☆ 4.7 Article

CADMA-Chem: A Computational Protocol Based on Chemical Properties Aimed to Design Multifunctional Antioxidants

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biotechnology & Applied Microbiology

Alzheimer's and Parkinson's disease therapies in the clinic

Puja Chopade et al.

Summary: This review examines past and present therapeutic strategies for Alzheimer's disease and Parkinson's disease, exploring trends in clinical trials and the shift towards targeting the root causes of disease progression. The study emphasizes the importance of inhibiting the underlying causes of neurodegeneration and highlights the under-utilization of delivery vehicles for therapeutics.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Effects of Polyphenols in Aging and Neurodegeneration Associated with Oxidative Stress

Francisca Rivas et al.

Summary: Aging is a biological, irreversible, progressive process influenced by genetic and environmental factors, leading to a gradual decline in physical and mental capacity and increased risk of neurodegenerative diseases. Antioxidant therapy can reduce oxidative damage, and polyphenols have potential antioxidant properties to prevent harmful oxidative processes associated with neurodegenerative disorders.

CURRENT MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Review Chemistry, Medicinal

The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone

Lucas Caruso et al.

Summary: Cardiovascular diseases are the leading cause of death worldwide. The traditional approach of developing cardiovascular drugs targeting a single molecule overlooks the multifactorial nature of the diseases. The current treatment strategy involves the combination of multiple drugs, and the development of multitarget drugs has become a promising strategy.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Genome-wide analysis of genetic predisposition to common polygenic cancers

Alireza Nazarian et al.

Summary: We investigated the genetic architecture of lung, breast, prostate, and colorectal cancers and identified novel SNPs and genes associated with these cancers, which will advance our understanding of the genetic heterogeneity of common cancers.

JOURNAL OF APPLIED GENETICS (2022)

添加到收藏夹

Review Clinical Neurology

A critical appraisal of MAO-B inhibitors in the treatment of Parkinson's disease

Wolfgang H. Jost

Summary: Since the 1980s, MAO-B inhibitors have gained significant status in the treatment of Parkinson's disease, but the neuroprotective effect of these inhibitors has often been misunderstood. Currently, rasagiline, selegiline, and safinamide are commonly used therapeutic options, but they are often not properly appreciated.

JOURNAL OF NEURAL TRANSMISSION (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

Anushruti Ashok et al.

Summary: Free radicals, generated during normal metabolic activities, play a crucial role in neurodegenerative diseases through oxidative stress, which disrupts redox balance. Antioxidant therapy, including nanoparticle-mediated delivery of antioxidant enzymes, shows promise in addressing the challenges of clinical translation in treating these diseases.

ANTIOXIDANTS (2022)

添加到收藏夹

Article Psychology, Clinical

Multifactorial causal beliefs and colorectal cancer screening: A structural equation modeling investigation

Caitlin Allen et al.

Summary: This study tested a conceptual model on the relationship between individuals' understanding of multifactorial nature of cancer and colorectal cancer screening, finding that multifactorial causal beliefs were associated with cancer risk perceptions and cancer cognitions, but not with colorectal cancer screening behavior. Further research is needed to determine if the model can be applied to other cancer-related health behaviors.

JOURNAL OF HEALTH PSYCHOLOGY (2022)

添加到收藏夹

Review Clinical Neurology

COMT Inhibitors in the Management of Parkinson's Disease

Margherita Fabbri et al.

Summary: Levodopa remains the standard treatment for Parkinson's disease, but its shortcomings have led to the development of additional therapies like COMT-Is, including entacapone and opicapone. These medications have shown similar efficacy in reducing motor fluctuations, with entacapone and opicapone also having a wider market than tolcapone. The combination of COMT-Is with new levodopa formulations shows promise in improving management of motor fluctuations.

CNS DRUGS (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

What are the challenges with multi-targeted drug design for complex diseases?

Agata Zieba et al.

Summary: Despite the challenges involved, the design of multi-target ligands for the treatment of complex diseases is worth the effort. Key aspects in the design include appropriate target selection, activity balancing, and ligand drug-likeness. In silico methods, such as inverse docking, pharmacophore modeling, machine learning, and network pharmacology, are valuable tools for the design of multi-target drugs.

EXPERT OPINION ON DRUG DISCOVERY (2022)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Exploring the multifactorial aspects of Gut Microbiome in Parkinson's Disease

Sujith Pavan et al.

Summary: Advanced research in health science has expanded our understanding of disease pathophysiology. Recent studies have revealed the link between Parkinson's Disease and gut microbiota, exploring the potential of gut microbial signatures as predictors and alternative treatment options.

FOLIA MICROBIOLOGICA (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

Daniel Mihai Teleanu et al.

Summary: This review summarizes the correlation between oxidative stress and neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. It also discusses the impact of oxidative stress on the inflammatory response. Antioxidants are considered potential therapeutic options for these disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

Shruti Shandilya et al.

Summary: Recent studies have shown the significant impact of gut microbiota on brain functions, particularly in oxidative stress and neuroprotection. Gut bacteria metabolites play a crucial role in the pathogenesis of neurodegenerative diseases.

JOURNAL OF ADVANCED RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Oxidative Stress, Vascular Endothelium, and the Pathology of Neurodegeneration in Retina

Xin Shi et al.

Summary: This article reviews the impact of oxidative stress (OS) on endothelial dysfunction (ED) in the retina and explores the mechanistic links between the two and their role in different retinal neurodegenerative diseases. Understanding the role of endothelial function may lead to new therapeutic approaches.

ANTIOXIDANTS (2022)

添加到收藏夹

Article Chemistry, Physical

Newly designed melatonin analogues with potential neuroprotective effects

Cesar Millan-Pacheco et al.

Summary: This study explored the molecular recognition between human COMT and two newly designed melatonin analogues, suggesting that these analogues may act as COMT inhibitors. The analysis of binding energies revealed that the binding energy between COMT and dm-115 is similar to that of L-dopa and slightly higher than that of dopamine.

THEORETICAL CHEMISTRY ACCOUNTS (2022)

添加到收藏夹

Review Gastroenterology & Hepatology

Non-alcoholic fatty liver disease development: A multifactorial pathogenic phenomena

Aamir Bashir et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder characterized by the accumulation of excessive fat in the liver. It can occur in both obese and non-obese individuals, and its development is a complex, multifactorial process. The imbalance between lipid uptake, synthesis, and metabolism in the liver is the underlying mechanism, but the exact progression mechanism is not fully understood.

LIVER RESEARCH (2022)

添加到收藏夹

Article Neurosciences

Multi-Target Drug Candidates for Multifactorial Alzheimer's Disease: AChE and NMDAR as Molecular Targets

Md. Sahab Uddin et al.

Summary: Alzheimer's disease is a common form of dementia in elderly people, with approved medications including ChEIs and NMDAR antagonists. Single-target therapies have shown to be unsuccessful in treating the multifactorial symptoms or disease progression of Alzheimer's, highlighting the need for diverse pharmacological targets in treatment.

MOLECULAR NEUROBIOLOGY (2021)

添加到收藏夹

Review Neurosciences

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

Gabriella Marucci et al.

Summary: Alzheimer's disease is characterized by cognitive decline and behavioral manifestations, with the most common treatment being cholinesterase inhibitors. Despite their limited efficacy and gastrointestinal side effects, ChE-Is remain a pharmacotherapeutic resource for AD treatment. Investigating combinations with other drug classes may offer renewed interest in the use of ChE-Is for adult-onset dementia disorders.

NEUROPHARMACOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Opicapone (Ongentys): A New COMT Inhibitor for the Treatment of Parkinson's Disease

Erin St Onge et al.

Summary: Opicapone, a newly FDA-approved COMT inhibitor, has shown to be safe and effective in reducing off episodes in PD patients when used as an adjunct to levodopa/carbidopa. Preclinical trials demonstrated marked S-COMT inhibition with acceptable safety and efficacy profile, while phase 3 clinical trials supported its efficacy compared to placebo and noninferiority to entacapone. Common adverse effects include dyskinesias, constipation, hypotension/syncope, increased blood creatine kinase, and weight loss.

ANNALS OF PHARMACOTHERAPY (2021)

添加到收藏夹

Review Neurosciences

Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases

Amalia Merelli et al.

Summary: Cerebral hypoxia-ischemia triggers various biological responses leading to neurodegeneration, but also activates self-defense mechanisms. Hypoxia inducible factor 1 alpha may induce overexpression of erythropoietin receptor, presenting a therapeutic opportunity for intervention.

JOURNAL OF ALZHEIMERS DISEASE (2021)

添加到收藏夹

Review Cell Biology

The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide

Yew Mun Lee et al.

Summary: Cellular ROS can drive important biological signaling pathways through redox signaling, with mitochondria and mitochondrial H2O2 potentially implicated in the pathogenesis of neurodegenerative diseases.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders

Annia Galano et al.

Summary: Melatonin and its derivatives have potential in antioxidant protection and neuroprotection, and chemistry research may lead to the discovery of new compounds. Research is also focused on the discovery of multifunctional pharmaceuticals for use in various diseases including neurodegenerative disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress

Anamaria Jurcau

Summary: With an aging population, the incidence of neurodegenerative diseases is on the rise, and current treatments primarily focus on symptom relief. Preventative measures such as a healthy lifestyle and avoidance of oxidative stress are recommended.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Monoamine Oxidase-B (MAO-B) Inhibitors in the Treatment of Alzheimer's and Parkinson's Disease

Zeynep Ozdemir et al.

Summary: This study reviewed 105 papers discussing the structures and usage of MAO-B inhibitors, as well as their potential effects in Alzheimer's and Parkinson's disease treatment. It also evaluated the inhibitory effects of 44 different compounds on the MAO-B enzyme. The study suggests that MAO-B inhibitor drugs effective in treating Parkinson's disease may also be effective in treating Alzheimer's disease.

CURRENT MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Review Clinical Neurology

Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials

Javed Ahmed et al.

Summary: Melatonin has potential neuroprotective effects in neonatal encephalopathy, but limited clinical evidence supports this. The role of Melatonin in the era of therapeutic hypothermia remains unclear, indicating a need for further research in well-designed clinical trials.

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY (2021)

添加到收藏夹

Review Chemistry, Medicinal

Multi-target Drug Design of Anti-Alzheimer's Disease based on Tacrine

Sen Tian et al.

Summary: The research progress of tacrine-based multi-target directed ligands (MTDLs) is summarized in this paper, showing their potential as effective treatment strategy for Alzheimer's disease. By targeting multiple sites, such as the active catalytic site and the peripheral anion site of AChE, these MTDLs can have dual-site inhibition effects. Additionally, they can be designed based on other theories of AD to modify the formation of beta-amyloid, enhance oxidation resistance, or chelate metals.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Demographic perspectives on the rise of longevity

James W. Vaupel et al.

Summary: This article reviews key strands of demographic research on past trends in human longevity and explores possible future trends in life expectancy at birth. Life expectancy has been increasing at a steady pace, leading to a more equal distribution of individual life spans, but there is considerable uncertainty in forecasting future trends.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Preclinical Evidence for the Interplay between Oxidative Stress and RIP1-Dependent Cell Death in Neurodegeneration: State of the Art and Possible Therapeutic Implications

Danuta Jantas et al.

Summary: Neurodegenerative diseases are common chronic conditions without definitive treatment. Oxidative stress and necroptosis are thought to be closely related to the pathogenesis of neurodegenerative diseases. Multi-potential neuroprotectants with antioxidant and anti-necroptotic properties may be an effective therapeutic strategy.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration

Tomohiro Nakamura et al.

Summary: Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases are characterized by progressive degeneration of synapses and neurons, often attributed to accumulated misfolded/aggregated proteins. Excessive reactive oxygen and nitrogen species in the brain may contribute to protein misfolding, potentially exacerbated by genetic mutations and environmental factors. Understanding the role of reactive nitrogen species in post-translational modifications of proteins could lead to therapeutic interventions for neurodegenerative diseases.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Current Trends in Neurodegeneration: Cross Talks between Oxidative Stress, Cell Death, and Inflammation

Tapan Behl et al.

Summary: The human body is complex and comprises various living cells and extracellular material forming tissues, organs, and organ systems. While most human cells turnover regularly, postmitotic nerve cells have the exceptional ability to regenerate and sustain throughout an individual's life to safeguard the central nervous system's functioning. Neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, result from factors like oxidative stress, cell death, and neuroinflammation, causing neuronal degradation and impacting the quality of life for millions worldwide.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Letter Clinical Neurology

Remarkable clinical responses of non-fluctuating Parkinson's disease (PD) after alternating catechol O-methyltransferase inhibitors: case series switching from entacapone 200 ∼ 300 mg/day to opicapone 25 mg/day

Kiyotaka Nakamagoe et al.

NEUROLOGICAL SCIENCES (2021)

添加到收藏夹

Review Nutrition & Dietetics

Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases

Joao V. S. Guerra et al.

Summary: The incidence of NCDs is increasing globally, with changes in dietary and physical activity patterns, as well as genetic factors, being main contributors. Understanding the molecular mechanisms of these diseases can help in developing more effective treatments. NCDs play a crucial role globally and have an impact on the progression and severity of COVID-19.

NUTRIENTS (2021)

添加到收藏夹

Review Psychiatry

Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders

Lindsay M. Melhuish Beaupre et al.

Summary: Melatonin, an ancient molecule found in various tissues, plays a role in promoting sleep and neuroprotection. With antioxidant and free radical scavenging properties, melatonin is crucial in mitochondria function. Declining levels of melatonin with age and in psychiatric disorders suggest its potential as a treatment for neurodegenerative diseases.

TRANSLATIONAL PSYCHIATRY (2021)

添加到收藏夹

Review Cell Biology

Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders

Adrian Mor et al.

Summary: Neurodegenerative disorders have a negative impact on patients' quality of life, with genetic background, oxidative stress, and mitochondrial damage being partly responsible for their development. Activation of the kynurenine pathway leads to the accumulation of neuroactive and pro-oxidative metabolites, increasing oxidative stress and disrupting cellular energy metabolism. Modulating KP activity may help alleviate symptoms of neurodegenerative disorders.

CELLS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative Stress and Neurodegeneration: Interconnected Processes in PolyQ Diseases

Ioannis Gkekas et al.

Summary: Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat expansions within disease-causing genes, leading to protein inclusions and oxidative stress. The interplay between oxidative stress, neurodegeneration, and neuroinflammation in polyQ diseases is discussed, with potential pharmaceutical interventions to delay disease progression.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Longevity leap: mind the healthspan gap

Armin Garmany et al.

Summary: Life expectancy has increased by three decades since the mid-twentieth century, but healthspan expansion has not followed suit due to the prevalence of chronic diseases. Contemporary efforts are focused on extending health horizon by integrating public and societal endeavors with emerging interventions targeting age-related multimorbidity and frailty. This multidimensional approach, boosted by modern technologies, aims to bridge the healthspan-lifespan gap for a future of global wellbeing.

NPJ REGENERATIVE MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews

Marta Perez-Gomez Moreta et al.

Summary: The study confirmed a low efficacy of AChEI in improving cognitive symptoms of patients with mild to moderate AD, especially in cognitive aspects. However, AChEI showed better effects in improving the global state, with donepezil being the most effective treatment. Nonetheless, there was no evidence of improvement in behavioral disturbances with the use of AChEI.

BIOMEDICINES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of Oxidative Damage in Alzheimer's Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery

Francesca Romana Buccellato et al.

Summary: Alzheimer's disease is a neurodegenerative disorder with no effective treatments, emphasizing the importance of discovering biomarkers for early diagnosis. Oxidative damage is involved in the molecular mechanisms linking amyloid-beta and hyperphosphorylated tau to microglia response, playing a crucial role in the pathogenesis of AD and neurodegeneration.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Free radical scavenging activity of newly designed sesamol derivatives

Laura M. Castro-Gonzalez et al.

Summary: This study focuses on the free radical scavenging activity of sesamol derivatives, showing their potential as antioxidants, with single electron transfer and formal hydrogen atom transfer identified as the main reaction mechanisms.

NEW JOURNAL OF CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Computationally designed p-coumaric acid analogs: searching for neuroprotective antioxidants

Miguel Reina et al.

Summary: A systematic search for new p-coumaric acid derivatives was conducted using a computer-assisted protocol, resulting in the selection of 10 derivatives with favorable drug-like behavior and lower toxicity. Three of these derivatives were identified as promising chemical antioxidants, potentially more effective than p-coumaric acid itself in combating oxidative stress. These findings suggest potential applications in developing new non-nitrocatechol inhibitors for Parkinson's disease treatment without the side effects of current inhibitors.

NEW JOURNAL OF CHEMISTRY (2021)

添加到收藏夹

Review Neurosciences

Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

Vanessa Silva Gontijo et al.

CURRENT NEUROPHARMACOLOGY (2020)

添加到收藏夹

Article Ophthalmology

Early retinal neurodegeneration in preclinical diabetic retinopathy: a multifactorial investigation

Ibrahim Toprak et al.

EYE (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders

Wei-Jia Kong et al.

PHARMACOLOGY & THERAPEUTICS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways

Mao-lin Wan et al.

BIOSCIENCE REPORTS (2020)

添加到收藏夹

Review Biochemical Research Methods

Treatment of Parkinson's Disease by MAO-B Inhibitors, New Therapies and Future Challenges - A Mini-Review

Della G. T. Parambi

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2020)

添加到收藏夹

Review Chemistry, Medicinal

Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives

Gagandeep Maan et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Review Clinical Neurology

Relevance of biomarkers across different neurodegenerative

Alexander J. Ehrenberg et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection

Ekta Singh et al.

MOLECULAR BIOLOGY REPORTS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative Stress, a Crossroad between Rare Diseases and Neurodegeneration

Carmen Espinos et al.

ANTIOXIDANTS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Computationally Designed Sesamol Derivatives Proposed as Potent Antioxidants

Laura M. Castro-Gonzalez et al.

ACS OMEGA (2020)

添加到收藏夹

Review Biochemical Research Methods

Organs-on-a-chip as model systems for multifactorial musculoskeletal diseases

Chiara Arrigoni et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration

Md Sahab Uddin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

Anna Picca et al.

ANTIOXIDANTS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Dominic S. A. Simpson et al.

ANTIOXIDANTS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration

Patrycja Michalska et al.

ANTIOXIDANTS (2020)

添加到收藏夹

Review Biology

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration

Andrey Y. Abramov et al.

LIFE-BASEL (2020)

添加到收藏夹

Article Chemistry, Physical

Computer-designed melatonin derivatives: potent peroxyl radical scavengers with no pro-oxidant behavior

Romina Castaneda-Arriaga et al.

THEORETICAL CHEMISTRY ACCOUNTS (2020)

添加到收藏夹

Review Neurosciences

Ceramide signalling in inherited and multifactorial brain metabolic diseases

Devesh C. Pant et al.

NEUROBIOLOGY OF DISEASE (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017

Günther Deuschl et al.

Lancet Public Health (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

Fiona Limanaqi et al.

ANTIOXIDANTS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Neuron-glia: understanding cellular copper homeostasis, its cross-talk and their contribution towards neurodegenerative diseases

Ashima Bhattacharjee et al.

METALLOMICS (2020)

添加到收藏夹

Review Chemistry, Medicinal

Emerging Proof of Protein Misfolding and Interactions in Multifactorial Alzheimer's Disease

Md Sahab Uddin et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Masha G. Savelieff et al.

CHEMICAL REVIEWS (2019)

添加到收藏夹

Review Clinical Neurology

Understanding multifactorial architecture of Parkinson's disease: pathophysiology to management

Ramandeep Kaur et al.

NEUROLOGICAL SCIENCES (2019)

添加到收藏夹

Review Chemistry, Medicinal

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

Viktoriya Ivasiv et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Review Endocrinology & Metabolism

Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease

Linda L. Demer et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

添加到收藏夹

Review Neurosciences

The role of zinc, copper, manganese and iron in neurodegenerative diseases

Leda Mezzaroba et al.

NEUROTOXICOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer's Disease

Sudip Dhakal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Dopamine, Oxidative Stress and Protein-Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases

Enrico Monzani et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Review Clinical Neurology

Inhibitors of MAO-B and COMT: their effects on brain dopamine levels and uses in Parkinson's disease

John P. M. Finberg

JOURNAL OF NEURAL TRANSMISSION (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Melatonin and its metabolites as chemical agents capable of directly repairing oxidized DNA

Adriana Perez-Gonzalez et al.

JOURNAL OF PINEAL RESEARCH (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

] Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimer's Disease: An Update

Matheus de Freitas Silva et al.

CURRENT MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Neurosciences

Changing Paradigm from one Target one Ligand Towards Multi-target Directed Ligand Design for Key Drug Targets of Alzheimer Disease: An Important Role of In Silico Methods in Multi-target Directed Ligands Design

Akhil Kumar et al.

CURRENT NEUROPHARMACOLOGY (2018)

添加到收藏夹

Article Oncology

Risk factors for prostate cancer: A multifactorial case-control study

Saima Shakil Malik et al.

CURRENT PROBLEMS IN CANCER (2018)

添加到收藏夹

Editorial Material Urology & Nephrology

Complex Polygenic Nature of Testicular Germ Cell Cancer Suggests Multifactorial Aetiology

Ewa Rajpert-De Meyts et al.

EUROPEAN UROLOGY (2018)

添加到收藏夹

Article Neurosciences

Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease

Cheng-Xin Gong et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

添加到收藏夹

Review Neurosciences

Multi-Faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer's Disease

Abhishek Ankur Balmik et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

添加到收藏夹

Review Neurosciences

The neuroprotective role of melatonin in neurological disorders

B. S. Alghamdi

JOURNAL OF NEUROSCIENCE RESEARCH (2018)

添加到收藏夹

Review Medicine, Research & Experimental

The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders

Roberta Giampietro et al.

MOLECULAR PHARMACEUTICS (2018)

添加到收藏夹

Article Chemistry, Medicinal

Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease

Kris Simone T. Dias et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Medicinal

Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation

Elena Simoni et al.

FUTURE MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Review Clinical Neurology

Multifactorial sleep disturbance in Parkinson's disease

J. Andrew Albers et al.

SLEEP MEDICINE (2017)

添加到收藏夹

Article Chemistry, Physical

Estimation of empirically fitted parameters for calculating pK a values of thiols in a fast and reliable way

Adriana Perez-Gonzalez et al.

THEORETICAL CHEMISTRY ACCOUNTS (2017)

添加到收藏夹

Review Clinical Neurology

The vascular facet of late-onset Alzheimer's disease: an essential factor in a complex multifactorial disorder

Yasser Iturria-Medina et al.

CURRENT OPINION IN NEUROLOGY (2017)

添加到收藏夹

Article Chemistry, Medicinal

Exploring Chemical Routes Relevant to the Toxicity of Paracetamol and Its meta-Analogue at a Molecular Level

Romina Castaneda-Arriaga et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties

Yan Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Review Neurosciences

Role of MicroRNA Let-7 in Modulating Multifactorial Aspect of Neurodegenerative Diseases: an Overview

Shamsuzzama et al.

MOLECULAR NEUROBIOLOGY (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Protein oxidation and peroxidation

Michael J. Davies

BIOCHEMICAL JOURNAL (2016)

添加到收藏夹

Review Chemistry, Medicinal

Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage

Yang Yu et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2016)

添加到收藏夹

Article Chemistry, Medicinal

Empirically Fitted Parameters for Calculating pKa Values with Small Deviations from Experiments Using a Simple Computational Strategy

Annia Galano et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer's Disease

Yingbo Fu et al.

MOLECULES (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Catechol-O-Methyltransferase Inhibitors in Parkinson's Disease

Thomas Mueller

DRUGS (2015)

添加到收藏夹

Article Chemistry, Physical

Site reactivity in the free radicals induced damage to leucine residues: a theoretical study

M. E. Medina et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2015)

添加到收藏夹

Article Chemistry, Physical

A proton-electron sequential transfer mechanism: theoretical evidence about its biological relevance

L. Munoz-Rugeles et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Modelling the chemical repair of protein carbon-centered radicals formed via oxidative damage with dihydrolipoic acid

Romina Castaneda-Arriaga et al.

RSC ADVANCES (2015)

添加到收藏夹

Article Chemistry, Physical

Hydrogen-Atom Abstraction from a Model Amino Acid: Dependence on the Attacking Radical

Ruth I. J. Amos et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2015)

添加到收藏夹

Article Endocrinology & Metabolism

Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis

Annia Galano et al.

JOURNAL OF PINEAL RESEARCH (2015)

添加到收藏夹

Article Gerontology

Lifespan and Healthspan: Past, Present, and Promise

Eileen M. Crimmins

GERONTOLOGIST (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multi-Target Drug Design Approaches for Multifactorial Diseases: From Neurodegenerative to Cardiovascular Applications

M. G. Katselou et al.

CURRENT MEDICINAL CHEMISTRY (2014)

添加到收藏夹

Article Pharmacology & Pharmacy

Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease

Kris Simone Tranches Dias et al.

Current Neuropharmacology (2014)

添加到收藏夹

Review Chemistry, Medicinal

Multifunctional compounds: Smart molecules for multifactorial diseases

Yogita Bansal et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

The kinetics of the reaction of nitrogen dioxide with iron(II)- and iron(III) cytochrome c

Anastasia S. Domazou et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

添加到收藏夹

Article Chemistry, Physical

Hydrogen Bonding Constrains Free Radical Reaction Dynamics at Serine and Threonine Residues in Peptides

Daniel A. Thomas et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2014)

添加到收藏夹

Review Environmental Sciences

Abnormal Copper Homeostasis: Mechanisms and Roles in Neurodegeneration

Mario Manto

TOXICS (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Computational Study on the Attack of •OH Radicals on Aromatic Amino Acids

J. I. Mujika et al.

CHEMISTRY-A EUROPEAN JOURNAL (2013)

添加到收藏夹

Article Chemistry, Medicinal

Understanding the Molecular Properties and Metabolism of Top Prescribed Drugs

Haizhen Zhong et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Computational Methodology for Accurate Predictions of Rate Constants in Solution: Application to the Assessment of Primary Antioxidant Activity

Annia Galano et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2013)

添加到收藏夹

Article Chemistry, Physical

A physicochemical examination of the free radical scavenging activity of Trolox: mechanism, kinetics and influence of the environment

Marta E. Alberto et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2013)

添加到收藏夹

Article Biochemical Research Methods

Catechol-O-methyltransferase in complex with substituted 3′-deoxyribose bisubstrate inhibitors

Manuel Ellermann et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

Elena Galea et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

John H. Viles

COORDINATION CHEMISTRY REVIEWS (2012)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

Henryk Kozlowski et al.

COORDINATION CHEMISTRY REVIEWS (2012)

添加到收藏夹

Article Chemistry, Medicinal

Is chemical synthetic accessibility computationally predictable for drug and lead-like molecules? A comparative assessment between medicinal and computational chemists

Pascal Bonnet

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)

添加到收藏夹

Article Chemistry, Medicinal

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

Jonah Cheung et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

添加到收藏夹

Article Chemistry, Organic

Reactivities of Amino Acid Derivatives Toward Hydrogen Abstraction by Cl• and OH•

Bun Chan et al.

JOURNAL OF ORGANIC CHEMISTRY (2012)

添加到收藏夹

Article Chemistry, Physical

Conformation-Dependent •OH/H2O2 Hydrogen Abstraction Reaction Cycles of Gly and Ala Residues: A Comparative Theoretical Study

Michael C. Owen et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2012)

添加到收藏夹

Article Chemistry, Physical

On the evolution of one-electron-oxidized deoxyguanosine in damaged DNA under physiological conditions: a DFT and ONIOM study on proton transfer and equilibrium

Annia Galano et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hydrogen Abstraction by Chlorine Atom from Amino Acids: Remarkable Influence of Polar Effects on Regioselectivity

Robert J. O'Reilly et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Probing the links between in vitro potency, ADMET and physicochemical parameters

M. Paul Gleeson et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Oxidative damage DNA: 8-oxoGua and 8-oxodG as molecular markers of cancer

Krzysztof Roszkowski et al.

MEDICAL SCIENCE MONITOR (2011)

添加到收藏夹

Article Chemistry, Physical

On the direct scavenging activity of melatonin towards hydroxyl and a series of peroxyl radicals

Annia Galano

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Reduction of protein radicals by GSH and ascorbate: potential biological significance

Janusz M. Gebicki et al.

AMINO ACIDS (2010)

添加到收藏夹

Article Chemistry, Physical

Primary Steps in the Reaction of OH Radicals with Peptide Systems: Perspective from a Study of Model Amides

Hoang Q. Doan et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Efficient repair of protein radicals by ascorbate

Anastasia S. Domazou et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

添加到收藏夹

Article

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

ATHANASIOS VALAVANIDIS et al.

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS (2009)

添加到收藏夹

Article Chemistry, Physical

Computational Study of Copper(II) Complexation and Hydrolysis in Aqueous Solutions Using Mixed Cluster/Continuum Models

Vyacheslav S. Bryantsev et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2009)

添加到收藏夹

Review Chemistry, Physical

Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions

Aleksandr V. Marenich et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2009)

添加到收藏夹

Article Chemistry, Multidisciplinary

Peculiar Stability of Amino Acids and Peptides from a Radical Perspective

Zachary I. Watts et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-induced Cell Death

Sonia Gandhi et al.

MOLECULAR CELL (2009)

添加到收藏夹

Review Chemistry, Multidisciplinary

Oxidatively generated damage to the guanine moiety of DNA: Mechanistic aspects and formation in cells

Jean Cadet et al.

ACCOUNTS OF CHEMICAL RESEARCH (2008)

添加到收藏夹

Article Cell Biology

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy Lights and Shadows

Domenico Pratico

MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)

添加到收藏夹

Review Chemistry, Medicinal

The chemical toxicology of 2-deoxyribose oxidation in DNA

Peter C. Dedon

CHEMICAL RESEARCH IN TOXICOLOGY (2008)

添加到收藏夹

Article Chemistry, Medicinal

Combinatorial QSAR modeling of chemical toxicants tested against Tetrahymena pyriformis

Hao Zhu et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)

添加到收藏夹

Review Chemistry, Medicinal

Multi-target-directed ligands to combat neurodegenerative diseases

Andrea Cavalli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

添加到收藏夹

Review Clinical Neurology

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

Anthony H. V. Schapira

LANCET NEUROLOGY (2008)

添加到收藏夹

Article Neurosciences

Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection

Nirit Lev et al.

NEUROTOXICOLOGY (2008)

添加到收藏夹

Article Pharmacology & Pharmacy

Inhibition of acetylcholinesterase by coumarins: The case of coumarin 106

Adyary Fallarero et al.

PHARMACOLOGICAL RESEARCH (2008)

添加到收藏夹

Article Chemistry, Medicinal

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: Safinamide and coumarin analogs

Claudia Binda et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure and reaction based evaluation of synthetic accessibility

Krisztina Boda et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative stress and neurodegeneration: where are we now?

Barry Halliwell

JOURNAL OF NEUROCHEMISTRY (2006)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and biological evaluation of a novel series of ortho-nitrated inhibitors of catechol-O-methyltransferase

DA Learmonth et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Computer-based de novo design of drug-like molecules

G Schneider et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

添加到收藏夹

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

添加到收藏夹

Article Chemistry, Physical

H-atom abstraction by thiyl radicals from peptides and cyclic dipeptides. A theoretical study of reaction rates

DL Reid et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2003)

添加到收藏夹

Article Chemistry, Medicinal

Molecular properties that influence the oral bioavailability of drug candidates

DF Veber et al.

JOURNAL OF MEDICINAL CHEMISTRY (2002)

添加到收藏夹

Article Chemistry, Physical

Electron affinities and ionization potentials of nucleotide bases

SD Wetmore et al.

CHEMICAL PHYSICS LETTERS (2000)

添加到收藏夹

Article Biochemistry & Molecular Biology

Copper-ligand interactions and physiological free radical processes. Part 3. Influence of histidine, salicylic acid and anthranilic acid on copper-driven fenton chemistry in vitro

S Gaubert et al.

FREE RADICAL RESEARCH (2000)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cytoprotective antioxidant function of tyrosine and tryptophan residues in transmembrane proteins

B Moosmann et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.