiovascular disease, obesity, and type 2 diabetes mellitus worldwide. Recent studies have found that miRNAs play crucial roles in the pathogenesis and progression of NAFLD, suggesting them as potential therapeutic targets.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

PLIP 2021: expanding the scope of the protein-ligand interaction profiler to DNA and RNA

Melissa F. Adasme et al.

Summary: With the growth of protein structure data, the analysis of molecular interactions between ligands and their target molecules becomes increasingly important. PLIP, a tool for protein-ligand interaction profiling, has been successful in detecting and visualizing these interactions, with applications ranging from characterizing docking experiments to evaluating novel ligand-protein complexes. Additionally, PLIP has been extended to encompass interactions with DNA and RNA, demonstrating its utility in scenarios such as cancer drug targeting DNA and RNA-protein complexes associated with neurological diseases.

NUCLEIC ACIDS RESEARCH (2021)

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Review Medicine, Research & Experimental

Anti-inflammatory effects of Rhodiola rosea L.: A review

Wei-ling Pu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Cell Biology

Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis

Petra Hirsova et al.

CELL DEATH & DISEASE (2020)

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Review Cell Biology

Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease

Ruibing Li et al.

AGING-US (2020)

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Review Biochemistry & Molecular Biology

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

Young-Ah Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Cell Biology

The Endothelium as a Driver of Liver Fibrosis and Regeneration

Erica Lafoz et al.

CELLS (2020)

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Review Biochemistry & Molecular Biology

Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives

Abdullah Hoter et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article Chemistry, Physical

RLDOCK: A New Method for Predicting RNA-Ligand Interactions

Li-Zhen Sun et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2020)

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Article Oncology

Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet

Bing Chen et al.

MOLECULAR MEDICINE REPORTS (2019)

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Review Physiology

Regulatory Non-coding RNAs Network in Non-alcoholic Fatty Liver Disease

Siti Aishah Sulaiman et al.

FRONTIERS IN PHYSIOLOGY (2019)

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Article Gastroenterology & Hepatology

Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH

Qianqian Guo et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Endocrinology & Metabolism

Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease

Meng Jiang et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Review Biochemistry & Molecular Biology

Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels

Xiaopei Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

MicroRNAs as a Novel Tool in the Diagnosis of Liver Lipid Dysregulation and Fatty Liver Disease

Jingwei Yu et al.

MOLECULES (2019)

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Review Biochemistry & Molecular Biology

Matrix metalloproteinases and liver fibrosis (translational aspects)

Elke Roeb

MATRIX BIOLOGY (2018)

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Review Gastroenterology & Hepatology

Apoptosis and non-alcoholic fatty liver diseases

Tatsuo Kanda et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Food Science & Technology

Altered expression of TRAIL on mouse T cells via ERR phosphorylation by Rhodiola rosea L. and its marker compounds

Andrey S. Marchev et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

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Article Cell Biology

Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways

Haiying Tang et al.

CELL STRESS & CHAPERONES (2016)

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Article Biochemistry & Molecular Biology

New functionality of RNAComposer: an application to shape the axis of miR160 precursor structure

Maciej Antczak et al.

ACTA BIOCHIMICA POLONICA (2016)

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Review Gastroenterology & Hepatology

Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis

Alexander Wree et al.

SEMINARS IN LIVER DISEASE (2016)

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Article Multidisciplinary Sciences

Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus

Meihong Wang et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

Preventive Effects of Rhodiola rosea L. on Bleomycin-Induced Pulmonary Fibrosis in Rats

Ke Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Physiology

Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease

Jarkko Soronen et al.

PHYSIOLOGICAL REPORTS (2016)

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Article Biochemistry & Molecular Biology

Genome-wide Analysis of Long Noncoding RNA Expression Profiles in Patients with Non-Alcoholic Fatty Liver Disease

Chuanzheng Sun et al.

IUBMB LIFE (2015)

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Review Gastroenterology & Hepatology

NAFLD: A multisystem disease

Christopher D. Byrne et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Biochemistry & Molecular Biology

Matrix metalloproteinases in liver injury, repair and fibrosis

Sergio Duarte et al.

MATRIX BIOLOGY (2015)

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Review Gastroenterology & Hepatology

Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis

Petra Hirsova et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2015)

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Article Cell Biology

Aberrant Hepatic MicroRNA Expression in Nonalcoholic Fatty Liver Disease

Yue Ying Feng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)

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Article Gastroenterology & Hepatology

Utility and Appropriateness of the Fatty Liver Inhibition of Progression (FLIP) Algorithm and Steatosis, Activity, and Fibrosis (SAF) Score in the Evaluation of Biopsies of Nonalcoholic Fatty Liver Disease

Pierre Bedossa

HEPATOLOGY (2014)

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Article Biochemical Research Methods

High-Throughput parallel blind Virtual Screening using BINDSURF

Irene Sanchez-Linares et al.

BMC BIOINFORMATICS (2012)

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Article Biochemistry & Molecular Biology

Discovery of hundreds of mirtrons in mouse and human small RNA data

Erik Ladewig et al.

GENOME RESEARCH (2012)

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Article Cell Biology

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

Masamichi Nagae et al.

JOURNAL OF CELL BIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Automated 3D structure composition for large RNAs

Mariusz Popenda et al.

NUCLEIC ACIDS RESEARCH (2012)

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Article Biochemical Research Methods

ViennaRNA Package 2.0

Ronny Lorenz et al.

ALGORITHMS FOR MOLECULAR BIOLOGY (2011)

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Article Biochemistry & Molecular Biology

The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS

Anna Tochowicz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Article Chemistry, Multidisciplinary

Open Babel: An open chemical toolbox

Noel M. O'Boyle et al.

JOURNAL OF CHEMINFORMATICS (2011)

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Article Chemistry, Medicinal

Synthesis of the Rhodiola rosea glycoside rosavin

S. A. Patov et al.

CHEMISTRY OF NATURAL COMPOUNDS (2006)

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Article Gastroenterology & Hepatology

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

DE Kleiner et al.

HEPATOLOGY (2005)

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Article Biochemistry & Molecular Biology

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

R Edgar et al.

NUCLEIC ACIDS RESEARCH (2002)

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Article Biochemical Research Methods

Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method

KJ Livak et al.

METHODS (2001)

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Article Gastroenterology & Hepatology

Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat

T Watanabe et al.

JOURNAL OF HEPATOLOGY (2001)

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Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death

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