☆ 4.7 Review

Advances of Epigenetic Biomarkers and Epigenome Editing for Early Diagnosis in Breast Cancer

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications

Gulab Sher et al.

Summary: Epigenetic alterations play a crucial role in the pathogenesis of breast cancer, including drug resistance and stemness features. Understanding and utilizing these modifications for breast cancer management is challenging, but holds promise for providing novel diagnostic, prognostic markers, and therapeutic options.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Specific expression and functions of circular RNAs

Sema Misir et al.

Summary: Circular RNAs (circRNAs) are a new class of RNA molecules that have a covalently closed circular structure. They play various biological roles in cellular processes and have important implications in understanding cellular physiology and disease pathogenesis. The specific regulatory mechanisms of circRNA expression are still poorly understood, but further research will help in utilizing circRNA as biomarkers and developing new therapeutic approaches.

CELL DEATH AND DIFFERENTIATION (2022)

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Review Biochemistry & Molecular Biology

Exosomes as a new frontier of cancer liquid biopsy

Dan Yu et al.

Summary: Liquid biopsy, a revolutionary strategy for cancer diagnosis and prognosis prediction, uses minimally invasive detection through biofluids such as blood, saliva, and urine. Exosomes, a subset of extracellular vesicles, play a crucial role in intercellular communication and are considered as potential biomarkers in liquid biopsy. However, the lack of high-quality separation and component analysis methods has limited the further clinical application of exosomes.

MOLECULAR CANCER (2022)

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Article Nanoscience & Nanotechnology

Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers

Xuelin Xia et al.

Summary: In this study, an amphiphilic affibody-drug conjugate was self-assembled into nanomicelles to prolong the circulation time of cancer-targeted therapy. The nanodrug showed excellent antitumor activity in HER2-positive ovarian and breast tumor models, eradicating both small and large tumors. The affibody-based nanoagent not only increased blood circulation time, but also enhanced tumor targeting and drug accumulation in the tumor.

NANO-MICRO LETTERS (2022)

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Article Oncology

Immunotherapy for early triple negative breast cancer: research agenda for the next decade

Paolo Tarantino et al.

Summary: Advancements in the treatment of localized triple negative breast cancer (TNBC) are reshaping the landscape of this disease, with the addition of pembrolizumab showing significant improvement in survival. However, there are still questions regarding patient selection, integration with other treatments, and minimizing side effects.

NPJ BREAST CANCER (2022)

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Review Oncology

Integrating circulating-free DNA (cfDNA) analysis into clinical practice: opportunities and challenges

Miguel Garcia-Pardo et al.

Summary: The identification of genomic alterations has revolutionised the management of solid tumor patients in the era of precision medicine. Recent advances in the detection and characterisation of circulating tumor DNA (ctDNA) have enabled liquid biopsy to be integrated into clinical practice, serving as a promising biomarker for prognostication, monitoring disease response, detection of minimal residual disease and early diagnosis. This Review discusses the current and future clinical applications of ctDNA primarily in non-small cell lung cancer and other solid tumors.

BRITISH JOURNAL OF CANCER (2022)

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Review Oncology

Liquid-Liquid Phase Separation in Cancer Signaling, Metabolism and Anticancer Therapy

Sebastian Igelmann et al.

Summary: Emerging evidence suggests that the organization of cells into membraneless sub-compartments, known as biological condensates, confers unique properties to cancer cells. Recent research has shown that genetic and epigenetic changes can drive the formation of these condensates, leading to the stable maintenance of cellular states. This review highlights the specific biological condensates in cancer, initiated by mutant oncoproteins, RNA-binding proteins, or lincRNAs, which regulate oncogenic gene expression programs and cancer metabolism. Targeting these oncogenic condensates with effective anticancer drugs could be a promising therapeutic approach.

CANCERS (2022)

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Review Oncology

Biorecognition Engineering Technologies for Cancer Diagnosis: A Systematic Literature Review of Non-Conventional and Plausible Sensor Development Methods

Kalaumari Mayoral-Pena et al.

Summary: Approximately 70% of cancer patients in developing countries are diagnosed at late stages, partly due to limited access to cost-effective and accurate diagnostic tools. This article reviews three emerging non-conventional technologies for cancer diagnostics: molecularly imprinted polymers, recombinant antibodies, and antibody mimetic molecules. These technologies offer promising and accessible alternatives to conventional antibodies, particularly in point-of-care cancer diagnostics in developing countries.

CANCERS (2022)

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Article Cell Biology

Reverting TP53 Mutation in Breast Cancer Cells: Prime Editing Workflow and Technical Considerations

Asmaa Y. Abuhamad et al.

Summary: Breast cancer is often caused by genetic alterations, particularly missense mutations, in the TP53 gene. This study used CRISPR-based gene editing technology, specifically the prime editing tool, to revert and introduce a specific TP53 mutation in breast cancer cell lines. Sanger sequencing was initially used but proved to be less sensitive than amplicon target sequencing, which detected the expected substitutions. The overall editing efficiency was low, suggesting the need for workflow and efficiency improvements in future experiments.

CELLS (2022)

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Review Biochemistry & Molecular Biology

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs

Miguel Angel Olmedo-Suarez et al.

Summary: Environmental factors play a significant role in severe chronic diseases, and their impact is mediated through interactions with genetics, physiology, and epigenetics. Epigenetic alterations, including modifications in DNA, histones, and noncoding RNAs, can be influenced by environmental exposures and contribute to the development of diseases. This review focuses on the role of noncoding RNAs in mediating the detrimental effects of environmental toxicants on health.

BIOMOLECULES (2022)

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Article Multidisciplinary Sciences

In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancer

Peng Ji et al.

Summary: The response rates of immune checkpoint inhibitors in TNBC patients are limited, indicating the presence of additional immune escape mechanisms. By using customized in vivo CRISPR screens and transcriptomic analysis, Lgals2 was identified as a potential regulator involved in immune escape in TNBC. Mechanistic studies showed that Lgals2 induced the polarization and proliferation of tumor-associated macrophages through the CSF1/CSF1R axis, resulting in the immunosuppressive microenvironment of TNBC. Blockade of LGALS2 using an inhibitory antibody effectively halted tumor growth and reversed immune suppression.

SCIENCE ADVANCES (2022)

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Review Oncology

Estrogen Receptor Bio-Activities Determine Clinical Endocrine Treatment Options in Estrogen Receptor-Positive Breast Cancer

Song Xia et al.

Summary: In the treatment of estrogen receptor positive breast cancer, estrogen receptors are the main targets. Recent studies have identified the PI3K/AKT/mTOR pathway, microRNA regulation, and other ER downstream signaling pathways as effective therapeutic targets. Several biomarkers have been established for diagnosis and prognosis. Gene mutations that lead to endocrine therapy resistance have been identified, and targeted drugs in combination with endocrine therapy have been developed to improve treatment efficacy. Combination therapy has been shown to be superior to monotherapy in clinical evaluation.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2022)

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Article Biology

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

Maarten H. Geurts et al.

Summary: Prime editing is a novel genome editing tool that can successfully model various gene mutations in human organ systems, demonstrating its broad potential applications. Despite encountering issues with varying editing efficiencies and undesired mutations, prime editing-repaired organoids showed no detectable off-target effects.

LIFE SCIENCE ALLIANCE (2021)

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Article Biotechnology & Applied Microbiology

Predicting the efficiency of prime editing guide RNAs in human cells

Hui Kwon Kim et al.

Summary: This study identified factors affecting PE2 efficiency through high-throughput evaluation and developed three computational models to predict pegRNA efficiency, which can be applied to edits of various types and positions. Spearman's correlations between 0.47 and 0.81 were found when testing the accuracy of the predictions using independent test data sets.

NATURE BIOTECHNOLOGY (2021)

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Review Genetics & Heredity

Molecular intrinsic versus clinical subtyping in breast cancer: A comprehensive review

Agata Szymiczek et al.

Summary: Breast cancer is a heterogeneous disease with challenges in classification. The traditional clinical subtyping method is not ideal, and the new classification model based on gene expression profiling may provide a more comprehensive understanding of disease heterogeneity. Research suggests that intrinsic subtypes offer clinically relevant information beyond clinical surrogates, so it is important to explore whether the current approach can be improved by gene expression profiling.

CLINICAL GENETICS (2021)

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Article Developmental Biology

The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish

Pourya Sarvari et al.

Summary: In zebrafish, the Rbx1 mutant larvae exhibit multi-layered cardiomyocytes phenotypes independent of ErbB signaling, but the specific expression of rbx1 in endothelial cells can normalize the abnormal cardiac wall morphology. Additionally, activation of Hedgehog signaling can ameliorate the multi-layered myocardial wall phenotype in rbx1 mutants, indicating the essential role of endothelial activity of Rbx1 in cardiac wall morphogenesis.

DEVELOPMENTAL BIOLOGY (2021)

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Article Genetics & Heredity

Biomolecular condensates at sites of DNA damage: More than just a phase*,**

Vincent Spegg et al.

Summary: Protein recruitment to DNA break sites is crucial for the DNA damage response, involving complex and finely regulated macromolecular interactions. While fixed stoichiometric binding interactions exist, highly dynamic multivalent interactions implicated in phase separation also play a key role in multi-protein assembly response to genotoxic stress. The study highlights the cooperative potential between clustered stoichiometric binding and phase separation in maintaining genome integrity through nuclear condensates.

DNA REPAIR (2021)

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Article Biochemistry & Molecular Biology

Combination of Near-Infrared Photoimmunotherapy Using Trastuzumab and Small Protein Mimetic for HER2-Positive Breast Cancer

Haruka Yamaguchi et al.

Summary: The study found that the combination therapy of NIR-PIT using HER2 Affibody and trastuzumab is more effective against HER2-positive breast cancer cells than using either alone. This combination therapy not only shows significant efficacy against HER2 low-expressing cancer cells, trastuzumab-resistant cells, and brain metastatic cells of breast cancer, but also exhibits strong fluorescence intensity in HER2-positive tumors in in vivo imaging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Epigenetic modifications in acute myeloid leukemia: The emerging role of circular RNAs (Review)

Mohammed Awal Issah et al.

Summary: Canonical epigenetic modifications, including histone modification, chromatin remodeling, and DNA methylation, play key roles in numerous cellular processes. Recent studies have shown an increase in research on epigenetic modifications of RNA, such as circRNAs, which may have important functions in diseases like acute myeloid leukemia. The epigenetic modification of circRNAs, particularly m(6)A, may become a potential diagnostic and therapeutic target for AML in the future.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis

Otilia Menyhart et al.

Summary: Multi-omics data integration offers unparalleled opportunities for understanding complex diseases like cancer, but faces challenges such as uneven maturity of different omics approaches and limited data processing capacity. Efforts to standardize sample processing, train experts for data analysis, and close the gap between data generation and processing are crucial for the translatability of theoretical findings.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Pharmacology & Pharmacy

Advanced Approaches to Breast Cancer Classification and Diagnosis

M. Zubair et al.

Summary: Breast cancer is highly heterogeneous, requiring early and advanced molecular diagnostic tools for accurate detection. Currently, only a few biomarkers have been approved by the FDA for assessing breast cancer. Advanced technologies such as portable biosensors hold promise for providing more precise diagnostics and guiding specific treatment methods.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Screening and predicted value of potential biomarkers for breast cancer using bioinformatics analysis

Xiaoyu Zeng et al.

Summary: Breast cancer is the most common cancer in women, and identifying new biomarkers is crucial for the diagnosis and treatment of breast cancer.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Identification of novel prognostic biomarkers by integrating multi-omics data in gastric cancer

Nannan Liu et al.

Summary: This study integrated multi-omics data of 293 primary gastric cancer patients to identify key driver genes and establish a prognostic model. Analysis of copy number alteration and somatic mutation data helped reveal molecular markers of genomic variation, while integrating gene transcription levels provided a unique perspective to discover dysregulated factors in transcriptional regulation.

BMC CANCER (2021)

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Review Pharmacology & Pharmacy

Integrating Molecular Biomarker Inputs Into Development and Use of Clinical Cancer Therapeutics

Anna D. Louie et al.

Summary: Biomarkers play a crucial role in cancer therapeutics, aiding in screening, classification, survival prediction, and treatment efficacy prediction. The application of machine learning techniques can help identify disease-relevant features and improve predictive models.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Immunology

Identification of a DNA Methylation-Driven Genes-Based Prognostic Model and Drug Targets in Breast Cancer: In silico Screening of Therapeutic Compounds and in vitro Characterization

Saisai Tian et al.

Summary: This study retrospectively analyzed over a thousand breast cancer patients and established a prognostic signature based on DNA methylation-driven genes. It was found that high-risk patients had lower immune activity and more mutated genes. Additionally, in silico screening identified several target genes and compounds with therapeutic potential for treating high-risk breast cancer patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy

Wen Yin et al.

Summary: This study evaluated the influence of different HER2-targeting affibody-based constructs on cell growth, in vivo targeting, and biodistribution, finding that the monomeric construct Z-ABD showed the most promising targeted delivery of the cytotoxic drug DM1.

PHARMACEUTICS (2021)

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Article Cell Biology

Histone variants at a glance

Paul B. Talbert et al.

Summary: Eukaryotic nucleosomes are organized by histones, with common histones deposited during S-phase and histone variants available throughout the cell cycle. Variants alter nucleosome structure and function, playing specialized roles in DNA repair, chromosome segregation, and transcriptional regulation.

JOURNAL OF CELL SCIENCE (2021)

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Article Biology

Epigenetic inheritance and evolution: a historian's perspective

Laurent Loison

Summary: This article examines the historical context of the growing interest in epigenetics in evolutionary theory, comparing modern epigenetics to Lamarckism and discussing the potential mechanisms of the Baldwin effect and genetic assimilation. It also considers how epigenetic inheritance could strengthen the causal relationship between adaptability and adaptation.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2021)

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Article Oncology

Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer

Halima Alsamri et al.

Summary: Carnosol, a natural polyphenol found in edible plants such as sage, rosemary, and oregano, induces histone hypoacetylation and inhibits p300 histone acetyltransferase activity in breast cancer cells, demonstrating potential anticancer activity.

FRONTIERS IN ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

The roles of epigenetics in cancer progression and

Jocelyn F. Chen et al.

Summary: Cancer metastasis poses a major challenge in cancer treatment, with reversible epigenetic mechanisms such as DNA methylation and histone modifications potentially playing a key role in controlling the process. Understanding these mechanisms may lead to new effective therapies targeting cancer metastasis.

BIOCHEMICAL JOURNAL (2021)

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Review Pharmacology & Pharmacy

A review of nanoparticle drug delivery systems responsive to endogenous breast cancer microenvironment

Tengteng Zou et al.

Summary: The breast cancer microenvironment, with its endogenous stimuli, plays a significant role in tumor growth. Researchers have developed innovative NDDS that respond to these internal stimuli for targeted drug delivery, involving materials, targeting molecules, drug loading, targeting position, and function to enhance drug efficacy in the tumor microenvironment.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Prime editing - an update on the field

Janine Scholefield et al.

GENE THERAPY (2021)

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Article Cell Biology

Identification and characterization of N6-methyladenosine modification of circRNAs in glioblastoma

Yuhao Zhang et al.

Summary: This study systematically characterized the N6-methyladenosine modification pattern of circular RNAs in glioblastoma, identifying potential roles of N6-methyladenosine-modified circRNAs in the development of GBM. Through comprehensive RNA methylation sequencing and bioinformatics analysis, key molecules associated with N6-methyladenosine-mediated GBM progression were identified for further investigation.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Multidisciplinary Sciences

In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy

Meiou Dai et al.

Summary: Through in vivo genome-wide CRISPR screening, tumor regulatory functions for components of the mTORC1/2 complex and YAP/Hippo pathway were identified in TNBC, showing that pharmacological inhibition of mTOR and YAP can reduce tumor growth in vivo.

NATURE COMMUNICATIONS (2021)

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Review Oncology

DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application

Chunhong Hu et al.

Summary: In summary, DNA methylation plays a crucial role in gene regulation and genome stability, and DNMT inhibitors can reverse epimutations, forming the basis for innovative cancer therapy strategies. Combining DNMT inhibitors with other treatments may offer new insights into more effective therapeutic approaches.

CLINICAL EPIGENETICS (2021)

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Review Medicine, General & Internal

Near infrared photoimmunotherapy for cancers: A translational perspective

Yasuhiro Maruoka et al.

Summary: Near-infrared photoimmunotherapy (NIR-PIT) is a highly-selective cancer treatment using a photoabsorbing dye, currently undergoing global phase III clinical trials and conditionally approved in Japan. In addition to rapid, selective cancer cell death, it also stimulates anti-tumour immunity and may have improved results in combination with immune-checkpoint inhibitors.

EBIOMEDICINE (2021)

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Review Oncology

Breast Cancer Aptamers: Current Sensing Targets, Available Aptamers, and Their Evaluation for Clinical Use in Diagnostics

Kathleen Varty et al.

Summary: Aptamers, short sequences of oligonucleotide or peptides, have gained popularity in oncology for their high specificity and binding affinity, making them ideal for sensing platforms. In this review, known aptamers for breast cancer detection are presented to aid researchers in understanding their advantages and disadvantages. The use of aptamers in breast cancer screening, diagnosis, and therapeutics shows promise, but further comparison of available aptamers and their corresponding biomarkers for breast cancer is needed.

CANCERS (2021)

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Review Oncology

Decoding LncRNAs

Lidia Borkiewicz et al.

Summary: Non-coding RNAs, particularly long non-coding RNAs, have gained attention for their significant roles in development, health, and disease, especially in the realm of tumor biology. Understanding the functions, structures, and interactomes of these molecules requires interdisciplinary efforts and the development of new methods. Research on lncRNAs has provided valuable insights into their involvement in diseases and their potential applications in medicine.

CANCERS (2021)

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Article Oncology

The Potential Use of Dynamics Changes of ctDNA and cfDNA in the Perioperative Period to Predict the Recurrence Risk in Early NSCLC

Xiaolong Zhao et al.

Summary: Postoperative circulating tumor DNA (ctDNA) is a promising method to predict the risk of recurrence in NSCLC patients. However, the amount of cell free DNA (cfDNA) significantly increases during surgery, and the dynamic changes of cfDNA combined with ctDNA can indicate the risk of recurrence accurately. Patients with positive ctDNA and decreased cfDNA after surgery have a higher risk of relapse.

FRONTIERS IN ONCOLOGY (2021)

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Review Nanoscience & Nanotechnology

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Shreelaxmi Gavas et al.

Summary: Nanotechnology has revolutionized cancer diagnosis and treatment by overcoming limitations of traditional therapies and multidrug resistance. Nanoparticles, with their unique advantages, offer new perspectives for cancer treatment. However, challenges still exist in research and clinical translation of nanotherapeutics.

NANOSCALE RESEARCH LETTERS (2021)

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Review Biochemistry & Molecular Biology

Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders

Vincenza Aliperti et al.

Summary: Understanding the functions and altered expression of lncRNAs in neurodevelopmental and mental health diseases is essential to comprehend the complex transcriptional processes in brain function. Exploiting lncRNAs as novel targets for treating neurological disorders shows promising potential.

NON-CODING RNA (2021)

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Article Biotechnology & Applied Microbiology

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

Pan Gao et al.

Summary: In mice, both the PE2 and HDR systems led to cell-specific loss of expression of an mRNA/long noncoding RNA gene pair with single nucleotide variants in TFBS. However, PE2 showed higher editing efficiency and lower off-target mutation risk compared to HDR.

GENOME BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The role of m6A modification in the biological functions and diseases

Xiulin Jiang et al.

Summary: This paper highlights the importance of m6A RNA modification in eukaryotic RNA, including the roles of m6A methyltransferases, demethylases, and binding proteins. It emphasizes the crucial role of m6A RNA modification in the development of human cancers and discusses its impact on the physiological and pathological progressions of hematopoietic, central nervous, and reproductive systems.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Oncology

Combining epigenetic drugs with other therapies for solid tumours - past lessons and future promise

Daphne Morel et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Cell Biology

Methods for analysis of circular RNAs

Poonam R. Pandey et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2020)

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Article Biochemistry & Molecular Biology

PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition

Li-Ting Wang et al.

EMBO REPORTS (2020)

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Review Biochemistry & Molecular Biology

A short guide to histone deacetylases including recent progress on class II enzymes

Suk-Youl Park et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Review Biochemistry & Molecular Biology

microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

Ranjana K. Kanchan et al.

MOLECULAR CANCER (2020)

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Review Biochemistry & Molecular Biology

Role of HDACs in normal and malignant hematopoiesis

Pan Wang et al.

MOLECULAR CANCER (2020)

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Review Multidisciplinary Sciences

The promise and challenge of therapeutic genome editing

Jennifer A. Doudna

NATURE (2020)

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Article Biochemistry & Molecular Biology

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

Tao Liu et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Biochemistry & Molecular Biology

HDAC3 functions as a positive regulator in Notch signal transduction

Francesca Ferrante et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Oncology

METTL14 promotes the migration and invasion of breast cancer cells by modulating N6-methyladenosine and hsa-miR-146a-5p expression

Dandan Yi et al.

ONCOLOGY REPORTS (2020)

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Article Oncology

Breast cancer early detection: A phased approach to implementation

Ophira Ginsburg et al.

CANCER (2020)

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Review Biochemistry & Molecular Biology

Protein Histidine Methylation

Sebastian Kwiatkowski et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2020)

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Article Cell Biology

Modulation of circRNA Metabolism by m6A Modification

Gaia Di Timoteo et al.

CELL REPORTS (2020)

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Review Genetics & Heredity

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Giorgio Milazzo et al.

GENES (2020)

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Article Genetics & Heredity

Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors

Duran Sueruen et al.

GENES (2020)

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Article Oncology

Decitabine Response in Breast Cancer Requires Efficient Drug Processing and Is Not Limited by Multidrug Resistance

Margaret L. Dahn et al.

MOLECULAR CANCER THERAPEUTICS (2020)

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Review Cell Biology

Epigenetics in Inflammatory Breast Cancer: Biological Features and Therapeutic Perspectives

Flavia Lima Costa Faldoni et al.

CELLS (2020)

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Review Biochemistry & Molecular Biology

Advances of epigenetic editing

Rutger A. F. Gjaltema et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

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Review Oncology

DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy

Jiayu Zhang et al.

CANCERS (2020)

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Review Biotechnology & Applied Microbiology

Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors

Andrew V. Anzalone et al.

NATURE BIOTECHNOLOGY (2020)

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Article Multidisciplinary Sciences

Partitioning of cancer therapeutics in nuclear condensates

Isaac A. Klein et al.

SCIENCE (2020)

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Editorial Material Biochemistry & Molecular Biology

Partitioning of Chemotherapeutics into Nuclear Condensates-Opening the Door to New Approaches for Drug Development

Thomas P. Howard et al.

MOLECULAR CELL (2020)

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Review Cell Biology

The roles of long noncoding RNAs in breast cancer metastasis

Lingxia Liu et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

Prime editing for functional repair in patient-derived disease models

Imre F. Schene et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Cell-free DNA concentration in patients with clinical or mammographic suspicion of breast cancer

Michal Peled et al.

SCIENTIFIC REPORTS (2020)

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Review Plant Sciences

Genome Edited Crops Touch the Market: A View on the Global Development and Regulatory Environment

Jochen Menz et al.

FRONTIERS IN PLANT SCIENCE (2020)

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Review Oncology

Non-Invasive Biomarkers for Early Detection of Breast Cancer

Jiawei Li et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yihan Yao et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Review Biochemistry & Molecular Biology

Circular RNA: metabolism, functions and interactions with proteins

Wei-Yi Zhou et al.

MOLECULAR CANCER (2020)

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Review Medicine, General & Internal

Challenges and achievements of liquid biopsy technologies employed in early breast cancer

Alfonso Alba-Bernal et al.

EBIOMEDICINE (2020)

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Article Cell Biology

Integrative Analysis of DNA Methylation and Gene Expression to Determine Specific Diagnostic Biomarkers and Prognostic Biomarkers of Breast Cancer

Ming Zhang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

An integrative multi-omics network-based approach identifies key regulators for breast cancer

Yi-Xiao Chen et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

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Review Genetics & Heredity

Combinatorial Epigenetic and Immunotherapy in Breast Cancer Management: A Literature Review

Yu-Ting Lee et al.

EPIGENOMES (2020)

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Review Genetics & Heredity

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BRCA1 promoter methylation in peripheral blood cells is associated with increased risk of breast cancer with BRCA1 promoter methylation

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MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer

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Cytotoxicity Mediated by Histone Deacetylase Inhibitors in Cancer Cells: Mechanisms and Potential Clinical Implications

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p300 (histone acetyltransferase) biomarker predicts prostate cancer biochemical recurrence and correlates with changes in epithelia nuclear size and shape

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Multivalent engagement of chromatin modifications by linked binding modules

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Tumour invasion and metastasis initiated by microRNA 10b in breast cancer

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CURRENT OPINION IN CELL BIOLOGY (2007)

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MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)

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Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation

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Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits

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Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole

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Histone deacetylase 3 (HDAC3) and other class IHDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

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KLF4, p21 and context-dependent opposing forces in cancer

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Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast

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DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

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Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability

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Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1

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Histone acetylation and deacetylation: importance in inflammatory lung diseases

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

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NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

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Sirtuins: Sir2-related NAD-dependent protein deacetylases

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Expression profile of histone deacetylase 1 in gastric cancer tissues

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Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

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