4.7 Article

Ginsenoside Compound K Ameliorates Development of Diabetic Kidney Disease through Inhibiting TLR4 Activation Induced by Microbially Produced Imidazole Propionate

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity

Jia-yi He et al.

Summary: Panax notoginseng, a traditional Chinese medicine, has beneficial effects on diabetic kidney disease (DKD) by alleviating podocyte injury through inhibiting apoptosis and mitochondrial damage. Rb1, the main active ingredient of Panax notoginseng, combines with aldose reductase to effectively mitigate the progression of diabetic kidney disease.

ACTA PHARMACOLOGICA SINICA (2022)

Article Gastroenterology & Hepatology

Gut microbiome and health: mechanistic insights

Willem M. de Vos et al.

Summary: The gut microbiota plays a crucial role in regulating host health and its deviations are linked with various diseases. Understanding the molecular aspects of the gut microbiota's influence on health can lead to the development of novel therapies.
Review Plant Sciences

Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis

Soo Hyun Park et al.

Summary: This study conducted a systematic review and meta-analysis to investigate the comprehensive effect of Panax ginseng on metabolic parameters representing metabolic diseases. The results showed that ginseng supplementation can act as an adjuvant in preventing the development of metabolic diseases by improving markers related to blood glucose, blood pressure, and blood lipids.

JOURNAL OF GINSENG RESEARCH (2022)

Review Plant Sciences

Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects

Longxing Miao et al.

Summary: This paper provides an overview of the pharmacokinetics and pharmacological properties of Ginsenoside Rb2, as well as its mechanism of action in the prevention and treatment of various diseases. However, its clinical efficacy has not been evaluated and further research is needed.

JOURNAL OF GINSENG RESEARCH (2022)

Article Urology & Nephrology

Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease

Hima Sapa et al.

Summary: Cardiovascular disease (CVD) is a major cause of mortality among people with diabetic kidney disease (DKD). Traditional CVD risk factors cannot sufficiently explain the pathophysiology. Uremic solutes TMAO, ADMA, and SDMA have been associated with CVD in kidney failure patients, but limited data exist for populations with diabetes and less severe kidney disease.

AMERICAN JOURNAL OF KIDNEY DISEASES (2022)

Article Food Science & Technology

Role of Microbial Metabolites of Histidine in the Development of Colitis

Jiaqi Wu et al.

Summary: Meat-derived metabolite imidazole propionate (IMP) has been found to have detrimental effects on intestinal health and may contribute to the relapse of colitis by impairing the intestinal barrier and affecting the proliferation of goblet cells via the dysregulation of the miR-146b/Notch1 axis.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

Article Pharmacology & Pharmacy

Characteristics of Serum Metabolites and Gut Microbiota in Diabetic Kidney Disease

Bo Zhang et al.

Summary: This study investigated the relationship between serum metabolites and gut microbiota in the progression of diabetic kidney disease (DKD). The results showed significant alterations in serum metabolites and the composition and function of gut microbiota in DKD. The study also identified potential metabolic and microbial targets for the treatment of DKD.

FRONTIERS IN PHARMACOLOGY (2022)

Article Endocrinology & Metabolism

The Gut Microbiome Composition Is Altered in Long-standing Type 1 Diabetes and Associates With Glycemic Control and Disease- Related Complications

Julia I. P. van Heck et al.

Summary: The gut microbiome in patients with type 1 diabetes is altered and associated with glycemic control and diabetes-related complications. Factors such as HbA(1c) and disease duration play a significant role in the variation of the gut microbiome, while micro- and macrovascular complications also contribute to this variation.

DIABETES CARE (2022)

Review Immunology

The Specific Alteration of Gut Microbiota in Diabetic Kidney Diseases-A Systematic Review and Meta-Analysis

Yuwei Wang et al.

Summary: This study found specific microbial features in the gut microbiota of patients with DKD, including the expansion of Escherichia, Citrobacter, and Klebsiella, and the depletion of Roseburia. These microbial taxa may be closely related to DKD and serve as promising targets for the management of DKD.

FRONTIERS IN IMMUNOLOGY (2022)

Article Biotechnology & Applied Microbiology

Host-microbiome protein-protein interactions capture disease-relevant pathways

Hao Zhou et al.

Summary: This study explores the potential mechanisms through which human-associated bacteria affect host health, with a focus on diseases such as IBD, CRC, obesity, and T2D. By leveraging publicly available data and analyzing metagenomic studies, the researchers identify differential targeting of bacterial genes that interact with human proteins involved in immune, oncogenic, apoptotic, and endocrine signaling pathways. This host-centric analysis provides valuable insights into the role of the microbiome in disease development.

GENOME BIOLOGY (2022)

Review Plant Sciences

Pharmacological potential of ginseng and its major component ginsenosides

Zubair Ahmed Ratan et al.

Summary: Ginseng, as a traditional herb in Asian countries, has been used for thousands of years and contains a variety of active ingredients with numerous benefits, but further high-quality evidence is needed to prove its medicinal value.

JOURNAL OF GINSENG RESEARCH (2021)

Review Urology & Nephrology

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

Denise Mafra et al.

Summary: The authors discuss how food and specific nutrients could affect the uraemic phenotype in chronic kidney disease (CKD). They suggest using a food-as-medicine approach to prevent and treat CKD. Unhealthy diets have been identified as a major risk factor for poor health outcomes, sparking interest in the concept of 'food as medicine', especially in metabolic diseases like CKD.

NATURE REVIEWS NEPHROLOGY (2021)

Article Oncology

Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K/ AKT/FOXO3 pathway

Hui Liu et al.

Summary: The study showed that Rg1 treatment effectively improved cell viability, reduced apoptosis, attenuated inflammatory response, and alleviated oxidative stress induced by high glucose. In addition, Rg1 treatment in DN rats model demonstrated anti-inflammatory and antioxidant activities, and regulated the PI3K/AKT/FOXO3 pathway both in vitro and in vivo, suggesting its potential as a therapeutic agent for DN treatment.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

Plasma Metabolome and Lipidome Associations with Type 2 Diabetes and Diabetic Nephropathy

Yan Ming Tan et al.

Summary: This study conducted untargeted metabolomics analysis of plasma samples from healthy controls, patients with diabetes mellitus and normal renal function, and early diabetic nephropathy patients using LC-MS. The results identified differential abundance of various metabolites in different groups, with sugars and lipids being elevated in diabetic patients and kidney disease patients, while other substances showed significant differences between groups.

METABOLITES (2021)

Review Medicine, General & Internal

Chronic kidney disease

Kamyar Kalantar-Zadeh et al.

Summary: Chronic kidney disease is a progressive disease with no cure, and preserving kidney function through lifestyle adjustments and pharmacological interventions can improve outcomes. A plant-dominant, low-protein, and low-salt diet may help mitigate glomerular hyperfiltration and preserve renal function. Various pharmacotherapies can also be used to alter intrarenal haemodynamics and protect the kidney from further damage.

LANCET (2021)

Article Endocrinology & Metabolism

Kidney disease in diabetes: From mechanisms to clinical presentation and treatment strategies

Carlo Alberto Ricciardi et al.

Summary: Metabolic and haemodynamic perturbations play a key role in the development and progression of diabetic kidney disease (DKD). Controlling metabolic, lipid, and blood pressure levels is crucial in slowing the progression of DKD. Therapies targeting haemodynamic perturbations, such as inhibitors of the renin-angiotensin-aldosterone system (RAAS) and SGLT2 inhibitors, have shown success in the prevention and management of DKD.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

Review Pharmacology & Pharmacy

Panax Ginseng CAMey. as Medicine: The Potential Use of Panax Ginseng CAMey. as a Remedy for Kidney Protection from a Pharmacological Perspective

De Jin et al.

Summary: Panax ginseng has therapeutic properties such as anti-inflammatory, immunity enhancement, and regulation of metabolism, making it a potential medicine for DKD. Studies have shown that Panax ginseng can alleviate pathological conditions in DKD and improve clinical symptoms in patients.

FRONTIERS IN PHARMACOLOGY (2021)

Review Endocrinology & Metabolism

Roles of Gut Microbial Metabolites in Diabetic Kidney Disease

Qing Fang et al.

Summary: This review summarizes the role of gut microbial metabolites in the development and progression of diabetic kidney disease, providing insights into possible mechanisms of DKD and exploring potential therapeutic approaches.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Integrative & Complementary Medicine

Ginsenoside Rh1 Improves Type 2 Diabetic Nephropathy through AMPK/PI3K/Akt-Mediated Inflammation and Apoptosis Signaling Pathway

Wen-Ya Su et al.

Summary: This study evaluates the ameliorative effects of ginsenoside Rh1 on obesity-linked diabetic nephropathy induced by high fat diet and streptozotocin. The results suggest that G-Rh1 shows potential in improving treatment of DN.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Review Urology & Nephrology

Innate immunity in diabetic kidney disease

Sydney C. W. Tang et al.

NATURE REVIEWS NEPHROLOGY (2020)

Article Chemistry, Multidisciplinary

Alterations of the Human Gut Microbiome in Chronic Kidney Disease

Zhigang Ren et al.

ADVANCED SCIENCE (2020)

Article Multidisciplinary Sciences

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Antonio Molinaro et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease

Xin Sheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Editorial Material Urology & Nephrology

Gut microbial short-chain fatty acids and the risk of diabetes

Wei Ling Lau et al.

NATURE REVIEWS NEPHROLOGY (2019)

Article Multidisciplinary Sciences

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Koichi Kikuchi et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

Ara Koh et al.

Review Endocrinology & Metabolism

TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation

Licio A. Velloso et al.

ENDOCRINE REVIEWS (2015)

Article Multidisciplinary Sciences

Role of Toll-like receptors in diabetic renal lesions in a miniature pig model

Yuanyuan Feng et al.

SCIENCE ADVANCES (2015)

Review Medicine, Research & Experimental

Molecular mechanisms of diabetic kidney disease

Kimberly Reidy et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)